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EA201101566A1 - Производные имидазола и их применение в качестве модуляторов циклинзависимых киназ - Google Patents

Производные имидазола и их применение в качестве модуляторов циклинзависимых киназ

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Publication number
EA201101566A1
EA201101566A1 EA201101566A EA201101566A EA201101566A1 EA 201101566 A1 EA201101566 A1 EA 201101566A1 EA 201101566 A EA201101566 A EA 201101566A EA 201101566 A EA201101566 A EA 201101566A EA 201101566 A1 EA201101566 A1 EA 201101566A1
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EA
Eurasian Patent Office
Prior art keywords
compounds
hydrogen
formula
kinaz
cylin
Prior art date
Application number
EA201101566A
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English (en)
Other versions
EA020017B1 (ru
Inventor
Стивен Хауард
Пол Нил Мортенсон
Стивен Дуглас Хискок
Элисон Джоу-Энн Вулфорд
Эндрью Джеймс Вудхед
Джанни Кессари
Марк О'Рейли
Майлз Стьюарт Конгрив
Клаудио Дагостин
Ён Шин Чо
Фань Ян
Кристин Сютун Чэнь
Кристофер Томас Брейн
Бхарат Лагу
Япин Ван
Сункю Ким
Джон Гриалдес
Майкл Джозеф Луццио
Лоренс Блас Перес
Ипинь Лу
Original Assignee
Новартис Аг
Астекс Терапьютикс Лимитед
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Application filed by Новартис Аг, Астекс Терапьютикс Лимитед filed Critical Новартис Аг
Publication of EA201101566A1 publication Critical patent/EA201101566A1/ru
Publication of EA020017B1 publication Critical patent/EA020017B1/ru

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Настоящее изобретение относится к соединениям формулы (I) и его солям, таутомерам, сольватам и N-оксидам; где Q обозначает СН или N; Х обозначает N, N-Oили CR; Y обозначает N, N-Oили CR; Rи Rнезависимо выбраны из группы, включающей водород и различные заместители, определенные в формуле изобретения; или Rи Rвместе с атомами, к которым они присоединены, связываются с образованием необязательно замещенного карбоциклического или гетероциклического ароматического или неароматического кольца, содержащего от 4 до 7 элементов; Rвыбран из группы, включающей водород и различные заместители; и Rвыбран из группы, включающей водород и v различные заместители, определенные в формуле изобретения. Настоящее изобретение также относится к фармацевтическим композициям, содержащим соединения формулы (I), способам получения соединений и применению соединений в медицине. Соединения формулы (I) обладают активностью в качестве ингибиторов киназ CDK и применимы для лечения, в частности пролиферативных заболеваний, таких как раковые заболевания.
EA201101566A 2009-04-30 2010-04-30 Производные имидазола и их применение в качестве модуляторов циклинзависимых киназ EA020017B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17429309P 2009-04-30 2009-04-30
PCT/GB2010/050725 WO2010125402A1 (en) 2009-04-30 2010-04-30 Imidazole derivatives and their use as modulators of cyclin dependent kinases

Publications (2)

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EA201101566A1 true EA201101566A1 (ru) 2012-05-30
EA020017B1 EA020017B1 (ru) 2014-08-29

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EA201101566A EA020017B1 (ru) 2009-04-30 2010-04-30 Производные имидазола и их применение в качестве модуляторов циклинзависимых киназ

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US (1) US8598217B2 (ru)
EP (1) EP2424843B1 (ru)
JP (1) JP2012525367A (ru)
KR (1) KR20120004542A (ru)
CN (1) CN102803225A (ru)
AU (1) AU2010243353B2 (ru)
BR (1) BRPI1016190A2 (ru)
CA (1) CA2759083A1 (ru)
EA (1) EA020017B1 (ru)
ES (1) ES2458872T3 (ru)
MX (1) MX2011011516A (ru)
PL (1) PL2424843T3 (ru)
PT (1) PT2424843E (ru)
WO (1) WO2010125402A1 (ru)

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RU2664118C2 (ru) * 2013-07-18 2018-08-15 Тайхо Фармасьютикал Ко., Лтд. Противоопухолевое лекарственное средство для прерывистого введения ингибитора fgfr
US10124003B2 (en) 2013-07-18 2018-11-13 Taiho Pharmaceutical Co., Ltd. Therapeutic agent for FGFR inhibitor-resistant cancer
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US8598217B2 (en) 2013-12-03
JP2012525367A (ja) 2012-10-22
PT2424843E (pt) 2014-06-02
EP2424843A1 (en) 2012-03-07
WO2010125402A1 (en) 2010-11-04
CN102803225A (zh) 2012-11-28
US20120101064A1 (en) 2012-04-26
BRPI1016190A2 (pt) 2017-03-28
EA020017B1 (ru) 2014-08-29
CA2759083A1 (en) 2010-11-04
MX2011011516A (es) 2011-11-18
KR20120004542A (ko) 2012-01-12
PL2424843T3 (pl) 2014-07-31
AU2010243353B2 (en) 2014-09-11
AU2010243353A1 (en) 2011-11-10
EP2424843B1 (en) 2014-03-26
ES2458872T3 (es) 2014-05-07

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