DK0950657T3 - Substituerede carbazoler, fremgangsmåde til deres fremstilling og deres anvendelse som sPLA2-inhibitorer - Google Patents

Substituerede carbazoler, fremgangsmåde til deres fremstilling og deres anvendelse som sPLA2-inhibitorer

Info

Publication number: DK0950657T3
Authority: DK; Denmark
Prior art keywords: preparation; spla2 inhibitors; substituted carbazoles; carbazoles; substituted
Prior art date: 1998-04-17

Application number

DK99302967T

Other languages

English (en)

Inventor

Nicholas James Bach

Jolie Anne Bastian

Gary Alan Hite

Edward David Mihelich

John Michael Morin Jr

Daniel Jon Sall

Robert Theodore Vasileff

Michael Dean Kinnick

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-17

Filing date

1999-04-16

Publication date

2004-11-22

1999-04-16 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2004-11-22 Application granted granted Critical

2004-11-22 Publication of DK0950657T3 publication Critical patent/DK0950657T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Communicable Diseases (AREA)
Physical Education & Sports Medicine (AREA)
Oncology (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Hematology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Diabetes (AREA)
Neurology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK99302967T 1998-04-17 1999-04-16 Substituerede carbazoler, fremgangsmåde til deres fremstilling og deres anvendelse som sPLA2-inhibitorer DK0950657T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US6232898A	1998-04-17	1998-04-17
EP99302967A EP0950657B1 (en)	1998-04-17	1999-04-16	Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitors

Publications (1)

Publication Number	Publication Date
DK0950657T3 true DK0950657T3 (da)	2004-11-22

Family

ID=22041763

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99302967T DK0950657T3 (da)	1998-04-17	1999-04-16	Substituerede carbazoler, fremgangsmåde til deres fremstilling og deres anvendelse som sPLA2-inhibitorer

Country Status (30)

