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DK3380487T3 - Additivsystemer til anvendelse i proteinpegylering - Google Patents

Additivsystemer til anvendelse i proteinpegylering Download PDF

Info

Publication number
DK3380487T3
DK3380487T3 DK16816042.2T DK16816042T DK3380487T3 DK 3380487 T3 DK3380487 T3 DK 3380487T3 DK 16816042 T DK16816042 T DK 16816042T DK 3380487 T3 DK3380487 T3 DK 3380487T3
Authority
DK
Denmark
Prior art keywords
pegyling
protein
additional systems
systems
additional
Prior art date
Application number
DK16816042.2T
Other languages
English (en)
Inventor
Matthew R Hickey
Antonio Ramirez
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of DK3380487T3 publication Critical patent/DK3380487T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/50Fibroblast growth factor [FGF]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/64Relaxins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK16816042.2T 2015-11-23 2016-11-22 Additivsystemer til anvendelse i proteinpegylering DK3380487T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562258644P 2015-11-23 2015-11-23
PCT/US2016/063313 WO2017091568A1 (en) 2015-11-23 2016-11-22 Additive systems for use in protein pegylation

Publications (1)

Publication Number Publication Date
DK3380487T3 true DK3380487T3 (da) 2020-12-07

Family

ID=57589163

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16816042.2T DK3380487T3 (da) 2015-11-23 2016-11-22 Additivsystemer til anvendelse i proteinpegylering

Country Status (16)

Country Link
US (3) US10617765B2 (da)
EP (2) EP3380487B1 (da)
JP (2) JP6921821B2 (da)
KR (1) KR102688003B1 (da)
CN (2) CN108350025B (da)
CY (1) CY1123699T1 (da)
DK (1) DK3380487T3 (da)
ES (1) ES2827776T3 (da)
HR (1) HRP20201832T1 (da)
HU (1) HUE052634T2 (da)
LT (1) LT3380487T (da)
PL (1) PL3380487T3 (da)
PT (1) PT3380487T (da)
RS (1) RS61072B1 (da)
SI (1) SI3380487T1 (da)
WO (1) WO2017091568A1 (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108350025B (zh) * 2015-11-23 2023-02-21 百时美施贵宝公司 用于蛋白质聚乙二醇化的添加剂体系
JP7441826B2 (ja) * 2018-09-11 2024-03-01 アンブルックス,インコーポレイテッド インターロイキン-2ポリペプチド抱合物およびその使用
CN111484551B (zh) * 2020-03-19 2022-02-11 北京翼方生物科技有限责任公司 一种聚乙二醇修饰的重组人碱性成纤维细胞生长因子

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19535571A1 (de) 1995-09-14 1997-03-20 Boehringer Mannheim Gmbh Pharmazeutische Kombinationspräparate und deren Verwendung zur Behandlung von Hämodialysepatienten
TWI240627B (en) 1996-04-26 2005-10-01 Chugai Pharmaceutical Co Ltd Erythropoietin solution preparation
EP0885613A1 (de) 1997-06-21 1998-12-23 Roche Diagnostics GmbH Verwendung von modifizierten Hämoglobinen zur Behandlung von Anämien und Kombinationspräparate umfassend Erythropoietin und modifiziertes Hämoglobin
DE19734293A1 (de) 1997-08-08 1999-02-11 Boehringer Mannheim Gmbh Verwendung von pharmazeutischen Kombinationspräparaten enthaltend Erythropoietin und Eisenpräparate zur Behandlung von rheumatischen Erkrankungen
DE602005025090D1 (de) * 2004-03-17 2011-01-13 Anticancer Inc Methoden zur steigerung der protein polyethylenglykol (peg) konjugation
TW200722521A (en) * 2005-06-01 2007-06-16 Alza Corp Novel bioconjugation reactions for acylating polyethylene glycol reagents
RS51998B (en) 2005-11-08 2012-04-30 Ambrx Inc. ACCELERATORS FOR MODIFICATION OF NON-NATURAL AMINO ACIDS AND NON-NATURAL AMINO ACID POLYPEPTIDES
CN107501407B (zh) * 2007-03-30 2022-03-18 Ambrx公司 经修饰fgf-21多肽和其用途
CA2899448C (en) 2013-01-30 2021-10-26 Avelas Biosciences, Inc. Selective delivery molecules and methods of use
WO2014176284A1 (en) 2013-04-22 2014-10-30 Avelas Biosciences, Inc. Selective drug delivery compositions and methods of use
CN114805532A (zh) 2014-10-24 2022-07-29 百时美施贵宝公司 修饰的fgf-21多肽及其用途
CN108350025B (zh) * 2015-11-23 2023-02-21 百时美施贵宝公司 用于蛋白质聚乙二醇化的添加剂体系

Also Published As

Publication number Publication date
SI3380487T1 (sl) 2020-11-30
PL3380487T3 (pl) 2020-12-28
CN115819494A (zh) 2023-03-21
CN108350025B (zh) 2023-02-21
CY1123699T1 (el) 2022-03-24
RS61072B1 (sr) 2020-12-31
KR102688003B1 (ko) 2024-07-23
US20200276319A1 (en) 2020-09-03
US10617765B2 (en) 2020-04-14
US11213589B2 (en) 2022-01-04
WO2017091568A8 (en) 2018-01-04
HRP20201832T1 (hr) 2021-01-08
JP2019503994A (ja) 2019-02-14
CN108350025A (zh) 2018-07-31
WO2017091568A1 (en) 2017-06-01
US20190351065A1 (en) 2019-11-21
US20220160883A1 (en) 2022-05-26
ES2827776T3 (es) 2021-05-24
EP3789395A1 (en) 2021-03-10
HUE052634T2 (hu) 2021-05-28
EP3380487A1 (en) 2018-10-03
EP3380487B1 (en) 2020-09-02
JP2021176890A (ja) 2021-11-11
JP6921821B2 (ja) 2021-08-18
KR20180081610A (ko) 2018-07-16
LT3380487T (lt) 2020-12-28
JP7257457B2 (ja) 2023-04-13
PT3380487T (pt) 2020-10-29

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DK3380487T3 (da) Additivsystemer til anvendelse i proteinpegylering