[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

EA200700658A1 - Фармацевтическая композиция, представляющая собой твердую дисперсию с полимерной матрицей, содержащей непрерывную фазу полидекстрозы и непрерывную фазу полимера, не являющегося полидекстрозой - Google Patents

Фармацевтическая композиция, представляющая собой твердую дисперсию с полимерной матрицей, содержащей непрерывную фазу полидекстрозы и непрерывную фазу полимера, не являющегося полидекстрозой

Info

Publication number
EA200700658A1
EA200700658A1 EA200700658A EA200700658A EA200700658A1 EA 200700658 A1 EA200700658 A1 EA 200700658A1 EA 200700658 A EA200700658 A EA 200700658A EA 200700658 A EA200700658 A EA 200700658A EA 200700658 A1 EA200700658 A1 EA 200700658A1
Authority
EA
Eurasian Patent Office
Prior art keywords
continuous
phase
pattern
polymer
polymetra
Prior art date
Application number
EA200700658A
Other languages
English (en)
Other versions
EA012850B1 (ru
Inventor
Мишель Бедо
Тьерри Брель
Стефен Байард
Изабель Рибьеро Дос Сантос
Original Assignee
Санофи-Авентис
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Санофи-Авентис filed Critical Санофи-Авентис
Publication of EA200700658A1 publication Critical patent/EA200700658A1/ru
Publication of EA012850B1 publication Critical patent/EA012850B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Настоящее изобретение относится к твердой фармацевтической композиции, представляющей собой твердую дисперсию, содержащую по меньшей мере одно активное вещество и фармацевтически приемлемую полимерную матрицу, отличающейся тем, что указанная фармацевтически приемлемая полимерная матрица содержит (i) полидекстрозу, способствующую расщеплению композиции в водной среде, в виде непрерывной фазы полидекстрозы в смеси с (ii) по меньшей мере одним полимером, не являющимся полидекстрозой, в виде непрерывной фазы указанного полимера, причем содержание указанной полидекстрозы составляет по меньшей мере 20 мас.% и содержание указанного по меньшей мере одного полимера, не являющегося полидекстрозой, составляет по меньшей мере 20 мас.% по отношению к общей массе указанной фармацевтически приемлемой полимерной матрицы.
EA200700658A 2004-09-17 2005-09-15 Фармацевтическая композиция, представляющая собой твердую дисперсию с полимерной матрицей, содержащей непрерывную фазу полидекстрозы и непрерывную фазу полимера, не являющегося полидекстрозой EA012850B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0409874A FR2875409B1 (fr) 2004-09-17 2004-09-17 Composition pharmaceutique comprenant une dispersion solide a matrice polymere comprenant une phase continue de polydextrose et une phase continue d'un polymere autre que du polydextrose
PCT/FR2005/002288 WO2006032762A2 (fr) 2004-09-17 2005-09-15 Composition pharmaceutique comprenant une dispersion solide a matrice polymere comprenant une phase continue de polydextrose et une phase continue d'un polymere autre que du polydextrose

Publications (2)

Publication Number Publication Date
EA200700658A1 true EA200700658A1 (ru) 2007-08-31
EA012850B1 EA012850B1 (ru) 2009-12-30

Family

ID=34948358

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200700658A EA012850B1 (ru) 2004-09-17 2005-09-15 Фармацевтическая композиция, представляющая собой твердую дисперсию с полимерной матрицей, содержащей непрерывную фазу полидекстрозы и непрерывную фазу полимера, не являющегося полидекстрозой

Country Status (17)

