DK3256483T3 - Hidtil ukendt c-3-triterpenon med omvendte c-17-amidderivater som hiv-hæmmere patentkrav - Google Patents
Hidtil ukendt c-3-triterpenon med omvendte c-17-amidderivater som hiv-hæmmere patentkrav Download PDFInfo
- Publication number
- DK3256483T3 DK3256483T3 DK16784277.2T DK16784277T DK3256483T3 DK 3256483 T3 DK3256483 T3 DK 3256483T3 DK 16784277 T DK16784277 T DK 16784277T DK 3256483 T3 DK3256483 T3 DK 3256483T3
- Authority
- DK
- Denmark
- Prior art keywords
- triterpenon
- unknown
- reverse
- amide derivatives
- hiv inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Oncology (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN623CH2015 | 2015-02-09 | ||
PCT/IB2016/000811 WO2016178092A2 (en) | 2015-02-09 | 2016-02-09 | C-3 novel triterpenone with c-28 reverse amide derivatives as hiv inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3256483T3 true DK3256483T3 (da) | 2020-03-23 |
Family
ID=57153504
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK16784277.2T DK3256483T3 (da) | 2015-02-09 | 2016-02-09 | Hidtil ukendt c-3-triterpenon med omvendte c-17-amidderivater som hiv-hæmmere patentkrav |
Country Status (22)
Country | Link |
---|---|
US (3) | US20170008921A1 (da) |
EP (1) | EP3256483B1 (da) |
JP (1) | JP2018505216A (da) |
KR (1) | KR20170110143A (da) |
CN (1) | CN107428797A (da) |
AU (1) | AU2016258274B2 (da) |
BR (1) | BR112017017109A2 (da) |
CA (1) | CA2975359A1 (da) |
CL (1) | CL2017002034A1 (da) |
CO (1) | CO2017008765A2 (da) |
CU (1) | CU24476B1 (da) |
DK (1) | DK3256483T3 (da) |
EA (1) | EA033264B1 (da) |
ES (1) | ES2780649T3 (da) |
IL (1) | IL253844A0 (da) |
MA (1) | MA40886B1 (da) |
MX (1) | MX2017010297A (da) |
PE (1) | PE20171433A1 (da) |
PH (1) | PH12017550077A1 (da) |
SG (1) | SG11201706189PA (da) |
WO (1) | WO2016178092A2 (da) |
ZA (1) | ZA201705253B (da) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20170129916A1 (en) | 2014-06-26 | 2017-05-11 | Hetero Research Foundation | Novel betulinic proline imidazole derivatives as hiv inhibitors |
MA40886B1 (fr) | 2015-02-09 | 2020-03-31 | Hetero Research Foundation | Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-28 en tant qu'inhibiteurs du vih |
WO2016147099A2 (en) * | 2015-03-16 | 2016-09-22 | Hetero Research Foundation | C-3 novel triterpenone with c-28 amide derivatives as hiv inhibitors |
AR107512A1 (es) | 2016-02-04 | 2018-05-09 | VIIV HEALTHCARE UK Nº 5 LTD | Triterpenoides modificados en c-3 y c-17 como inhibidores del vih-1 |
WO2018029604A1 (en) * | 2016-08-08 | 2018-02-15 | Hetero Labs Limited | C-3 novel triterpenone with c-17 reverse amide derivatives as hiv inhibitors |
WO2019150300A1 (en) | 2018-02-02 | 2019-08-08 | Glaxosmithkline Intellectual Property (No.2) Limited | Crystalline forms of 4-(((3ar,5ar,5br,7ar,9s,11ar,11br,13as)-3a-((r)-2-((4-chlorobenzyl)(2-(dimethylamino)ethyl)amino)-1-hydroxyethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-2-oxo-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2h-cyclopenta[a]chrysen-9-yl)oxy)-2,2-dimethyl-4-oxobutanoic acid |
CN109705189B (zh) * | 2018-12-29 | 2020-06-05 | 中国医学科学院药用植物研究所 | 具有式i所示结构的三萜衍生物及其制备方法和应用 |
EP3924362A4 (en) * | 2019-02-11 | 2022-10-26 | Hetero Labs Limited | NEW TRITERPENONE DERIVATIVES AS HIV Inhibitors |
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HUP9701080A3 (en) | 1997-06-23 | 1999-05-28 | Gene Res Lab Inc New York N | Pharmaceutical composition containing a compound of antiviral activity and a hydroximic acid ester derivative |
