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DK353385D0 - Fremstilling af 3-acylamino-1-hydroxy-2-azetidinoner og herved forekommende n-hydroxybeskyttelsesgrupper - Google Patents

Fremstilling af 3-acylamino-1-hydroxy-2-azetidinoner og herved forekommende n-hydroxybeskyttelsesgrupper

Info

Publication number
DK353385D0
DK353385D0 DK353385A DK353385A DK353385D0 DK 353385 D0 DK353385 D0 DK 353385D0 DK 353385 A DK353385 A DK 353385A DK 353385 A DK353385 A DK 353385A DK 353385 D0 DK353385 D0 DK 353385D0
Authority
DK
Denmark
Prior art keywords
hydroxy
azetidinones
acylamino
preparation
necessary
Prior art date
Application number
DK353385A
Other languages
English (en)
Other versions
DK353385A (da
Inventor
Richard H Mueller
Jakob-Matthias Drossard
Peter H Ermann
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of DK353385D0 publication Critical patent/DK353385D0/da
Publication of DK353385A publication Critical patent/DK353385A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/08—Hydroxylamino compounds or their ethers or esters
    • C07C239/20—Hydroxylamino compounds or their ethers or esters having oxygen atoms of hydroxylamino groups etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Accommodation For Nursing Or Treatment Tables (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Cephalosporin Compounds (AREA)
DK353385A 1984-08-03 1985-08-02 Fremstilling af 3-acylamino-1-hydroxy-2-azetidinoner og herved forekommende n-hydroxybeskyttelsesgrupper DK353385A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/637,260 US4581170A (en) 1984-08-03 1984-08-03 N-hydroxyl protecting groups and process and intermediates for the preparation of 3-acylamino-1-hydroxy-2-azetidinones

Publications (2)

Publication Number Publication Date
DK353385D0 true DK353385D0 (da) 1985-08-02
DK353385A DK353385A (da) 1986-02-04

Family

ID=24555200

Family Applications (1)

Application Number Title Priority Date Filing Date
DK353385A DK353385A (da) 1984-08-03 1985-08-02 Fremstilling af 3-acylamino-1-hydroxy-2-azetidinoner og herved forekommende n-hydroxybeskyttelsesgrupper

Country Status (12)

Country Link
US (1) US4581170A (da)
EP (2) EP0170280B1 (da)
JP (2) JPH06732B2 (da)
AT (1) ATE58896T1 (da)
AU (2) AU589567B2 (da)
CA (1) CA1268780C (da)
DE (1) DE3580803D1 (da)
DK (1) DK353385A (da)
FI (1) FI852974L (da)
IE (2) IE58758B1 (da)
NZ (1) NZ212750A (da)
ZA (1) ZA855492B (da)

