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EA201001273A1 - Ингибиторы вируса гепатита с - Google Patents

Ингибиторы вируса гепатита с

Info

Publication number
EA201001273A1
EA201001273A1 EA201001273A EA201001273A EA201001273A1 EA 201001273 A1 EA201001273 A1 EA 201001273A1 EA 201001273 A EA201001273 A EA 201001273A EA 201001273 A EA201001273 A EA 201001273A EA 201001273 A1 EA201001273 A1 EA 201001273A1
Authority
EA
Eurasian Patent Office
Prior art keywords
hepatitis
virus inhibitors
compounds
virus
methods
Prior art date
Application number
EA201001273A
Other languages
English (en)
Other versions
EA018313B1 (ru
Inventor
Кэрол Бачанд
Маконен Белема
Даниэль Х. Дэон
Эндрю К. Гуд
Джейсон Гудрих
Клинт А. Джеймс
Рико Лавуа
Омар Д. Лопез
Алан Мартел
Николас А. Минвелл
Ван Н. Нгуен
Джеффри Ли Ромин
Эдвард Х. Рюдигер
Лоуренс Б. Снайдер
Денис Р. Ст. Лоран
Фуканг Янг
Дэвид Р. Лэнгли
Гэн Ванг
Лоуренс Г. Хаманн
Original Assignee
Бристол-Маерс Сквибб Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бристол-Маерс Сквибб Компани filed Critical Бристол-Маерс Сквибб Компани
Publication of EA201001273A1 publication Critical patent/EA201001273A1/ru
Publication of EA018313B1 publication Critical patent/EA018313B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Изобретение отностится к соедиенниям формулы I, композициям и способам лечения инфекции, обусловленной вирусом гепатита С (ВГС). Также раскрыты фармацевтические композиции, содержащие такие соединения, и способы использования этих соедиенений для лечения ВГС инфекции.
EA201001273A 2008-02-13 2009-02-06 Ингибиторы вируса гепатита с EA018313B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2827708P 2008-02-13 2008-02-13
PCT/US2009/033380 WO2009102633A1 (en) 2008-02-13 2009-02-06 Hepatitis c virus inhibitors

Publications (2)

Publication Number Publication Date
EA201001273A1 true EA201001273A1 (ru) 2011-08-30
EA018313B1 EA018313B1 (ru) 2013-07-30

Family

ID=40581591

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201001273A EA018313B1 (ru) 2008-02-13 2009-02-06 Ингибиторы вируса гепатита с

Country Status (28)

Country Link
US (1) US8147818B2 (ru)
EP (1) EP2245027B1 (ru)
JP (1) JP5455933B2 (ru)
KR (1) KR101624365B1 (ru)
CN (1) CN102143959B (ru)
AR (1) AR070366A1 (ru)
AT (1) ATE555109T1 (ru)
AU (1) AU2009214997B2 (ru)
BR (1) BRPI0908240A2 (ru)
CA (1) CA2715559A1 (ru)
CL (1) CL2009000324A1 (ru)
CO (1) CO6290682A2 (ru)
CY (1) CY1112999T1 (ru)
DK (1) DK2245027T3 (ru)
EA (1) EA018313B1 (ru)
ES (1) ES2384911T3 (ru)
HK (1) HK1143812A1 (ru)
HR (1) HRP20120523T1 (ru)
IL (1) IL207459A (ru)
MX (1) MX2010008749A (ru)
NZ (1) NZ587322A (ru)
PE (1) PE20091381A1 (ru)
PL (1) PL2245027T3 (ru)
PT (1) PT2245027E (ru)
SI (1) SI2245027T1 (ru)
TW (1) TWI458482B (ru)
WO (1) WO2009102633A1 (ru)
ZA (1) ZA201005484B (ru)

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SI2245027T1 (sl) 2012-08-31
EP2245027B1 (en) 2012-04-25
KR20100124290A (ko) 2010-11-26
CL2009000324A1 (es) 2010-09-21
US20090202478A1 (en) 2009-08-13
CY1112999T1 (el) 2016-04-13
CA2715559A1 (en) 2009-08-20
NZ587322A (en) 2012-04-27
BRPI0908240A2 (pt) 2017-10-10
JP2011511840A (ja) 2011-04-14
CN102143959B (zh) 2014-10-22
ATE555109T1 (de) 2012-05-15
IL207459A (en) 2015-06-30
CN102143959A (zh) 2011-08-03
AU2009214997B2 (en) 2013-09-26
IL207459A0 (en) 2010-12-30
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ZA201005484B (en) 2012-01-25
PE20091381A1 (es) 2009-09-18
CO6290682A2 (es) 2011-06-20
EA018313B1 (ru) 2013-07-30
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US8147818B2 (en) 2012-04-03
AU2009214997A1 (en) 2009-08-20
AR070366A1 (es) 2010-03-31
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DK2245027T3 (da) 2012-08-06
MX2010008749A (es) 2010-08-31
TWI458482B (zh) 2014-11-01
KR101624365B1 (ko) 2016-05-25
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