US6670345B1 (en) | 1997-09-30 | 2003-12-30 | Dabur Research Foundation | Betulinic acid derivatives for inhabiting cancer growth and process for the manufacture of betulinic acid |
US6427248B1 (en) | 1997-10-09 | 2002-08-06 | David M. Albert | Grip-enhancing glove |
CN1326462A (zh) | 1998-11-18 | 2001-12-12 | 达布尔研究基金会 | 新的桦木酸衍生物,所述衍生物的制备方法以及它们作为癌症生长抑制剂的应用 |
WO2001007646A2 (de) | 1999-07-21 | 2001-02-01 | Martin Heinkelein | Verfahren zur quantifizierung der antiviralen wirkung antiviraler wirkstoffe |
DE69917684T2 (de) | 1999-09-09 | 2005-07-21 | Dabur Research Foundation, Sahibabad | Betulinsäure-derivate mit antiangiogener wirkung, verfahren zur herstellung solcher derivate und deren verwendung für die behandlung tumorassoziierter angiogenese |
CA2446748C (en) | 2001-05-11 | 2011-03-08 | University Of Ottawa | Anxiolytic marcgraviaceae compositions containing betulinic acid, betulinic acid derivatives, and methods |
WO2003037908A1 (en) | 2001-10-31 | 2003-05-08 | Ribapharm Inc. | Antiviral combination therapy and compositions |
EP1594885B8 (de) | 2003-02-11 | 2009-03-25 | Novelix Pharmaceuticals, Inc. | Medikament zur wachstumsinhibierung von tumoren |
US7026305B2 (en) | 2003-04-14 | 2006-04-11 | Meharry Medical College | Anti-HIV agents with dual sites of action |
AU2005224260A1 (en) | 2004-03-17 | 2005-09-29 | Panacos Pharmaceuticals, Inc. | Pharmaceuticals salts of 3-O-(3',3'-dimethylsuccinyl) betulinic acid |
MX2007005129A (es) | 2004-10-27 | 2007-09-11 | Daiichi Sankyo Co Ltd | Compuesto de benceno que tiene 2 o mas sustituyentes. |
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EP1869063A2 (en) | 2005-03-29 | 2007-12-26 | Regents Of The University Of Minnesota | Methods of manufacturing bioactive 3-esters of betulinic aldehyde and betulinic acid |
CA2609280A1 (en) | 2005-06-22 | 2007-01-04 | Myriad Genetics, Inc. | Antiviral compounds |
CN101287744A (zh) | 2005-06-22 | 2008-10-15 | 美瑞德生物工程公司 | 抗病毒化合物 |
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FI121468B (fi) | 2006-06-07 | 2010-11-30 | Valtion Teknillinen | Betuliiniperäiset yhdisteet antimikrobisina aineina |
FI20065389A (fi) | 2006-06-07 | 2007-12-31 | Valtion Teknillinen | Betuliiniperäiset yhdisteet kasvien tuholaisten syönnin estäjinä |
WO2008127364A2 (en) | 2006-10-13 | 2008-10-23 | Myriad Genetics, Inc. | Antiviral compounds and use thereof |
WO2008115281A2 (en) | 2006-10-16 | 2008-09-25 | Myriad Genetics, Inc. | Compounds for treating viral infections |
AR063546A1 (es) * | 2006-11-03 | 2009-01-28 | Panacos Pharmaceuticals Inc | DERIVADOS DE TRITERPENO, METODOS PARA SU PREPARACION, COMPOSICIONES FARMACEUTICAS QUE LOS COMPRENDEN Y SU USO EN LA FABRICACION DE MEDICAMENTOS PARA EL TRATAMIENTO DE INFECCIoN POR EL VIRUS VIH. |
US20110152229A1 (en) | 2006-11-22 | 2011-06-23 | Duke University | Betulinic acid derivatives as anti-hiv agents |
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CN101977924A (zh) | 2008-01-03 | 2011-02-16 | Viro化学制药公司 | 新的c-21-酮基羽扇烷衍生物、其制备方法和应用 |
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US20170129916A1 (en) | 2014-06-26 | 2017-05-11 | Hetero Research Foundation | Novel betulinic proline imidazole derivatives as hiv inhibitors |
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MA40886B1 (fr) | 2015-02-09 | 2020-03-31 | Hetero Research Foundation | Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-28 en tant qu'inhibiteurs du vih |
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WO2018025247A1 (en) | 2016-08-05 | 2018-02-08 | Hetero Labs Limited | C-3 novel triterpenone with c-28 diamide derivatives as hiv inhibitors |
