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EA201071170A1 - Аналоги 1' - замещённого карба-нуклеозида для противовирусного лечения - Google Patents

Аналоги 1' - замещённого карба-нуклеозида для противовирусного лечения

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Publication number
EA201071170A1
EA201071170A1 EA201071170A EA201071170A EA201071170A1 EA 201071170 A1 EA201071170 A1 EA 201071170A1 EA 201071170 A EA201071170 A EA 201071170A EA 201071170 A EA201071170 A EA 201071170A EA 201071170 A1 EA201071170 A1 EA 201071170A1
Authority
EA
Eurasian Patent Office
Prior art keywords
nucleoside
analogues
triazinyl
substituted carbon
virus treatment
Prior art date
Application number
EA201071170A
Other languages
English (en)
Other versions
EA020659B1 (ru
Inventor
Томас Батлер
Эзоп Чо
Чонг Ю. Ким
Оливер Л. Саундерс
Лицзюнь Чжан
Джей Пэрриш
Original Assignee
Джилид Сайэнс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40887058&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201071170(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Джилид Сайэнс, Инк. filed Critical Джилид Сайэнс, Инк.
Publication of EA201071170A1 publication Critical patent/EA201071170A1/ru
Publication of EA020659B1 publication Critical patent/EA020659B1/ru

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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/12—Antivirals
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
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    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
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    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
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  • Chemical & Material Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)

Abstract

В изобретении предложены пирроло[1,2-f][1,2,4]триазинил-, имидазо[1,5-f][1,2,4]триазинил-, имидазо[1,2-f][1,2,4]триазинил- и [1,2,4]триазоло[4,3-f][1,2,4]триазинилнуклеозиды, а также нуклеозид фосфаты и пролекарства указанных соединений, причем положение 1' сахара в составе нуклеозида является замещенным. Предложенные соединения, композиции и способы подходят для лечения вирусных инфекций, вызываемых, в частности инфекций, вызываемых вирусом гепатита С.
EA201071170A 2008-04-23 2009-04-22 1'-замещённые карбануклеозидные аналоги для противовирусной терапии EA020659B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4726308P 2008-04-23 2008-04-23
US13944908P 2008-12-19 2008-12-19
PCT/US2009/041447 WO2009132135A1 (en) 2008-04-23 2009-04-22 1' -substituted carba-nucleoside analogs for antiviral treatment

Publications (2)

Publication Number Publication Date
EA201071170A1 true EA201071170A1 (ru) 2011-08-30
EA020659B1 EA020659B1 (ru) 2014-12-30

Family

ID=40887058

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EA201071128A EA019883B1 (ru) 2008-04-23 2009-04-22 Карбануклеозидные аналоги для противовирусной терапии
EA201071170A EA020659B1 (ru) 2008-04-23 2009-04-22 1'-замещённые карбануклеозидные аналоги для противовирусной терапии

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US (5) US8012941B2 (ru)
EP (3) EP2268642B1 (ru)
JP (4) JP5425187B2 (ru)
KR (3) KR101681559B1 (ru)
CN (3) CN104262345B (ru)
AP (2) AP3076A (ru)
AR (1) AR071395A1 (ru)
AU (2) AU2009240630B2 (ru)
BR (2) BRPI0910455B8 (ru)
CA (2) CA2722177C (ru)
CO (2) CO6321235A2 (ru)
CY (4) CY1113647T1 (ru)
DK (3) DK2937350T3 (ru)
EA (2) EA019883B1 (ru)
EC (2) ECSP10010609A (ru)
ES (3) ES2398684T3 (ru)
HK (3) HK1152709A1 (ru)
HR (3) HRP20130048T1 (ru)
HU (3) HUE038946T2 (ru)
IL (2) IL208515A (ru)
LT (2) LT2937350T (ru)
LU (1) LUC00193I2 (ru)
ME (1) ME03089B (ru)
MX (2) MX2010011661A (ru)
NO (1) NO2937350T3 (ru)
NZ (2) NZ588670A (ru)
PL (3) PL2280973T3 (ru)
PT (3) PT2280973E (ru)
RS (2) RS57092B1 (ru)
SI (3) SI2937350T1 (ru)
TW (2) TW201334784A (ru)
WO (2) WO2009132123A1 (ru)
ZA (2) ZA201007713B (ru)

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US9724360B2 (en) 2014-10-29 2017-08-08 Gilead Sciences, Inc. Methods for treating Filoviridae virus infections
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US10251904B2 (en) 2015-09-16 2019-04-09 Gilead Sciences, Inc. Methods for treating arenaviridae and coronaviridae virus infections
US10675296B2 (en) 2017-07-11 2020-06-09 Gilead Sciences, Inc. Compositions comprising an RNA polymerase inhibitor and cyclodextrin for treating viral infections
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BR122021021135B1 (pt) * 2009-09-21 2022-08-30 Gilead Sciences, Inc Compostos análogos de 2-flúor substituído carba-nucleosídeo, composição farmacêutica e uso dos compostos análogos de 2´-flúoro substituído carbonucleosídeo
CN102596961B (zh) 2009-10-30 2015-12-02 詹森药业有限公司 咪唑并[1，2-b]哒嗪衍生物及其作为PDE10抑制剂的用途
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KR101879887B1 (ko) * 2010-09-20 2018-07-18 길리애드 사이언시즈, 인코포레이티드 항바이러스 치료용 2'-플루오로 치환된 카바-누클레오시드 유사체
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RS56975B1 (sr) 2011-09-16 2018-05-31 Gilead Pharmasset Llc Metode za lečenje hcv-a
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