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EA201500266A1 - Ингибиторы репликации вирусов гриппа - Google Patents

Ингибиторы репликации вирусов гриппа

Info

Publication number
EA201500266A1
EA201500266A1 EA201500266A EA201500266A EA201500266A1 EA 201500266 A1 EA201500266 A1 EA 201500266A1 EA 201500266 A EA201500266 A EA 201500266A EA 201500266 A EA201500266 A EA 201500266A EA 201500266 A1 EA201500266 A1 EA 201500266A1
Authority
EA
Eurasian Patent Office
Prior art keywords
patient
pharmaceutically acceptable
biological sample
acceptable salt
structural formula
Prior art date
Application number
EA201500266A
Other languages
English (en)
Other versions
EA030188B1 (ru
Inventor
Пол Чарифсон
Майкл П. Кларк
Упул К. Бандарадже
Рэнди С. Бетил
Джон Дж. Корт
Хунбо Дэн
Иоана Друту
Джон П. Даффи
Люк Фармер
Хуай Гао
Вэньсинь Гу
Дилан Х. Джейкобс
Джозеф М. Кеннеди
Марк В. Ледебур
Брайан Ледфорд
Франсуа Мальте
Эмануэле Перола
Тяньшэн Ван
М. Вудс Ваннамэйкер
Рэндал Бирн
Йи Чжоу
Чао Линь
Минь Цзян
Стивен Джоунс
Урсула А. Джерманн
Original Assignee
Вертекс Фармасьютикалз Инкорпорейтед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42537408&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201500266(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Вертекс Фармасьютикалз Инкорпорейтед filed Critical Вертекс Фармасьютикалз Инкорпорейтед
Publication of EA201500266A1 publication Critical patent/EA201500266A1/ru
Publication of EA030188B1 publication Critical patent/EA030188B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение относится к новым соединениям общей формулы (IA)или его фармацевтически приемлемой соли, где обозначения, указанные в структурной формуле (IA), представлены в описании выше. Соединение, представленное структурной формулой (IA), или его фармацевтически приемлемая соль полезно для ингибирования репликации вируса гриппа в биологическом образце или у пациента, а также для уменьшения количества вирусов гриппа в биологическом образце или у пациента и для лечения гриппа у пациента, которые включают введение в указанный биологический образец или пациенту эффективного количества соединения, представленного структурной формулой (IA). Настоящее изобретение также относится к фармацевтической композиции, содержащей эффективное количество соединения формулы (IA) или его фармацевтически приемлемой соли и фармацевтически приемлемый носитель, наполнитель или разбавитель.
EA201500266A 2009-06-17 2010-06-17 Ингибиторы репликации вирусов гриппа EA030188B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18771309P 2009-06-17 2009-06-17
US28778109P 2009-12-18 2009-12-18

Publications (2)

Publication Number Publication Date
EA201500266A1 true EA201500266A1 (ru) 2015-10-30
EA030188B1 EA030188B1 (ru) 2018-07-31

Family

ID=42537408

Family Applications (3)

Application Number Title Priority Date Filing Date
EA201500871A EA037529B1 (ru) 2009-06-17 2010-06-17 Способ получения соединения для ингибирования репликации вирусов гриппа
EA201500266A EA030188B1 (ru) 2009-06-17 2010-06-17 Ингибиторы репликации вирусов гриппа
EA201270032A EA025276B1 (ru) 2009-06-17 2010-06-17 (2S,3S)-3-((2-(5-ФТОР-1Н-ПИРРОЛО[2,3-b]ПИРИДИН-3-ИЛ)-5-ФТОРПИРИМИДИН-4-ИЛ)АМИНО)БИЦИКЛО[2,2,2]ОКТАН-2-КАРБОНОВАЯ КИСЛОТА, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ВКЛЮЧАЮЩАЯ ЕЁ, И СПОСОБЫ ПРИМЕНЕНИЯ УКАЗАННОГО СОЕДИНЕНИЯ

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA201500871A EA037529B1 (ru) 2009-06-17 2010-06-17 Способ получения соединения для ингибирования репликации вирусов гриппа

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA201270032A EA025276B1 (ru) 2009-06-17 2010-06-17 (2S,3S)-3-((2-(5-ФТОР-1Н-ПИРРОЛО[2,3-b]ПИРИДИН-3-ИЛ)-5-ФТОРПИРИМИДИН-4-ИЛ)АМИНО)БИЦИКЛО[2,2,2]ОКТАН-2-КАРБОНОВАЯ КИСЛОТА, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ВКЛЮЧАЮЩАЯ ЕЁ, И СПОСОБЫ ПРИМЕНЕНИЯ УКАЗАННОГО СОЕДИНЕНИЯ

Country Status (38)

Country Link
US (7) US20120171245A1 (ru)
EP (3) EP3141252B8 (ru)
JP (6) JP5721706B2 (ru)
KR (3) KR101702609B1 (ru)
CN (5) CN104151312B (ru)
AP (1) AP3631A (ru)
AR (1) AR077130A1 (ru)
AU (1) AU2010262905B2 (ru)
BR (1) BRPI1011993A2 (ru)
CA (1) CA2764177C (ru)
CL (1) CL2011003192A1 (ru)
CO (1) CO6491048A2 (ru)
CY (2) CY1118246T1 (ru)
DK (2) DK2442809T3 (ru)
EA (3) EA037529B1 (ru)
EC (1) ECSP12011610A (ru)
ES (2) ES2692396T3 (ru)
GE (3) GEP20207129B (ru)
HK (4) HK1204322A1 (ru)
HR (2) HRP20161577T1 (ru)
HU (1) HUE031048T2 (ru)
IL (2) IL216980B (ru)
LT (2) LT2442809T (ru)
ME (1) ME02558B (ru)
MX (2) MX348066B (ru)
NZ (2) NZ597059A (ru)
PE (2) PE20160127A1 (ru)
PH (1) PH12015501678A1 (ru)
PL (2) PL3141252T3 (ru)
PT (2) PT3141252T (ru)
RS (2) RS55341B1 (ru)
SG (3) SG10201405827PA (ru)
SI (2) SI3141252T1 (ru)
TR (1) TR201815272T4 (ru)
TW (4) TWI574963B (ru)
UY (1) UY32717A (ru)
WO (1) WO2010148197A1 (ru)
ZA (2) ZA201109127B (ru)

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