ATE377600T1 - Imidazopyrazine als cdk-inhibitoren - Google Patents
Imidazopyrazine als cdk-inhibitorenInfo
- Publication number
- ATE377600T1 ATE377600T1 AT03754658T AT03754658T ATE377600T1 AT E377600 T1 ATE377600 T1 AT E377600T1 AT 03754658 T AT03754658 T AT 03754658T AT 03754658 T AT03754658 T AT 03754658T AT E377600 T1 ATE377600 T1 AT E377600T1
- Authority
- AT
- Austria
- Prior art keywords
- imidazopyrazine
- cdk inhibitors
- cdk
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Virology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41299702P | 2002-09-23 | 2002-09-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE377600T1 true ATE377600T1 (de) | 2007-11-15 |
Family
ID=32030951
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03754658T ATE377600T1 (de) | 2002-09-23 | 2003-09-19 | Imidazopyrazine als cdk-inhibitoren |
Country Status (19)
Country | Link |
---|---|
US (2) | US6919341B2 (de) |
EP (1) | EP1543008B1 (de) |
JP (1) | JP4799864B2 (de) |
KR (1) | KR20050057520A (de) |
CN (1) | CN1694886A (de) |
AR (1) | AR041347A1 (de) |
AT (1) | ATE377600T1 (de) |
AU (1) | AU2003272476B2 (de) |
CA (1) | CA2499756C (de) |
DE (1) | DE60317353T2 (de) |
ES (1) | ES2293015T3 (de) |
HK (1) | HK1072056A1 (de) |
MX (1) | MXPA05003120A (de) |
MY (1) | MY134589A (de) |
NZ (2) | NZ538685A (de) |
PE (1) | PE20050081A1 (de) |
TW (1) | TW200413378A (de) |
WO (1) | WO2004026877A1 (de) |
ZA (1) | ZA200502375B (de) |
Families Citing this family (82)
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WO1999001124A1 (en) * | 1996-12-03 | 1999-01-14 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
US20020058286A1 (en) * | 1999-02-24 | 2002-05-16 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto and analogues thereof |
WO2003089434A2 (en) | 2002-04-19 | 2003-10-30 | Cellular Genomics, Inc. | IMIDAZO[1,2-a]PYRAZIN-8-YLAMINES METHOD OF MAKING AND METHOD OF USE THEREOF |
DK1506203T3 (da) * | 2002-08-23 | 2007-05-14 | Sloan Kettering Inst Cancer | Syntese af epothiloner, mellemprodukter deraf, analoger deraf og anvendelser deraf |
US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
WO2004022562A1 (en) * | 2002-09-09 | 2004-03-18 | Cellular Genomics, Inc. | 6-ARYL-IMIDAZO[1,2-a]PYRAZIN-8-YLAMINES, METHOD OF MAKING, AND METHOD OF USE THEREOF |
ES2293015T3 (es) * | 2002-09-23 | 2008-03-16 | Schering Corporation | Imidazopirazinas como inhibidores de cinasas dependientes de ciclinas. |
US7576085B2 (en) * | 2002-09-23 | 2009-08-18 | Schering Corporation | Imidazopyrazines as cyclin dependent kinase inhibitors |
AU2003275031B2 (en) * | 2002-09-23 | 2006-08-17 | Schering Corporation | Novel imidazopyrazines as cyclin dependent kinase inhibitors |
US7189723B2 (en) * | 2003-02-10 | 2007-03-13 | Cgi Pharmaceuticals, Inc. | Certain 8-heteroaryl-6-phenyl-imidazo[1,2-a]pyrazines as modulators of kinase activity |
US7157460B2 (en) * | 2003-02-20 | 2007-01-02 | Sugen Inc. | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors |
US7186832B2 (en) * | 2003-02-20 | 2007-03-06 | Sugen Inc. | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors |
US20060183746A1 (en) * | 2003-06-04 | 2006-08-17 | Currie Kevin S | Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds |