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US4670553A (en) * 1982-01-04 1987-06-02 E. R. Squibb & Sons, Inc. 2-oxo-1-(aminocarbonylaminosulfonyl-aminocarbonyl)azetidines
DE3768523D1 (de) * 1986-02-18 1991-04-18 Squibb & Sons Inc ((2,2,2-trichloroethoxy)methoxy)amin.
US5037974A (en) * 1988-05-23 1991-08-06 Merck & Co., Inc. Cyclization process for synthesis of a beta-lactam carbapenem intermediate
US5631365A (en) 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
US6068993A (en) * 1997-07-02 2000-05-30 Biobras Sa Vector for expression of heterologous protein and methods for extracting recombinant protein and for purifying isolated recombinant insulin
US6982251B2 (en) * 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
WO2002058733A2 (en) * 2001-01-26 2002-08-01 Schering Corporation Combinations of bile acid sequestrant(s) and sterol absorption inhibitor(s) and treatments for vascular indications
HU230435B1 (hu) * 2001-01-26 2016-06-28 Merck Sharp & Dohme Corp Szubsztituált azetidinon vegyületek alkalmazása szitoszterinémia kezelésére
EP1353694B1 (en) * 2001-01-26 2007-12-19 Schering Corporation Combinations of ezetimibe with aspirine for treating vascular conditions
DE60220269T2 (de) * 2001-01-26 2008-01-17 Schering Corp. Kombinationen eines hemmers der sterolabsorption und eines kardiovaskulären wirkstoffes zur behandlung von kardiovaskulären indikationen
SI1353696T1 (sl) * 2001-01-26 2007-04-30 Schering Corp Kombinacije aktivatorja(-ev) peroksisomskega proliferatorja aktivirajocega receptorja (PPAR) in inhibitorja(-ev) absorpcije sterola in oblike zdravljenja za vaskularne indikacije
CA2434488A1 (en) * 2001-01-26 2002-08-01 Harry R. Davis Combinations of nicotinic acid and derivatives thereof and sterol absorption inhibitor(s) and treatments for vascular indications
US7071181B2 (en) * 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
US20060287254A1 (en) * 2001-01-26 2006-12-21 Schering Corporation Use of substituted azetidinone compounds for the treatment of sitosterolemia
EP1392287B8 (en) * 2001-05-25 2007-01-10 Schering Corporation Use of substituted azetidinone derivatives in the treatment of Alzheimer's disease
US20030119808A1 (en) * 2001-09-21 2003-06-26 Schering Corporation Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects
US7053080B2 (en) * 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
AU2002335770B2 (en) * 2001-09-21 2005-08-18 Merck Sharp & Dohme Corp. Methods for treating or preventing vascular inflammation using sterol absorption inhibitor(s)
US7056906B2 (en) * 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
DK1429756T3 (da) * 2001-09-21 2007-03-19 Schering Corp Behandling af xanthoma med azetidinonderivater som sterolabsorptionsinhibitorer
WO2004043457A1 (en) * 2002-11-06 2004-05-27 Schering Corporation Cholesterol absorptions inhibitors for the treatment of autoimmune disorders
MXPA05009503A (es) * 2003-03-07 2005-10-18 Schering Corp Compuestos de azetidinona sustituidos, formulaciones y usos de los mismos para el tratamiento de hipercolesterolemia.
US7459442B2 (en) * 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
MXPA05009502A (es) * 2003-03-07 2005-10-18 Schering Corp Compuestos de azetidinona sustituidos, formulaciones y usos de los mismos para el tratamiento de hipercolesterolemia.
ES2318274T3 (es) * 2003-03-07 2009-05-01 Schering Corporation Compuestos de azetidinona sustituida, formulaciones y uso de los mismos para el tratamiento de hipercolesterolemia.
CA2544309A1 (en) * 2003-11-05 2005-05-26 Schering Corporation Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions
US9367793B2 (en) 2013-03-04 2016-06-14 Hello Inc. Wearable device with magnets distanced from exterior surfaces of the wearable device
US9406220B2 (en) 2013-03-04 2016-08-02 Hello Inc. Telemetry system with tracking receiver devices
US9530089B2 (en) 2013-03-04 2016-12-27 Hello Inc. Wearable device with overlapping ends coupled by magnets of a selected width, length and depth
US9357922B2 (en) 2013-03-04 2016-06-07 Hello Inc. User or patient monitoring systems with one or more analysis tools
US9445651B2 (en) 2013-03-04 2016-09-20 Hello Inc. Wearable device with overlapping ends coupled by magnets
US9420856B2 (en) 2013-03-04 2016-08-23 Hello Inc. Wearable device with adjacent magnets magnetized in different directions
US9436903B2 (en) 2013-03-04 2016-09-06 Hello Inc. Wearable device with magnets with a defined distance between adjacent magnets
US9420857B2 (en) 2013-03-04 2016-08-23 Hello Inc. Wearable device with interior frame
US9149189B2 (en) 2013-03-04 2015-10-06 Hello, Inc. User or patient monitoring methods using one or more analysis tools
