|
US5250534A
(en)
*
|
1990-06-20 |
1993-10-05 |
Pfizer Inc. |
Pyrazolopyrimidinone antianginal agents
|
|
GB9114760D0
(en)
*
|
1991-07-09 |
1991-08-28 |
Pfizer Ltd |
Therapeutic agents
|
|
US5734053A
(en)
*
|
1992-06-26 |
1998-03-31 |
Pfizer Inc |
Purinone antianginal agents
|
|
GB9213623D0
(en)
*
|
1992-06-26 |
1992-08-12 |
Pfizer Ltd |
Therapeutic agents
|
|
GB9218322D0
(en)
*
|
1992-08-28 |
1992-10-14 |
Pfizer Ltd |
Therapeutic agents
|
|
GB9315017D0
(en)
*
|
1993-07-20 |
1993-09-01 |
Glaxo Lab Sa |
Chemical compounds
|
|
FI951367A
(fi)
*
|
1994-03-28 |
1995-09-29 |
Japan Energy Corp |
Puriinijohdannaiset ja tulehdustautien tukahduttajat (suppressantit)
|
|
US5776962A
(en)
*
|
1994-08-03 |
1998-07-07 |
Cell Pathways, Inc. |
Lactone compounds for treating patient with precancerous lesions
|
|
US5696159A
(en)
*
|
1994-08-03 |
1997-12-09 |
Cell Pathways, Inc. |
Lactone compounds for treating patients with precancerous lesions
|
|
DE19501480A1
(de)
*
|
1995-01-19 |
1996-07-25 |
Bayer Ag |
9-substituierte 2-(2-n-Alkoxyphenyl)-purin-6-one
|
|
US6046206A
(en)
*
|
1995-06-07 |
2000-04-04 |
Cell Pathways, Inc. |
Method of treating a patient having a precancerous lesions with amide quinazoline derivatives
|
|
US6232312B1
(en)
|
1995-06-07 |
2001-05-15 |
Cell Pathways, Inc. |
Method for treating patient having precancerous lesions with a combination of pyrimidopyrimidine derivatives and esters and amides of substituted indenyl acetic acides
|
|
US6262059B1
(en)
|
1995-06-07 |
2001-07-17 |
Cell Pathways, Inc. |
Method of treating a patient having precancerous lesions with quinazoline derivatives
|
|
US6046216A
(en)
*
|
1995-06-07 |
2000-04-04 |
Cell Pathways, Inc. |
Method of treating a patient having precancerous lesions with phenyl pyridinone derivatives
|
|
US5874440A
(en)
*
|
1995-06-07 |
1999-02-23 |
Cell Pathways, Inc. |
Method of treating a patient having precancerous lesions with phenyl pyrimidinone derivatives
|
|
US6060477A
(en)
*
|
1995-06-07 |
2000-05-09 |
Cell Pathways, Inc. |
Method of treating a patient having precancerous lesions with phenyl cycloamino pyrimidinone derivatives
|
|
US6200980B1
(en)
|
1995-06-07 |
2001-03-13 |
Cell Pathways, Inc. |
Method of treating a patient having precancerous lesions with phenyl purinone derivatives
|
|
USRE37234E1
(en)
|
1996-11-01 |
2001-06-19 |
Nitromed, Inc. |
Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses
|
|
JP2001504457A
(ja)
*
|
1996-11-01 |
2001-04-03 |
ニトロメド インコーポレーテッド |
ニトロソ化およびニトロシル化ホスホジエステラーゼ阻害剤化合物、組成物及びその使用法
|
|
US5958926A
(en)
|
1996-11-01 |
1999-09-28 |
Nitromed, Inc. |
Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
|
|
US6331543B1
(en)
|
1996-11-01 |
2001-12-18 |
Nitromed, Inc. |
Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
|
|
DE19702785A1
(de)
*
|
1997-01-27 |
1998-07-30 |
Bayer Ag |
Neue cyclische Harnstoffderivate
|
|
KR100441229B1
(ko)
|
1997-04-25 |
2004-07-22 |
화이자 인코포레이티드 |
타입 5 시클릭 구아노신 3',5'-모노포스페이트 포스포디에스테라제(ｃＧＭＰ ＰＤＥ5)를 억제하는 성기능 장애 치료용 피라졸로피리미디논
|
|
CA2238283C
(en)
|
1997-05-30 |
2002-08-20 |
Cell Pathways, Inc. |
Method for identifying compounds for inhibition of neoplastic lesions, pharmaceutical compositions from such compounds and uses of such compounds and compositions for treating neoplastic lesions
|
|
US5858694A
(en)
*
|
1997-05-30 |
1999-01-12 |
Cell Pathways, Inc. |
Method for identifying compounds for inhibition of cancerous lesions
|
|
US6472425B1
(en)
|
1997-10-31 |
2002-10-29 |
Nitromed, Inc. |
Methods for treating female sexual dysfunctions
|
|
CH693954A5
(de)
|
1997-11-12 |
2004-05-14 |
Bayer Ag |
2-Phenyl-substituierte Imidazotriazinone als Phosphodiesterase Inhibitoren.