WO2005014599A1 (en) * | 2003-06-04 | 2005-02-17 | Cellular Genomics, Inc. | Imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of bruton’s tyrosine kinase by such compounds |
US7393848B2 (en) | 2003-06-30 | 2008-07-01 | Cgi Pharmaceuticals, Inc. | Certain heterocyclic substituted imidazo[1,2-A]pyrazin-8-ylamines and methods of inhibition of Bruton's tyrosine kinase by such compounds |
WO2005019220A2 (en) * | 2003-08-11 | 2005-03-03 | Cellular Genomics Inc. | Substituted imidazo[1,2-a]pyrazines as modulators of kinase activity |
EP1694686A1 (de) | 2003-12-19 | 2006-08-30 | Takeda San Diego, Inc. | Kinaseinhibitoren |
US7550598B2 (en) | 2004-08-18 | 2009-06-23 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
AU2005276231A1 (en) * | 2004-08-27 | 2006-03-02 | Cyclacel Limited | Purine and pyrimidine CDK inhibitors and their use for the treatment of autoimmune diseases |
WO2006044687A2 (en) * | 2004-10-15 | 2006-04-27 | Takeda San Diego, Inc. | Kinase inhibitors |
EP2397478A1 (de) * | 2005-01-14 | 2011-12-21 | CGI Pharmaceuticals, Inc. | 1,3-diaryl-substituierte Harnstoffe als Modulatoren der Kinaseaktivität |
US7777040B2 (en) | 2005-05-03 | 2010-08-17 | Cgi Pharmaceuticals, Inc. | Certain substituted ureas, as modulators of kinase activity |
CA2620223A1 (en) * | 2005-09-02 | 2007-03-08 | Abbott Laboratories | Novel imidazo based heterocycles |
JP2009507843A (ja) * | 2005-09-09 | 2009-02-26 | シェーリング コーポレイション | アザ縮合サイクリン依存性キナーゼ阻害剤 |
US8119655B2 (en) * | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
WO2007058942A2 (en) * | 2005-11-10 | 2007-05-24 | Schering Corporation | Imidazopyrazines as protein kinase inhibitors |
CA2628534A1 (en) * | 2005-11-10 | 2007-05-18 | Schering Corporation | Methods for inhibiting protein kinases |
WO2007138072A2 (en) * | 2006-05-31 | 2007-12-06 | Galapagos N.V. | Triazolopyrazine compounds useful for the treatment of degenerative & inflammatory diseases |
MX2008015747A (es) * | 2006-06-06 | 2008-12-19 | Schering Corp | Imidazopirazinas como inhibidores de la proteina quinasa. |
US20090175852A1 (en) | 2006-06-06 | 2009-07-09 | Schering Corporation | Imidazopyrazines as protein kinase inhibitors |
EP2223925A1 (de) * | 2006-10-09 | 2010-09-01 | Takeda Pharmaceutical Company Limited | Kinase-Inhibitoren |
US20100120717A1 (en) | 2006-10-09 | 2010-05-13 | Brown Jason W | Kinase inhibitors |
AR063581A1 (es) * | 2006-11-08 | 2009-02-04 | Schering Corp | Imidazopirazinas como inhibidores de proteina quinasa |
CA2669982A1 (en) * | 2006-11-17 | 2008-05-29 | Schering Corporation | Combination therapy for proliferative disorders |
EP2086540B8 (de) * | 2006-12-01 | 2011-03-02 | Galapagos N.V. | Triazolopyridinverbindungen zur behandlung von degenerations- und entzündungskrankheiten |
US20080249305A1 (en) * | 2007-03-27 | 2008-10-09 | Calderwood David J | Novel imidazole based heterocycles |
US8148369B2 (en) * | 2007-05-10 | 2012-04-03 | Janssen Pharmaceutica Nv | Fused pyrazine compounds useful for the treatment of degenerative and inflammatory diseases |
