EA201390222A1 - Гетероциклическое соединение и его применение - Google Patents
Гетероциклическое соединение и его применениеInfo
- Publication number
- EA201390222A1 EA201390222A1 EA201390222A EA201390222A EA201390222A1 EA 201390222 A1 EA201390222 A1 EA 201390222A1 EA 201390222 A EA201390222 A EA 201390222A EA 201390222 A EA201390222 A EA 201390222A EA 201390222 A1 EA201390222 A1 EA 201390222A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- application
- heterocyclic compound
- compound
- adhd
- schizophrenia
- Prior art date
Links
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- UUDAMDVQRQNNHZ-UHFFFAOYSA-N (S)-AMPA Chemical compound CC=1ONC(=O)C=1CC(N)C(O)=O UUDAMDVQRQNNHZ-UHFFFAOYSA-N 0.000 abstract 1
- 102000003678 AMPA Receptors Human genes 0.000 abstract 1
- 108090000078 AMPA Receptors Proteins 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
Предложено соединение, соответствующее формуле (I)где каждый символ является таким, как определено в описании, или его соль, которые обладают активностью усиления рецептора АМРА (α-амино-3-гидрокси-5-метил-4-изоксазолпропионовая кислота). Соединение по настоящему изобретению пригодно в качестве профилактического или терапевтического средства от депрессии, шизофрении, болезни Альцгеймера или синдрома дефицита внимания и гиперактивности (ADHD) и т.п.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010179577 | 2010-08-10 | ||
| PCT/JP2011/068497 WO2012020848A1 (en) | 2010-08-10 | 2011-08-09 | Heterocyclic compound and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201390222A1 true EA201390222A1 (ru) | 2013-08-30 |
| EA022078B1 EA022078B1 (ru) | 2015-10-30 |
Family
ID=44534564
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201390222A EA022078B1 (ru) | 2010-08-10 | 2011-08-09 | Гетероциклическое соединение и его применение |
Country Status (39)
| Country | Link |
|---|---|
| US (11) | US8575154B2 (ru) |
| EP (1) | EP2603513B1 (ru) |
| JP (2) | JP5788496B2 (ru) |
| KR (1) | KR101852215B1 (ru) |
| CN (2) | CN104926837A (ru) |
| AR (1) | AR082618A1 (ru) |
| AU (1) | AU2011290126B2 (ru) |
| BR (1) | BR112013002250B1 (ru) |
| CA (1) | CA2807460C (ru) |
| CL (1) | CL2013000380A1 (ru) |
| CO (1) | CO6680700A2 (ru) |
| CR (1) | CR20130066A (ru) |
| CY (1) | CY1123507T1 (ru) |
| DK (1) | DK2603513T3 (ru) |
| DO (1) | DOP2013000030A (ru) |
| EA (1) | EA022078B1 (ru) |
| EC (1) | ECSP13012478A (ru) |
| ES (1) | ES2793723T3 (ru) |
| GE (1) | GEP20156216B (ru) |
| HR (1) | HRP20200844T1 (ru) |
| HU (1) | HUE049460T2 (ru) |
| IL (1) | IL224452A (ru) |
| LT (1) | LT2603513T (ru) |
| MA (1) | MA34509B1 (ru) |
| MX (1) | MX349470B (ru) |
| MY (1) | MY165908A (ru) |
| NZ (1) | NZ607593A (ru) |
| PE (1) | PE20131116A1 (ru) |
| PH (1) | PH12013500247A1 (ru) |
| PL (1) | PL2603513T3 (ru) |
| PT (1) | PT2603513T (ru) |
| RS (1) | RS60311B1 (ru) |
| SG (1) | SG187656A1 (ru) |
| SI (1) | SI2603513T1 (ru) |
| TW (1) | TWI504604B (ru) |
| UA (1) | UA111594C2 (ru) |
| UY (1) | UY33551A (ru) |
| WO (1) | WO2012020848A1 (ru) |
| ZA (1) | ZA201301120B (ru) |
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| KR101852215B1 (ko) * | 2010-08-10 | 2018-04-25 | 다케다 야쿠힌 고교 가부시키가이샤 | 헤테로시클릭 화합물 및 이의 용도 |
