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DK3687996T3 - Salte af pyrrolotriazinderivater anvendelige som tam-inhibitorer - Google Patents

Salte af pyrrolotriazinderivater anvendelige som tam-inhibitorer Download PDF

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Publication number
DK3687996T3
DK3687996T3 DK18783341.3T DK18783341T DK3687996T3 DK 3687996 T3 DK3687996 T3 DK 3687996T3 DK 18783341 T DK18783341 T DK 18783341T DK 3687996 T3 DK3687996 T3 DK 3687996T3
Authority
DK
Denmark
Prior art keywords
salts
pyrrolotriazine derivatives
derivatives use
tam inhibitors
tam
Prior art date
Application number
DK18783341.3T
Other languages
English (en)
Inventor
Jiacheng Zhou
Qun Li
Zhongjiang Jia
Yongzhong Wu
Yongchun Pan
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
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Publication of DK3687996T3 publication Critical patent/DK3687996T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK18783341.3T 2017-09-27 2018-09-26 Salte af pyrrolotriazinderivater anvendelige som tam-inhibitorer DK3687996T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762564070P 2017-09-27 2017-09-27
US201862714196P 2018-08-03 2018-08-03
PCT/US2018/052925 WO2019067594A1 (en) 2017-09-27 2018-09-26 SALTS OF PYRROLOTRIAZINE DERIVATIVES USEFUL AS TAM INHIBITORS

Publications (1)

Publication Number Publication Date
DK3687996T3 true DK3687996T3 (da) 2022-01-10

Family

ID=63794769

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Application Number Title Priority Date Filing Date
DK18783341.3T DK3687996T3 (da) 2017-09-27 2018-09-26 Salte af pyrrolotriazinderivater anvendelige som tam-inhibitorer

Country Status (33)

Country Link
US (3) US10633387B2 (da)
EP (2) EP3687996B1 (da)
JP (2) JP7504791B2 (da)
KR (1) KR20200088308A (da)
CN (1) CN111386273B (da)
AU (2) AU2018342471B2 (da)
BR (1) BR112020006145A2 (da)
CA (1) CA3077308A1 (da)
CL (2) CL2020000791A1 (da)
CO (1) CO2020005009A2 (da)
CR (1) CR20200179A (da)
CY (1) CY1124952T1 (da)
DK (1) DK3687996T3 (da)
EC (1) ECSP20021655A (da)
ES (1) ES2904458T3 (da)
GE (1) GEP20227429B (da)
HU (1) HUE057190T2 (da)
IL (1) IL273579A (da)
JO (1) JOP20200081A1 (da)
LT (1) LT3687996T (da)
MA (1) MA50655B1 (da)
MD (1) MD3687996T2 (da)
MX (1) MX2020003375A (da)
PE (1) PE20210002A1 (da)
PH (1) PH12020550143A1 (da)
PL (1) PL3687996T3 (da)
PT (1) PT3687996T (da)
RS (1) RS62872B1 (da)
SA (1) SA520411638B1 (da)
SG (1) SG11202002821UA (da)
SI (1) SI3687996T1 (da)
TW (1) TWI821200B (da)
WO (1) WO2019067594A1 (da)

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* Cited by examiner, † Cited by third party
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CA3047403A1 (en) 2016-12-22 2018-06-28 Cadent Therapeutics, Inc. Nmda receptor modulators and uses thereof
MA50655B1 (fr) * 2017-09-27 2021-11-30 Incyte Corp Sels de dérivés de pyrrolotriazine utiles en tant qu'inhibiteurs de tam
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CU24647B1 (es) 2018-08-03 2023-02-13 Cadent Therapeutics Inc Moduladores del receptor nmda heteroaromático
TW202140027A (zh) * 2020-03-06 2021-11-01 美商英塞特公司 包含ａｘｌ／ｍｅｒ及ｐｄ—１／ｐｄ／ｌ１抑制劑之組合療法
JP7556604B2 (ja) 2020-07-10 2024-09-26 範恩柯爾生物科技（中山）有限公司 トリアジン系化合物およびその組成物と用途
CN115028648B (zh) * 2021-03-03 2024-08-30 武汉誉祥医药科技有限公司 三并环化合物及其药物组合物和应用
JPWO2023286719A1 (da) * 2021-07-13 2023-01-19

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Also Published As

Publication number Publication date
TWI821200B (zh) 2023-11-11
PH12020550143A1 (en) 2020-12-07
AU2018342471B2 (en) 2023-08-24
CN111386273A (zh) 2020-07-07
WO2019067594A1 (en) 2019-04-04
US10633387B2 (en) 2020-04-28
US20220227770A1 (en) 2022-07-21
PL3687996T3 (pl) 2022-02-21
RS62872B1 (sr) 2022-02-28
JOP20200081A1 (ar) 2020-04-30
JP7504791B2 (ja) 2024-06-24
IL273579A (en) 2020-05-31
CA3077308A1 (en) 2019-04-04
CO2020005009A2 (es) 2020-05-29
AU2018342471A1 (en) 2020-04-23
JP2024059647A (ja) 2024-05-01
MD3687996T2 (ro) 2022-04-30
KR20200088308A (ko) 2020-07-22
TW201920186A (zh) 2019-06-01
CN111386273B (zh) 2024-06-14
EP3687996A1 (en) 2020-08-05
US20190112313A1 (en) 2019-04-18
SI3687996T1 (sl) 2022-04-29
AU2023270198A1 (en) 2023-12-14
SA520411638B1 (ar) 2024-03-28
EP3988552A1 (en) 2022-04-27
CY1124952T1 (el) 2023-01-05
CL2022001014A1 (es) 2022-11-18
GEP20227429B (en) 2022-10-25
JP2020535168A (ja) 2020-12-03
SG11202002821UA (en) 2020-04-29
PE20210002A1 (es) 2021-01-05
EP3687996B1 (en) 2021-11-03
ES2904458T3 (es) 2022-04-05
US11104682B2 (en) 2021-08-31
MA50655B1 (fr) 2021-11-30
CR20200179A (es) 2020-11-02
BR112020006145A2 (pt) 2020-10-20
PT3687996T (pt) 2022-01-21
US20200347065A1 (en) 2020-11-05
MX2020003375A (es) 2020-08-03
CL2020000791A1 (es) 2020-09-25
HUE057190T2 (hu) 2022-04-28
ECSP20021655A (es) 2020-07-31
MA50655A (fr) 2021-06-02
LT3687996T (lt) 2022-01-10

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