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DK3124610T3 - Hbv-behandling - Google Patents

Hbv-behandling Download PDF

Info

Publication number
DK3124610T3
DK3124610T3 DK16188642.9T DK16188642T DK3124610T3 DK 3124610 T3 DK3124610 T3 DK 3124610T3 DK 16188642 T DK16188642 T DK 16188642T DK 3124610 T3 DK3124610 T3 DK 3124610T3
Authority
DK
Denmark
Prior art keywords
hbv treatment
hbv
treatment
Prior art date
Application number
DK16188642.9T
Other languages
English (en)
Inventor
Michael Wayne Graham
Peter French
Yixiang Lu
Tiejun Li
Yuncheng Sun
Xiaojun Tang
Li Shan
York Yuan Yuan Zhu
Original Assignee
Benitec Biopharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN201010522003.3A external-priority patent/CN101979557B/zh
Priority claimed from CN201010522005.2A external-priority patent/CN101979558B/zh
Priority claimed from CN201010521948.3A external-priority patent/CN101979553B/zh
Priority claimed from CN201010521975.0A external-priority patent/CN101979555B/zh
Priority claimed from CN201010521962.3A external-priority patent/CN101979554B/zh
Priority claimed from CN201010521990.5A external-priority patent/CN101979556B/zh
Priority claimed from CN201010521972.7A external-priority patent/CN102021170B/zh
Priority claimed from PCT/CN2011/071107 external-priority patent/WO2012109798A1/en
Application filed by Benitec Biopharma Ltd filed Critical Benitec Biopharma Ltd
Application granted granted Critical
Publication of DK3124610T3 publication Critical patent/DK3124610T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering N.A.
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/50Physical structure
    • C12N2310/53Physical structure partially self-complementary or closed
    • C12N2310/531Stem-loop; Hairpin

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Control Of Eletrric Generators (AREA)
DK16188642.9T 2010-10-28 2011-10-27 Hbv-behandling DK3124610T3 (da)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
CN201010522003.3A CN101979557B (zh) 2010-10-28 2010-10-28 一种siRNA分子及其在抗病毒药物中的应用
CN201010522005.2A CN101979558B (zh) 2010-10-28 2010-10-28 一种靶向乙型肝炎病毒基因的siRNA分子及其应用
CN201010521948.3A CN101979553B (zh) 2010-10-28 2010-10-28 一种干扰HBV基因的siRNA分子及其抗病毒应用
CN201010521975.0A CN101979555B (zh) 2010-10-28 2010-10-28 一种小干扰rna分子及其应用
CN201010521962.3A CN101979554B (zh) 2010-10-28 2010-10-28 一种干扰HBV基因的siRNA分子及其应用
CN201010521990.5A CN101979556B (zh) 2010-10-28 2010-10-28 一种siRNA靶向分子及其应用
CN201010521972.7A CN102021170B (zh) 2010-10-28 2010-10-28 一种干扰乙型肝炎病毒基因的siRNA分子及其应用
PCT/CN2011/071107 WO2012109798A1 (en) 2011-02-18 2011-02-18 Hbv treatment
EP11835635.1A EP2633051B1 (en) 2010-10-28 2011-10-27 Hbv treatment

Publications (1)

Publication Number Publication Date
DK3124610T3 true DK3124610T3 (da) 2019-06-11

Family

ID=45993174

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16188642.9T DK3124610T3 (da) 2010-10-28 2011-10-27 Hbv-behandling

Country Status (20)