| EP2694472B1 (en) | 2011-04-05 | 2020-03-11 | Takeda Pharmaceutical Company Limited | Sulfonamide derivative and use thereof |
| EP2813508B1 (en) * | 2012-02-08 | 2018-01-31 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
| BR112015031249A2 (pt) * | 2013-06-13 | 2017-07-25 | Veroscience Llc | método de tratamento, método para tratar um distúrbio metabólico ou um elemento chave do mesmo, método para normalizar um ritmo diário de liberação de dopamina no sumn, método para estimular a liberação de dopamina de neurônios dopaminérgicos no sumn de um indivíduo e composição farmacêutica |
| PL3013813T3 (pl) | 2013-06-27 | 2019-10-31 | Pfizer | Związki heteroaromatyczne i ich zastosowanie jako ligandy dopaminy d1 |
| MY181117A (en) | 2013-12-03 | 2020-12-18 | Fmc Corp | Pyrrolidinone herbicides |
| US11589583B2 (en) | 2013-12-03 | 2023-02-28 | Fmc Corporation | Pyrrolidinones herbicides |
| EP3164386B1 (en) | 2014-07-02 | 2020-10-07 | FMC Corporation | Piperidinone herbicides |
| HUE047582T2 (hu) | 2014-12-08 | 2020-05-28 | Fmc Corp | 3-oxo-3-(arilamino)propanoátok, eljárás elõállításukra és felhasználásuk pirrolidinonok elõállításában |
| CN107466290B (zh) | 2015-04-10 | 2021-08-03 | Fmc公司 | 作为除草剂的取代的环酰胺 |
| CA2979417C (en) | 2015-04-27 | 2022-11-01 | E I Du Pont De Nemours And Company | Butyrolactones as herbicides |
| CN107835814B (zh) | 2015-04-29 | 2021-07-23 | 詹森药业有限公司 | 氮杂苯并咪唑及其作为ampa受体调节剂的用途 |
| BR112017023038A2 (pt) * | 2015-04-29 | 2018-07-03 | Janssen Pharmaceutica Nv | imidazopirazinas e pirazolopirimidinas e seu uso como moduladores do receptor ampa |
| BR112017021859B1 (pt) | 2015-05-12 | 2022-05-10 | Fmc Corporation | Composto, composições herbicidas, mistura herbicida e método para o controle do crescimento de vegetação indesejada |
| US10906873B2 (en) | 2015-05-29 | 2021-02-02 | Fmc Corporation | Substituted cyclic amides as herbicides |
| EP3303321A1 (en) | 2015-06-02 | 2018-04-11 | E. I. du Pont de Nemours and Company | Substituted cyclic amides and their use as herbicides |
| WO2017023515A1 (en) | 2015-07-31 | 2017-02-09 | E. I. Du Pont De Nemours And Company | Cyclic n-carboxamide compounds useful as herbicides |
| ES2744437T3 (es) * | 2015-08-06 | 2020-02-25 | Hoffmann La Roche | Procedimientos para la preparación de derivados ácidos de GalNAc |
| US20170181292A1 (en) * | 2015-12-16 | 2017-06-22 | Rohm And Haas Electronic Materials Llc | Method for forming organic coating on nickel surface |
| CN105669731B (zh) * | 2016-01-10 | 2017-06-30 | 沧州普瑞东方科技有限公司 | 一种4‑(4‑烷基环己氧基)苯硼酸的合成方法 |
| JP7325328B2 (ja) | 2016-12-21 | 2023-08-14 | エフ エム シー コーポレーション | ニトロン除草剤 |
| CN107892697B (zh) | 2016-12-26 | 2020-11-03 | 郑州泰基鸿诺医药股份有限公司 | 一种[1,3]噻嗪-2-胺类化合物及应用，药物组合物 |
| SG11201908640TA (en) | 2017-03-21 | 2019-10-30 | Fmc Corp | Pyrrolidinones and a process to prepare them |
| CA3057300A1 (en) | 2017-03-21 | 2018-09-27 | Fmc Corporation | Herbicidal mixture, composition and method |
| AR111967A1 (es) | 2017-05-30 | 2019-09-04 | Fmc Corp | Amidas herbicidas |
| AR111839A1 (es) | 2017-05-30 | 2019-08-21 | Fmc Corp | Lactamas 3-sustituidas herbicidas |
| JP7250687B2 (ja) | 2017-10-06 | 2023-04-03 | 武田薬品工業株式会社 | 複素環化合物 |
| WO2019070043A1 (ja) | 2017-10-06 | 2019-04-11 | 武田薬品工業株式会社 | 複素環化合物 |
| WO2021229294A1 (en) * | 2020-05-15 | 2021-11-18 | Takeda Pharmaceutical Company Limited | Treatment for depression |