Country Link
US (1) US9084730B2 (ru)
EP (1) EP1791524B1 (ru)
JP (1) JP5224812B2 (ru)
KR (1) KR101342193B1 (ru)
CN (2) CN102247601A (ru)
AU (1) AU2005286396B2 (ru)
BR (1) BRPI0515390A (ru)
CA (1) CA2579673C (ru)
EA (1) EA012850B1 (ru)
FR (1) FR2875409B1 (ru)
IL (1) IL181773A0 (ru)
MA (1) MA28858B1 (ru)
MX (1) MX2007003162A (ru)
NO (1) NO20071853L (ru)
NZ (1) NZ553780A (ru)
WO (1) WO2006032762A2 (ru)
ZA (1) ZA200702214B (ru)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0610308A8 (pt) 2005-05-26 2017-04-25 Neuron Systems Inc Composições e métodos para o tratamento de doença retinal
AU2007212197B2 (en) * 2006-02-09 2012-12-13 Merck Sharp & Dohme Corp. Polymer formulations of CETP inhibitors
US20100080852A1 (en) * 2007-05-03 2010-04-01 Ronald Arthur Beyerinck Phamaceutical composition comprising nanoparticles and casein
FR2921835B1 (fr) * 2007-10-05 2012-05-04 Soc Dexploitation De Produits Pour Les Industries Chimiques Seppic Composition d'enrobage comprenant du polydextrose, procede pour sa preparation et utilisation pour enrober les formes solides ingerables
FR2930149B1 (fr) * 2008-04-17 2011-02-18 Sanofi Aventis Association de dronedarone avec au moins un diuretique, son application en therapeutique
EP3195862A1 (en) 2008-04-17 2017-07-26 Sanofi Use of dronedarone for the preparation of a medicament for use in the prevention of cardiovascular hospitalization or in the prevention of atrial fibrillation
EP2116239A1 (en) * 2008-04-29 2009-11-11 Sanofi-Aventis Method for managing the risks associated with an increase in serum creatinine during dronedarone treatment
US8728516B2 (en) * 2009-04-30 2014-05-20 Abbvie Inc. Stabilized lipid formulation of apoptosis promoter
TWI540132B (zh) * 2009-06-08 2016-07-01 亞培公司 Ｂｃｌ-２族群抑制劑之口服醫藥劑型
TWI532484B (zh) * 2009-06-08 2016-05-11 艾伯維有限公司 包含凋亡促進劑之固態分散劑
CN102078307B (zh) * 2009-12-01 2012-11-07 天津市汉康医药生物技术有限公司 一种盐酸决奈达隆固体分散体的药物组合物及其制备方法
JP5885670B2 (ja) 2009-12-11 2016-03-15 アルデイラ セラピューティクス， インコーポレイテッド 黄斑変性の処置のための組成物および方法
WO2011135581A2 (en) 2010-04-28 2011-11-03 Cadila Healthcare Limited Pharmaceutical compositions of dronedarone
WO2011135582A2 (en) 2010-04-28 2011-11-03 Cadila Healthcare Limited Pharmaceutical compositions of dronedarone
WO2011146483A1 (en) 2010-05-17 2011-11-24 Aerie Pharmaceuticals, Inc. Drug delivery devices for delivery of ocular therapeutic agents
WO2012001673A1 (en) * 2010-06-28 2012-01-05 Mapi Pharma Holdings (Cyprus) Limited Amorphous form of dronedarone
US8602215B2 (en) 2010-06-30 2013-12-10 Sanofi Methods for reducing the risk of an adverse dronedarone/beta-blockers interaction in a patient suffering from atrial fibrillation
CN102342907A (zh) * 2010-07-30 2012-02-08 江苏恒瑞医药股份有限公司 决奈达隆固体分散体及其制备方法
WO2012023024A2 (en) 2010-08-17 2012-02-23 Lupin Limited Controlled release formulations of dronedarone
UA113500C2 (xx) 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
US9204667B2 (en) * 2010-12-01 2015-12-08 R.J. Reynolds Tobacco Company Smokeless tobacco pastille and injection molding process for forming smokeless tobacco products
WO2013024411A1 (en) 2011-08-12 2013-02-21 Lupin Limited Co-milled formulation of dronedarone
CA2864858A1 (en) 2012-02-20 2013-08-29 Lupin Limited Bilayer tablet of dronedarone
CN103054820B (zh) * 2012-08-22 2016-07-13 石药集团中奇制药技术（石家庄）有限公司 一种盐酸决奈达隆药物组合物及其制备方法
CN105120866B (zh) 2013-01-23 2020-02-14 奥尔德拉医疗公司 与毒性醛相关的疾病和治疗
KR20190033643A (ko) 2013-01-31 2019-03-29 길리애드 파마셋 엘엘씨 두 항바이러스 화합물의 병용 제형물
PL3038601T3 (pl) 2013-08-27 2020-08-24 Gilead Pharmasset Llc Formulacja złożona dwóch związków przeciwwirusowych
TWI721947B (zh) 2014-06-11 2021-03-21 美商基利法瑪席特有限責任公司 抗病毒化合物的固態形式
KR102664994B1 (ko) 2015-08-21 2024-05-13 알데이라 테라퓨틱스, 아이엔씨. 중수소화 화합물 및 이의 용도
WO2018046642A1 (en) 2016-09-09 2018-03-15 Merck Patent Gmbh Process for the manufacture of a solid pharmaceutical adminstration form
CN111356451A (zh) 2017-10-10 2020-06-30 奥尔德拉医疗公司 炎性病症的治疗
US12006298B2 (en) 2018-08-06 2024-06-11 Aldeyra Therapeutics, Inc. Polymorphic compounds and uses thereof
WO2020198064A1 (en) 2019-03-26 2020-10-01 Aldeyra Therapeutics, Inc. Ophthalmic formulations and uses thereof
US12098132B2 (en) 2019-05-02 2024-09-24 Aldeyra Therapeutics, Inc. Process for preparation of aldehyde scavenger and intermediates
CA3137301A1 (en) 2019-05-02 2020-11-05 Aldeyra Therapeutics, Inc. Polymorphic compounds and uses thereof
CN115697336A (zh) 2020-05-13 2023-02-03 奥尔德拉医疗公司 药物制剂及其用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3612212A1 (de) * 1986-04-11 1987-10-15 Basf Ag Verfahren zur herstellung von festen pharmazeutischen formen
GB8613689D0 (en) * 1986-06-05 1986-07-09 Euro Celtique Sa Pharmaceutical composition
US5456932A (en) * 1987-04-20 1995-10-10 Fuisz Technologies Ltd. Method of converting a feedstock to a shearform product and product thereof
CA2095776C (en) * 1992-05-12 2007-07-10 Richard C. Fuisz Rapidly dispersable compositions containing polydextrose
FR2692575B1 (fr) * 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
US5935600A (en) * 1993-09-10 1999-08-10 Fuisz Technologies Ltd. Process for forming chewable quickly dispersing comestible unit and product therefrom
TW487582B (en) * 1995-08-11 2002-05-21 Nissan Chemical Ind Ltd Method for converting sparingly water-soluble medical substance to amorphous state
FR2761266B1 (fr) * 1997-03-28 1999-07-02 Sanofi Sa Composition pharmaceutique formee par granulation humide pour l'administration orale d'un derive du n-piperidino-3- pyrazolecarboxamide, de ses sels et de leurs solvates
DE19938672C2 (de) * 1999-08-06 2001-11-22 Biop Biopolymer Gmbh Verfahren zur Herstellung einer thermoplastischen Polymermischung auf Stärkebasis durch reaktive Extrusion
AU2002304387A1 (en) * 2001-06-22 2003-01-08 Pfizer Products Inc. Pharmaceutical compositions containing a solid dispersion of a poorly-soluble drug in a matrix and a solubility-enhancing polymer
US6566347B1 (en) * 2001-08-22 2003-05-20 Duquesne University Of The Holy Ghost Controlled release pharmaceutical