Country Link
US (2) US9080174B2 (da)
EP (2) EP3124610B1 (da)
KR (2) KR101903778B1 (da)
CN (1) CN103370415B (da)
AU (1) AU2011320437B2 (da)
BR (1) BR112013010525A2 (da)
CA (1) CA2853613C (da)
CY (1) CY1121894T1 (da)
DK (1) DK3124610T3 (da)
ES (1) ES2730393T3 (da)
HR (1) HRP20190995T1 (da)
HU (1) HUE044426T2 (da)
LT (1) LT3124610T (da)
PL (1) PL3124610T3 (da)
PT (1) PT3124610T (da)
RS (1) RS58982B1 (da)
RU (1) RU2620966C2 (da)
SI (1) SI3124610T1 (da)
TR (1) TR201908127T4 (da)
WO (1) WO2012055362A1 (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA118951C2 (uk) 2011-04-21 2019-04-10 Айоніс Фармасьютікалз, Інк. Модулювання експресії вірусу гепатиту b (hbv)
SG11201507496UA (en) 2013-04-17 2015-11-27 Pfizer N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
CN105002214B (zh) * 2015-04-08 2018-07-17 许中伟 用于载体表达的复合多联gRNA和RNAi的表达框架
AU2016257150B2 (en) * 2015-05-06 2022-03-31 Benitec IP Holdings Inc. Reagents for treatment of hepatitis B virus (HBV) infection and use thereof
EP3332007A4 (en) 2015-08-07 2019-07-17 Arrowhead Pharmaceuticals, Inc. RNA INTERFERENCE THERAPY FOR HEPATITIS B VIRUS INFECTION
TWI840950B (zh) 2016-03-14 2024-05-01 瑞士商赫孚孟拉羅股份公司 用於降低pd-l1表現之寡核苷酸
SG11201809753YA (en) * 2016-05-05 2018-12-28 Benitec Biopharma Ltd Reagents for treatment of hepatitis b virus (hbv) infection and use thereof
MA45496A (fr) 2016-06-17 2019-04-24 Hoffmann La Roche Molécules d'acide nucléique pour la réduction de l'arnm de padd5 ou pad7 pour le traitement d'une infection par l'hépatite b
JOP20170161A1 (ar) 2016-08-04 2019-01-30 Arrowhead Pharmaceuticals Inc عوامل RNAi للعدوى بفيروس التهاب الكبد ب
CN108929870B (zh) * 2017-05-19 2020-01-24 百奥迈科生物技术有限公司 抑制HBV的siRNA分子及其应用
KR102585898B1 (ko) 2017-10-16 2023-10-10 에프. 호프만-라 로슈 아게 B형 간염 감염을 치료하기 위한 PAPD5 및 PAPD7 mRNA의 감소용 핵산 분자
CN112055749A (zh) 2018-04-05 2020-12-08 豪夫迈·罗氏有限公司 Fubp1抑制剂用于治疗乙型肝炎病毒感染的用途
BR112020026973A2 (pt) 2018-07-03 2021-04-06 F. Hoffmann-La Roche Ag Oligonucleotídeos para modulação da expressão tau
EP3821013A1 (en) 2018-07-13 2021-05-19 F. Hoffmann-La Roche AG Oligonucleotides for modulating rtel1 expression
CN115516091A (zh) 2019-12-19 2022-12-23 豪夫迈·罗氏有限公司 Cops3抑制剂用于治疗乙型肝炎病毒感染的用途
JP2023506954A (ja) 2019-12-19 2023-02-20 エフ. ホフマン-ラ ロシュ エージー. B型肝炎ウイルス感染を処置するためのsaraf阻害剤の使用
WO2021122910A1 (en) 2019-12-19 2021-06-24 F. Hoffmann-La Roche Ag Use of sbds inhibitors for treating hepatitis b virus infection
JP2023506546A (ja) 2019-12-19 2023-02-16 エフ. ホフマン-ラ ロシュ エージー. B型肝炎ウイルス感染症を処置するためのsept9阻害剤の使用
EP4200419A2 (en) 2020-08-21 2023-06-28 F. Hoffmann-La Roche AG Use of a1cf inhibitors for treating hepatitis b virus infection
TW202246500A (zh) 2021-02-02 2022-12-01 瑞士商赫孚孟拉羅股份公司 用於抑制 rtel1 表現之增強型寡核苷酸
EP4448106A1 (en) 2021-12-17 2024-10-23 Hoffmann-La Roche Inc. Combination of oligonucleotides for modulating rtel1 and fubp1
US20240309383A1 (en) * 2023-02-24 2024-09-19 Suzhou Sanegene Bio Inc. Small interfering rna targeting hbv and uses thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030206887A1 (en) * 1992-05-14 2003-11-06 David Morrissey RNA interference mediated inhibition of hepatitis B virus (HBV) using short interfering nucleic acid (siNA)
US6218181B1 (en) 1998-03-18 2001-04-17 The Salk Institute For Biological Studies Retroviral packaging cell line
CA2323726C (en) 1998-03-20 2005-02-08 Benitec Australia Ltd. Control of gene expression
AUPP249298A0 (en) 1998-03-20 1998-04-23 Ag-Gene Australia Limited Synthetic genes and genetic constructs comprising same I
IL151781A0 (en) 2000-03-16 2003-04-10 Genetica Inc Methods and compositions for rna interference
EP1424895B1 (en) 2001-09-13 2009-08-12 California Institute Of Technology Method for expression of small antiviral rna molecules within a cell
CA2494772C (en) 2002-08-29 2015-12-01 The Board Of Trustees Of The Leland Stanford Junior University Circular nucleic acid vectors, and methods for making and using the same
CA2527907A1 (en) 2003-06-03 2004-12-09 Benitec Australia Limited Double-stranded hairpin rnas for rnai
KR101246862B1 (ko) 2004-03-05 2013-03-27 베니텍 리미티드 RNAi 제제의 동시 전달을 위한 다중 프로모터 발현카세트
WO2006084209A2 (en) 2005-02-03 2006-08-10 Benitec, Inc. Rnai expression constructs
US8008468B2 (en) * 2005-02-16 2011-08-30 Benitec, Inc. RNAi expression constructs with liver-specific enhancer/promoter
AR057252A1 (es) * 2005-12-27 2007-11-21 Alcon Mfg Ltd Inhibicion de rho quinasa mediada por arni para el tratamiento de trastornos oculares
US8129510B2 (en) 2006-03-30 2012-03-06 The Board Of Trustees Of The Leland Stanford Junior University Minigene expression cassette
CN101684478B (zh) * 2009-06-26 2012-02-29 武汉大学 一种串联表达小干扰rna重组慢病毒载体的构建方法
CN101979556B (zh) 2010-10-28 2015-01-21 百奥迈科生物技术有限公司 一种siRNA靶向分子及其应用

