DK3380487T3 - Additivsystemer til anvendelse i proteinpegylering - Google Patents
Additivsystemer til anvendelse i proteinpegylering Download PDFInfo
- Publication number
- DK3380487T3 DK3380487T3 DK16816042.2T DK16816042T DK3380487T3 DK 3380487 T3 DK3380487 T3 DK 3380487T3 DK 16816042 T DK16816042 T DK 16816042T DK 3380487 T3 DK3380487 T3 DK 3380487T3
- Authority
- DK
- Denmark
- Prior art keywords
- pegyling
- protein
- additional systems
- systems
- additional
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/64—Relaxins
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562258644P | 2015-11-23 | 2015-11-23 | |
PCT/US2016/063313 WO2017091568A1 (en) | 2015-11-23 | 2016-11-22 | Additive systems for use in protein pegylation |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3380487T3 true DK3380487T3 (da) | 2020-12-07 |
Family
ID=57589163
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK16816042.2T DK3380487T3 (da) | 2015-11-23 | 2016-11-22 | Additivsystemer til anvendelse i proteinpegylering |
Country Status (16)
Country | Link |
---|---|
US (3) | US10617765B2 (da) |
EP (2) | EP3380487B1 (da) |
JP (2) | JP6921821B2 (da) |
KR (1) | KR102688003B1 (da) |
CN (2) | CN108350025B (da) |
CY (1) | CY1123699T1 (da) |
DK (1) | DK3380487T3 (da) |
ES (1) | ES2827776T3 (da) |
HR (1) | HRP20201832T1 (da) |
HU (1) | HUE052634T2 (da) |
LT (1) | LT3380487T (da) |
PL (1) | PL3380487T3 (da) |
PT (1) | PT3380487T (da) |
RS (1) | RS61072B1 (da) |
SI (1) | SI3380487T1 (da) |
WO (1) | WO2017091568A1 (da) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108350025B (zh) * | 2015-11-23 | 2023-02-21 | 百时美施贵宝公司 | 用于蛋白质聚乙二醇化的添加剂体系 |
JP7441826B2 (ja) * | 2018-09-11 | 2024-03-01 | アンブルックス,インコーポレイテッド | インターロイキン-2ポリペプチド抱合物およびその使用 |
CN111484551B (zh) * | 2020-03-19 | 2022-02-11 | 北京翼方生物科技有限责任公司 | 一种聚乙二醇修饰的重组人碱性成纤维细胞生长因子 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19535571A1 (de) | 1995-09-14 | 1997-03-20 | Boehringer Mannheim Gmbh | Pharmazeutische Kombinationspräparate und deren Verwendung zur Behandlung von Hämodialysepatienten |
TWI240627B (en) | 1996-04-26 | 2005-10-01 | Chugai Pharmaceutical Co Ltd | Erythropoietin solution preparation |
EP0885613A1 (de) | 1997-06-21 | 1998-12-23 | Roche Diagnostics GmbH | Verwendung von modifizierten Hämoglobinen zur Behandlung von Anämien und Kombinationspräparate umfassend Erythropoietin und modifiziertes Hämoglobin |
DE19734293A1 (de) | 1997-08-08 | 1999-02-11 | Boehringer Mannheim Gmbh | Verwendung von pharmazeutischen Kombinationspräparaten enthaltend Erythropoietin und Eisenpräparate zur Behandlung von rheumatischen Erkrankungen |
DE602005025090D1 (de) * | 2004-03-17 | 2011-01-13 | Anticancer Inc | Methoden zur steigerung der protein polyethylenglykol (peg) konjugation |
TW200722521A (en) * | 2005-06-01 | 2007-06-16 | Alza Corp | Novel bioconjugation reactions for acylating polyethylene glycol reagents |
