DK3864022T3 - Neuroaktive steroider substitueret i Position 10 med en cyklisk gruppe til anvendelse til behandlingen af CNS-lidelser - Google Patents
Neuroaktive steroider substitueret i Position 10 med en cyklisk gruppe til anvendelse til behandlingen af CNS-lidelser Download PDFInfo
- Publication number
- DK3864022T3 DK3864022T3 DK19797472.8T DK19797472T DK3864022T3 DK 3864022 T3 DK3864022 T3 DK 3864022T3 DK 19797472 T DK19797472 T DK 19797472T DK 3864022 T3 DK3864022 T3 DK 3864022T3
- Authority
- DK
- Denmark
- Prior art keywords
- treatment
- cyclic group
- cns disorders
- neuroactive steroids
- steroids substituted
- Prior art date
Links
- 208000015114 central nervous system disease Diseases 0.000 title 1
- 125000004122 cyclic group Chemical group 0.000 title 1
- 150000003431 steroids Chemical group 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
- C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/008—Ketals at position 17
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/0065—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified
- C07J7/007—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified not substituted in position 17 alfa
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
- C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862745109P | 2018-10-12 | 2018-10-12 | |
| PCT/US2019/055926 WO2020077255A1 (en) | 2018-10-12 | 2019-10-11 | Neuroactive steroids substituted in position 10 with a cyclic group for use in the treatment of cns disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3864022T3 true DK3864022T3 (da) | 2023-12-18 |
Family
ID=68425315
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK19797472.8T DK3864022T3 (da) | 2018-10-12 | 2019-10-11 | Neuroaktive steroider substitueret i Position 10 med en cyklisk gruppe til anvendelse til behandlingen af CNS-lidelser |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US11634453B2 (da) |
| EP (2) | EP4321519A3 (da) |
| JP (2) | JP2022504607A (da) |
| CN (1) | CN113166193A (da) |
| AR (1) | AR116695A1 (da) |
| AU (1) | AU2019357040A1 (da) |
| BR (1) | BR112021009428A2 (da) |
| CA (1) | CA3115805A1 (da) |
| DK (1) | DK3864022T3 (da) |
| ES (1) | ES2966055T3 (da) |
| IL (1) | IL282183A (da) |
| MX (2) | MX2021004159A (da) |
| TW (1) | TWI835884B (da) |
| WO (1) | WO2020077255A1 (da) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2681835C2 (ru) | 2012-01-23 | 2019-03-13 | Сейдж Терапьютикс, Инк. | Лекарственные формы нейроактивных стероидов и способы лечения нарушений цнс |
| RS62761B1 (sr) | 2012-08-21 | 2022-01-31 | Sage Therapeutics Inc | Alopregnanolon za lečenje refraktornog epileptičkog statusa |
| WO2015195962A1 (en) | 2014-06-18 | 2015-12-23 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| JOP20200195A1 (ar) | 2014-09-08 | 2017-06-16 | Sage Therapeutics Inc | سترويدات وتركيبات نشطة عصبياً، واستخداماتها |
| DK3224269T3 (da) | 2014-11-27 | 2020-05-25 | Sage Therapeutics Inc | Sammensætninger og fremgangsmåder til behandling af cns-forstyrrelser |
| KR20230079470A (ko) | 2016-08-23 | 2023-06-07 | 세이지 테라퓨틱스, 인크. | 결정질 19-노르 c3,3-이치환된 c21-n-피라졸릴 스테로이드 |