WO2018029604A1 (en) | 2016-08-08 | 2018-02-15 | Hetero Labs Limited | C-3 novel triterpenone with c-17 reverse amide derivatives as hiv inhibitors |
WO2018029602A1 (en) | 2016-08-08 | 2018-02-15 | Hetero Labs Limited | C-3 novel triterpenone with c-28 heterocycle derivatives as hiv inhibitors |
WO2018029610A1 (en) | 2016-08-09 | 2018-02-15 | Hetero Labs Limited | C-3 novel triterpenone with c-17 n-amide derivatives as hiv inhibitors |
US20180097839A1 (en) | 2016-10-01 | 2018-04-05 | Neeraj S. Upasani | Systems, apparatuses, and methods for platform security |
WO2018069857A1 (en) | 2016-10-12 | 2018-04-19 | Hetero Labs Limited | C-3 novel triterpenone with c-17 reverse amide heterocycle derivatives as hiv inhibitors |
-
2016
- 2016-02-08 MA MA40886A patent/MA40886B1/fr unknown
- 2016-02-09 CU CU2017000102A patent/CU24476B1/es unknown
- 2016-02-09 EA EA201791807A patent/EA033264B1/ru not_active IP Right Cessation
- 2016-02-09 CN CN201680009544.1A patent/CN107428797A/zh active Pending
- 2016-02-09 MX MX2017010297A patent/MX2017010297A/es unknown
- 2016-02-09 PE PE2017001370A patent/PE20171433A1/es unknown
- 2016-02-09 DK DK16784277.2T patent/DK3256483T3/da active
- 2016-02-09 US US15/019,599 patent/US20170008921A1/en not_active Abandoned
- 2016-02-09 KR KR1020177024961A patent/KR20170110143A/ko unknown
- 2016-02-09 CA CA2975359A patent/CA2975359A1/en not_active Abandoned
- 2016-02-09 US US15/549,678 patent/US10533035B2/en active Active - Reinstated
- 2016-02-09 JP JP2017559931A patent/JP2018505216A/ja not_active Ceased
- 2016-02-09 ES ES16784277T patent/ES2780649T3/es active Active
- 2016-02-09 EP EP16784277.2A patent/EP3256483B1/en active Active
- 2016-02-09 BR BR112017017109A patent/BR112017017109A2/pt not_active Application Discontinuation
- 2016-02-09 AU AU2016258274A patent/AU2016258274B2/en not_active Ceased
- 2016-02-09 SG SG11201706189PA patent/SG11201706189PA/en unknown
- 2016-02-09 WO PCT/IB2016/000811 patent/WO2016178092A2/en active Application Filing
-
2017
- 2017-08-03 ZA ZA2017/05253A patent/ZA201705253B/en unknown
- 2017-08-06 IL IL253844A patent/IL253844A0/en unknown
- 2017-08-08 PH PH12017550077A patent/PH12017550077A1/en unknown
- 2017-08-09 CL CL2017002034A patent/CL2017002034A1/es unknown
- 2017-08-28 CO CONC2017/0008765A patent/CO2017008765A2/es unknown
-
2019
- 2019-11-19 US US16/688,400 patent/US11034718B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
JP2018505216A (ja) | 2018-02-22 |
WO2016178092A8 (en) | 2017-09-21 |
ES2780649T3 (es) | 2020-08-26 |
KR20170110143A (ko) | 2017-10-10 |
AU2016258274A1 (en) | 2017-09-07 |
US20200087342A1 (en) | 2020-03-19 |
EA201791807A1 (ru) | 2018-01-31 |
EP3256483B1 (en) | 2019-12-11 |
SG11201706189PA (en) | 2017-08-30 |
US11034718B2 (en) | 2021-06-15 |
BR112017017109A2 (pt) | 2018-04-03 |
WO2016178092A2 (en) | 2016-11-10 |
CU20170102A7 (es) | 2018-01-10 |
WO2016178092A3 (en) | 2017-01-05 |
CL2017002034A1 (es) | 2018-04-27 |
US20170008921A1 (en) | 2017-01-12 |
PE20171433A1 (es) | 2017-09-26 |
US20180215780A1 (en) | 2018-08-02 |
CA2975359A1 (en) | 2016-11-10 |
EA033264B1 (ru) | 2019-09-30 |
PH12017550077A1 (en) | 2018-02-12 |
AU2016258274B2 (en) | 2019-12-05 |
CN107428797A (zh) | 2017-12-01 |
MA40886B1 (fr) | 2020-03-31 |
US10533035B2 (en) | 2020-01-14 |
CU24476B1 (es) | 2020-03-04 |
MX2017010297A (es) | 2018-11-12 |
EP3256483A2 (en) | 2017-12-20 |
IL253844A0 (en) | 2017-09-28 |
CO2017008765A2 (es) | 2017-11-10 |
ZA201705253B (en) | 2020-01-29 |
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