Country	Link
EP (2)	EP0950657B1 (da)
JP (2)	JPH11322713A (da)
KR (2)	KR19990083232A (da)
CN (1)	CN1149193C (da)
AR (2)	AR018186A1 (da)
AT (2)	ATE268756T1 (da)
AU (2)	AU753436B2 (da)
BR (2)	BR9902365A (da)
CA (2)	CA2269262A1 (da)
CO (2)	CO5031247A1 (da)
CZ (2)	CZ137099A3 (da)
DE (2)	DE69918590T2 (da)
DK (1)	DK0950657T3 (da)
DZ (1)	DZ2769A1 (da)
EA (2)	EA002347B1 (da)
ES (2)	ES2226286T3 (da)
HU (2)	HUP9901220A3 (da)
ID (2)	ID23761A (da)
IL (2)	IL129485A0 (da)
NO (2)	NO314400B1 (da)
NZ (3)	NZ335251A (da)
PE (2)	PE20000432A1 (da)
PL (2)	PL332566A1 (da)
PT (1)	PT950657E (da)
SG (2)	SG81976A1 (da)
SI (1)	SI0950657T1 (da)
TR (2)	TR199900853A2 (da)
TW (1)	TWI238160B (da)
YU (2)	YU18999A (da)
ZA (2)	ZA992771B (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1011670A4 (en) *	1997-08-28	2004-10-27	Lilly Co Eli	PROCESS FOR TREATING NON-RHUMATOID POLYARTHRITIS
DZ2769A1 (fr) *	1998-04-17	2003-12-01	Lilly Co Eli	Composés tricycliques substitués.
JP2002542148A (ja) *	1998-12-21	2002-12-10	イーライ・リリー・アンド・カンパニー	敗血症の処置のための組み合わせ療法
CA2379208A1 (en) *	1999-07-19	2001-01-25	Eli Lilly & Company	Spla2 inhibitors
US6706752B1 (en)	1999-07-19	2004-03-16	Eli Lilly And Company	sPLA2 inhibitors
US20040102442A1 (en) *	2000-06-29	2004-05-27	Kohji Hanasaki	Remedies for alzheimer's disease
AU2001267825A1 (en) *	2000-06-29	2002-01-08	Shionogi And Co., Ltd.	Remedies for cirrhosis
ATE375171T1 (de) *	2000-06-29	2007-10-15	Anthera Pharmaceuticals Inc	Heilmittel für krebs
CA2413582A1 (en) *	2000-07-14	2002-01-24	Eli Lilly And Company	Use of a spla2 inhibitor for the treatment of sepsis
CA2431028A1 (en) *	2000-12-18	2002-06-27	Ho-Shen Lin	Tetracyclic carbazole derivates and their use as spla2 inhibitors
WO2002079154A1 (en) *	2001-03-28	2002-10-10	Eli Lilly And Company	Substituted carbazoles as inhibitors of spla2
AUPS282602A0 (en)	2002-06-07	2002-06-27	Garvan Institute Of Medical Research	Method of inhibiting cell proliferation
DE10249055A1 (de)	2002-10-22	2004-05-06	Bayer Cropscience Ag	2-Phenyl-2-substituierte-1,3-diketone
JO3598B1 (ar)	2006-10-10	2020-07-05	Infinity Discovery Inc	الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
EP1988098A1 (en) *	2007-04-27	2008-11-05	AEterna Zentaris GmbH	Novel Tetrahydrocarbazole Derivatives as Ligands of G-protein Coupled Receptors
MY161992A (en)	2008-03-26	2017-05-31	Daiichi Sankyo Co Ltd	Novel tetrahydroisoquinoline derivative
PE20091838A1 (es)	2008-04-09	2009-12-18	Infinity Pharmaceuticals Inc	Inhibidores de amida hidrolasa de acido graso
EP2379538A4 (en)	2009-01-22	2013-01-02	Orchid Res Lab Ltd	HETEROCYCLIC COMPOUNDS AS A PHOSOPHODIESTERASE HEMMER
US8541581B2 (en)	2009-04-07	2013-09-24	Infinity Pharmaceuticals, Inc.	Inhibitors of fatty acid amide hydrolase
ES2493916T3 (es)	2009-04-07	2014-09-12	Infinity Pharmaceuticals, Inc.	Inhibidores de hidrolasa de amida de ácidos grasos
KR101888026B1 (ko)	2010-02-03	2018-08-13	인피니티 파마슈티컬스, 인코포레이티드	지방산 아미드 하이드롤라제 저해제
AR088377A1 (es)	2011-10-20	2014-05-28	Siena Biotech Spa	Proceso para la preparacion de 6-cloro-2,3,4,9-tetrahidro-1h-carbazol-1-carboxamida y compuestos intermedios de esta
CN102816107B (zh) *	2012-08-20	2015-06-03	东南大学	咔唑衍生物及其制备方法与用途
IN2015DN03939A (da)	2012-11-30	2015-10-02	Ge Healthcare Ltd
US10709798B2 (en)	2012-11-30	2020-07-14	Ge Healthcare Limited	Crystallization process of tricyclic indole derivatives
EP3248230B1 (de) *	2015-01-20	2020-05-06	cynora GmbH	Verwendung organischer moleküle in optoelektronischen bauelementen
CN108707104A (zh) *	2018-08-07	2018-10-26	北京恒信卓元科技有限公司	2-氯-1h-咔唑-1,4(9h)-二酮的合成方法

Family Cites Families (15)

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US3579534A (en) *	1969-05-09	1971-05-18	American Cyanamid Co	Tetrahydrocarbazolecarboxylates
US3939177A (en) *	1972-11-22	1976-02-17	Sterling Drug Inc.	4-Aminomethyl-9-benzyl-1,2,3,4-tetrahydrocarbazoles
US3979391A (en) *	1972-11-22	1976-09-07	Sterling Drug Inc.	1,2,3,4-Tetrahydrocarbazoles
PT95692A (pt) *	1989-10-27	1991-09-13	American Home Prod	Processo para a preparacao de derivados de acidos indole-,indeno-,piranoindole- e tetra-hidrocarbazole-alcanoicos, ou quais sao uteis como inibidores de pla2 e da lipoxigenase
US5420289A (en) *	1989-10-27	1995-05-30	American Home Products Corporation	Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase
US5472978A (en) *	1991-07-05	1995-12-05	Merck Sharp & Dohme Ltd.	Aromatic compounds, pharmaceutical compositions containing them and their use in therapy
MY110227A (en) *	1991-08-12	1998-03-31	Ciba Geigy Ag	1-acylpiperindine compounds.
IL109309A (en) *	1993-04-16	2000-06-29	Lilly Co Eli	1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them
IL109311A0 (en) *	1993-04-16	1994-07-31	Lilly Co Eli	1H-indole-3-acetamide sPla2 inhibitors
DE69610793T2 (de) *	1995-06-23	2001-05-03	Eli Lilly And Co., Indianapolis	6-Subsitituierte-1,2,3,4-tetrahydro-9H-Carbazole und 7-substituierte-1OH-Cyclohepta(7,6-B)-Indole
ES2159347T3 (es) *	1995-12-13	2001-10-01	Lilly Co Eli	Naftil-acetamidas como inhibidores de spla2.
EA003992B1 (ru) *	1996-10-30	2003-12-25	Эли Лилли Энд Компани	Замещенные трициклические соединения
JP2001517707A (ja) *	1997-09-26	2001-10-09	イーライ・リリー・アンド・カンパニー	嚢胞性繊維症の処置方法
JP2001522884A (ja) *	1997-11-14	2001-11-20	イーライ・リリー・アンド・カンパニー	アルツハイマー病の処置方法
DZ2769A1 (fr) *	1998-04-17	2003-12-01	Lilly Co Eli	Composés tricycliques substitués.

