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CO6170402A2 - Derivados de amidas como ligandos de canales ionicos y composiciones farmaceuticas y metodos para usar los mismos - Google Patents

Derivados de amidas como ligandos de canales ionicos y composiciones farmaceuticas y metodos para usar los mismos

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Publication number
CO6170402A2
CO6170402A2 CO08097232A CO08097232A CO6170402A2 CO 6170402 A2 CO6170402 A2 CO 6170402A2 CO 08097232 A CO08097232 A CO 08097232A CO 08097232 A CO08097232 A CO 08097232A CO 6170402 A2 CO6170402 A2 CO 6170402A2
Authority
CO
Colombia
Prior art keywords
carbon atoms
alkyl
halo
independently
c6alkoxy
Prior art date
Application number
CO08097232A
Other languages
English (en)
Inventor
Michael Kelly
Carl J Kaub
John Kincaid
Satynarahana Janagani
Guoxian Wu
Zhiliang Wei
Kiran Sahasrabudhe
Matthew Duncton
Ravindra Upasani
Yunfeng Fang
Matthew Cox
Original Assignee
Renovis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Renovis Inc filed Critical Renovis Inc
Publication of CO6170402A2 publication Critical patent/CO6170402A2/es

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
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    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
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    • A61K31/16—Amides, e.g. hydroxamic acids
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
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    • C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
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Abstract

1.- Un compuesto de acuerdo con la fórmula (I):o una sal, solvato o profármaco farmacéuticamente aceptable del mismo, y estereoisómeros y tautómeros del mismo, en donde: cada uno de W, Z y X es independientemente N o CR4; y Y es CR4&#39' L es -(CR5=CR6)- o -(C=C)-; R1 es bicicloarilo o bicicloheteroarilo sustituido o no sustituido; R3 es CR6´R7R8; cada R4 es independientemente hidrógeno, alquilo de 1 a 6 átomos de carbono, hidroxilo-alquilo de 1 a 6 átomos de carbono, alquilamino de 1 a 6 átomos de carbono, alcoxi de 1 a 6 átomos de carbono, amino-alcoxi de 1 a 6 átomos de carbono, amino sustituido-alcoxi de 1 a 6 átomos de carbono, dialquilamino de 1 a 6 átomos de carbono-alcoxi de 1 a 6 átomos de carbono, cicloalquilo-alcoxi de 1 a 6 átomos de carbono, alcoxicarbonilo de 1 a 6 átomos de carbono, alquilarilamino de 1 a 6 átomos de carbono, arilo-alquiloxi de 1 a 6 átomos de carbono, amino, arilo, arilo-alquilo de 1 a 6 átomos de carbono, sulfóxido, sulfona, sulfanilo, aminosulfonilo, arilsulfonilo, ácido sulfúrico, éster de ácido sulfúrico, azido, carboxi, carbamoilo, ciano, cicloheteroalquilo, dialquilamino de 1 a 6 átomos de carbono, halo, heteroariloxi, heteroarilo, heteroalquilo, hidroxilo, nitro o tio; R4'' es alquilo, trihaloalquilo, alcoxi, sulfona o halo; cada uno de R5 y R6 es independientemente H o alquilo de 1 a 6 átomos de carbono; y R6´ es hidrógeno, halo o alquilo de 1 a 6 átomos de carbono; cada uno de R7 y R8 es independientemente halo o alquilo de 1 a 6 átomos de carbono; o R7 y R8 forman juntos un anillo cicloalquilo de 3 a 8 átomos de carbono.
CO08097232A 2006-02-23 2008-09-15 Derivados de amidas como ligandos de canales ionicos y composiciones farmaceuticas y metodos para usar los mismos CO6170402A2 (es)

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US77594906P 2006-02-23 2006-02-23
US77593006P 2006-02-23 2006-02-23
US77605606P 2006-02-23 2006-02-23
US77603306P 2006-02-23 2006-02-23
US77606406P 2006-02-23 2006-02-23
US77610506P 2006-02-23 2006-02-23
US77610606P 2006-02-23 2006-02-23
US77605706P 2006-02-23 2006-02-23
US77594506P 2006-02-23 2006-02-23
US77605806P 2006-02-23 2006-02-23
US83990306P 2006-08-24 2006-08-24
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CO (1) CO6170402A2 (es)
EA (1) EA200870287A1 (es)
GB (1) GB2452142A (es)
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DE102011014994A1 (de) * 2011-03-23 2012-09-27 Otto Bock Healthcare Gmbh Prothesenfußeinsatz und Prothesenfuß
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AR045979A1 (es) * 2003-04-28 2005-11-23 Astrazeneca Ab Amidas heterociclicas
TW200526631A (en) * 2003-10-07 2005-08-16 Renovis Inc Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
US20060035939A1 (en) * 2004-07-14 2006-02-16 Japan Tobacco Inc. 3-Aminobenzamide compounds and inhibitors of vanilloid receptor subtype 1 (VR1) activity

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JP2009527575A (ja) 2009-07-30
KR20080098670A (ko) 2008-11-11
CA2641781A1 (en) 2007-09-07
MA30267B1 (fr) 2009-03-02
GB0814753D0 (en) 2008-09-24
GB2452142A8 (en) 2009-03-18
IL193346A0 (en) 2009-08-03
US20100004222A1 (en) 2010-01-07
GB2452142A (en) 2009-02-25
NO20083898L (no) 2008-10-30
TNSN08328A1 (en) 2009-12-29

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