Also Published As

Publication number Publication date
US20130296401A1 (en) 2013-11-07
CN103370415A (zh) 2013-10-23
US9080174B2 (en) 2015-07-14
RS58982B1 (sr) 2019-08-30
EP3124610B1 (en) 2019-03-06
TR201908127T4 (tr) 2019-06-21
RU2013124422A (ru) 2014-12-10
CA2853613A1 (en) 2012-05-03
US9410154B2 (en) 2016-08-09
KR101903778B1 (ko) 2018-10-04
AU2011320437A1 (en) 2013-06-13
LT3124610T (lt) 2019-08-12
WO2012055362A1 (en) 2012-05-03
HRP20190995T1 (hr) 2019-08-09
PL3124610T3 (pl) 2019-09-30
PT3124610T (pt) 2019-06-14
CA2853613C (en) 2020-03-24
CN103370415B (zh) 2017-05-31
KR20140071949A (ko) 2014-06-12
HUE044426T2 (hu) 2019-10-28
EP2633051B1 (en) 2016-09-14
KR20180110186A (ko) 2018-10-08
CY1121894T1 (el) 2020-10-14
RU2620966C2 (ru) 2017-05-30
EP2633051A4 (en) 2014-04-23
AU2011320437B2 (en) 2017-03-16
EP3124610A1 (en) 2017-02-01
US20150344885A1 (en) 2015-12-03
SI3124610T1 (sl) 2019-08-30
ES2730393T3 (es) 2019-11-11
EP2633051A1 (en) 2013-09-04
BR112013010525A2 (pt) 2016-08-02

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