| KR20200096596A (ko) | 2017-12-08 | 2020-08-12 | 세이지 테라퓨틱스, 인크. | Cns 장애의 치료를 위한 중수소화 21 -[4-시아노-피라졸-1 -일]-19-노르-프레간-3. 알파-올-20-온 유도체 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| BR9506779A (pt) * | 1994-02-14 | 1997-10-14 | Cocensys Inc | Composto composição farmacéutica método para modular o complexo ionóforo receptor gaba-cloreto em um paciente animal pela ligação ao sitio neuroesteróide no dito complexo método para tratar ou evitar estresse ou ansiedade em um paciente animal método para aliviar ou evitar isônia pms ou pnd em um paciente animal método para tratar ou evitar perturbacões na disposicão de ánimo em um paciente animal e método para induzir anestesia em um paciente animal |
| US5939545A (en) * | 1994-02-14 | 1999-08-17 | Cocensys, Inc. | Method, compositions, and compounds for allosteric modulation of the gaba receptor by members of the androstane and pregnane series |
| PT808325E (pt) | 1994-11-23 | 2001-06-29 | Cocensys Inc | Series de androstanos e pregnanos para modulacao alosterica do receptor de gaba |
| KR102400891B1 (ko) | 2012-12-18 | 2022-05-20 | 워싱톤 유니버시티 | 신경활성 19-알콕시-17-치환된 스테로이드, 그의 전구약물, 및 그를 사용한 치료 방법 |
| TW202426002A (zh) * | 2014-10-16 | 2024-07-01 | 美商賽吉醫療公司 | 用於治療中樞神經系統(cns)病症之組合物及方法 |
| US20210101928A1 (en) | 2017-12-22 | 2021-04-08 | Sage Therapeutics, Inc. | Compositions and methods for treating cns disorders |
| CN118085004A (zh) | 2017-12-22 | 2024-05-28 | 萨奇治疗股份有限公司 | 治疗中枢神经系统疾病的组合物和方法 |
| US20230257415A1 (en) | 2019-06-27 | 2023-08-17 | Sage Therapeutics, Inc. | Compounds for treating cns disorders |
| TW202114696A (zh) | 2019-06-27 | 2021-04-16 | 美商賽吉醫療公司 | 用於治療cns病症之組合物及方法 |
| AR121609A1 (es) | 2020-03-18 | 2022-06-22 | Sage Therapeutics Inc | Esteroides neuroactivos y sus métodos de uso |
| US20230250129A1 (en) | 2020-06-24 | 2023-08-10 | Sage Therapeutics, Inc. | Neuroactive steroids and compositions thereof |
-
2019
- 2019-10-11 DK DK19797472.8T patent/DK3864022T3/da active
- 2019-10-11 AU AU2019357040A patent/AU2019357040A1/en active Pending
- 2019-10-11 EP EP23197779.4A patent/EP4321519A3/en active Pending
- 2019-10-11 WO PCT/US2019/055926 patent/WO2020077255A1/en unknown
- 2019-10-11 MX MX2021004159A patent/MX2021004159A/es unknown
- 2019-10-11 AR ARP190102913A patent/AR116695A1/es unknown
- 2019-10-11 EP EP19797472.8A patent/EP3864022B1/en active Active
- 2019-10-11 JP JP2021519712A patent/JP2022504607A/ja active Pending
- 2019-10-11 CA CA3115805A patent/CA3115805A1/en active Pending
- 2019-10-11 ES ES19797472T patent/ES2966055T3/es active Active
- 2019-10-11 CN CN201980079330.5A patent/CN113166193A/zh active Pending
- 2019-10-11 US US17/284,206 patent/US11634453B2/en active Active
- 2019-10-11 BR BR112021009428-8A patent/BR112021009428A2/pt unknown
- 2019-10-14 TW TW108136955A patent/TWI835884B/zh active
-
2021
- 2021-04-08 IL IL282183A patent/IL282183A/en unknown
- 2021-04-09 MX MX2024011494A patent/MX2024011494A/es unknown
-
2024
- 2024-02-14 JP JP2024020461A patent/JP2024040444A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20210340172A1 (en) | 2021-11-04 |
| US20240051987A1 (en) | 2024-02-15 |
| WO2020077255A1 (en) | 2020-04-16 |
| AU2019357040A1 (en) | 2021-05-20 |