|
|
US5852035A
(en)
*
|
1997-12-12 |
1998-12-22 |
Cell Pathways, Inc. |
Method for inhibiting neoplastic cells and related conditions by exposure to substituted N- arylmethyl and heterocyclmethyl-1H-pyrazolo (3,4-B) quinolin-4-amines
|
|
US6410584B1
(en)
*
|
1998-01-14 |
2002-06-25 |
Cell Pathways, Inc. |
Method for inhibiting neoplastic cells with indole derivatives
|
|
US6046199A
(en)
*
|
1998-01-14 |
2000-04-04 |
Cell Pathways, Inc. |
Method of inhibiting neoplastic cells with tetracyclic pyrido[3,4-B]indole derivatives
|
|
US5942520A
(en)
*
|
1998-01-27 |
1999-08-24 |
Cell Pathways, Inc. |
Method for inhibiting neoplastic cells by exposure to substituted N-cycloalkylmethyl-1-H-pyrazolo (3,4-B) quinolone-4 amines
|
|
US5990117A
(en)
*
|
1998-04-15 |
1999-11-23 |
Cell Pathways, Inc. |
Method for inhibiting neoplastic cells and related conditions by exposure to quinazoline derivatives
|
|
ATE247117T1
(de)
|
1998-04-20 |
2003-08-15 |
Pfizer |
Pyrazolopyrimidinone cgmp pde5 inhibitoren zur behandlung von sexualfunktionsstörungen
|
|
AU4501199A
(en)
*
|
1998-06-03 |
1999-12-20 |
Almirall Prodesfarma S.A. |
8-phenylxanthine derivatives and their use as phosphodiesterase inhibitors
|
|
US6180629B1
(en)
|
1998-08-14 |
2001-01-30 |
Cell Pathways, Inc. |
[4,5]-Fused-1,3-disubstituted-1,2-diazine-6-one derivatives with nitrogen containing substitutents in position one for the treatment of neoplasia
|
|
US6268372B1
(en)
|
1998-09-11 |
2001-07-31 |
Cell Pathways, Inc. |
Method for inhibiting neoplastic cells and related conditions by exposure to 2,9-disubstituted purin-6-ones
|
|
US6124303A
(en)
*
|
1998-09-11 |
2000-09-26 |
Cell Pathways, Inc. |
Method for inhibiting neoplastic cells and related conditions by exposure to 9-substituted 2-(2-N-aloxyphenyl) purin-6-ones
|
|
US6130053A
(en)
*
|
1999-08-03 |
2000-10-10 |
Cell Pathways, Inc. |
Method for selecting compounds for inhibition of neoplastic lesions
|
|
US6200771B1
(en)
|
1998-10-15 |
2001-03-13 |
Cell Pathways, Inc. |
Method of using a novel phosphodiesterase in pharmaceutical screeing to identify compounds for treatment of neoplasia
|
|
GB9823102D0
(en)
|
1998-10-23 |
1998-12-16 |
Pfizer Ltd |
Pharmaceutically active compounds
|
|
US6133271A
(en)
*
|
1998-11-19 |
2000-10-17 |
Cell Pathways, Inc. |
Method for inhibiting neoplastic cells and related conditions by exposure thienopyrimidine derivatives
|
|
US6187779B1
(en)
|
1998-11-20 |
2001-02-13 |
Cell Pathways, Inc. |
Method for inhibiting neoplastic cells and related conditions by exposure to 2,8-disubstituted quinazoline derivatives
|
|
US6369092B1
(en)
|
1998-11-23 |
2002-04-09 |
Cell Pathways, Inc. |