RS51998B (en) | 2005-11-08 | 2012-04-30 | Ambrx Inc. | ACCELERATORS FOR MODIFICATION OF NON-NATURAL AMINO ACIDS AND NON-NATURAL AMINO ACID POLYPEPTIDES |
CN107501407B (zh) * | 2007-03-30 | 2022-03-18 | Ambrx公司 | 经修饰fgf-21多肽和其用途 |
CA2899448C (en) | 2013-01-30 | 2021-10-26 | Avelas Biosciences, Inc. | Selective delivery molecules and methods of use |
WO2014176284A1 (en) | 2013-04-22 | 2014-10-30 | Avelas Biosciences, Inc. | Selective drug delivery compositions and methods of use |
CN114805532A (zh) | 2014-10-24 | 2022-07-29 | 百时美施贵宝公司 | 修饰的fgf-21多肽及其用途 |
CN108350025B (zh) * | 2015-11-23 | 2023-02-21 | 百时美施贵宝公司 | 用于蛋白质聚乙二醇化的添加剂体系 |
-
2016
- 2016-11-22 CN CN201680067897.7A patent/CN108350025B/zh active Active
- 2016-11-22 EP EP16816042.2A patent/EP3380487B1/en active Active
- 2016-11-22 CN CN202211743414.4A patent/CN115819494A/zh active Pending
- 2016-11-22 EP EP20189107.4A patent/EP3789395A1/en active Pending
- 2016-11-22 WO PCT/US2016/063313 patent/WO2017091568A1/en active Application Filing
- 2016-11-22 KR KR1020187017508A patent/KR102688003B1/ko active IP Right Grant
- 2016-11-22 LT LTEP16816042.2T patent/LT3380487T/lt unknown
- 2016-11-22 SI SI201630957T patent/SI3380487T1/sl unknown
- 2016-11-22 JP JP2018526713A patent/JP6921821B2/ja active Active
- 2016-11-22 DK DK16816042.2T patent/DK3380487T3/da active
- 2016-11-22 RS RS20201382A patent/RS61072B1/sr unknown
- 2016-11-22 HU HUE16816042A patent/HUE052634T2/hu unknown
- 2016-11-22 US US15/776,923 patent/US10617765B2/en active Active
- 2016-11-22 PT PT168160422T patent/PT3380487T/pt unknown
- 2016-11-22 ES ES16816042T patent/ES2827776T3/es active Active
- 2016-11-22 PL PL16816042T patent/PL3380487T3/pl unknown
-
2020
- 2020-02-21 US US16/797,361 patent/US11213589B2/en active Active
- 2020-11-19 HR HRP20201832TT patent/HRP20201832T1/hr unknown
- 2020-11-20 CY CY20201101102T patent/CY1123699T1/el unknown
-
2021
- 2021-07-28 JP JP2021123154A patent/JP7257457B2/ja active Active
- 2021-12-03 US US17/541,636 patent/US20220160883A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
SI3380487T1 (sl) | 2020-11-30 |
PL3380487T3 (pl) | 2020-12-28 |
CN115819494A (zh) | 2023-03-21 |
CN108350025B (zh) | 2023-02-21 |
CY1123699T1 (el) | 2022-03-24 |
RS61072B1 (sr) | 2020-12-31 |
KR102688003B1 (ko) | 2024-07-23 |
US20200276319A1 (en) | 2020-09-03 |
US10617765B2 (en) | 2020-04-14 |
US11213589B2 (en) | 2022-01-04 |
WO2017091568A8 (en) | 2018-01-04 |
HRP20201832T1 (hr) | 2021-01-08 |
JP2019503994A (ja) | 2019-02-14 |
CN108350025A (zh) | 2018-07-31 |
WO2017091568A1 (en) | 2017-06-01 |
US20190351065A1 (en) | 2019-11-21 |
US20220160883A1 (en) | 2022-05-26 |
ES2827776T3 (es) | 2021-05-24 |
EP3789395A1 (en) | 2021-03-10 |
HUE052634T2 (hu) | 2021-05-28 |
EP3380487A1 (en) | 2018-10-03 |
EP3380487B1 (en) | 2020-09-02 |
JP2021176890A (ja) | 2021-11-11 |
JP6921821B2 (ja) | 2021-08-18 |
KR20180081610A (ko) | 2018-07-16 |
LT3380487T (lt) | 2020-12-28 |
JP7257457B2 (ja) | 2023-04-13 |
PT3380487T (pt) | 2020-10-29 |
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