Also Published As

Publication number Publication date
CA2579673C (fr) 2014-11-18
FR2875409B1 (fr) 2010-05-07
CA2579673A1 (fr) 2006-03-30
NZ553780A (en) 2010-08-27
KR20070055601A (ko) 2007-05-30
WO2006032762A3 (fr) 2006-06-01
JP2008513421A (ja) 2008-05-01
HK1111608A1 (en) 2008-08-15
AU2005286396A1 (en) 2006-03-30
EA012850B1 (ru) 2009-12-30
MA28858B1 (fr) 2007-09-03
JP5224812B2 (ja) 2013-07-03
WO2006032762A2 (fr) 2006-03-30
US9084730B2 (en) 2015-07-21
ZA200702214B (en) 2008-09-25
US20070243257A1 (en) 2007-10-18
EP1791524B1 (fr) 2014-11-19
NO20071853L (no) 2007-06-15
IL181773A0 (en) 2007-07-04
CN102247601A (zh) 2011-11-23
BRPI0515390A (pt) 2008-07-22
CN101039657B (zh) 2012-07-18
KR101342193B1 (ko) 2013-12-16
FR2875409A1 (fr) 2006-03-24
CN101039657A (zh) 2007-09-19
AU2005286396B2 (en) 2011-08-11
MX2007003162A (es) 2007-05-16
EP1791524A2 (fr) 2007-06-06

