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EA199900301A2 - Замещенные трициклические соединения - Google Patents

Замещенные трициклические соединения

Info

Publication number
EA199900301A2
EA199900301A2 EA199900301A EA199900301A EA199900301A2 EA 199900301 A2 EA199900301 A2 EA 199900301A2 EA 199900301 A EA199900301 A EA 199900301A EA 199900301 A EA199900301 A EA 199900301A EA 199900301 A2 EA199900301 A2 EA 199900301A2
Authority
EA
Eurasian Patent Office
Prior art keywords
tricyclic compounds
substituted tricyclic
compounds
substituted
cfla
Prior art date
Application number
EA199900301A
Other languages
English (en)
Other versions
EA002347B1 (ru
EA199900301A3 (ru
Inventor
Бенджамин Алан Андерсон
Николас Джеймс Бах
Жоли Анн Бастиан
Нэнси Кей Харн
Ричард Вальтц Харпер
Гари Алан Хайт
Майкл Дин Кинник
Хо-Шен Лин
Ричард Джеймс Лончарик
Джон МакНейлл МакДжилл III
Эдвард Дэвид Михелик
Джон Майкл мл. Морин
Майкл ЛеРой Филлипс
Майкл Энрико Ричетт
Дэниел Джон Солл
Джейсон Скотт Сойер
Ричард Вальтер Шевитц
Роберт Теодор Василефф
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA199900301A2 publication Critical patent/EA199900301A2/ru
Publication of EA199900301A3 publication Critical patent/EA199900301A3/ru
Publication of EA002347B1 publication Critical patent/EA002347B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Описан класс новых трициклических соединений, а также применение таких соединений для ингибирования сФЛАопосредованного высвобождения жирных кислот для лечений состояний, таких как септический шок.
EA199900301A 1998-04-17 1999-04-16 Замещенные трициклические соединения EA002347B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6232898A 1998-04-17 1998-04-17

Publications (3)

Publication Number Publication Date
EA199900301A2 true EA199900301A2 (ru) 1999-10-28
EA199900301A3 EA199900301A3 (ru) 2000-04-24
EA002347B1 EA002347B1 (ru) 2002-04-25

Family

ID=22041763

Family Applications (2)

Application Number Title Priority Date Filing Date
EA199900301A EA002347B1 (ru) 1998-04-17 1999-04-16 Замещенные трициклические соединения
EA199900303A EA002816B1 (ru) 1998-04-17 1999-04-16 Производные карбазола

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA199900303A EA002816B1 (ru) 1998-04-17 1999-04-16 Производные карбазола

Country Status (30)

