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EA200870287A1 - Амидные производные в качестве лигандов ионных каналов и фармацевтические композиции и способы их применения - Google Patents

Амидные производные в качестве лигандов ионных каналов и фармацевтические композиции и способы их применения

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Publication number
EA200870287A1
EA200870287A1 EA200870287A EA200870287A EA200870287A1 EA 200870287 A1 EA200870287 A1 EA 200870287A1 EA 200870287 A EA200870287 A EA 200870287A EA 200870287 A EA200870287 A EA 200870287A EA 200870287 A1 EA200870287 A1 EA 200870287A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pharmaceutical compositions
ional
ligands
channels
methods
Prior art date
Application number
EA200870287A
Other languages
English (en)
Inventor
Майкл Г. Келли
Карл Дж. Коб
Джон Кинкейд
Сатьянараяна Джанагани
Госянь У
Чжи-Лян Вэй
Киран Сахасрабудхе
Мэттью Данктон
Равиндра Б. Упасани
Юньфэн Фан
Мэттью Кокс
Original Assignee
Реновис, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Реновис, Инк. filed Critical Реновис, Инк.
Priority claimed from PCT/US2007/004912 external-priority patent/WO2007100758A2/en
Publication of EA200870287A1 publication Critical patent/EA200870287A1/ru

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    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
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    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
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    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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Abstract

Описываются соединения, которые имеют формулу, представленную следующей формулой (I). Соединения можно получить в виде фармацевтических композиций, и можно применять для предотвращения или лечения различных состояний у млекопитающего, включая человека, включающих в качестве примеров боль, воспаление, травматическое повреждение и другие.
EA200870287A 2006-02-23 2007-02-22 Амидные производные в качестве лигандов ионных каналов и фармацевтические композиции и способы их применения EA200870287A1 (ru)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US77606406P 2006-02-23 2006-02-23
US77593006P 2006-02-23 2006-02-23
US77605606P 2006-02-23 2006-02-23
US77603306P 2006-02-23 2006-02-23
US77594906P 2006-02-23 2006-02-23
US77610506P 2006-02-23 2006-02-23
US77610606P 2006-02-23 2006-02-23
US77605706P 2006-02-23 2006-02-23
US77594506P 2006-02-23 2006-02-23
US77605806P 2006-02-23 2006-02-23
US83990306P 2006-08-24 2006-08-24
US83999406P 2006-08-24 2006-08-24
PCT/US2007/004912 WO2007100758A2 (en) 2005-02-28 2007-02-22 Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same

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CO (1) CO6170402A2 (ru)
EA (1) EA200870287A1 (ru)
GB (1) GB2452142A (ru)
IL (1) IL193346A0 (ru)
MA (1) MA30267B1 (ru)
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DE102011014994A1 (de) * 2011-03-23 2012-09-27 Otto Bock Healthcare Gmbh Prothesenfußeinsatz und Prothesenfuß
JP6866583B2 (ja) * 2016-07-05 2021-04-28 Dic株式会社 液晶化合物

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AR045979A1 (es) * 2003-04-28 2005-11-23 Astrazeneca Ab Amidas heterociclicas
TW200526631A (en) * 2003-10-07 2005-08-16 Renovis Inc Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
US20060035939A1 (en) * 2004-07-14 2006-02-16 Japan Tobacco Inc. 3-Aminobenzamide compounds and inhibitors of vanilloid receptor subtype 1 (VR1) activity

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JP2009527575A (ja) 2009-07-30
KR20080098670A (ko) 2008-11-11
CA2641781A1 (en) 2007-09-07
MA30267B1 (fr) 2009-03-02
GB0814753D0 (en) 2008-09-24
GB2452142A8 (en) 2009-03-18
CO6170402A2 (es) 2010-06-18
IL193346A0 (en) 2009-08-03
US20100004222A1 (en) 2010-01-07
GB2452142A (en) 2009-02-25
NO20083898L (no) 2008-10-30
TNSN08328A1 (en) 2009-12-29

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