WO2008138843A1 (en) * | 2007-05-10 | 2008-11-20 | Galapagos N.V. | Imidazopyridines and triazolopyrimidines useful for the treatment of joint degenerative & inflammatory diseases |
JP2010529195A (ja) * | 2007-06-14 | 2010-08-26 | シェーリング コーポレイション | プロテインキナーゼの阻害剤としてのイミダゾピラジン |
DE102007032349A1 (de) * | 2007-07-11 | 2009-01-15 | Bayer Healthcare Ag | Imidazo-, Pyrazolopyrazine und Imidazotriazine und ihre Verwendung |
WO2009017701A2 (en) * | 2007-07-31 | 2009-02-05 | Schering Corporation | Anti-mitotic agent and aurora kinase inhibitor combination as anti-cancer treatment |
GB0716292D0 (en) * | 2007-08-21 | 2007-09-26 | Biofocus Dpi Ltd | Imidazopyrazine compounds |
PE20091074A1 (es) * | 2007-12-13 | 2009-07-26 | Bayer Healthcare Ag | Triazolotriazinas y triazolopirazinas y su uso |
AU2009215191A1 (en) | 2008-02-13 | 2009-08-20 | Gilead Connecticut, Inc. | 6-aryl-imidaz0[l, 2-a] pyrazine derivatives, method of making, and method of use thereof |
DE102008023801A1 (de) | 2008-05-15 | 2009-11-19 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Imidazo- und Triazolopyrimidine, Imidazo- und Pyrazolopyrazine und Imidazotriazine |
SG10201707798SA (en) | 2008-12-08 | 2017-10-30 | Gilead Connecticut Inc | Imidazopyrazine syk inhibitors |
TWI478922B (zh) | 2008-12-08 | 2015-04-01 | Gilead Connenticut Inc | 作為脾臟酪胺酸激酶(Syk)抑制劑之咪唑並吡化合物 |
US8450321B2 (en) | 2008-12-08 | 2013-05-28 | Gilead Connecticut, Inc. | 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor |
KR20120034613A (ko) * | 2009-04-16 | 2012-04-12 | 센트로 내셔널 드 인베스티가시오네스 온콜로지카스 (씨엔아이오) | 키나아제 억제제로서 사용을 위한 이미다조피라진 |
WO2011028638A1 (en) | 2009-09-04 | 2011-03-10 | Schering Corporation | Modulators of cell cycle checkpoints and their use in combination with checkpoint kinase inhibitors |
JP5641664B2 (ja) | 2009-10-30 | 2014-12-17 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプJanssen Pharmaceutica Naamloze Vennootschap | イミダゾ[1,2−b]ピリダジン誘導体およびPDE10阻害剤としてのそれらの使用 |
ES2524576T3 (es) | 2010-01-29 | 2014-12-10 | Nerviano Medical Sciences S.R.L. | Derivados de 6,7-dihidroimidazo[1,5-a]pirazin-8(5H)-ona como moduladores de proteína cinasa |
AR080754A1 (es) | 2010-03-09 | 2012-05-09 | Janssen Pharmaceutica Nv | Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10 |
US9562056B2 (en) | 2010-03-11 | 2017-02-07 | Gilead Connecticut, Inc. | Imidazopyridines Syk inhibitors |
CA2793279A1 (en) | 2010-03-18 | 2011-09-22 | Ulrich Klar | Imidazopyrazines |
CA2801031A1 (en) | 2010-06-01 | 2011-12-08 | Bayer Intellectual Property Gmbh | Substituted imidazopyrazines |
EA021240B1 (ru) | 2010-06-09 | 2015-05-29 | Янссен Фармацевтика Нв | Производные 5,6-дигидро-2h-[1,4]оксазин-3-иламина в качестве ингибиторов бета-секретазы (bace) |
EP2651945A1 (de) * | 2010-12-17 | 2013-10-23 | Bayer Intellectual Property GmbH | 6-substituierte imidazopyrazine zur verwendung als mps-1- und tkk-inhibitoren zur behandlung von hyperproliferativen erkrankungen |
CN103403006B (zh) | 2010-12-17 | 2015-11-25 | 拜耳知识产权有限责任公司 | 在过度增殖性病症的治疗中用作mps-1和tkk抑制剂的6-硫代-取代的咪唑并吡嗪 |
WO2012080234A1 (en) * | 2010-12-17 | 2012-06-21 | Bayer Pharma Aktiengesellschaft | Substituted 6-imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders |
