DK3329001T3 - Genomredigeringssystemer og anvendelsesfremgangsmåder - Google Patents
Genomredigeringssystemer og anvendelsesfremgangsmåder Download PDFInfo
- Publication number
- DK3329001T3 DK3329001T3 DK16750569.2T DK16750569T DK3329001T3 DK 3329001 T3 DK3329001 T3 DK 3329001T3 DK 16750569 T DK16750569 T DK 16750569T DK 3329001 T3 DK3329001 T3 DK 3329001T3
- Authority
- DK
- Denmark
- Prior art keywords
- editing systems
- application procedures
- procedures
- application
- editing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562198049P | 2015-07-28 | 2015-07-28 | |
| PCT/US2016/044489 WO2017019867A1 (en) | 2015-07-28 | 2016-07-28 | Genome editing systems and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3329001T3 true DK3329001T3 (da) | 2021-12-20 |
Family
ID=56682266
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16750569.2T DK3329001T3 (da) | 2015-07-28 | 2016-07-28 | Genomredigeringssystemer og anvendelsesfremgangsmåder |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20180208945A1 (da) |
| EP (1) | EP3329001B1 (da) |
| JP (1) | JP6937740B2 (da) |
| CN (1) | CN107849562B (da) |
| DK (1) | DK3329001T3 (da) |
| WO (1) | WO2017019867A1 (da) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6261500B2 (ja) | 2011-07-22 | 2018-01-17 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ヌクレアーゼ切断特異性の評価および改善 |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| US9340800B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | Extended DNA-sensing GRNAS |
| US9737604B2 (en) | 2013-09-06 | 2017-08-22 | President And Fellows Of Harvard College | Use of cationic lipids to deliver CAS9 |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| ES2802984T3 (es) | 2014-02-11 | 2021-01-22 | Univ Colorado Regents | Ingeniería del genoma multiplex mediante CRISPR |
| AU2015298571B2 (en) | 2014-07-30 | 2020-09-03 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| IL310721A (en) | 2015-10-23 | 2024-04-01 | Harvard College | Nucleobase editors and their uses |
| US10017760B2 (en) | 2016-06-24 | 2018-07-10 | Inscripta, Inc. | Methods for generating barcoded combinatorial libraries |
| JP2019520069A (ja) | 2016-07-13 | 2019-07-18 | ディーエスエム アイピー アセッツ ビー．ブイ．Ｄｓｍ Ｉｐ Ａｓｓｅｔｓ Ｂ．Ｖ． | 藻類宿主細胞用のｃｒｉｓｐｒ−ｃａｓシステム |
| CA3032699A1 (en) | 2016-08-03 | 2018-02-08 | President And Fellows Of Harvard College | Adenosine nucleobase editors and uses thereof |
| EP3497214B1 (en) | 2016-08-09 | 2023-06-28 | President and Fellows of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| EP3500671B1 (en) | 2016-08-17 | 2024-07-10 | The Broad Institute, Inc. | Method of selecting target sequences for the design of guide rnas |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| GB2573062A (en) | 2016-10-14 | 2019-10-23 | Harvard College | AAV delivery of nucleobase editors |
| US10745677B2 (en) | 2016-12-23 | 2020-08-18 | President And Fellows Of Harvard College | Editing of CCR5 receptor gene to protect against HIV infection |
| WO2018165504A1 (en) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| JP2020510439A (ja) | 2017-03-10 | 2020-04-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | シトシンからグアニンへの塩基編集因子 |
| IL306092A (en) | 2017-03-23 | 2023-11-01 | Harvard College | Nucleic base editors that include nucleic acid programmable DNA binding proteins |
| WO2018204777A2 (en) | 2017-05-05 | 2018-11-08 | The Broad Institute, Inc. | Methods for identification and modification of lncrna associated with target genotypes and phenotypes |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| US9982279B1 (en) | 2017-06-23 | 2018-05-29 | Inscripta, Inc. | Nucleic acid-guided nucleases |