1999
- 1999-04-14 DZ DZ990069A patent/DZ2769A1/xx active
- 1999-04-15 IL IL12948599A patent/IL129485A0/xx unknown
- 1999-04-15 IL IL12948399A patent/IL129483A0/xx unknown
- 1999-04-15 ID IDP990341D patent/ID23761A/id unknown
- 1999-04-15 ID IDP990340D patent/ID23287A/id unknown
- 1999-04-16 PT PT99302967T patent/PT950657E/pt unknown
- 1999-04-16 YU YU18999A patent/YU18999A/sh unknown
- 1999-04-16 NO NO19991821A patent/NO314400B1/no not_active IP Right Cessation
- 1999-04-16 EA EA199900301A patent/EA002347B1/ru not_active IP Right Cessation
- 1999-04-16 AU AU23817/99A patent/AU753436B2/en not_active Ceased
- 1999-04-16 TR TR1999/00853A patent/TR199900853A2/xx unknown
- 1999-04-16 TW TW088106130A patent/TWI238160B/zh not_active IP Right Cessation
- 1999-04-16 KR KR1019990013436A patent/KR19990083232A/ko not_active Application Discontinuation
- 1999-04-16 NZ NZ335251A patent/NZ335251A/xx unknown
- 1999-04-16 AR ARP990101770A patent/AR018186A1/es not_active Application Discontinuation
- 1999-04-16 AT AT99302941T patent/ATE268756T1/de not_active IP Right Cessation
- 1999-04-16 SI SI9930650T patent/SI0950657T1/xx unknown
- 1999-04-16 TR TR1999/00843A patent/TR199900843A2/xx unknown
- 1999-04-16 HU HU9901220A patent/HUP9901220A3/hu unknown
- 1999-04-16 CO CO99022884A patent/CO5031247A1/es unknown
- 1999-04-16 JP JP11109629A patent/JPH11322713A/ja not_active Withdrawn
- 1999-04-16 AU AU23819/99A patent/AU753547B2/en not_active Ceased
- 1999-04-16 PE PE1999000314A patent/PE20000432A1/es not_active Application Discontinuation
- 1999-04-16 SG SG9901681A patent/SG81976A1/en unknown
- 1999-04-16 KR KR1019990013438A patent/KR100586761B1/ko not_active IP Right Cessation
- 1999-04-16 BR BR9902365-2A patent/BR9902365A/pt not_active IP Right Cessation
- 1999-04-16 EA EA199900303A patent/EA002816B1/ru not_active IP Right Cessation
- 1999-04-16 SG SG9901869A patent/SG81977A1/en unknown
- 1999-04-16 ES ES99302967T patent/ES2226286T3/es not_active Expired - Lifetime
- 1999-04-16 EP EP99302967A patent/EP0950657B1/en not_active Expired - Lifetime
- 1999-04-16 HU HU9901221A patent/HUP9901221A3/hu unknown
- 1999-04-16 CZ CZ991370A patent/CZ137099A3/cs unknown
- 1999-04-16 JP JP15240099A patent/JP4435330B2/ja not_active Expired - Fee Related
- 1999-04-16 DK DK99302967T patent/DK0950657T3/da active
- 1999-04-16 CA CA002269262A patent/CA2269262A1/en not_active Abandoned
- 1999-04-16 NZ NZ507564A patent/NZ507564A/xx unknown
- 1999-04-16 ZA ZA9902771A patent/ZA992771B/xx unknown
- 1999-04-16 PL PL99332566A patent/PL332566A1/xx not_active Application Discontinuation
- 1999-04-16 PL PL99332565A patent/PL332565A1/xx not_active Application Discontinuation
- 1999-04-16 CA CA002269246A patent/CA2269246C/en not_active Expired - Fee Related
- 1999-04-16 CZ CZ991369A patent/CZ136999A3/cs unknown
- 1999-04-16 BR BR9901279-0A patent/BR9901279A/pt not_active IP Right Cessation
- 1999-04-16 NZ NZ335253A patent/NZ335253A/xx unknown
- 1999-04-16 AT AT99302967T patent/ATE271037T1/de active
- 1999-04-16 DE DE69918590T patent/DE69918590T2/de not_active Expired - Lifetime
- 1999-04-16 ZA ZA9902772A patent/ZA992772B/xx unknown
- 1999-04-16 ES ES99302941T patent/ES2222663T3/es not_active Expired - Lifetime
- 1999-04-16 NO NO19991822A patent/NO312240B1/no not_active IP Right Cessation
- 1999-04-16 EP EP99302941A patent/EP0952149B1/en not_active Expired - Lifetime
- 1999-04-16 PE PE1999000320A patent/PE20000476A1/es not_active Application Discontinuation
- 1999-04-16 DE DE69917833T patent/DE69917833T2/de not_active Expired - Lifetime
- 1999-04-16 CN CNB991079574A patent/CN1149193C/zh not_active Expired - Fee Related
- 1999-04-16 YU YU19199A patent/YU19199A/sh unknown
- 1999-04-16 AR ARP990101771A patent/AR018593A1/es active IP Right Grant
- 1999-04-16 CO CO99022897A patent/CO5011054A1/es unknown