US9204798B2 (en) 2013-03-04 2015-12-08 Hello, Inc. System for monitoring health, wellness and fitness with feedback
US9339188B2 (en) 2013-03-04 2016-05-17 James Proud Methods from monitoring health, wellness and fitness with feedback
US9526422B2 (en) 2013-03-04 2016-12-27 Hello Inc. System for monitoring individuals with a monitoring device, telemetry system, activity manager and a feedback system
US9553486B2 (en) 2013-03-04 2017-01-24 Hello Inc. Monitoring system and device with sensors that is remotely powered
US9345403B2 (en) 2013-03-04 2016-05-24 Hello Inc. Wireless monitoring system with activity manager for monitoring user activity
US9430938B2 (en) 2013-03-04 2016-08-30 Hello Inc. Monitoring device with selectable wireless communication
US9345404B2 (en) 2013-03-04 2016-05-24 Hello Inc. Mobile device that monitors an individuals activities, behaviors, habits or health parameters
US9532716B2 (en) 2013-03-04 2017-01-03 Hello Inc. Systems using lifestyle database analysis to provide feedback
US9848776B2 (en) 2013-03-04 2017-12-26 Hello Inc. Methods using activity manager for monitoring user activity
US9298882B2 (en) 2013-03-04 2016-03-29 Hello Inc. Methods using patient monitoring devices with unique patient IDs and a telemetry system
US9159223B2 (en) 2013-03-04 2015-10-13 Hello, Inc. User monitoring device configured to be in communication with an emergency response system or team
US9055791B2 (en) 2013-03-04 2015-06-16 Hello Inc. Wearable device with overlapping ends coupled by magnets operating with a selectable strength
US9582748B2 (en) 2013-03-04 2017-02-28 Hello Inc. Base charging station for monitoring device
US9424508B2 (en) 2013-03-04 2016-08-23 Hello Inc. Wearable device with magnets having first and second polarities
US9634921B2 (en) 2013-03-04 2017-04-25 Hello Inc. Wearable device coupled by magnets positioned in a frame in an interior of the wearable device with at least one electronic circuit
US9662015B2 (en) 2013-03-04 2017-05-30 Hello Inc. System or device with wearable devices having one or more sensors with assignment of a wearable device user identifier to a wearable device user
US9432091B2 (en) 2013-03-04 2016-08-30 Hello Inc. Telemetry system with wireless power receiver and monitoring devices
US9330561B2 (en) 2013-03-04 2016-05-03 Hello Inc. Remote communication systems and methods for communicating with a building gateway control to control building systems and elements
US9427189B2 (en) 2013-03-04 2016-08-30 Hello Inc. Monitoring system and device with sensors that are responsive to skin pigmentation
US9361572B2 (en) 2013-03-04 2016-06-07 Hello Inc. Wearable device with magnets positioned at opposing ends and overlapped from one side to another
US9737214B2 (en) 2013-03-04 2017-08-22 Hello Inc. Wireless monitoring of patient exercise and lifestyle
US9407097B2 (en) 2013-03-04 2016-08-02 Hello Inc. Methods using wearable device with unique user ID and telemetry system
US9704209B2 (en) 2013-03-04 2017-07-11 Hello Inc. Monitoring system and device with sensors and user profiles based on biometric user information
US9320434B2 (en) 2013-03-04 2016-04-26 Hello Inc. Patient monitoring systems and messages that send alerts to patients only when the patient is awake
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FR2442240A1 (fr) * 1978-11-27 1980-06-20 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-substitue 7-amino thiazolyl acetamido cephalosporanique comportant un groupement eliminable sur le radical amino, leur procede de preparation et leur application a la synthese de produits actifs comme medicaments
US4337197A (en) * 1980-10-31 1982-06-29 E. R. Squibb & Sons, Inc. O-sulfated β-lactam hydroxamic acids and intermediates
US4939253A (en) * 1982-08-04 1990-07-03 E. R. Squibb & Sons, Inc. 2-oxoazetidin-1-yloxy acetic acids and analogs
NZ205642A (en) * 1982-10-06 1986-08-08 Squibb & Sons Inc Beta-lactams and pharmaceutical compositions

Also Published As

Publication number Publication date
AU4535685A (en) 1986-02-06
IE58771B1 (en) 1993-11-03
EP0371004A1 (en) 1990-05-30
CA1262357A (en) 1989-10-17
JPH06732B2 (ja) 1994-01-05
JPS6147445A (ja) 1986-03-07
JPH069528A (ja) 1994-01-18
IE851917L (en) 1986-02-03
IE58758B1 (en) 1993-11-03
AU589567B2 (en) 1989-10-19
DE3580803D1 (de) 1991-01-17
AU614663B2 (en) 1991-09-05
NZ212750A (en) 1989-04-26
ZA855492B (en) 1986-03-26
DK353385A (da) 1986-02-04
AU4083589A (en) 1990-02-08
US4581170A (en) 1986-04-08
CA1268780C (en) 1990-05-08
EP0170280A1 (en) 1986-02-05
JPH0662532B2 (ja) 1994-08-17
FI852974A0 (fi) 1985-08-01
EP0170280B1 (en) 1990-12-05
FI852974L (fi) 1986-02-04
ATE58896T1 (de) 1990-12-15

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Legal Events

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