| US10011849B1 (en) | 2017-06-23 | 2018-07-03 | Inscripta, Inc. | Nucleic acid-guided nucleases |
| CN111094573A (zh) * | 2017-07-12 | 2020-05-01 | 梅约医学教育与研究基金会 | 有效靶向敲入或基因置换的材料和方法 |
| EP3652312A1 (en) * | 2017-07-14 | 2020-05-20 | Editas Medicine, Inc. | Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| EP3676376A2 (en) | 2017-08-30 | 2020-07-08 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| CN111757937A (zh) | 2017-10-16 | 2020-10-09 | 布罗德研究所股份有限公司 | 腺苷碱基编辑器的用途 |
| WO2019099982A1 (en) * | 2017-11-17 | 2019-05-23 | The Johns Hopkins University | Compositions and methods for efficient genome editing |
| EP3707253A1 (en) | 2017-12-15 | 2020-09-16 | Danisco US Inc. | Cas9 variants and methods of use |
| WO2019131505A1 (ja) * | 2017-12-26 | 2019-07-04 | 国立大学法人徳島大学 | 糸状菌細胞に対するタンパク質導入法およびその成果物 |
| US20210071202A1 (en) * | 2018-03-29 | 2021-03-11 | Jichi Medical University | Genome editing method, composition, cell, cell preparation, and method for producing cell preparation |
| US11981892B2 (en) | 2018-04-16 | 2024-05-14 | University Of Massachusetts | Compositions and methods for improved gene editing |
| US20220010305A1 (en) * | 2018-10-31 | 2022-01-13 | Novozymes A/S | Genome Editing by Guided Endonuclease and Single-stranded Oligonucleotide |
| WO2020191245A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| WO2020198697A1 (en) * | 2019-03-28 | 2020-10-01 | Intellia Therapeutics, Inc. | Compositions and methods comprising a ttr guide rna and a polynucleotide encoding an rna-guided dna binding agent |
| WO2020236967A1 (en) | 2019-05-20 | 2020-11-26 | The Broad Institute, Inc. | Random crispr-cas deletion mutant |
| US20220348912A1 (en) | 2019-06-20 | 2022-11-03 | University Of Massachusetts | Compositions and methods for improved gene editing |
| WO2021041922A1 (en) | 2019-08-30 | 2021-03-04 | The Broad Institute, Inc. | Crispr-associated mu transposase systems |
| WO2021086606A1 (en) | 2019-10-28 | 2021-05-06 | Danisco Us Inc | Microbial host cells for the production of heterologous cyanuric acid hydrolases and biuret hydrolases |
| KR20230019843A (ko) | 2020-05-08 | 2023-02-09 | 더 브로드 인스티튜트, 인코퍼레이티드 | 표적 이중 가닥 뉴클레오티드 서열의 두 가닥의 동시 편집을 위한 방법 및 조성물 |
| WO2022095929A1 (en) * | 2020-11-06 | 2022-05-12 | The University Of Hong Kong | Transferable type i-f crispr-cas genome editing system |
| CN114410635B (zh) * | 2022-03-29 | 2022-06-14 | 中国科学院天津工业生物技术研究所 | 威尼斯镰刀菌内源U6启动子及其基于CRISPR/Cas9的基因编辑方法 |
| CN117025651B (zh) * | 2023-10-08 | 2023-12-19 | 西北农林科技大学深圳研究院 | 一种欧文氏菌中漆酶基因敲除的方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5107065A (en) | 1986-03-28 | 1992-04-21 | Calgene, Inc. | Anti-sense regulation of gene expression in plant cells |
| JP3110452B2 (ja) | 1990-05-09 | 2000-11-20 | ノボ ノルディスク アクティーゼルスカブ | エンドグルカナーゼ酵素を含んでなるセルラーゼ調製物 |
| EP0562003B2 (en) | 1990-12-10 | 2015-04-01 | Danisco US Inc. | Improved saccharification of cellulose by cloning and amplification of the beta-glucosidase gene of trichoderma reesei |
| US8592194B2 (en) | 2007-10-09 | 2013-11-26 | Danisco Us Inc. | Glucoamylase variants with altered properties |
| WO2013141680A1 (en) | 2012-03-20 | 2013-09-26 | Vilnius University | RNA-DIRECTED DNA CLEAVAGE BY THE Cas9-crRNA COMPLEX |
| MX2014013402A (es) | 2012-05-11 | 2014-11-26 | Danisco Inc | Uso de alfa-amilasa de aspergillus clavatus para sacarificacion. |
| KR101656237B1 (ko) * | 2012-10-23 | 2016-09-12 | 주식회사 툴젠 | 표적 DNA에 특이적인 가이드 RNA 및 Cas 단백질을 암호화하는 핵산 또는 Cas 단백질을 포함하는, 표적 DNA를 절단하기 위한 조성물 및 이의 용도 |
| IL293526A (en) * | 2012-12-12 | 2022-08-01 | Harvard College | Providing, engineering and optimizing systems, methods and compositions for sequence manipulation and therapeutic applications |
