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EA200700982A1 - Производные хинолина и изохинолина, замещённые в 5-ом положении, способ их получения и их применение в качестве противовоспалительных средств - Google Patents

Производные хинолина и изохинолина, замещённые в 5-ом положении, способ их получения и их применение в качестве противовоспалительных средств

Info

Publication number
EA200700982A1
EA200700982A1 EA200700982A EA200700982A EA200700982A1 EA 200700982 A1 EA200700982 A1 EA 200700982A1 EA 200700982 A EA200700982 A EA 200700982A EA 200700982 A EA200700982 A EA 200700982A EA 200700982 A1 EA200700982 A1 EA 200700982A1
Authority
EA
Eurasian Patent Office
Prior art keywords
izohinolina
quinoline
derivatives
substituted
production
Prior art date
Application number
EA200700982A
Other languages
English (en)
Other versions
EA013076B1 (ru
Inventor
Штефан Ярох
Хартмут Ревинкель
Хайке Шэкке
Норберт Шмес
Вернер Скубалла
Маттиас Шнайдер
Ян Хюбнер
Орлин Петроф
Кристиан Динтер
Original Assignee
Байер Шеринг Фарма Акциенгезельшафт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE102005020331A external-priority patent/DE102005020331A1/de
Application filed by Байер Шеринг Фарма Акциенгезельшафт filed Critical Байер Шеринг Фарма Акциенгезельшафт
Publication of EA200700982A1 publication Critical patent/EA200700982A1/ru
Publication of EA013076B1 publication Critical patent/EA013076B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Изобретение относится к соединениям общей формулы (IIa) или (IIb)и их применению в качестве лекарственных средств.
EA200700982A 2004-11-12 2005-11-11 Производные хинолина и изохинолина, замещенные в 5-м положении, способ их получения и их применение в качестве противовоспалительных средств EA013076B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102004055633A DE102004055633A1 (de) 2004-11-12 2004-11-12 5-substituierte Chinolin- und Isochinolin-Derivate, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
DE102005020331A DE102005020331A1 (de) 2005-04-26 2005-04-26 5-substituierte Chinolin- und Isochinolin-Derivate, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
PCT/EP2005/012531 WO2006050998A1 (de) 2004-11-12 2005-11-11 5-substituierte chinolin- und isochinolin-derivate; ein verfahren zu ihrer herstellung und ihre verwendung als entzündungshemmer

Publications (2)

Publication Number Publication Date
EA200700982A1 true EA200700982A1 (ru) 2007-10-26
EA013076B1 EA013076B1 (ru) 2010-02-26

Family

ID=35613753

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200700982A EA013076B1 (ru) 2004-11-12 2005-11-11 Производные хинолина и изохинолина, замещенные в 5-м положении, способ их получения и их применение в качестве противовоспалительных средств

Country Status (31)

Country Link
EP (1) EP1844039B1 (ru)
JP (1) JP4460608B2 (ru)
KR (1) KR101168462B1 (ru)
CN (1) CN101124220B (ru)
AR (1) AR051767A1 (ru)
AU (1) AU2005303926B2 (ru)
BR (1) BRPI0517797A (ru)
CA (1) CA2586689C (ru)
CY (1) CY1110520T1 (ru)
DE (2) DE102004055633A1 (ru)
DK (1) DK1844039T3 (ru)
EA (1) EA013076B1 (ru)
ES (1) ES2329599T3 (ru)
GT (1) GT200500330A (ru)
HK (1) HK1112243A1 (ru)
HR (1) HRP20090509T1 (ru)
IL (1) IL182933A (ru)
ME (2) MEP13608A (ru)
MX (1) MX2007005736A (ru)
MY (1) MY141780A (ru)
NO (1) NO332405B1 (ru)
NZ (1) NZ555064A (ru)
PA (1) PA8652701A1 (ru)
PE (1) PE20061052A1 (ru)
PL (1) PL1844039T3 (ru)
PT (1) PT1844039E (ru)
RS (2) RS20070205A (ru)
SI (1) SI1844039T1 (ru)
TW (1) TWI311559B (ru)
UY (1) UY29213A1 (ru)
WO (1) WO2006050998A1 (ru)

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RU2480454C2 (ru) * 2007-04-18 2013-04-27 Интендис Гмбх Способ приготовления нестероидных противовоспалительных средств и их промежуточные соединения