Similar Documents

Publication Publication Date Title
EA200700658A1 (ru) Фармацевтическая композиция, представляющая собой твердую дисперсию с полимерной матрицей, содержащей непрерывную фазу полидекстрозы и непрерывную фазу полимера, не являющегося полидекстрозой
RS51527B (en) Extended release tablet formulation containing pramipexole or a pharmaceutically acceptable salt thereof, method for manufacturing the same and use thereof
BR0115946A (pt) Composições de resina de polipropileno
EP2004172A4 (en) ACTIVE INK PROCESSING, STRUCTURES AND COMPOSITIONS FOR NASOLACRIMAL SYSTEM
WO2008098019A3 (en) Polymer formulations for delivery of bioactive agents
EP2123257A3 (en) Stable high Vitamin C content polyol-in-oil emulsified system and its preparation
WO2009080661A3 (en) High oil content o/w emulsions stabilized with a hydrophobically modified inulin and a hydrophilic acrylic polymer
NO20062798L (no) Anvendelse av en vannholdig dispersjon av i det minste en bio-nedbrytbar polymer inneholdende i det minste et stabiliseringsmiddel for fremstilling av en vanndig filmdannende sammensetning
DE60220049D1 (de) Pharmazeutische zusammensetzungen enthaltend eine feste dispersion eines im wasser schwerlöslichen arzneimittels und ein löslichkeitsteigerndes polymer
MX2007013065A (es) Derivados de dihidrobenzofurano y usos de los mismos.
EP2277947A3 (en) Composite materials based on carbon nanotubes and polymer matrices and processes for obtaining same
EP2072084A3 (fr) Compositions cosmétiques contenant un copolymère cationique, une silicone aminée et un polymère cationique et leurs utilisations
BRPI0714450A8 (pt) Processo para preparar partículas poliméricas absorvedoras de água, partículas poliméricas absorvedoras de água, uso das partículas poliméricas, e, artigos de higiene
PL1608698T3 (pl) Spienione polimery winyloaromatyczne i sposób ich wytwarzania
MXPA05003591A (es) Materiales basados en ciclodextrina, composiciones y usos relacionados a los mismos.
BR0307344A (pt) Composições farmacêuticas de dispersões amorfas de fármacos e materiais formadores de microfase lipofìlica
AR050203A1 (es) Procedimiento para la preparacion de composiciones acuosas de principios activos dificilmente solubles en agua.
UA97396C2 (ru) Фармацевтическая композиция пролонгированного высвобождения, содержащая пасиреотид памоат в микрочастицах
BR0307278A (pt) Formulação oral de liberação imediata, e, método para preparar uma formulação
CL2009000980A1 (es) Uso de (s)-n-(2-(1,6,8-tetrahidro-2h-inden[5,4-b]furan-8-il)etil]propionamida en combinacion con una o más drogas seleccionadas de un grupo definido para preparar un medicamento útil para la prevencion o tratamiento de la depresión o desórdenes de ansiedad (divisional de la solicitud 749-2006).
WO2005065656A3 (en) Stabilized pharmaceutical solid compositions of low-solubility drugs, poloxamers, and stabilizing polymers
BR0315027A (pt) Polìmeros para proteger materiais de danos
BR0308710A (pt) conjugados poliméricos antimicrobianos
BRPI0604969A (pt) dispersão aquosa, composição, pelìcula, adesivo, e, métodos para estabilizar e para liberar um ou mais ingredientes ativos
BR0312814A (pt) Levamisol / avermectinas ou similares em solvente de pirrolidona

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU