EA200401183A1 - Применение ингибиторов il-18 в качестве диагностического маркера - Google Patents
Применение ингибиторов il-18 в качестве диагностического маркераInfo
- Publication number
- EA200401183A1 EA200401183A1 EA200401183A EA200401183A EA200401183A1 EA 200401183 A1 EA200401183 A1 EA 200401183A1 EA 200401183 A EA200401183 A EA 200401183A EA 200401183 A EA200401183 A EA 200401183A EA 200401183 A1 EA200401183 A1 EA 200401183A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- inhibitors
- application
- diagnostic marker
- atherosclerosis
- medicament
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 239000003550 marker Substances 0.000 title 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Изобретение относится к применению ингибитора IL-18 для получения лекарственного средства для лечения и/или предотвращения атеросклероза.Отчет о международном поиске был опубликован 2002.05.10.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00109606 | 2000-05-05 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200401183A1 true EA200401183A1 (ru) | 2004-12-30 |
| EA007014B1 EA007014B1 (ru) | 2006-06-30 |
Family
ID=8168631
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200201175A EA005410B1 (ru) | 2000-05-05 | 2001-04-30 | Применение ингибиторов il-18 для лечения и/или предотвращения атеросклероза |
| EA200401183A EA007014B1 (ru) | 2000-05-05 | 2001-04-30 | Применение il-18 в качестве диагностического маркера |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200201175A EA005410B1 (ru) | 2000-05-05 | 2001-04-30 | Применение ингибиторов il-18 для лечения и/или предотвращения атеросклероза |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US20040076628A1 (ru) |
| EP (1) | EP1278540B1 (ru) |
| JP (1) | JP5122053B2 (ru) |
| KR (2) | KR100798545B1 (ru) |
| CN (2) | CN1250286C (ru) |
| AR (1) | AR035640A1 (ru) |
| AT (1) | ATE395075T1 (ru) |
| AU (2) | AU2001267390B2 (ru) |
| BG (1) | BG65881B1 (ru) |
| BR (1) | BRPI0110506B8 (ru) |
| CA (1) | CA2407895C (ru) |
| CY (1) | CY1110385T1 (ru) |
| CZ (1) | CZ300792B6 (ru) |
| DE (1) | DE60134009D1 (ru) |
| DK (1) | DK1278540T3 (ru) |
| EA (2) | EA005410B1 (ru) |
| EE (1) | EE05056B1 (ru) |
| ES (1) | ES2305082T3 (ru) |
| HK (2) | HK1055681A1 (ru) |
| HR (1) | HRP20020828A2 (ru) |
| HU (1) | HU229375B1 (ru) |
| IL (2) | IL152567A0 (ru) |
| ME (1) | ME00554B (ru) |
| MX (1) | MXPA02010895A (ru) |
| NO (1) | NO329821B1 (ru) |
| PL (1) | PL209371B1 (ru) |
| PT (1) | PT1278540E (ru) |
| RS (1) | RS50926B (ru) |
| SI (1) | SI1278540T1 (ru) |
| SK (1) | SK287761B6 (ru) |
| UA (2) | UA78492C2 (ru) |
| WO (1) | WO2001085201A2 (ru) |
| ZA (1) | ZA200208228B (ru) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001236807A1 (en) * | 2000-02-10 | 2001-08-20 | Abbott Laboratories | Antibodies that bind human interleukin-18 and methods of making and using |
| EA006767B1 (ru) * | 2001-01-29 | 2006-04-28 | Апплайд Резеч Системз Арс Холдинг Н.В. | Применение ингибитора il-18 для приготовления лекарственного средства для лечения и/или профилактики заболевания сердца |
| EE05263B1 (et) | 2001-05-25 | 2010-02-15 | Ares Trading S.A. | IL-18 inhibiitorite kasutamine kesknrvissteemi kahjustuste raviks v?i ennetamiseks |
| US6797727B2 (en) * | 2001-07-16 | 2004-09-28 | Transition Therapeutics Inc. | Use of rhein or diacerhein compounds for the treatment or prevention of vascular diseases |
| US8729124B2 (en) | 2002-03-05 | 2014-05-20 | Pronova Biopharma Norge As | Use of EPA and DHA in secondary prevention |
| GB0210212D0 (en) * | 2002-05-03 | 2002-06-12 | Univ Southampton | Effects of dietary N-3 and N-6 pufa intake on atheromatous plaque stability |
| ME00548B (me) * | 2002-03-22 | 2011-10-10 | Serono Lab | Korišćenje inhibitora il-18 za liječenje i/ili prevenciju perifernih vaskularnih bolesti |
| BRPI0408246A (pt) * | 2003-03-11 | 2006-03-01 | Applied Research Systems | vetores de expressão que compreendem o promotor ie2 do mcmv |
| PL1622939T3 (pl) | 2003-05-13 | 2012-08-31 | Merck Serono Sa | Aktywne warianty białka wiążącego IL-18 i ich medyczne zastosowania |
| US7968684B2 (en) * | 2003-11-12 | 2011-06-28 | Abbott Laboratories | IL-18 binding proteins |
| DE602005018914D1 (de) * | 2004-04-15 | 2010-03-04 | Athera Biotechnologies Ab | Annexin zur prävention von der ruptur des plaques |
| CN101219208B (zh) * | 2005-01-04 | 2010-08-11 | 健能隆医药技术（上海）有限公司 | 白介素-22的医药用途 |
| SI2267024T1 (sl) | 2005-06-03 | 2012-09-28 | Ares Trading Sa | Proizvodnja rekombinantnega IL-18 vezavnega proteina |
| ES2375831T3 (es) | 2005-06-10 | 2012-03-06 | Ares Trading S.A. | Procedimiento para la purificación de prote�?nas de unión a il-18. |
| RU2013110874A (ru) | 2010-08-25 | 2014-09-27 | Ф.Хоффманн-Ля Рош Аг | Антитела против il-18r1 и их применения |
| JOP20200308A1 (ar) | 2012-09-07 | 2017-06-16 | Novartis Ag | جزيئات إرتباط il-18 |
| MD707Z (ru) * | 2013-01-18 | 2014-07-31 | Институт Зоологии Академии Наук Молдовы | Метод идентификации полиморфных последовательностей 4а/4б гена эндотелиальной синтетазы оксида азота |
| KR102512797B1 (ko) | 2013-09-05 | 2023-03-22 | 에이비2 바이오 에스에이 | 염증성 질환에서 il-18 결합 단백질(ｉｌ-18ｂｐ) |
| CN107660150B (zh) | 2015-03-05 | 2023-10-24 | Ab2生物股份有限公司 | Il-18结合蛋白(il-18bp)和抗体在炎性疾病中 |
| CN110273591B (zh) | 2019-08-13 | 2023-12-12 | 上海杉脉电子科技发展有限公司 | 一种单动力微型智能锁 |
| TW202233675A (zh) | 2020-10-29 | 2022-09-01 | 瑞士商諾華公司 | Ｉｌ－１８拮抗劑用於治療和／或預防異位性皮炎或相關病症之用途 |
| CN112972655A (zh) * | 2021-04-16 | 2021-06-18 | 武汉大学 | 白细胞介素12在制备预防、缓解和/或治疗主动脉瘤药物中的应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5985863A (en) * | 1996-09-12 | 1999-11-16 | Vertex Pharmaceuticals, Inc. | Compositions and methods for decreasing IGIF and IFN-γ production by administering an ICE inhibitor |
| US5877197A (en) * | 1996-12-16 | 1999-03-02 | Karanewsky; Donald S. | C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
| IL121860A0 (en) * | 1997-08-14 | 1998-02-22 | Yeda Res & Dev | Interleukin-18 binding proteins their preparation and use |
| CA2276216A1 (en) * | 1998-06-24 | 1999-12-24 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | An artificial peptide capable of neutralizing the biological activity of interleukin-18 |
| EP0987552A3 (en) * | 1998-08-31 | 2000-06-07 | Pfizer Products Inc. | Diarylsulfonylurea binding proteins |