| CN113943294A (zh) * | 2020-07-15 | 2022-01-18 | 成都海博为药业有限公司 | 一种作为btk抑制剂的化合物及其制备方法与用途 |
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| DE19704923A1 (de) | 1997-02-10 | 1998-08-13 | Hoechst Schering Agrevo Gmbh | Klebstoffhaltige Schädlingsbekämpfungsmittel |
| WO2001032013A1 (en) | 1999-11-04 | 2001-05-10 | Colorado State University Research Foundation | Method and device for attracting insects |
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| FR2854634B1 (fr) * | 2003-05-05 | 2005-07-08 | Servier Lab | Nouveaux derives de thiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2865474B1 (fr) | 2004-01-26 | 2008-06-13 | Servier Lab | Nouveaux derives de benzothiazines fluorees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2879201B1 (fr) | 2004-12-10 | 2007-02-16 | Servier Lab | Nouveaux derives de benzothiazine et benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| WO2007147208A1 (en) | 2006-06-23 | 2007-12-27 | Nufarm Australia Limited | Phenoxy alkanoate herbicidal composition and method of preparation and use |
| MX2009006243A (es) | 2006-12-11 | 2009-08-12 | Lilly Co Eli | Potenciadores del receptor ampa. |
| US20080167374A1 (en) | 2007-01-09 | 2008-07-10 | Loveland Products, Inc. | Pesticide composition and method of use |
| JP2011503002A (ja) | 2007-11-05 | 2011-01-27 | シェーリング コーポレイション | γセクレターゼ調節剤 |
| WO2009086303A2 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| US20110118236A1 (en) | 2008-03-25 | 2011-05-19 | Michiyo Mochizuki | Heterocyclic compound |
| JP2009248543A (ja) * | 2008-04-11 | 2009-10-29 | Fujifilm Corp | 光情報記録媒体および情報記録方法 |
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| US20120129846A1 (en) | 2008-11-06 | 2012-05-24 | Zhaoning Zhu | Gamma secretase modulators |
| TW201030002A (en) | 2009-01-16 | 2010-08-16 | Bristol Myers Squibb Co | Bicyclic compounds for the reduction of beta-amyloid production |
| JP2012051806A (ja) | 2009-02-26 | 2012-03-15 | Eisai R & D Management Co Ltd | イミダゾリルピラジン誘導体 |
| FR2943342B1 (fr) | 2009-03-20 | 2011-03-04 | Servier Lab | Nouveaux derives de benzothiadiazepines,leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| WO2010140339A1 (ja) | 2009-06-01 | 2010-12-09 | 武田薬品工業株式会社 | 複素環化合物 |
| CN102482276A (zh) | 2009-07-13 | 2012-05-30 | 武田药品工业株式会社 | 杂环化合物及其用途 |
| WO2011036885A1 (ja) | 2009-09-25 | 2011-03-31 | 武田薬品工業株式会社 | 複素環化合物 |
| WO2011036889A1 (ja) | 2009-09-25 | 2011-03-31 | 武田薬品工業株式会社 | 複素環化合物 |
| KR101852215B1 (ko) * | 2010-08-10 | 2018-04-25 | 다케다 야쿠힌 고교 가부시키가이샤 | 헤테로시클릭 화합물 및 이의 용도 |
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2011
- 2011-08-09 KR KR1020137006113A patent/KR101852215B1/ko active Active
- 2011-08-09 BR BR112013002250-7A patent/BR112013002250B1/pt active IP Right Grant
- 2011-08-09 HR HRP20200844TT patent/HRP20200844T1/hr unknown
- 2011-08-09 PH PH1/2013/500247A patent/PH12013500247A1/en unknown
- 2011-08-09 ES ES11749944T patent/ES2793723T3/es active Active
- 2011-08-09 JP JP2013506362A patent/JP5788496B2/ja active Active
- 2011-08-09 CA CA2807460A patent/CA2807460C/en active Active
- 2011-08-09 NZ NZ607593A patent/NZ607593A/en unknown
- 2011-08-09 LT LTEP11749944.2T patent/LT2603513T/lt unknown
