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ITMI20040874A1 - Derivati indolici ed azaindolici con azione antitumorale - Google Patents

Derivati indolici ed azaindolici con azione antitumorale

Info

Publication number
ITMI20040874A1
ITMI20040874A1 IT000874A ITMI20040874A ITMI20040874A1 IT MI20040874 A1 ITMI20040874 A1 IT MI20040874A1 IT 000874 A IT000874 A IT 000874A IT MI20040874 A ITMI20040874 A IT MI20040874A IT MI20040874 A1 ITMI20040874 A1 IT MI20040874A1
Authority
IT
Italy
Prior art keywords
azaindolic
indolic
derivatives
tumoral
action
Prior art date
Application number
IT000874A
Other languages
English (en)
Inventor
Paolo Celestini
Carlo Farina
Stefania Gagliardi
Paola Misiano
Franco Zunino
Original Assignee
Ist Naz Stud Cura Dei Tumori
Nikem Research Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ist Naz Stud Cura Dei Tumori, Nikem Research Srl filed Critical Ist Naz Stud Cura Dei Tumori
Priority to IT000874A priority Critical patent/ITMI20040874A1/it
Publication of ITMI20040874A1 publication Critical patent/ITMI20040874A1/it
Priority to JP2007510035A priority patent/JP2007535520A/ja
Priority to AU2005237788A priority patent/AU2005237788A1/en
Priority to CA002564249A priority patent/CA2564249A1/en
Priority to PCT/EP2005/051908 priority patent/WO2005105213A2/en
Priority to US11/579,237 priority patent/US20070248672A1/en
Priority to EP05743013A priority patent/EP1750687A2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IT000874A 2004-04-30 2004-04-30 Derivati indolici ed azaindolici con azione antitumorale ITMI20040874A1 (it)

Priority Applications (7)

Application Number Priority Date Filing Date Title
IT000874A ITMI20040874A1 (it) 2004-04-30 2004-04-30 Derivati indolici ed azaindolici con azione antitumorale
JP2007510035A JP2007535520A (ja) 2004-04-30 2005-04-27 抗腫瘍作用を有するインドール及びアザインドール誘導体
AU2005237788A AU2005237788A1 (en) 2004-04-30 2005-04-27 Indole and azaindole derivatives with antitumor action
CA002564249A CA2564249A1 (en) 2004-04-30 2005-04-27 Indole and azaindole derivatives with antitumor action
PCT/EP2005/051908 WO2005105213A2 (en) 2004-04-30 2005-04-27 Indole and azaindole derivatives with antitumor action
US11/579,237 US20070248672A1 (en) 2004-04-30 2005-04-27 Indole and Azaindole Derivatives with Antitumor Action
EP05743013A EP1750687A2 (en) 2004-04-30 2005-04-27 Indole and azaindole derivatives with antitumor action

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT000874A ITMI20040874A1 (it) 2004-04-30 2004-04-30 Derivati indolici ed azaindolici con azione antitumorale

Publications (1)

Publication Number Publication Date
ITMI20040874A1 true ITMI20040874A1 (it) 2004-07-30

Family

ID=34968098

Family Applications (1)

Application Number Title Priority Date Filing Date
IT000874A ITMI20040874A1 (it) 2004-04-30 2004-04-30 Derivati indolici ed azaindolici con azione antitumorale

Country Status (7)

Country Link
US (1) US20070248672A1 (it)
EP (1) EP1750687A2 (it)
JP (1) JP2007535520A (it)
AU (1) AU2005237788A1 (it)
CA (1) CA2564249A1 (it)
IT (1) ITMI20040874A1 (it)
WO (1) WO2005105213A2 (it)

