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DOP2016000140A - Inhibidores de syk - Google Patents

Inhibidores de syk

Info

Publication number
DOP2016000140A
DOP2016000140A DO2016000140A DO2016000140A DOP2016000140A DO P2016000140 A DOP2016000140 A DO P2016000140A DO 2016000140 A DO2016000140 A DO 2016000140A DO 2016000140 A DO2016000140 A DO 2016000140A DO P2016000140 A DOP2016000140 A DO P2016000140A
Authority
DO
Dominican Republic
Prior art keywords
compounds
formula
syk inhibitors
syk
inhibitors
Prior art date
Application number
DO2016000140A
Other languages
English (en)
Inventor
Peter A Blomgren
Jeffrey E Kropf
Seung H Lee
Jennifer R Lo
Scott A Mitchell
Aaron C Schmitt
Jin-Ming Xiong
Jianjun Xu
Zhongdong Zhao
Sundaramoorthi Swaminathan
Kevin S Currie
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52350364&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DOP2016000140(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of DOP2016000140A publication Critical patent/DOP2016000140A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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Abstract

LA PRESENTE DESCRIPCIÓN SE REFIERE A COMPUESTOS QUE SON INHIBIDORES DE SYK Y SU USO EN EL TRATAMIENTO DE VARIOS ESTADOS DE ENFERMEDAD, INCLUYENDO EL CÁNCER Y LAS ENFERMEDADES INFLAMATORIAS. EN REALIZACIONES PARTICULARES, LA ESTRUCTURA DE LOS COMPUESTOS ESTÁ DADA POR LA FÓRMULA I: FÓRMULA I EN DONDE R1, R2, R3, Y R4 SON COMO SE DESCRIBE EN EL PRESENTE DOCUMENTO. LA PRESENTE DESCRIPCIÓN PROPORCIONA ADICIONALMENTE COMPOSICIONES FARMACÉUTICAS QUE INCLUYEN UN COMPUESTO DE FÓRMULA I, O SALES O CO-CRISTALES FARMACÉUTICAMENTE ACEPTABLES DEL MISMO, Y MÉTODOS PARA USAR ESTOS COMPUESTOS Y COMPOSICIONES PARA TRATAR CONDICIONES MEDIADAS POR SYK.
DO2016000140A 2013-12-23 2016-06-15 Inhibidores de syk DOP2016000140A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361920407P 2013-12-23 2013-12-23

Publications (1)

Publication Number Publication Date
DOP2016000140A true DOP2016000140A (es) 2016-06-30

Family

ID=52350364

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2016000140A DOP2016000140A (es) 2013-12-23 2016-06-15 Inhibidores de syk

Country Status (42)

Country Link
US (5) US9968601B2 (es)
EP (2) EP3342773B9 (es)
JP (3) JP6243062B2 (es)
KR (3) KR101925859B1 (es)
CN (2) CN107746405B (es)
AP (1) AP2016009274A0 (es)
AR (1) AR098912A1 (es)
AU (3) AU2014370010B2 (es)
BR (1) BR112016014643B1 (es)
CA (1) CA2875877C (es)
CL (1) CL2016001537A1 (es)
CR (1) CR20160287A (es)
CU (1) CU20160097A7 (es)
CY (1) CY1120104T1 (es)
DK (2) DK3087075T3 (es)
DO (1) DOP2016000140A (es)
EA (2) EA031131B1 (es)
ES (2) ES2851335T3 (es)
GT (1) GT201600123A (es)
HK (2) HK1251563A1 (es)
HR (2) HRP20180460T1 (es)
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IL (1) IL245846B (es)
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MD (1) MD4666C1 (es)
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NZ (1) NZ721175A (es)
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PT (2) PT3342773T (es)
RS (1) RS57182B1 (es)
SG (3) SG11201604491VA (es)
SI (2) SI3087075T1 (es)
SV (1) SV2016005229A (es)
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UA (1) UA118463C2 (es)
UY (1) UY35898A (es)
WO (1) WO2015100217A1 (es)
ZA (1) ZA201800913B (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2745871C (en) 2008-12-08 2018-02-20 Gilead Connecticut, Inc. Imidazopyrazine syk inhibitors
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