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DK3889173T5 - Optimeret faktor viii-gen - Google Patents

Optimeret faktor viii-gen Download PDF

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Publication number
DK3889173T5
DK3889173T5 DK20204866.6T DK20204866T DK3889173T5 DK 3889173 T5 DK3889173 T5 DK 3889173T5 DK 20204866 T DK20204866 T DK 20204866T DK 3889173 T5 DK3889173 T5 DK 3889173T5
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DK
Denmark
Prior art keywords
factor viii
viii gene
optimized factor
optimized
gene
Prior art date
Application number
DK20204866.6T
Other languages
English (en)
Other versions
DK3889173T3 (da
Inventor
Siyuan Tan
Robert T Peters
Original Assignee
Bioverativ Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51354568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3889173(T5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bioverativ Therapeutics Inc filed Critical Bioverativ Therapeutics Inc
Publication of DK3889173T3 publication Critical patent/DK3889173T3/da
Application granted granted Critical
Publication of DK3889173T5 publication Critical patent/DK3889173T5/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK20204866.6T 2013-02-15 2014-02-14 Optimeret faktor viii-gen DK3889173T5 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361765626P 2013-02-15 2013-02-15
EP14751254.5A EP2956477B2 (en) 2013-02-15 2014-02-14 Optimized factor viii gene

Publications (2)

Publication Number Publication Date
DK3889173T3 DK3889173T3 (da) 2023-10-09
DK3889173T5 true DK3889173T5 (da) 2024-08-05

Family

ID=51354568

Family Applications (2)

Application Number Title Priority Date Filing Date
DK20204866.6T DK3889173T5 (da) 2013-02-15 2014-02-14 Optimeret faktor viii-gen
DK14751254.5T DK2956477T4 (da) 2013-02-15 2014-02-14 Optimeret faktor viii-gen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK14751254.5T DK2956477T4 (da) 2013-02-15 2014-02-14 Optimeret faktor viii-gen

Country Status (13)

Country Link
US (3) US10370431B2 (da)
EP (3) EP3889173B1 (da)
DK (2) DK3889173T5 (da)
ES (2) ES2959747T3 (da)
FI (2) FI2956477T4 (da)
HR (2) HRP20210185T4 (da)
HU (2) HUE053136T2 (da)
LT (2) LT2956477T (da)
PL (2) PL2956477T5 (da)
PT (2) PT3889173T (da)
RS (2) RS61387B2 (da)
SI (2) SI2956477T2 (da)
WO (1) WO2014127215A1 (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3889173T5 (da) 2013-02-15 2024-08-05 Bioverativ Therapeutics Inc Optimeret faktor viii-gen
JP2018506261A (ja) * 2014-08-13 2018-03-08 ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィアＴｈｅ Ｃｈｉｌｄｒｅｎ’Ｓ Ｈｏｓｐｉｔａｌ Ｏｆ Ｐｈｉｌａｄｅｌｐｈｉａ 止血疾患を治療するための変異因子ｖｉｉｉのゲノム組込及び発現のための改良された発現カセット
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EA036944B1 (ru) 2015-11-13 2021-01-19 Баксалта Инкорпорейтед Вирусные векторы, кодирующие рекомбинантные варианты fviii с повышенной экспрессией для генной терапии гемофилии a
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CA3055900A1 (en) * 2016-03-20 2017-09-28 The Trustees Of The University Of Pennsylvania Codon optimization and ribosome profiling for increasing transgene expression in chloroplasts of higher plants
CN111918674A (zh) 2018-02-01 2020-11-10 比奥维拉迪维治疗股份有限公司 表达因子viii的慢病毒载体的用途
AU2019306194A1 (en) 2018-07-16 2021-02-04 Baxalta GmbH Gene therapy of hemophilia A using viral vectors encoding recombinant FVIII variants with increased expression
TWI851647B (zh) 2019-01-16 2024-08-11 日商武田藥品工業股份有限公司 用於a型血友病基因治療之編碼表現增加之重組fviii變異體的病毒載體
KR20210151785A (ko) * 2019-03-13 2021-12-14 제너레이션 바이오 컴퍼니 비바이러스성 dna 벡터 및 fviii 치료제 발현을 위한 이의 용도
CN110295150A (zh) * 2019-07-17 2019-10-01 天津润德生物科技有限公司 一类腺依赖病毒病毒重组质粒、重组病毒及构建方法
JP2022546525A (ja) * 2019-09-02 2022-11-04 ビオテスト・アクチエンゲゼルシャフト 延長された半減期を有する第ｖｉｉｉ因子タンパク質
WO2021119357A2 (en) 2019-12-12 2021-06-17 Baxalta Incorporated Gene therapy of hemophilia a using viral vectors encoding recombinant fviii variants with increased expression
CN117858895A (zh) 2021-06-14 2024-04-09 武田药品工业株式会社 使用表达增强的编码重组fviii变体的病毒载体的血友病a基因疗法
TW202323274A (zh) * 2021-08-23 2023-06-16 美商百歐維拉提夫治療公司 優化因子viii基因
WO2023135273A2 (en) 2022-01-14 2023-07-20 Anjarium Biosciences Ag Compositions of dna molecules encoding factor viii, methods of making thereof, and methods of use thereof
WO2023205300A2 (en) * 2022-04-20 2023-10-26 Asklepios Biopharmaceutical, Inc. Therapeutic adeno-associated virus using codon optimized nucleic acid encoding factor viii

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