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EP1779848A1 (en) 2005-10-28 2007-05-02 Nikem Research S.R.L. V-ATPase inhibitors for the treatment of inflammatory and autoimmune diseases
JP2010503677A (ja) 2006-09-15 2010-02-04 シェーリング コーポレイション 脂質代謝の障害を治療するためのアゼチジノン誘導体
WO2008079346A1 (en) 2006-12-21 2008-07-03 Vertex Pharmaceuticals Incorporated 5-cyan0-4- (pyrrolo [2, 3b] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors
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US20110038852A1 (en) * 2009-06-10 2011-02-17 3-V Biosciences, Inc. Antivirals that target transporters, carriers, and ion channels
SI2442809T1 (sl) 2009-06-17 2017-01-31 Vertex Pharmaceuticals Incorporated Inhibitorji replikacije virusov gripe
IN2012DN02555A (it) * 2009-10-07 2015-08-28 Karobio Ab
US8691830B2 (en) 2010-10-25 2014-04-08 G1 Therapeutics, Inc. CDK inhibitors
HRP20161092T1 (hr) 2010-10-25 2016-10-21 G1 Therapeutics, Inc. Cdk inhibitori
JP2013545816A (ja) 2010-12-16 2013-12-26 バーテックス ファーマシューティカルズ インコーポレイテッド インフルエンザウイルス複製阻害物質
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
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EP3216792B1 (en) 2012-03-29 2020-05-27 G1 Therapeutics, Inc. Lactam kinase inhibitors
DK2900667T3 (da) * 2012-09-21 2019-08-26 Vivolux Ab Middel og fremgangsmåde til behandling af faste tumorer
CN105407723A (zh) 2013-03-15 2016-03-16 G1治疗公司 高效的抗赘生剂和抗增生剂
CN105407889B (zh) 2013-03-15 2018-06-01 G1治疗公司 针对Rb阳性异常细胞增殖的HSPC节制性治疗
MA38569A1 (fr) * 2013-04-23 2017-03-31 Esteve Labor Dr Composés pyrazino[1,2-a]indole, leur préparation et utilisation dans des médicaments
CN105849105B (zh) 2013-11-13 2018-02-13 沃泰克斯药物股份有限公司 制备流感病毒复制抑制剂的方法
CA2930103A1 (en) 2013-11-13 2015-05-21 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
US20150297608A1 (en) 2014-04-17 2015-10-22 G1 Therapeutics, Inc. Tricyclic Lactams for Use as Anti-Neoplastic and Anti-Proliferative Agents
EP3191098A4 (en) 2014-09-12 2018-04-25 G1 Therapeutics, Inc. Combinations and dosing regimes to treat rb-positive tumors
WO2016040848A1 (en) 2014-09-12 2016-03-17 G1 Therapeutics, Inc. Treatment of rb-negative tumors using topoisomerase inhibitors in combination with cyclin dependent kinase 4/6 inhibitors
EP3294717B1 (en) 2015-05-13 2020-07-29 Vertex Pharmaceuticals Inc. Methods of preparing inhibitors of influenza viruses replication
WO2016183120A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
HK1254661A1 (zh) 2015-06-17 2019-07-26 Pfizer Inc. 三環化合物以及它們作為磷酸二酯酶抑制劑的用途
EP3371173A4 (en) * 2015-11-02 2019-06-19 Carmel-Haifa University Economic Corporation Ltd. APOPTOSIS ASSOCIATED PROTEIN IN MIMETIC COMPOUNDS OF THE TGF-BETA SIGNALING PATH (ARTS), COMPOSITIONS, METHODS AND USES THEREOF IN INDUCING THE DIFFERENTIATION AND / OR APOPTOSIS OF PREMALIGNES AND MALIGNING CELLS FOR THE RECONSTRUCTION OF THEIR NORMAL PHENOTYPES
GB201521059D0 (en) 2015-11-30 2016-01-13 Isis Innovation Inhibitors of metallo-beta-lactamases
JP7229162B2 (ja) 2017-01-06 2023-02-27 ジー１ セラピューティクス， インコーポレイテッド 癌の治療に対する併用療法
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US10988479B1 (en) 2020-06-15 2021-04-27 G1 Therapeutics, Inc. Morphic forms of trilaciclib and methods of manufacture thereof
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Also Published As

Publication number Publication date
WO2005105213A3 (en) 2006-06-22
CA2564249A1 (en) 2005-11-10
EP1750687A2 (en) 2007-02-14
AU2005237788A1 (en) 2005-11-10
US20070248672A1 (en) 2007-10-25
JP2007535520A (ja) 2007-12-06
WO2005105213A2 (en) 2005-11-10

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