Method for treating neoplasia by exposure to substituted benzimidazole derivatives
|
|
US6034099A
(en)
*
|
1998-11-24 |
2000-03-07 |
Cell Pathways, Inc. |
Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones
|
|
US6077842A
(en)
*
|
1998-11-24 |
2000-06-20 |
Cell Pathways, Inc. |
Method of inhibiting neoplastic cells with pyrazolopyridylpyridazinone derivatives
|
|
US6486155B1
(en)
|
1998-11-24 |
2002-11-26 |
Cell Pathways Inc |
Method of inhibiting neoplastic cells with isoquinoline derivatives
|
|
US6025394A
(en)
|
1999-01-29 |
2000-02-15 |
Cell Pathways, Inc. |
Method for treating patients with acne by administering substituted sulfonyl indenyl acetic acids, amides and alcohols
|
|
US6020379A
(en)
*
|
1999-02-19 |
2000-02-01 |
Cell Pathways, Inc. |
Position 7 substituted indenyl-3-acetic acid derivatives and amides thereof for the treatment of neoplasia
|
|
TWI265925B
(en)
|
1999-10-11 |
2006-11-11 |
Pfizer |
Pyrazolo[4,3-d]pyrimidin-7-ones useful in inhibiting type 5 cyclic guanosine 3',5'-monophosphate phosphodiesterases(cGMP PDE5), process and intermediates for their preparation, their uses and composition comprising them
|
|
GB9924020D0
(en)
|
1999-10-11 |
1999-12-15 |
Pfizer Ltd |
Pharmaceutically active compounds
|
|
PL357522A1
(en)
|
1999-10-11 |
2004-07-26 |
Pfizer, Inc. |
5-(2-substituted-5-heterocyclylsulphonylpyrid-3-yl)-dihydropyrazolo[4,3-d]pyrimidin-7-ones as phosphodiesterase inhibitors
|
|
US6555547B1
(en)
|
2000-02-28 |
2003-04-29 |
Cell Pathways, Inc. |
Method for treating a patient with neoplasia by treatment with a vinca alkaloid derivative
|
|
US6569638B1
(en)
|
2000-03-03 |
2003-05-27 |
Cell Pathways, Inc |
Method for screening compounds for the treatment of neoplasia
|
|
CA2438099A1
(en)
*
|
2001-02-08 |
2002-12-12 |
Memory Pharmaceuticals Corporation |
Trifluoromethylpurines as phosphodiesterase 4 inhibitors
|
|
GB0106661D0
(en)
*
|
2001-03-16 |
2001-05-09 |
Pfizer Ltd |
Pharmaceutically active compounds
|
|
US6770645B2
(en)
|
2001-03-16 |
2004-08-03 |
Pfizer Inc. |
Pharmaceutically active compounds
|
|
EP1392314B1
(de)
*
|
2001-05-09 |
2006-12-20 |
Bayer HealthCare AG |
NEUE VERWENDUNG VON 2-[2-Ethoxy-5-(4-methyl-piperazin-1-sulfonyl)-phenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-on
|
|
US6479493B1
(en)
|
2001-08-23 |
2002-11-12 |
Cell Pathways, Inc. |
Methods for treatment of type I diabetes
|
|
EP1312363A1
(en)
*
|
2001-09-28 |
2003-05-21 |
Pfizer Products Inc. |
Methods of treatment and kits comprising a growth hormone secretagogue
|
|
US7342884B2
(en)
*
|
2002-03-13 |
2008-03-11 |
Harmonic, Inc. |
Method and apparatus for one directional communications in bidirectional communications channel