Also Published As

Publication number	Publication date
NO991821D0 (no)	1999-04-16
PL332565A1 (en)	1999-10-25
CO5011054A1 (es)	2001-02-28
DE69918590D1 (de)	2004-08-19
HU9901221D0 (en)	1999-06-28
KR19990083233A (ko)	1999-11-25
ATE271037T1 (de)	2004-07-15
AR018186A1 (es)	2001-10-31
EA002347B1 (ru)	2002-04-25
PE20000476A1 (es)	2000-06-02
SI0950657T1 (en)	2005-02-28
ATE268756T1 (de)	2004-06-15
PL332566A1 (en)	1999-10-25
JPH11322713A (ja)	1999-11-24
EP0950657B1 (en)	2004-07-14
EA002816B1 (ru)	2002-10-31
CA2269246C (en)	2009-08-25
BR9901279A (pt)	2000-05-02
EA199900303A3 (ru)	2000-04-24
EA199900301A3 (ru)	2000-04-24
NZ507564A (en)	2002-10-25
EP0952149B1 (en)	2004-06-09
YU18999A (sh)	2002-08-12
NO991822D0 (no)	1999-04-16
NO991821L (no)	1999-10-18
ES2226286T3 (es)	2005-03-16
CZ137099A3 (cs)	1999-11-17
ZA992772B (en)	2002-07-16
HU9901220D0 (en)	1999-06-28
JP2000026416A (ja)	2000-01-25
CO5031247A1 (es)	2001-04-27
BR9902365A (pt)	2001-04-24
TR199900843A2 (xx)	2000-02-21
NO312240B1 (no)	2002-04-15
NO314400B1 (no)	2003-03-17
EP0952149A2 (en)	1999-10-27
SG81976A1 (en)	2001-07-24
DE69917833D1 (de)	2004-07-15
PT950657E (pt)	2004-11-30
HU9901220A (hu)	2000-04-28
PE20000432A1 (es)	2000-05-23
HUP9901221A3 (en)	2001-11-28
NO991822L (no)	1999-10-18
DE69918590T2 (de)	2005-07-21
HUP9901220A3 (en)	2001-11-28
NZ335251A (en)	2000-11-24
AR018593A1 (es)	2001-11-28
ID23287A (id)	2000-04-05
HU9901221A (hu)	2000-04-28
TWI238160B (en)	2005-08-21
IL129483A0 (en)	2000-02-29
ES2222663T3 (es)	2005-02-01
AU753436B2 (en)	2002-10-17
AU753547B2 (en)	2002-10-24
EP0950657A3 (en)	2001-08-16
NZ335253A (en)	2000-11-24
ZA992771B (en)	2002-04-18
CN1253948A (zh)	2000-05-24
KR100586761B1 (ko)	2006-06-08
EA199900303A2 (ru)	1999-10-28
KR19990083232A (ko)	1999-11-25
AU2381799A (en)	1999-10-28
AU2381999A (en)	1999-10-28
TR199900853A3 (tr)	1999-11-22
CA2269262A1 (en)	1999-10-17
JP4435330B2 (ja)	2010-03-17
CA2269246A1 (en)	1999-10-17
CN1149193C (zh)	2004-05-12
SG81977A1 (en)	2001-07-24
ID23761A (id)	2000-05-11
DE69917833T2 (de)	2005-07-14
EP0952149A3 (en)	2001-08-16
TR199900853A2 (xx)	1999-11-22
EP0950657A2 (en)	1999-10-20
DZ2769A1 (fr)	2003-12-01
CZ136999A3 (cs)	1999-11-17
IL129485A0 (en)	2000-02-29
EA199900301A2 (ru)	1999-10-28
YU19199A (sh)	2002-08-12

