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EA200702670A1 - Препарат тиенопиридинового ингибитора агрегации тромбоцитов - Google Patents

Препарат тиенопиридинового ингибитора агрегации тромбоцитов

Info

Publication number
EA200702670A1
EA200702670A1 EA200702670A EA200702670A EA200702670A1 EA 200702670 A1 EA200702670 A1 EA 200702670A1 EA 200702670 A EA200702670 A EA 200702670A EA 200702670 A EA200702670 A EA 200702670A EA 200702670 A1 EA200702670 A1 EA 200702670A1
Authority
EA
Eurasian Patent Office
Prior art keywords
thyenopyridine
inhibitor
preparation
platelet aggregation
platelet
Prior art date
Application number
EA200702670A
Other languages
English (en)
Other versions
EA011693B1 (ru
Inventor
Дэвид Брайан Дзинник
Тамара Бет Эдельман
Питер Ллойд Орен
Роберт Луис Терник
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37198935&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200702670(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA200702670A1 publication Critical patent/EA200702670A1/ru
Publication of EA011693B1 publication Critical patent/EA011693B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

Раскрыта композиция, содержащая соединение формулы Iспособ ее производства и применения.
EA200702670A 2005-06-10 2006-06-06 Препарат тиенопиридинового ингибитора агрегации тромбоцитов EA011693B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68918305P 2005-06-10 2005-06-10
PCT/US2006/021860 WO2006135605A2 (en) 2005-06-10 2006-06-06 Formulation of a thienopyridine platelet aggregation inhibitor

Publications (2)

Publication Number Publication Date
EA200702670A1 true EA200702670A1 (ru) 2008-04-28
EA011693B1 EA011693B1 (ru) 2009-04-28

Family

ID=37198935

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200702670A EA011693B1 (ru) 2005-06-10 2006-06-06 Препарат тиенопиридинового ингибитора агрегации тромбоцитов

Country Status (35)

Country Link
US (1) US20080176893A1 (ru)
EP (1) EP1896019B1 (ru)
JP (1) JP2008543755A (ru)
KR (2) KR20100076050A (ru)
CN (1) CN101193633B (ru)
AR (1) AR054283A1 (ru)
AT (1) ATE441413T1 (ru)
AU (1) AU2006258102B2 (ru)
BR (1) BRPI0611350B8 (ru)
CA (1) CA2611668C (ru)
CY (1) CY1109502T1 (ru)
DE (1) DE602006008942D1 (ru)
DK (1) DK1896019T3 (ru)
DO (1) DOP2006000126A (ru)
EA (1) EA011693B1 (ru)
EC (1) ECSP077984A (ru)
ES (1) ES2330373T3 (ru)
HK (1) HK1116422A1 (ru)
HR (1) HRP20090516T1 (ru)
IL (1) IL187830A0 (ru)
MA (1) MA29688B1 (ru)
MX (1) MX2007015431A (ru)
MY (1) MY151038A (ru)
NO (1) NO20076317L (ru)
NZ (1) NZ564003A (ru)
PE (1) PE20070320A1 (ru)
PL (1) PL1896019T3 (ru)
PT (1) PT1896019E (ru)
RS (1) RS51194B (ru)
SI (1) SI1896019T1 (ru)
TN (1) TNSN07466A1 (ru)
TW (1) TWI318571B (ru)
UA (1) UA91051C2 (ru)
WO (1) WO2006135605A2 (ru)
ZA (1) ZA200710697B (ru)

