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EA200702048A1 - Фармакокинетически улучшенные соединения - Google Patents

Фармакокинетически улучшенные соединения

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Publication number
EA200702048A1
EA200702048A1 EA200702048A EA200702048A EA200702048A1 EA 200702048 A1 EA200702048 A1 EA 200702048A1 EA 200702048 A EA200702048 A EA 200702048A EA 200702048 A EA200702048 A EA 200702048A EA 200702048 A1 EA200702048 A1 EA 200702048A1
Authority
EA
Eurasian Patent Office
Prior art keywords
improved compounds
pharmacokinetically improved
compounds
pharmacokinetically
rock2
Prior art date
Application number
EA200702048A
Other languages
English (en)
Other versions
EA022875B1 (ru
Inventor
Алессандра Бартолоцци
Пол Свитнэм
Стюарт Кемпбелл
Хоуп Фоудоулакис
Брайан Кирк
Сайя Рам
Original Assignee
Сурфейс Логикс Инк.
Бартолоции, Алессандра
Пол Свитнэм
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сурфейс Логикс Инк., Бартолоции, Алессандра, Пол Свитнэм filed Critical Сурфейс Логикс Инк.
Publication of EA200702048A1 publication Critical patent/EA200702048A1/ru
Publication of EA022875B1 publication Critical patent/EA022875B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A—HUMAN NECESSITIES
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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    • A61P19/00—Drugs for skeletal disorders
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
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    • B82—NANOTECHNOLOGY
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    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
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    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
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  • Nanotechnology (AREA)
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  • Crystallography & Structural Chemistry (AREA)
  • Materials Engineering (AREA)
  • General Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Composite Materials (AREA)
  • Physics & Mathematics (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
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Abstract

Изобретение относится к ингибиторам ROCK1 и ROCK2 и способам модулирования фармакокинетических и/или фармакодинамических свойств таких соединений. Также представлены способы ингибирования ROCK1 и/или ROCK2, применимые для лечения заболеваний.
EA200702048A 2005-03-25 2006-03-27 Производные 4-(индазол-5-ил-амино)-2-фенилхиназолина EA022875B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66516505P 2005-03-25 2005-03-25
PCT/US2006/011271 WO2006105081A2 (en) 2005-03-25 2006-03-27 Pharmacokinetically improved compounds

Publications (2)

Publication Number Publication Date
EA200702048A1 true EA200702048A1 (ru) 2008-04-28
EA022875B1 EA022875B1 (ru) 2016-03-31

Family

ID=37054004

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200702048A EA022875B1 (ru) 2005-03-25 2006-03-27 Производные 4-(индазол-5-ил-амино)-2-фенилхиназолина

Country Status (21)

Country Link
US (6) US8357693B2 (ru)
EP (1) EP1865958B1 (ru)
JP (2) JP2008534518A (ru)
KR (1) KR20080081122A (ru)
CN (1) CN101208094B (ru)
AU (1) AU2006230159A1 (ru)
BR (1) BRPI0622285A2 (ru)
CA (1) CA2602254C (ru)
CR (1) CR9465A (ru)
EA (1) EA022875B1 (ru)
EC (1) ECSP077836A (ru)
ES (1) ES2549397T3 (ru)
GE (1) GEP20105029B (ru)
IL (1) IL186299A0 (ru)
MX (1) MX2007011859A (ru)
NO (1) NO20075145L (ru)
NZ (1) NZ562083A (ru)
SG (1) SG155163A1 (ru)
UA (1) UA96126C2 (ru)
WO (1) WO2006105081A2 (ru)
ZA (1) ZA200708858B (ru)

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