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EA201890146A1 - СПОСОБЫ ЛЕЧЕНИЯ СОЛИДНЫХ ОПУХОЛЕЙ С ИСПОЛЬЗОВАНИЕМ КОМБИНИРОВАННОЙ ТЕРАПИИ ИНГИБИТОРОМ mTOR В ВИДЕ НАНОЧАСТИЦ - Google Patents

СПОСОБЫ ЛЕЧЕНИЯ СОЛИДНЫХ ОПУХОЛЕЙ С ИСПОЛЬЗОВАНИЕМ КОМБИНИРОВАННОЙ ТЕРАПИИ ИНГИБИТОРОМ mTOR В ВИДЕ НАНОЧАСТИЦ

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Publication number
EA201890146A1
EA201890146A1 EA201890146A EA201890146A EA201890146A1 EA 201890146 A1 EA201890146 A1 EA 201890146A1 EA 201890146 A EA201890146 A EA 201890146A EA 201890146 A EA201890146 A EA 201890146A EA 201890146 A1 EA201890146 A1 EA 201890146A1
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EA
Eurasian Patent Office
Prior art keywords
methods
nanoparticles
mtor inhibitor
treatment
solid tumors
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Application number
EA201890146A
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English (en)
Inventor
Нейл П. Дисэй
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АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи
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Publication of EA201890146A1 publication Critical patent/EA201890146A1/ru

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
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    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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Abstract

Настоящее изобретение относится к способам и композициям для лечения солидной опухоли посредством введения композиций, содержащих наночастицы, которые содержат ингибитор mTOR (такой как лекарственное средство семейства "лимусов", например сиролимус или его производное) и альбумин, в комбинации с композициями, содержащими второе терапевтическое средство.
EA201890146A 2015-06-29 2016-06-29 СПОСОБЫ ЛЕЧЕНИЯ СОЛИДНЫХ ОПУХОЛЕЙ С ИСПОЛЬЗОВАНИЕМ КОМБИНИРОВАННОЙ ТЕРАПИИ ИНГИБИТОРОМ mTOR В ВИДЕ НАНОЧАСТИЦ EA201890146A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562186325P 2015-06-29 2015-06-29
PCT/US2016/040202 WO2017004267A1 (en) 2015-06-29 2016-06-29 Methods of treating solid tumors using nanoparticle mtor inhibitor combination therapy

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EA201890146A1 true EA201890146A1 (ru) 2018-06-29

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US (2) US20180153863A1 (ru)
EP (1) EP3313382A4 (ru)
JP (1) JP2018521058A (ru)
KR (2) KR20180019229A (ru)
CN (1) CN107921006A (ru)
AU (1) AU2016287508B2 (ru)
CA (1) CA2990726A1 (ru)
CL (1) CL2017003457A1 (ru)
EA (1) EA201890146A1 (ru)
HK (1) HK1247093A1 (ru)
IL (1) IL256333B2 (ru)
MX (1) MX2017016492A (ru)
NZ (1) NZ738929A (ru)
WO (1) WO2017004267A1 (ru)

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CL2017003457A1 (es) 2018-05-11
AU2016287508A1 (en) 2018-02-01
JP2018521058A (ja) 2018-08-02
EP3313382A4 (en) 2019-03-06
US20230263779A1 (en) 2023-08-24
IL256333B2 (en) 2023-03-01
EP3313382A1 (en) 2018-05-02
IL256333B (en) 2022-11-01
CA2990726A1 (en) 2017-01-05
KR20180019229A (ko) 2018-02-23
IL256333A (en) 2018-02-28
WO2017004267A1 (en) 2017-01-05
AU2016287508B2 (en) 2021-10-14
US20180153863A1 (en) 2018-06-07
NZ738929A (en) 2024-01-26
CN107921006A (zh) 2018-04-17
MX2017016492A (es) 2018-08-16
HK1247093A1 (zh) 2018-09-21

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