WO2012080230A1 (en) | 2010-12-17 | 2012-06-21 | Bayer Pharma Aktiengesellschaft | 6 substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders |
EA022409B1 (ru) * | 2010-12-22 | 2015-12-30 | Янссен Фармацевтика Нв | Производные 5,6-дигидроимидазо[1,2-а]пиразин-8-иламина, пригодные в качестве ингибиторов бета-секретазы (васе) |
SI2681219T1 (sl) | 2011-03-01 | 2016-02-29 | Janssen Pharmaceutica, N.V. | Derivati 6,7-dihidro-pirazolo(1,5-a)pirazin-4-ilamina uporabni kot inhibitorji beta-sekretaze (BACE) |
ES2534973T3 (es) | 2011-03-09 | 2015-04-30 | Janssen Pharmaceutica N.V. | Derivados de 3,4-dihidro-pirrolo[1,2-a]pirazin-1-ilamina útiles como inhibidores de beta-secretasa (BACE) |
MX344600B (es) | 2011-06-27 | 2016-12-20 | Janssen Pharmaceutica Nv | Derivados de 1-aril-4-metil-[1,2,4]triazolo[4,3-a]quinoxalina. |
WO2014001314A1 (en) | 2012-06-26 | 2014-01-03 | Janssen Pharmaceutica Nv | Combinations comprising pde 2 inhibitors such as 1-aryl-4-methyl- [1,2,4] triazolo [4,3-a] quinoxaline compounds and pde 10 inhibitors for use in the treatment of neurological or metabolic disorders |
CN104411314B (zh) | 2012-07-09 | 2017-10-20 | 詹森药业有限公司 | 磷酸二酯酶10的抑制剂 |
CN105283457B (zh) | 2013-06-12 | 2018-09-18 | 詹森药业有限公司 | 作为β-分泌酶(BACE)抑制剂的4-氨基-6-苯基-5,6-二氢咪唑并[1,5-A]吡嗪衍生物 |
CN105324383B (zh) | 2013-06-12 | 2017-10-31 | 詹森药业有限公司 | 作为β‑分泌酶(BACE)抑制剂的4‑氨基‑6‑苯基‑6,7‑二氢[1,2,3]三唑并[1,5‑A]吡嗪衍生物 |
WO2014198851A1 (en) | 2013-06-12 | 2014-12-18 | Janssen Pharmaceutica Nv | 4-amino-6-phenyl-5,6-dihydroimidazo[1,5-a]pyrazin-3(2h)-one derivatives as inhibitors of beta-secretase (bace) |
CN105431137A (zh) | 2013-07-30 | 2016-03-23 | 吉利德康涅狄格公司 | Syk抑制剂的制剂 |
NZ715776A (en) | 2013-07-30 | 2017-04-28 | Gilead Connecticut Inc | Polymorph of syk inhibitors |
DK3076976T3 (da) | 2013-12-04 | 2020-12-07 | Kronos Bio Inc | Fremgangsmåder til behandling af cancer |
TWI735853B (zh) | 2013-12-23 | 2021-08-11 | 美商克洛諾斯生技有限公司 | 脾酪胺酸激酶抑制劑 |
US9290505B2 (en) | 2013-12-23 | 2016-03-22 | Gilead Sciences, Inc. | Substituted imidazo[1,2-a]pyrazines as Syk inhibitors |
US10087195B2 (en) * | 2014-05-28 | 2018-10-02 | Shanghai Fochon Pharmaceutical Co., Ltd. | Certain protein kinase inhibitors |
CA2955180A1 (en) | 2014-07-14 | 2016-01-21 | Gilead Sciences, Inc. | Combinations comprising entospletinib and a vinca-alkaloid for treating cancers |
WO2016096979A1 (en) | 2014-12-18 | 2016-06-23 | Janssen Pharmaceutica Nv | 2,3,4,5-tetrahydropyridin-6-amine and 3,4-dihydro-2h-pyrrol-5-amine compound inhibitors of beta-secretase |
WO2017087409A1 (en) | 2015-11-18 | 2017-05-26 | Genzyme Corporation | Biomarker of polycystic kidney disease and uses thereof |
KR102399996B1 (ko) | 2017-08-25 | 2022-05-20 | 길리애드 사이언시즈, 인코포레이티드 | Syk 억제제의 다형체 |
KR20210131372A (ko) | 2019-02-22 | 2021-11-02 | 크로노스 바이오, 인코포레이티드 | Syk 억제제로서의 축합된 피라진의 고체 형태 |
TW202214634A (zh) * | 2020-06-09 | 2022-04-16 | 大陸商賽諾哈勃藥業(成都)有限公司 | 雜環化合物及其衍生物 |
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PL365170A1 (en) | 2000-07-26 | 2004-12-27 | Bristol-Myers Squibb Company | N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl] carboxamide inhibitors of cyclin dependent kinases |