Country Link
EP (2) EP0950657B1 (ru)
JP (2) JPH11322713A (ru)
KR (2) KR19990083232A (ru)
CN (1) CN1149193C (ru)
AR (2) AR018186A1 (ru)
AT (2) ATE268756T1 (ru)
AU (2) AU753436B2 (ru)
BR (2) BR9902365A (ru)
CA (2) CA2269262A1 (ru)
CO (2) CO5031247A1 (ru)
CZ (2) CZ137099A3 (ru)
DE (2) DE69918590T2 (ru)
DK (1) DK0950657T3 (ru)
DZ (1) DZ2769A1 (ru)
EA (2) EA002347B1 (ru)
ES (2) ES2226286T3 (ru)
HU (2) HUP9901220A3 (ru)
ID (2) ID23761A (ru)
IL (2) IL129485A0 (ru)
NO (2) NO314400B1 (ru)
NZ (3) NZ335251A (ru)
PE (2) PE20000432A1 (ru)
PL (2) PL332566A1 (ru)
PT (1) PT950657E (ru)
SG (2) SG81976A1 (ru)
SI (1) SI0950657T1 (ru)
TR (2) TR199900853A2 (ru)
TW (1) TWI238160B (ru)
YU (2) YU18999A (ru)
ZA (2) ZA992771B (ru)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1011670A4 (en) * 1997-08-28 2004-10-27 Lilly Co Eli PROCESS FOR TREATING NON-RHUMATOID POLYARTHRITIS
DZ2769A1 (fr) * 1998-04-17 2003-12-01 Lilly Co Eli Composés tricycliques substitués.
JP2002542148A (ja) * 1998-12-21 2002-12-10 イーライ・リリー・アンド・カンパニー 敗血症の処置のための組み合わせ療法
CA2379208A1 (en) * 1999-07-19 2001-01-25 Eli Lilly & Company Spla2 inhibitors
US6706752B1 (en) 1999-07-19 2004-03-16 Eli Lilly And Company sPLA2 inhibitors
US20040102442A1 (en) * 2000-06-29 2004-05-27 Kohji Hanasaki Remedies for alzheimer's disease
AU2001267825A1 (en) * 2000-06-29 2002-01-08 Shionogi And Co., Ltd. Remedies for cirrhosis
ATE375171T1 (de) * 2000-06-29 2007-10-15 Anthera Pharmaceuticals Inc Heilmittel für krebs
CA2413582A1 (en) * 2000-07-14 2002-01-24 Eli Lilly And Company Use of a spla2 inhibitor for the treatment of sepsis
CA2431028A1 (en) * 2000-12-18 2002-06-27 Ho-Shen Lin Tetracyclic carbazole derivates and their use as spla2 inhibitors
WO2002079154A1 (en) * 2001-03-28 2002-10-10 Eli Lilly And Company Substituted carbazoles as inhibitors of spla2
AUPS282602A0 (en) 2002-06-07 2002-06-27 Garvan Institute Of Medical Research Method of inhibiting cell proliferation
DE10249055A1 (de) 2002-10-22 2004-05-06 Bayer Cropscience Ag 2-Phenyl-2-substituierte-1,3-diketone
JO3598B1 (ar) 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
EP1988098A1 (en) * 2007-04-27 2008-11-05 AEterna Zentaris GmbH Novel Tetrahydrocarbazole Derivatives as Ligands of G-protein Coupled Receptors
MY161992A (en) 2008-03-26 2017-05-31 Daiichi Sankyo Co Ltd Novel tetrahydroisoquinoline derivative
PE20091838A1 (es) 2008-04-09 2009-12-18 Infinity Pharmaceuticals Inc Inhibidores de amida hidrolasa de acido graso
EP2379538A4 (en) 2009-01-22 2013-01-02 Orchid Res Lab Ltd HETEROCYCLIC COMPOUNDS AS A PHOSOPHODIESTERASE HEMMER
US8541581B2 (en) 2009-04-07 2013-09-24 Infinity Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
ES2493916T3 (es) 2009-04-07 2014-09-12 Infinity Pharmaceuticals, Inc. Inhibidores de hidrolasa de amida de ácidos grasos
KR101888026B1 (ko) 2010-02-03 2018-08-13 인피니티 파마슈티컬스, 인코포레이티드 지방산 아미드 하이드롤라제 저해제
AR088377A1 (es) 2011-10-20 2014-05-28 Siena Biotech Spa Proceso para la preparacion de 6-cloro-2,3,4,9-tetrahidro-1h-carbazol-1-carboxamida y compuestos intermedios de esta
CN102816107B (zh) * 2012-08-20 2015-06-03 东南大学 咔唑衍生物及其制备方法与用途
IN2015DN03939A (ru) 2012-11-30 2015-10-02 Ge Healthcare Ltd
US10709798B2 (en) 2012-11-30 2020-07-14 Ge Healthcare Limited Crystallization process of tricyclic indole derivatives
EP3248230B1 (de) * 2015-01-20 2020-05-06 cynora GmbH Verwendung organischer moleküle in optoelektronischen bauelementen
CN108707104A (zh) * 2018-08-07 2018-10-26 北京恒信卓元科技有限公司 2-氯-1h-咔唑-1,4(9h)-二酮的合成方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3579534A (en) * 1969-05-09 1971-05-18 American Cyanamid Co Tetrahydrocarbazolecarboxylates
US3939177A (en) * 1972-11-22 1976-02-17 Sterling Drug Inc. 4-Aminomethyl-9-benzyl-1,2,3,4-tetrahydrocarbazoles
US3979391A (en) * 1972-11-22 1976-09-07 Sterling Drug Inc. 1,2,3,4-Tetrahydrocarbazoles
PT95692A (pt) * 1989-10-27 1991-09-13 American Home Prod Processo para a preparacao de derivados de acidos indole-,indeno-,piranoindole- e tetra-hidrocarbazole-alcanoicos, ou quais sao uteis como inibidores de pla2 e da lipoxigenase
US5420289A (en) * 1989-10-27 1995-05-30 American Home Products Corporation Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase
US5472978A (en) * 1991-07-05 1995-12-05 Merck Sharp & Dohme Ltd. Aromatic compounds, pharmaceutical compositions containing them and their use in therapy
MY110227A (en) * 1991-08-12 1998-03-31 Ciba Geigy Ag 1-acylpiperindine compounds.
IL109309A (en) * 1993-04-16 2000-06-29 Lilly Co Eli 1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them
IL109311A0 (en) * 1993-04-16 1994-07-31 Lilly Co Eli 1H-indole-3-acetamide sPla2 inhibitors
DE69610793T2 (de) * 1995-06-23 2001-05-03 Eli Lilly And Co., Indianapolis 6-Subsitituierte-1,2,3,4-tetrahydro-9H-Carbazole und 7-substituierte-1OH-Cyclohepta(7,6-B)-Indole
ES2159347T3 (es) * 1995-12-13 2001-10-01 Lilly Co Eli Naftil-acetamidas como inhibidores de spla2.
EA003992B1 (ru) * 1996-10-30 2003-12-25 Эли Лилли Энд Компани Замещенные трициклические соединения
JP2001517707A (ja) * 1997-09-26 2001-10-09 イーライ・リリー・アンド・カンパニー 嚢胞性繊維症の処置方法
JP2001522884A (ja) * 1997-11-14 2001-11-20 イーライ・リリー・アンド・カンパニー アルツハイマー病の処置方法
DZ2769A1 (fr) * 1998-04-17 2003-12-01 Lilly Co Eli Composés tricycliques substitués.