| EP1110969A4 (en) * | 1998-09-01 | 2002-01-09 | Hayashibara Biochem Lab | INTERLEUKIN 18 BINDING PROTEIN |
-
2001
- 2001-04-30 EA EA200201175A patent/EA005410B1/ru not_active IP Right Cessation
- 2001-04-30 KR KR1020077014038A patent/KR100798545B1/ko active IP Right Grant
- 2001-04-30 CZ CZ20023644A patent/CZ300792B6/cs not_active IP Right Cessation
- 2001-04-30 UA UA2002129704A patent/UA78492C2/uk unknown
- 2001-04-30 AU AU2001267390A patent/AU2001267390B2/en not_active Expired
- 2001-04-30 UA UAA200507913A patent/UA87658C2/ru unknown
- 2001-04-30 MX MXPA02010895A patent/MXPA02010895A/es active IP Right Grant
- 2001-04-30 AU AU6739001A patent/AU6739001A/xx active Pending
- 2001-04-30 EP EP01945064A patent/EP1278540B1/en not_active Expired - Lifetime
- 2001-04-30 JP JP2001581854A patent/JP5122053B2/ja not_active Expired - Lifetime
- 2001-04-30 SI SI200130832T patent/SI1278540T1/sl unknown
- 2001-04-30 KR KR1020027014755A patent/KR20030016254A/ko not_active Application Discontinuation
- 2001-04-30 US US10/275,341 patent/US20040076628A1/en not_active Abandoned
- 2001-04-30 BR BRPI0110506A patent/BRPI0110506B8/pt not_active IP Right Cessation
- 2001-04-30 CN CNB018090540A patent/CN1250286C/zh not_active Expired - Lifetime
- 2001-04-30 EE EEP200200620A patent/EE05056B1/xx unknown
- 2001-04-30 PT PT01945064T patent/PT1278540E/pt unknown
- 2001-04-30 PL PL365697A patent/PL209371B1/pl unknown
- 2001-04-30 AT AT01945064T patent/ATE395075T1/de active
- 2001-04-30 WO PCT/EP2001/004843 patent/WO2001085201A2/en active IP Right Grant
- 2001-04-30 RS YUP-826/02A patent/RS50926B/sr unknown
- 2001-04-30 SK SK1556-2002A patent/SK287761B6/sk not_active IP Right Cessation
- 2001-04-30 ME MEP-2008-640A patent/ME00554B/me unknown
- 2001-04-30 CA CA2407895A patent/CA2407895C/en not_active Expired - Lifetime
- 2001-04-30 CN CN2006100092901A patent/CN1841066B/zh not_active Expired - Lifetime
- 2001-04-30 DK DK01945064T patent/DK1278540T3/da active
- 2001-04-30 HU HU0301991A patent/HU229375B1/hu unknown
- 2001-04-30 DE DE60134009T patent/DE60134009D1/de not_active Expired - Lifetime
- 2001-04-30 ES ES01945064T patent/ES2305082T3/es not_active Expired - Lifetime
- 2001-04-30 EA EA200401183A patent/EA007014B1/ru not_active IP Right Cessation
- 2001-04-30 IL IL15256701A patent/IL152567A0/xx unknown
- 2001-05-04 AR ARP010102129A patent/AR035640A1/es unknown
-
2002
- 2002-10-11 ZA ZA2002/08228A patent/ZA200208228B/en unknown
- 2002-10-16 HR HRP20020828 patent/HRP20020828A2/hr not_active Application Discontinuation
- 2002-10-24 BG BG107218A patent/BG65881B1/bg unknown
- 2002-10-31 IL IL152567A patent/IL152567A/en active IP Right Grant
- 2002-11-05 NO NO20025307A patent/NO329821B1/no not_active IP Right Cessation
-
2003
- 2003-11-05 HK HK03107981A patent/HK1055681A1/xx not_active IP Right Cessation
-
2007
- 2007-03-02 HK HK07102380.7A patent/HK1094909A1/xx not_active IP Right Cessation
-
2008
- 2008-06-30 CY CY20081100684T patent/CY1110385T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC4A | Registration of transfer of a eurasian patent by assignment | ||
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM |
|
| MK4A | Patent expired |
Designated state(s): RU |