EP1345941A1 (de) * | 2000-12-20 | 2003-09-24 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Cyclin-abhängige kinase (cdk) und glycogen synthase kinase-3 inhibitoren |
EP1363702A4 (de) * | 2001-01-30 | 2007-08-22 | Cytopia Pty Ltd | Verfahren zur hemmung von kinasen |
WO2003089434A2 (en) | 2002-04-19 | 2003-10-30 | Cellular Genomics, Inc. | IMIDAZO[1,2-a]PYRAZIN-8-YLAMINES METHOD OF MAKING AND METHOD OF USE THEREOF |
ES2293015T3 (es) * | 2002-09-23 | 2008-03-16 | Schering Corporation | Imidazopirazinas como inhibidores de cinasas dependientes de ciclinas. |
AU2003275031B2 (en) * | 2002-09-23 | 2006-08-17 | Schering Corporation | Novel imidazopyrazines as cyclin dependent kinase inhibitors |
-
2003
- 2003-09-19 ES ES03754658T patent/ES2293015T3/es not_active Expired - Lifetime
- 2003-09-19 CN CNA038251779A patent/CN1694886A/zh active Pending
- 2003-09-19 CA CA2499756A patent/CA2499756C/en not_active Expired - Fee Related
- 2003-09-19 MX MXPA05003120A patent/MXPA05003120A/es active IP Right Grant
- 2003-09-19 KR KR1020057004841A patent/KR20050057520A/ko not_active Application Discontinuation
- 2003-09-19 US US10/665,005 patent/US6919341B2/en not_active Expired - Lifetime
- 2003-09-19 JP JP2004537904A patent/JP4799864B2/ja not_active Expired - Fee Related
- 2003-09-19 TW TW092125979A patent/TW200413378A/zh unknown
- 2003-09-19 AU AU2003272476A patent/AU2003272476B2/en not_active Ceased
- 2003-09-19 WO PCT/US2003/029209 patent/WO2004026877A1/en active IP Right Grant
- 2003-09-19 AT AT03754658T patent/ATE377600T1/de not_active IP Right Cessation
- 2003-09-19 DE DE60317353T patent/DE60317353T2/de not_active Expired - Lifetime
- 2003-09-19 PE PE2003000961A patent/PE20050081A1/es not_active Application Discontinuation
- 2003-09-19 NZ NZ538685A patent/NZ538685A/en unknown
- 2003-09-19 NZ NZ563374A patent/NZ563374A/en unknown
- 2003-09-19 MY MYPI20033585A patent/MY134589A/en unknown
- 2003-09-19 EP EP03754658A patent/EP1543008B1/de not_active Expired - Lifetime
- 2003-09-22 AR ARP030103441A patent/AR041347A1/es unknown
-
2005
- 2005-01-31 US US11/047,524 patent/US7432265B2/en not_active Expired - Fee Related
- 2005-03-22 ZA ZA200502375A patent/ZA200502375B/en unknown
- 2005-06-27 HK HK05105312A patent/HK1072056A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2499756C (en) | 2011-07-12 |
KR20050057520A (ko) | 2005-06-16 |
JP4799864B2 (ja) | 2011-10-26 |
TW200413378A (en) | 2004-08-01 |
EP1543008A1 (de) | 2005-06-22 |
MXPA05003120A (es) | 2005-06-22 |
US7432265B2 (en) | 2008-10-07 |
AU2003272476B2 (en) | 2007-07-05 |
MY134589A (en) | 2007-12-31 |
ES2293015T3 (es) | 2008-03-16 |
US20040063715A1 (en) | 2004-04-01 |
WO2004026877A1 (en) | 2004-04-01 |
ZA200502375B (en) | 2005-09-27 |
PE20050081A1 (es) | 2005-03-01 |
CA2499756A1 (en) | 2004-04-01 |
US20050130980A1 (en) | 2005-06-16 |
AU2003272476A1 (en) | 2004-04-08 |
EP1543008B1 (de) | 2007-11-07 |
CN1694886A (zh) | 2005-11-09 |
DE60317353T2 (de) | 2008-08-28 |
HK1072056A1 (en) | 2005-08-12 |
US6919341B2 (en) | 2005-07-19 |
DE60317353D1 (de) | 2007-12-20 |
AR041347A1 (es) | 2005-05-11 |
NZ538685A (en) | 2008-02-29 |
NZ563374A (en) | 2009-06-26 |
JP2006507253A (ja) | 2006-03-02 |
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