|
|
US7208516B2
(en)
|
2002-03-20 |
2007-04-24 |
Celgene Corporation |
Methods of the treatment of psoriatic arthritis using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
|
|
US6962940B2
(en)
|
2002-03-20 |
2005-11-08 |
Celgene Corporation |
(+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof
|
|
US7893101B2
(en)
|
2002-03-20 |
2011-02-22 |
Celgene Corporation |
Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof
|
|
US7276529B2
(en)
|
2002-03-20 |
2007-10-02 |
Celgene Corporation |
Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
|
|
DE10232113A1
(de)
|
2002-07-16 |
2004-01-29 |
Bayer Ag |
Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel
|
|
WO2004014913A2
(en)
*
|
2002-08-08 |
2004-02-19 |
Memory Pharmaceuticals Corporation |
Derivatives of 2-trifluormethyl-6-aminopurine as phosphodiesterase 4 inhibitors
|
|
US7335654B2
(en)
*
|
2002-08-08 |
2008-02-26 |
Memory Pharmaceuticals Corporation |
Phosphodiesterase 4 inhibitors
|
|
AU2003282510A1
(en)
*
|
2002-10-11 |
2004-05-04 |
Bristol-Myers Squibb Company |
Hexahydro-benzimidazolone compounds useful as anti-inflammatory agents
|
|
NZ543636A
(en)
*
|
2003-06-06 |
2009-07-31 |
Arexis Ab |
Use of fused heterocyclic compounds as SCCE inhibitors for the treatment of skin conditions or cancer
|
|
DE102004023069A1
(de)
*
|
2004-05-11 |
2005-12-08 |
Bayer Healthcare Ag |
Neue Darreichungsformen des PDE 5-Inhibitors Vardenafil
|
|
DE102005001989A1
(de)
*
|
2005-01-15 |
2006-07-20 |
Bayer Healthcare Ag |
Intravenöse Formulierungen von PDE-Inhibitoren
|
|
DE102005009241A1
(de)
*
|
2005-03-01 |
2006-09-07 |
Bayer Healthcare Ag |
Arzneiformen mit kontrollierter Bioverfügbarkeit
|
|
DE102005009240A1
(de)
|
2005-03-01 |
2006-09-07 |
Bayer Healthcare Ag |
Arzneiformen mit verbesserten pharmakokinetischen Eigenschaften
|
|
WO2007039075A2
(en)
*
|
2005-09-29 |
2007-04-12 |
Bayer Healthcare Ag |
Pde inhibitors and combinations thereof for the treatment of urological disorders
|
|
GB0601951D0
(en)
|
2006-01-31 |
2006-03-15 |
Novartis Ag |
Organic compounds
|
|
US20100184769A1
(en)
*
|
2007-06-13 |
2010-07-22 |
Bayer Schering Pharma Aktiengesellschaft |
Pde inhibitors for the treatment of hearing impairment
|
|
US20110190192A1
(en)
*
|
2009-12-15 |
2011-08-04 |
Cebix Inc. |
Methods for treating erectile dysfunction in patients with insulin-dependent diabetes
|
|
CN104710323B
(zh)
*
|
2013-12-11 |
2018-05-15 |
中国疾病预防控制中心寄生虫病预防控制所 |
具有杀螺活性的水杨酰胺酯类化合物及其制备和用途
|
|
MX2016014384A
(es)
|
2014-06-23 |
2017-01-20 |
Celgene Corp |
Apremilast para el tratamiento de una enfermedad del higado o una anormalidad en la funcion del higado.
|