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EA201490166A1 - Фторированные арилалкиламинокарбоксамидные производные - Google Patents

Фторированные арилалкиламинокарбоксамидные производные

Info

Publication number
EA201490166A1
EA201490166A1 EA201490166A EA201490166A EA201490166A1 EA 201490166 A1 EA201490166 A1 EA 201490166A1 EA 201490166 A EA201490166 A EA 201490166A EA 201490166 A EA201490166 A EA 201490166A EA 201490166 A1 EA201490166 A1 EA 201490166A1
Authority
EA
Eurasian Patent Office
Prior art keywords
fluorinated
derivatives
fluorinated arylalkyl
aminocarboxamide derivatives
aminocarboxamide
Prior art date
Application number
EA201490166A
Other languages
English (en)
Other versions
EA022973B1 (ru
Inventor
Паоло Певарелло
Original Assignee
Ньюрон Фармасьютикалс С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ньюрон Фармасьютикалс С.П.А. filed Critical Ньюрон Фармасьютикалс С.П.А.
Publication of EA201490166A1 publication Critical patent/EA201490166A1/ru
Publication of EA022973B1 publication Critical patent/EA022973B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
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    • C07C237/14—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings
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Abstract

Описаны фторированные арилалкиламинокарбоксамидные производные формулы (I), где W, J, n, R, R, R, R, R, Rи Rимеют значения, которые определены в спецификации, и их фармацевтически приемлемые соли, фармацевтические композиции, содержащие их в качестве активных ингредиентов, и их применение в качестве модуляторов натриевых и/или кальциевых каналов, применимых для предупреждения, облегчения и лечения патологий в широком диапазоне, в том числе неврологических, психиатрических, сердечно-сосудистых, воспалительных, глазных, урологических и желудочно-кишечных заболеваний, где указанные выше механизмы описаны как играющие патологическую роль.
EA201490166A 2011-06-27 2012-05-29 Фторированные арилалкиламинокарбоксамидные производные EA022973B1 (ru)

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