Also Published As

Publication number Publication date
DK0950657T3 (da) 2004-11-22
NO991821D0 (no) 1999-04-16
PL332565A1 (en) 1999-10-25
CO5011054A1 (es) 2001-02-28
DE69918590D1 (de) 2004-08-19
HU9901221D0 (en) 1999-06-28
KR19990083233A (ko) 1999-11-25
ATE271037T1 (de) 2004-07-15
AR018186A1 (es) 2001-10-31
EA002347B1 (ru) 2002-04-25
PE20000476A1 (es) 2000-06-02
SI0950657T1 (en) 2005-02-28
ATE268756T1 (de) 2004-06-15
PL332566A1 (en) 1999-10-25
JPH11322713A (ja) 1999-11-24
EP0950657B1 (en) 2004-07-14
EA002816B1 (ru) 2002-10-31
CA2269246C (en) 2009-08-25
BR9901279A (pt) 2000-05-02
EA199900303A3 (ru) 2000-04-24
EA199900301A3 (ru) 2000-04-24
NZ507564A (en) 2002-10-25
EP0952149B1 (en) 2004-06-09
YU18999A (sh) 2002-08-12
NO991822D0 (no) 1999-04-16
NO991821L (no) 1999-10-18
ES2226286T3 (es) 2005-03-16
CZ137099A3 (cs) 1999-11-17
ZA992772B (en) 2002-07-16
HU9901220D0 (en) 1999-06-28
JP2000026416A (ja) 2000-01-25
CO5031247A1 (es) 2001-04-27
BR9902365A (pt) 2001-04-24
TR199900843A2 (xx) 2000-02-21
NO312240B1 (no) 2002-04-15
NO314400B1 (no) 2003-03-17
EP0952149A2 (en) 1999-10-27
SG81976A1 (en) 2001-07-24
DE69917833D1 (de) 2004-07-15
PT950657E (pt) 2004-11-30
HU9901220A (hu) 2000-04-28
PE20000432A1 (es) 2000-05-23
HUP9901221A3 (en) 2001-11-28
NO991822L (no) 1999-10-18
DE69918590T2 (de) 2005-07-21
HUP9901220A3 (en) 2001-11-28
NZ335251A (en) 2000-11-24
AR018593A1 (es) 2001-11-28
ID23287A (id) 2000-04-05
HU9901221A (hu) 2000-04-28
TWI238160B (en) 2005-08-21
IL129483A0 (en) 2000-02-29
ES2222663T3 (es) 2005-02-01
AU753436B2 (en) 2002-10-17
AU753547B2 (en) 2002-10-24
EP0950657A3 (en) 2001-08-16
NZ335253A (en) 2000-11-24
ZA992771B (en) 2002-04-18
CN1253948A (zh) 2000-05-24
KR100586761B1 (ko) 2006-06-08
EA199900303A2 (ru) 1999-10-28
KR19990083232A (ko) 1999-11-25
AU2381799A (en) 1999-10-28
AU2381999A (en) 1999-10-28
TR199900853A3 (tr) 1999-11-22
CA2269262A1 (en) 1999-10-17
JP4435330B2 (ja) 2010-03-17
CA2269246A1 (en) 1999-10-17
CN1149193C (zh) 2004-05-12
SG81977A1 (en) 2001-07-24
ID23761A (id) 2000-05-11
DE69917833T2 (de) 2005-07-14
EP0952149A3 (en) 2001-08-16
TR199900853A2 (xx) 1999-11-22
EP0950657A2 (en) 1999-10-20
DZ2769A1 (fr) 2003-12-01
CZ136999A3 (cs) 1999-11-17
IL129485A0 (en) 2000-02-29
YU19199A (sh) 2002-08-12

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU