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EA201690980A1 - Комбинированная терапия, включающая ингибитор mdm2 и один или более дополнительных фармацевтически активных агентов, для лечения различных видов рака - Google Patents

Комбинированная терапия, включающая ингибитор mdm2 и один или более дополнительных фармацевтически активных агентов, для лечения различных видов рака

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Publication number
EA201690980A1
EA201690980A1 EA201690980A EA201690980A EA201690980A1 EA 201690980 A1 EA201690980 A1 EA 201690980A1 EA 201690980 A EA201690980 A EA 201690980A EA 201690980 A EA201690980 A EA 201690980A EA 201690980 A1 EA201690980 A1 EA 201690980A1
Authority
EA
Eurasian Patent Office
Prior art keywords
active agents
pharmaceutically active
additional pharmaceutically
mdm2 inhibitor
cancer types
Prior art date
Application number
EA201690980A
Other languages
English (en)
Other versions
EA036942B1 (ru
Inventor
Шон Кэнпил
Джуд Кэнон
Пол Хьюз
Джонатан Д. Олинер
Ричард Дж. Риклес
Анн Й. Саики
Original Assignee
Эмджен Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эмджен Инк. filed Critical Эмджен Инк.
Publication of EA201690980A1 publication Critical patent/EA201690980A1/ru
Publication of EA036942B1 publication Critical patent/EA036942B1/ru

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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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Abstract

В настоящем изобретении предлагается комбинированная терапия, включающая ингибитор MDM2 и один или более дополнительных фармацевтически активных агентов, конкретно для лечения различных видов рака. Кроме того, изобретение относится к фармацевтическим композициям, которые содержат ингибитор MDM2 и один или более дополнительных фармацевтически активных агентов для лечения различных видов рака.
EA201690980A 2013-11-11 2014-11-11 Применение amg232 в комбинации с цитарабином или децитабином для лечения острого миелогенного лейкоза EA036942B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361902717P 2013-11-11 2013-11-11
PCT/US2014/065034 WO2015070224A2 (en) 2013-11-11 2014-11-11 Combination therapy including an mdm2 inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers

Publications (2)

Publication Number Publication Date
EA201690980A1 true EA201690980A1 (ru) 2016-09-30
EA036942B1 EA036942B1 (ru) 2021-01-18

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Application Number Title Priority Date Filing Date
EA202092456A EA202092456A3 (ru) 2013-11-11 2014-11-11 Комбинированная терапия, включающая ингибитор mdm2 и один или более дополнительных фармацевтически активных агентов, для лечения различных видов рака
EA201690980A EA036942B1 (ru) 2013-11-11 2014-11-11 Применение amg232 в комбинации с цитарабином или децитабином для лечения острого миелогенного лейкоза

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US (3) US20160287569A1 (ru)
EP (2) EP4039256A1 (ru)
JP (5) JP2016535795A (ru)
KR (3) KR20220167335A (ru)
CN (2) CN112933236A (ru)
AP (1) AP2016009243A0 (ru)
AU (3) AU2014346354A1 (ru)
BR (1) BR112016010564A2 (ru)
CA (1) CA2930244A1 (ru)
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DK (1) DK3068393T5 (ru)
EA (2) EA202092456A3 (ru)
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HR (1) HRP20220718T1 (ru)
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LT (1) LT3068393T (ru)
MA (1) MA39094B1 (ru)
MX (6) MX2020001550A (ru)
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NZ (2) NZ758548A (ru)
PH (1) PH12016500871A1 (ru)
PL (1) PL3068393T3 (ru)
PT (1) PT3068393T (ru)
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SG (1) SG10201902429PA (ru)
SI (1) SI3068393T1 (ru)
TN (1) TN2016000176A1 (ru)
UA (1) UA120750C2 (ru)
WO (1) WO2015070224A2 (ru)

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