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CN101600431B (zh) * 2006-12-07 2011-09-07 第一三共株式会社 具有改进贮存稳定性的药物组合物
WO2008072535A1 (ja) * 2006-12-07 2008-06-19 Daiichi Sankyo Company, Limited 低置換度ヒドロキシプロピルセルロースを含有する医薬組成物
CN101594863B (zh) * 2006-12-07 2011-12-07 第一三共株式会社 具有改进稳定性的涂膜制剂
US20110201814A1 (en) * 2006-12-07 2011-08-18 Daiichi Sankyo Company Limited Method for producing solid preparation
AU2007333302A1 (en) * 2006-12-07 2008-06-19 Eli Lilly And Company An article comprising prasugrel
TWI428151B (zh) * 2006-12-07 2014-03-01 Daiichi Sankyo Co Ltd 含有甘露醇或乳糖之固形製劑
TWI417295B (zh) * 2007-03-02 2013-12-01 Daiichi Sankyo Co Ltd 高純度之普拉斯克列鹽酸鹽之製法
CN101686681B (zh) 2007-04-27 2015-04-01 锡德克斯药物公司 包含氯吡格雷和磺基烷基醚环糊精的制剂和其使用方法
GB2450117A (en) * 2007-06-13 2008-12-17 Reckitt Benckiser Healthcare A water- and oxygen-occlusive blister tablet pack
WO2009098142A1 (en) * 2008-02-06 2009-08-13 Helm Ag Prasugrel salts with improved properties
EP2107061A1 (en) * 2008-04-02 2009-10-07 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of optically enriched clopidogrel
ES2353853T3 (es) 2008-04-25 2011-03-07 Sandoz Ag SAL HIDROGENOSULFATO DE 2-ACETOXI-5-("ALFA"-CICLOPROPILCARBONIL-2-FLUORBENCIL)-4,5,6,7-TETRAHIDROTIENO[3,2-c]PIRIDINA Y SU PREPARACIÓN.
SI2398468T1 (sl) * 2009-02-17 2017-03-31 Krka, D.D., Novo Mesto Farmacevtske sestave, ki obsegajo prasugrel ali njegove farmacevtsko sprejemljive kislinske adicijske soli in postopek za njihovo pripravo
KR101991367B1 (ko) * 2009-05-13 2019-06-21 사이덱스 파마슈티칼스, 인크. 프라수그렐 및 사이클로덱스트린 유도체를 포함하는 약학 조성물 및 그의 제조 및 사용 방법
DE102009036646A1 (de) 2009-08-07 2011-02-10 Ratiopharm Gmbh Prasugrel in nicht-kristalliner Form und pharmazeutische Zusammensetzung davon
JP2013032289A (ja) * 2009-10-28 2013-02-14 Daiichi Sankyo Co Ltd ワックス安定製剤
WO2011052499A1 (ja) * 2009-10-28 2011-05-05 第一三共株式会社 貯蔵安定性が改善された医薬組成物
WO2011092720A2 (en) * 2010-02-01 2011-08-04 Msn Laboratories Limited Pharmaceutical composition of prasugrel and its pharmaceutically acceptable salts
EP2409685A3 (en) 2010-07-19 2012-02-01 Sanovel Ilac Sanayi ve Ticaret A.S. Orally-disintegrating formulations of prasugrel
TR201007926A1 (tr) 2010-07-19 2012-02-21 Sanovel İlaç San.Ve Ti̇c.A.Ş. Prasugrel tablet formülasyonları.
TR201006802A1 (tr) * 2010-08-17 2012-03-21 Sanovel İlaç San. Ve Ti̇c. A.Ş. Prasugrelin oral yolla dağılan formülasyonları.
TR201005900A1 (tr) 2010-07-19 2012-02-21 Sanovel İlaç San. Ve Ti̇c. A.Ş. Geliştirilmiş stabiliteye sahip prasugrel granülleri.
CZ2011872A3 (cs) 2011-12-22 2013-07-03 Zentiva, K.S. Farmaceutická formulace prasugrelu hydrobromidu
US8603537B2 (en) 2012-04-02 2013-12-10 Egis Pharmaceuticals Plc Prasugrel containing quickly released stable oral pharmaceutical compositions
WO2014060554A1 (en) 2012-10-19 2014-04-24 Sanovel Ilac Sanayi Ve Ticaret A.S. Prasugrel formulations
EP2722036A1 (en) 2012-10-19 2014-04-23 Sanovel Ilac Sanayi ve Ticaret A.S. Solid oral formulations of prasugrel
CN102993210A (zh) * 2012-12-19 2013-03-27 苏春华 一种吡啶并噻吩的新化合物
EP2979693A1 (en) 2014-08-01 2016-02-03 Zaklady Farmaceutyczne Polpharma SA Pharmaceutical composition comprising prasugrel or pharmaceutically acceptable salt thereof and process for its preparation
WO2016122421A1 (en) 2015-01-29 2016-08-04 Pharmactive Ilaç Sanayi Ve Ticaret A.Ş. Stable pharmaceutical compositions containing prasugrel base
EP3158993A1 (en) 2015-10-22 2017-04-26 Zaklady Farmaceutyczne Polpharma SA Process for preparing a tablet comprising prasugrel or pharmaceutically acceptable salt thereof
CN107304216A (zh) * 2016-04-20 2017-10-31 陕西合成药业股份有限公司 噻吩吡啶类衍生物及其制备方法和用途
HU231079B1 (hu) 2016-06-23 2020-06-29 Richter Gedeon Nyrt. Eljárás nagytisztaságú Prasugrel előállítására bromopentil szennyezés eltávolításával
GR1009230B (el) 2016-10-12 2018-02-22 Φαρματεν Αβεε Φαρμακευτικο σκευασμα που περιλαμβανει βεσυλικη πρασουγρελη