- 2011-08-09 TW TW100128311A patent/TWI504604B/zh active
- 2011-08-09 CN CN201510259936.0A patent/CN104926837A/zh active Pending
- 2011-08-09 US US13/206,113 patent/US8575154B2/en active Active
- 2011-08-09 MX MX2013001614A patent/MX349470B/es active IP Right Grant
- 2011-08-09 SI SI201131887T patent/SI2603513T1/sl unknown
- 2011-08-09 US US13/816,137 patent/US9150591B2/en active Active
- 2011-08-09 AR ARP110102905A patent/AR082618A1/es active IP Right Grant
- 2011-08-09 PL PL11749944T patent/PL2603513T3/pl unknown
- 2011-08-09 EP EP11749944.2A patent/EP2603513B1/en active Active
- 2011-08-09 RS RS20200574A patent/RS60311B1/sr unknown
- 2011-08-09 GE GEAP201113021A patent/GEP20156216B/en unknown
- 2011-08-09 EA EA201390222A patent/EA022078B1/ru not_active IP Right Cessation
- 2011-08-09 SG SG2013007463A patent/SG187656A1/en unknown
- 2011-08-09 HU HUE11749944A patent/HUE049460T2/hu unknown
- 2011-08-09 WO PCT/JP2011/068497 patent/WO2012020848A1/en active Application Filing
- 2011-08-09 PT PT117499442T patent/PT2603513T/pt unknown
- 2011-08-09 DK DK11749944.2T patent/DK2603513T3/da active
- 2011-08-09 CN CN201180048970.3A patent/CN103180326B/zh active Active
- 2011-08-09 UY UY0001033551A patent/UY33551A/es not_active Application Discontinuation
- 2011-08-09 MA MA35708A patent/MA34509B1/fr unknown
- 2011-08-09 PE PE2013000244A patent/PE20131116A1/es active IP Right Grant
- 2011-08-09 MY MYPI2013000428A patent/MY165908A/en unknown
- 2011-08-09 AU AU2011290126A patent/AU2011290126B2/en active Active
- 2011-09-08 UA UAA201302884A patent/UA111594C2/uk unknown
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2013
- 2013-01-28 IL IL224452A patent/IL224452A/en active IP Right Grant
- 2013-02-05 DO DO2013000030A patent/DOP2013000030A/es unknown
- 2013-02-07 CL CL2013000380A patent/CL2013000380A1/es unknown
- 2013-02-12 ZA ZA2013/01120A patent/ZA201301120B/en unknown
- 2013-02-18 CR CR20130066A patent/CR20130066A/es unknown
- 2013-02-22 US US13/774,635 patent/US8778934B2/en active Active
- 2013-02-22 US US13/774,707 patent/US8916551B2/en active Active
- 2013-03-06 EC ECSP13012478 patent/ECSP13012478A/es unknown
- 2013-03-07 CO CO13046020A patent/CO6680700A2/es active IP Right Grant
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2014
- 2014-11-13 US US14/540,699 patent/US20150073137A1/en not_active Abandoned
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2015
- 2015-07-21 US US14/804,935 patent/US9499568B2/en active Active
- 2015-07-29 JP JP2015149216A patent/JP6113789B2/ja active Active
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2016
- 2016-10-10 US US15/289,650 patent/US9884875B2/en active Active
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2017
- 2017-12-18 US US15/845,621 patent/US20180162875A1/en not_active Abandoned
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2019
- 2019-01-24 US US16/256,773 patent/US10654874B2/en active Active
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2020
- 2020-03-23 US US16/827,316 patent/US11279713B2/en active Active
- 2020-05-25 CY CY20201100475T patent/CY1123507T1/el unknown
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2024
- 2024-03-01 US US18/592,897 patent/US20240360156A1/en active Pending
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