Publication	Publication Date	Title
DK0950657T3 (da)	2004-11-22	Substituerede carbazoler, fremgangsmåde til deres fremstilling og deres anvendelse som sPLA2-inhibitorer
DK1076657T3 (da)	2004-11-08	Hidtil ukendte hydroxyindoler, deres anvendelse som inhibitorer for phosphodiesterase 4 og fremgangsmåde til deres fremstilling
NO20012058D0 (no)	2001-04-26	2-ureido-tiazolderivater, fremgangsmåte for deres fremstilling og anvendelse som antitumormidler
NO20032229D0 (no)	2003-05-16	Fremgangsmåter for behandling av p38kinase-assosierte tilstander og pyrrolotriazin forbindelser nyttige som kinase inhibitorer
DK1244647T3 (da)	2006-09-25	Quinzolinderivater som VIGF-inhibitorer
NO20011575L (no)	2001-05-28	Substituerte 3-cyanokinoliner som proteintyrosin-kinase- inhibitorer
NO20011574D0 (no)	2001-03-28	Substituerte 3-cyanokinoliner som proteintyrosin-kinsase- inhibitorer
DK1425014T3 (da)	2007-04-10	Diarylcycloalkylderivater, fremgangsmåde til deres fremstilling og deres anvendelse som PPAR-aktivatorer
NO20012158D0 (no)	2001-05-02	Substituerte 2-fenylbenzimidazoler, fremgangsmåte til fremstilling og anvendelse derav
DK1268431T3 (da)	2007-12-10	3-Cyanoquinoliner, 3-cyano-1,6-naphthyridiner og 3-cyano-1,7-naphthyridiner som proteinkinaseinhibitorer
NO20015065L (no)	2001-10-18	Pyrazolobenzodiazepiner som CDK2-inhibitorer
NO20026010L (no)	2002-12-13	Substituerte quinazolinderivater og deres anvendelse som inhibitorer
NO20006029D0 (no)	2000-11-28	Pyrazolinderivater, deres fremstilling og anvendelse som legemidler
DK1330455T3 (da)	2005-12-05	Hidtil ukendte 7-azaindoler, deres anvendelse som inhibitorer for phosphodiesterase 4 og fremgangsmåde til deres fremstilling
NO20015062L (no)	2001-10-18	Substituerte 3-cyano-[1.7],[1.5]og[1.8]-naftyridin- inhibitorer for tyrosin-kinaser
NO20034434D0 (no)	2003-10-03	Indolinoner substituert i 6-stilling og deres anvendelse som kinase-inhibitorer
NO20040210L (no)	2004-03-03	Fenylacetamido-tiazolderivater, fremgangsmate for deres fremstilling og deres anvendelse som antitumormidler
DK0795547T3 (da)	2000-09-18	(Aminoalkyl- og acylaminoalkyl-oxy)benzyloxyquinoliner, fremgangsmåde til deres fremstilling og deres anvendelse som bradyk
DK1098891T3 (da)	2005-12-12	Polycycliske thiazolidin-2-yliden-aminer, fremgangsmåde til fremstilling deraf og deres anvendelse som lægemidler
DK1214302T3 (da)	2004-02-16	Substituerede 3-phenyl-5-alkoxy-1,3,4-oxadiazol-2-oner og deres anvendelse som lipasehæmmere
NO331195B1 (no)	2011-10-31	Fremgangsmate for fremstilling av halogen-substituerte monosulfider og deres hydroksymonosulfid-evkivalenter som mellomprodukter.
NO20013735D0 (no)	2001-07-30	Fremgangsmåte til fremstilling av di-iso-butaner, di-iso- butener og di-n-butener fra feltbutaner
NO20025884D0 (no)	2002-12-06	2-aminotiazolinderivater og deres anvendelse som NO- syntaseinhibitorer
DK1341758T3 (da)	2006-10-30	Coniosetin og derivater af denne, fremgangsmåde til fremstilling og anvendelse af samme
DK0981950T3 (da)	2001-07-09	Fremgangsm,åde til formering af phyllocactus