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FI101150B (fi) * 1991-09-09 1998-04-30 Sankyo Co Menetelmä lääkeaineina käyttökelpoisten tetrahydrotienopyridiinin johd annaisten valmistamiseksi
DK1298132T3 (da) * 2000-07-06 2007-03-12 Sankyo Co Hydropyridinderivatsyreadditionssalte
JP4001199B2 (ja) * 2000-07-06 2007-10-31 第一三共株式会社 ヒドロピリジン誘導体酸付加塩
EP1243524A3 (en) * 2001-03-16 2004-04-07 Pfizer Products Inc. Pharmaceutical kit for oxygen-sensitive drugs
JP4394873B2 (ja) * 2001-12-19 2010-01-06 武田薬品工業株式会社 酸素に不安定な化合物を含有する固形組成物およびその安定化方法
SI21302A (sl) * 2002-10-11 2004-04-30 LEK farmacevtska dru�ba d.d. Stabiliziran farmacevtski izdelek z amorfno aktivno učinkovino
US20050020554A1 (en) * 2003-06-06 2005-01-27 Ahmed Salah U. Stability of hormone formulations
PL379195A1 (pl) * 2003-08-05 2006-07-24 Zentiva, A.S. Sposoby stabilizacji atorwastatyny

Also Published As

Publication number Publication date
CN101193633B (zh) 2011-12-14
DK1896019T3 (da) 2009-10-26
TNSN07466A1 (en) 2009-03-17
RS51194B (sr) 2010-10-31
KR20100076050A (ko) 2010-07-05
ES2330373T3 (es) 2009-12-09
CA2611668C (en) 2013-10-15
EP1896019B1 (en) 2009-09-02
AU2006258102B2 (en) 2011-09-15
JP2008543755A (ja) 2008-12-04
NO20076317L (no) 2008-02-29
WO2006135605A2 (en) 2006-12-21
NZ564003A (en) 2011-07-29
ECSP077984A (es) 2008-01-23
MA29688B1 (fr) 2008-08-01
CY1109502T1 (el) 2014-08-13
CN101193633A (zh) 2008-06-04
IL187830A0 (en) 2008-04-13
EP1896019A2 (en) 2008-03-12
ZA200710697B (en) 2009-08-26
PT1896019E (pt) 2009-11-19
PL1896019T3 (pl) 2010-01-29
TWI318571B (en) 2009-12-21
PE20070320A1 (es) 2007-05-12
TW200718420A (en) 2007-05-16
BRPI0611350B8 (pt) 2021-05-25
ATE441413T1 (de) 2009-09-15
BRPI0611350A2 (pt) 2010-12-07
HK1116422A1 (en) 2008-12-24
UA91051C2 (ru) 2010-06-25
HRP20090516T1 (en) 2009-10-31
AR054283A1 (es) 2007-06-13
KR20080008413A (ko) 2008-01-23
WO2006135605A3 (en) 2007-04-12
BRPI0611350B1 (pt) 2020-09-15
DOP2006000126A (es) 2006-12-15
AU2006258102A1 (en) 2006-12-21
US20080176893A1 (en) 2008-07-24
MY151038A (en) 2014-03-31
DE602006008942D1 (en) 2009-10-15
SI1896019T1 (sl) 2010-01-29
CA2611668A1 (en) 2006-12-21
EA011693B1 (ru) 2009-04-28
MX2007015431A (es) 2008-02-21

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Designated state(s): AZ BY KG MD TJ TM

QB4A Registration of a licence in a contracting state
QB4A Registration of a licence in a contracting state
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM KZ