EA201790717A1 - Способы и композиции для индукции защитного иммунитета против инфекции вирусом иммунодефицита человека - Google Patents
Способы и композиции для индукции защитного иммунитета против инфекции вирусом иммунодефицита человекаInfo
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- EA201790717A1 EA201790717A1 EA201790717A EA201790717A EA201790717A1 EA 201790717 A1 EA201790717 A1 EA 201790717A1 EA 201790717 A EA201790717 A EA 201790717A EA 201790717 A EA201790717 A EA 201790717A EA 201790717 A1 EA201790717 A1 EA 201790717A1
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- Prior art keywords
- immunity against
- protective immunity
- compositions
- methods
- immunodeficiency virus
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- A—HUMAN NECESSITIES
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- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/295—Polyvalent viral antigens; Mixtures of viral and bacterial antigens
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
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- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10041—Use of virus, viral particle or viral elements as a vector
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- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24141—Use of virus, viral particle or viral elements as a vector
- C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
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- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
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- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
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- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
Описаны композиции, вакцины и способы индукции защитного иммунитета против вируса иммунодефицита человека (ВИЧ). Гетерологичные комбинированные вакцины, состоящие из одного или более вирусных экспрессирующих векторов и выделенного антигенного полипептида, индуцировали сильный защитный иммунитет против инфекций ВИЧ одного или множества субтипов.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462056059P | 2014-09-26 | 2014-09-26 | |
PCT/US2015/051891 WO2016049287A1 (en) | 2014-09-26 | 2015-09-24 | Methods and compositions for inducing protective immunity against human immunodeficiency virus infection |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201790717A1 true EA201790717A1 (ru) | 2018-02-28 |
EA037583B1 EA037583B1 (ru) | 2021-04-16 |
Family
ID=55581992
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201790717A EA037583B1 (ru) | 2014-09-26 | 2015-09-24 | Способы и композиции для индукции защитного иммунитета против инфекции вирусом иммунодефицита человека |
EA202092521A EA202092521A1 (ru) | 2014-09-26 | 2015-09-24 | Способы и композиции для индукции защитного иммунитета против инфекции вирусом иммунодефицита человека |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA202092521A EA202092521A1 (ru) | 2014-09-26 | 2015-09-24 | Способы и композиции для индукции защитного иммунитета против инфекции вирусом иммунодефицита человека |
Country Status (28)
Country | Link |
---|---|
US (4) | US10137191B2 (ru) |
EP (2) | EP3868398A1 (ru) |
JP (2) | JP6438575B2 (ru) |
KR (2) | KR102159626B1 (ru) |
CN (2) | CN106999571B (ru) |
AP (1) | AP2017009846A0 (ru) |
AU (2) | AU2015320574B2 (ru) |
BR (1) | BR112017005917A2 (ru) |
CA (1) | CA2961024A1 (ru) |
CY (1) | CY1124254T1 (ru) |
DK (1) | DK3197489T3 (ru) |
EA (2) | EA037583B1 (ru) |
ES (1) | ES2865150T3 (ru) |
HR (1) | HRP20210608T1 (ru) |
HU (1) | HUE053585T2 (ru) |
IL (2) | IL251114B (ru) |
LT (1) | LT3197489T (ru) |
MA (1) | MA40765B1 (ru) |
MX (2) | MX2017003946A (ru) |
MY (1) | MY175620A (ru) |
PH (1) | PH12017500449A1 (ru) |
PL (1) | PL3197489T3 (ru) |
PT (1) | PT3197489T (ru) |
RS (1) | RS61902B1 (ru) |
SG (1) | SG11201702110RA (ru) |
SI (1) | SI3197489T1 (ru) |
WO (1) | WO2016049287A1 (ru) |
ZA (1) | ZA201702053B (ru) |
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MY175620A (en) * | 2014-09-26 | 2020-07-02 | Beth Israel Deaconess Medical Ct Inc | Methods and compositions for inducing protective immunity against human immunodeficiency virus infection |
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CN110494159A (zh) * | 2016-09-02 | 2019-11-22 | 扬森疫苗与预防公司 | 在接受抗逆转录病毒治疗的对象中诱导针对人类免疫缺陷病毒感染的免疫应答的方法 |
HUE052008T2 (hu) | 2016-09-15 | 2021-04-28 | Janssen Vaccines & Prevention Bv | Trimert stabilizáló HIV-burokfehérje-mutációk |
EA202090049A1 (ru) * | 2017-06-15 | 2020-04-15 | Янссен Вэксинс Энд Превеншн Б.В. | Поксвирусные векторы, кодирующие антигены вич, и способы их применения |
BR112020000867A2 (pt) | 2017-07-19 | 2020-07-21 | Janssen Vaccines & Prevention B.V. | mutações da proteína do envelope do hiv estabilizando o trímero |
US20190022212A1 (en) | 2017-07-21 | 2019-01-24 | Beth Israel Deaconess Medical Center, Inc. | Methods for safe induction of cross-clade immunity against human immunodeficiency virus infection in human |
WO2019055888A1 (en) * | 2017-09-18 | 2019-03-21 | Janssen Vaccines & Prevention B.V. | METHODS OF INDUCING AN IMMUNE RESPONSE AGAINST HUMAN IMMUNODEFICIENCY VIRUS INFECTION IN SUBJECTS UNDER ANTIRETROVIRAL TREATMENT |
US11517618B2 (en) * | 2018-09-25 | 2022-12-06 | Janssen Vaccines & Prevention B.V. | Method of inducing an immune response against human immunodeficiency virus by co-localized administration of vaccine components |
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WO2020237052A1 (en) * | 2019-05-22 | 2020-11-26 | Janssen Vaccines & Prevention B.V. | Methods for inducing an immune response against human immunodeficiency virus infection in subjects undergoing antiretroviral treatment |
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JP7454645B2 (ja) | 2019-07-16 | 2024-03-22 | ギリアード サイエンシーズ, インコーポレイテッド | Hivワクチン並びにその作製方法及び使用方法 |
AU2020381082B2 (en) * | 2019-11-07 | 2022-09-22 | Janssen Vaccines & Prevention B.V. | Protein purification |
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WO2023198815A1 (en) | 2022-04-14 | 2023-10-19 | Janssen Vaccines & Prevention B.V. | Sequential administration of adenoviruses |
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