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US7297700B2 (en) 2005-03-24 2007-11-20 Renovis, Inc. Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
TWI464148B (zh) 2006-03-16 2014-12-11 Evotec Us Inc 作為ｐ２ｘ7調節劑之雙環雜芳基化合物與其用途
RU2431502C2 (ru) * 2006-07-07 2011-10-20 Бош Энд Ломб Инкорпорейтед Фармацевтические композиции для лечения сухости глаз
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PT2051710E (pt) * 2006-08-07 2012-02-08 Bausch & Lomb Composições e métodos para tratar, reduzir, melhorar ou aliviar doenças oftálmicas do segmento posterior
EP2056799B1 (en) * 2006-08-31 2013-07-31 Bausch & Lomb Incorporated Compositions and methods for treating or preventing glaucoma or progression thereof
US20110105559A1 (en) * 2006-09-11 2011-05-05 Rohrs Brian R Compositions and Methods for Treating, Controlling, Reducing, Ameliorating, or Preventing Allergy
JP2010502723A (ja) * 2006-09-11 2010-01-28 ボーシュ アンド ローム インコーポレイティド アレルギーを治療、または制御、または軽減、または改善、または予防するための組成物と方法
US20110104159A1 (en) * 2006-09-11 2011-05-05 Rohrs Brian R Compositions and methods for treating, controlling, reducing, ameliorating, or preventing allergy
CA2666685A1 (en) * 2006-11-09 2008-05-22 Bausch & Lomb, Incorporated Synthesis of selected stereoisomers of certain substituted alcohols
JP5725539B2 (ja) * 2007-04-18 2015-05-27 インテンディス ゲゼルシャフト ミット ベシュレンクテル ハフツング 非ステロイド抗炎症剤及びその中間体の製造方法
EP2016935A1 (en) * 2007-07-09 2009-01-21 Intendis GmbH Pharmaceutical composition for topical application of poorly soluble compounds
US20090042936A1 (en) * 2007-08-10 2009-02-12 Ward Keith W Compositions and Methods for Treating or Controlling Anterior-Segment Inflammation
US20090087443A1 (en) * 2007-09-27 2009-04-02 Bartels Stephen P Pharmacological Adjunctive Treatment Associated with Glaucoma Filtration Surgery
WO2009058585A2 (en) * 2007-11-01 2009-05-07 Bausch & Lomb Incorporated Non-aqueous water-miscible materials as vehicles for drug delivery
US20110077270A1 (en) * 2009-04-21 2011-03-31 Pfeffer Bruce A Compositions and Methods for Treating Ocular Inflammation with Lower Risk of Increased Intraocular Pressure
CN101983961B (zh) * 2010-11-24 2012-05-09 浙江启明生化科技有限公司 5-氨基-2-甲基喹啉的制备方法
US20120316199A1 (en) 2011-06-07 2012-12-13 Ward Keith W Compositions and methods for treating, controlling, reducing, or ameliorating inflammatory pain
WO2017137375A1 (en) 2016-02-12 2017-08-17 Bayer Animal Health Gmbh Mapracorat for use in the treatment of canine dermatitis
CN106800493B (zh) * 2017-01-16 2020-06-30 宜昌尚诺德生物医药科技有限公司 一种芳硝基还原为芳胺的方法
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Publication number Priority date Publication date Assignee Title
RU2480454C2 (ru) * 2007-04-18 2013-04-27 Интендис Гмбх Способ приготовления нестероидных противовоспалительных средств и их промежуточные соединения

Also Published As

Publication number Publication date
RS51161B (sr) 2010-10-31
HK1112243A1 (en) 2008-08-29
AR051767A1 (es) 2007-02-07
TWI311559B (en) 2009-07-01
CN101124220B (zh) 2012-04-25
CY1110520T1 (el) 2015-04-29
HRP20090509T1 (hr) 2009-11-30
WO2006050998A1 (de) 2006-05-18
MY141780A (en) 2010-06-30
TW200640913A (en) 2006-12-01
KR20070084192A (ko) 2007-08-24
NO20072963L (no) 2007-08-03
CA2586689A1 (en) 2006-05-18
DE502005007725D1 (de) 2009-08-27
AU2005303926B2 (en) 2011-05-19
RS20070205A (en) 2008-11-28
MX2007005736A (es) 2007-09-07
EP1844039B1 (de) 2009-07-15
ES2329599T3 (es) 2009-11-27
NO332405B1 (no) 2012-09-10
KR101168462B1 (ko) 2012-07-27
DE102004055633A1 (de) 2006-05-18
JP4460608B2 (ja) 2010-05-12
GT200500330A (es) 2006-09-21
ME00155B (me) 2010-10-10
SI1844039T1 (sl) 2009-12-31
NZ555064A (en) 2009-09-25
CN101124220A (zh) 2008-02-13
MEP13608A (en) 2010-06-10
PA8652701A1 (es) 2006-07-03
DK1844039T3 (da) 2009-11-09
PE20061052A1 (es) 2006-11-08
EP1844039A1 (de) 2007-10-17
PL1844039T3 (pl) 2009-12-31
PT1844039E (pt) 2009-10-19
BRPI0517797A (pt) 2008-10-21
CA2586689C (en) 2012-04-17
IL182933A (en) 2011-10-31
JP2008519803A (ja) 2008-06-12
UY29213A1 (es) 2006-05-31
EA013076B1 (ru) 2010-02-26
IL182933A0 (en) 2007-09-20
AU2005303926A1 (en) 2006-05-18

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