| TWI835884B (zh) | 2024-03-21 |
| IL282183A (en) | 2021-05-31 |
| EP4321519A2 (en) | 2024-02-14 |
| JP2024040444A (ja) | 2024-03-25 |
| JP2022504607A (ja) | 2022-01-13 |
| TW202027753A (zh) | 2020-08-01 |
| AR116695A1 (es) | 2021-06-02 |
| CA3115805A1 (en) | 2020-04-16 |
| BR112021009428A2 (pt) | 2021-08-31 |
| CN113166193A (zh) | 2021-07-23 |
| EP3864022B1 (en) | 2023-09-20 |
| MX2021004159A (es) | 2021-09-08 |
| EP3864022A1 (en) | 2021-08-18 |
| US11634453B2 (en) | 2023-04-25 |
| EP4321519A3 (en) | 2024-05-01 |
| MX2024011494A (es) | 2024-09-26 |
| ES2966055T3 (es) | 2024-04-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK3864022T3 (da) | Neuroaktive steroider substitueret i Position 10 med en cyklisk gruppe til anvendelse til behandlingen af CNS-lidelser | |
| DK3668509T3 (da) | Fremgangsmåde til behandling af amyotrofisk lateralsklerose med pridopidin | |
| DK3119397T3 (da) | Heterocykliske forbindelser til anvendelse i behandling af PI3K-gamma-medierede lidelser | |
| DK2968218T3 (da) | Kombination til behandling af parkinsons sygdom | |
| DK3861601T3 (da) | Indretning med element til engangsbrug | |
| DK3269716T3 (da) | Hidtil ukendte forbindelser og farmaceutiske sammensætninger deraf til behandling af inflammatoriske lidelser | |
| DK3440062T3 (da) | Fremgangsmåde til fremstillingen af enantiomerisk berigede isoxazolinforbindelser - krystallinsk toluensolvat af (s)-afoxolaner | |
| DK3213955T3 (da) | Forbedret anlæg til genopladning med ledning af et køretøj | |
| DK3102213T3 (da) | Farmaceutiske sammensætninger til behandlingen af inflammatoriske lidelser | |
| DK3445734T3 (da) | Fremgangsmåde til fremstilling af en svelle til anvendelse inden for sporoverbygning | |
| DK3240538T3 (da) | Anvendelse af masitinib til behandling af en underpopulation af patienter med amyotrofisk lateralsklerose | |
| DK3507408T3 (da) | Fremgangsmåde til fremstilling af nonwoven | |
| DK3515455T3 (da) | Forbindelser til behandling af lidelser i lipoproteinmetabolismen | |
| DK3256466T3 (da) | 1-heterocyclyl-isochromanylforbindelser og analoger til behandling af cns-forstyrrelser | |
| DK3452583T3 (da) | Konstruerede nukleaser, der er nyttige til behandling af hæmofili a | |
| DK3191120T3 (da) | Anvendelse af IL-17-antagonister for at hæmme progressionen af strukturel skade hos patienter med psoriasisgigt | |
| FR3029292B1 (fr) | Dispositif de correction du decalage de tension d'un pont de wheatstone | |
| DK3612208T3 (da) | Coversin til behandlingen af autoimmune sygdomme med blisterdannelse | |
| DK3192524T3 (da) | Hgf præparat egnet til behandling af neurologiske lidelser | |
| DK3432895T3 (da) | Blodpladepelletlysat til anvendelse til behandling af neurologiske forstyrrelser | |
| DK3578562T3 (da) | L-valinatamidbenzoxaborolderivater til behandling af parasitiske sygdomme | |
| DK3837149T3 (da) | Skinnekøretøj med en snebeskyttelsesindretning til et koblingsområde af skinnekøretøjet | |
| MA46567A (fr) | Formes cristallines de l'éravacycline | |
| DK2964185T3 (da) | Præparater til behandlingen af søvnrelaterede luftvejslidelser | |
| DK3463328T3 (da) | Seladelpar til behandling af primær biliær cholangitis |