| US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| WO2014102688A1 (en) * | 2012-12-27 | 2014-07-03 | Cellectis | New design matrix for improvement of homology-directed gene targeting |
| EP3004349B1 (en) * | 2013-05-29 | 2018-03-28 | Cellectis S.A. | A method for producing precise dna cleavage using cas9 nickase activity |
| WO2015054507A1 (en) * | 2013-10-10 | 2015-04-16 | Pronutria, Inc. | Nutritive polypeptide production systems, and methods of manufacture and use thereof |
| NL2013178B1 (en) * | 2014-07-14 | 2016-09-13 | Van Oossanen & Ass B V | Vessel comprising an aft foil oriented to provide a forwardly directed component of lift force. |
| JP6725513B2 (ja) * | 2014-12-16 | 2020-07-22 | ダニスコ・ユーエス・インク | ヘルパー株媒介型真菌ゲノム改変用の組成物および方法 |
| AU2015362784B2 (en) * | 2014-12-16 | 2021-05-13 | Danisco Us Inc | Fungal genome modification systems and methods of use |
| WO2016110453A1 (en) * | 2015-01-06 | 2016-07-14 | Dsm Ip Assets B.V. | A crispr-cas system for a filamentous fungal host cell |
-
2016
- 2016-07-28 WO PCT/US2016/044489 patent/WO2017019867A1/en active Application Filing
- 2016-07-28 CN CN201680043665.8A patent/CN107849562B/zh active Active
- 2016-07-28 JP JP2018503753A patent/JP6937740B2/ja active Active
- 2016-07-28 EP EP16750569.2A patent/EP3329001B1/en active Active
- 2016-07-28 DK DK16750569.2T patent/DK3329001T3/da active
- 2016-07-28 US US15/746,479 patent/US20180208945A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2018525983A (ja) | 2018-09-13 |
| WO2017019867A1 (en) | 2017-02-02 |
| CN107849562A (zh) | 2018-03-27 |
| EP3329001B1 (en) | 2021-09-22 |
| US20180208945A1 (en) | 2018-07-26 |
| CN107849562B (zh) | 2021-10-26 |
| JP6937740B2 (ja) | 2021-09-22 |
| EP3329001A1 (en) | 2018-06-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK3329001T3 (da) | Genomredigeringssystemer og anvendelsesfremgangsmåder | |
| DK3265947T3 (da) | Fremgangsmåde og system til kryptering | |
| DK3380101T3 (da) | Eif4-a-inhiberende forbindelser og fremgangsmåder relateret dertil | |
| KR20180084749A (ko) | 멀티뷰 디스플레이 및 관련 시스템과 방법 | |
| DK3373883T3 (da) | Medicinsk teknologistation og anvendelsesfremgangsmåde | |
| DK3354282T3 (da) | Glycan-terapeutiske midler og relaterede fremgangsmåder deraf | |
| DK3368534T3 (da) | Valbenazin-ditosylat og polymorfer deraf | |
| DK3280441T3 (da) | Anti-sortilin-antistoffer og fremgangsmåder til anvendelse deraf | |
| DK3258951T3 (da) | Anti-pvrig antistoffer og fremgangsmåder for anvendelse | |
| DK3234152T3 (da) | Svampegenommodificeringssystemer og anvendelsesfremgangsmåder | |
| DK3398022T3 (da) | Systemer og fremgangsmåder til tilpasning af uav-bane | |
| DK3194908T3 (da) | Overvågningssystemer og fremgangsmåder | |
| DK3265571T3 (da) | Fler-vektorsystem og anvendelse heraf | |
| DK3362344T3 (da) | Dynamisk styrede foliesystemer og fremgangsmåder | |
| DK3485201T3 (da) | Ventilationssystem og fremgangsmåde | |
| DK3244946T3 (da) | Infusionsindretningssystem og anordning | |
| DK3175588T3 (da) | Systemer og fremgangsmåder til beskedredigering | |
| DK3304394T3 (da) | Fremgangsmåder og systemer til godkendelse | |
| DK3357000T3 (da) | Systemer og fremgangsmåder til cancerdetektering | |
| DK3209773T3 (da) | Prolintolerante tripeptidylpeptidaser og anvendelser deraf | |
| DK3346056T3 (da) | Rengøringssystem og fremgangsmåde | |
| DK3265641T3 (da) | Stigørenhed og fremgangsmåde | |
| DK3384079T3 (da) | Fibrøs konstruktion og fremgangsmåder i forbindelse hermed | |
| DK3692009T3 (da) | Biocementationsfremgangsmåde og system | |
| DK3359773T3 (da) | Datasystemer, anordninger og fremgangsmåder |