[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

DK2665749T3 - Anti-il1rap-antistoffer og deres anvendelse til behandling af faste tumorer - Google Patents

Anti-il1rap-antistoffer og deres anvendelse til behandling af faste tumorer Download PDF

Info

Publication number
DK2665749T3
DK2665749T3 DK12705387.4T DK12705387T DK2665749T3 DK 2665749 T3 DK2665749 T3 DK 2665749T3 DK 12705387 T DK12705387 T DK 12705387T DK 2665749 T3 DK2665749 T3 DK 2665749T3
Authority
DK
Denmark
Prior art keywords
cells
il1rap
antibody
agent
cell
Prior art date
Application number
DK12705387.4T
Other languages
English (en)
Inventor
Thoas Fioretos
Marcus Järås
Original Assignee
Cantargia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45755402&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2665749(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cantargia Ab filed Critical Cantargia Ab
Application granted granted Critical
Publication of DK2665749T3 publication Critical patent/DK2665749T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/245—IL-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
    • A61K51/1033—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants against receptors for cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Claims (14)

1. Middel omfattende eller bestående af et antistof med specificitet for interleukin-1 receptor-accessory-protein (IL1RAP) til anvendelse i behandling eller forebyggelse af en fast tumor hos en patient, hvor tumoren omfatter celler der udviser lige eller højere ekspressionsniveauer af IL1RAP end i den Philadelphiapositive cellelinje KU812 (ATCC 378), hvor midlet er i stand til at dræbe cellerne ved at inducere antistof-afhængig celle-medieret cytotoxicitet (ADCC), og hvor den faste tumor er valgt fra gruppen bestående af brystcancer, lungecancer, kolorektalcancer, og melanomer.
2. Middel til anvendelse ifølge krav 1, hvor den faste tumor er et melanom.
3. Middel til anvendelse ifølge krav 1 eller 2, hvor antistoffet er humant eller humaniseret.
4. Middel til anvendelse ifølge et hvilket som helst af de foregående krav yderligere omfattende en bestanddel for at forhøje in v/Vo-halveringstiden af midlet.
5. Middel til anvendelse ifølge krav 4, hvor bestanddelen til at forhøje in vivo-halveringstiden er valgt fra gruppen bestående af polyethylenglycol (PEG), humant serum albumin, glycosyleringsgrupper, fedtsyrer og dextran.
6. Middel til anvendelse ifølge et hvilket som helst af de foregående krav yderligere omfattende en cytotoxisk bestanddel.
7. Middel omfattende eller bestående af et antistof eller antigen-bindende fragment deraf med specificitet for interleukin-1 receptor-accessory-protein (IL1RAP) til anvendelse i en fremgangsmåde til diagnose afen fast tumor i en patient, hvor tumoren omfatter celler der udviser lige eller højere ekspressionsniveauer af IL1RAP end i den Philadelphia-positive cellelinje KU812 (ATCC 378), og hvor den faste tumor er valgt fra gruppen bestående af brystcancer, lungecancer, ko I o re kta I cancer, melanomer, lymfomer, og ovariecancer.
8. Middel til anvendelse ifølge krav 7 hvor den faste tumor er et melanom.
9. Middel til anvendelse ifølge krav 7 eller 8, hvor det antigen-bindende fragment er valgt fra gruppen bestående af enkeltkæde-Fv, disulfid-bundet Fv, domæneantistoffer, Fab-fragmenter, Fab'-fragmenter og F(ab)2-fragmenter.
10. Middel til anvendelse ifølge et hvilket som helst af kravene 7 til 9, hvor antistoffet eller antigen-bindende fragment deraf er humant eller humaniseret.
11. Middel til anvendelse ifølge et hvilket som helst af kravene 7 to 10 yderligere omfattende en bestanddel for at forhøje in wVo-halveringstiden af midlet.
12. Middel til anvendelse ifølge krav 11 hvor bestanddelen til at forhøje in vivo-halveringstiden er valgt fra gruppen bestående af polyethylenglycol (PEG), humant serum albumin, glycosyleringsgrupper, fedtsyrer og dextran.
13. Middel til anvendelse ifølge et hvilket som helst af kravene 7 til 12 yderligere omfattende en detekterbar bestanddel.
14. Anvendelse in vitro af et middel omfattende eller bestående af et antistof eller antigen- bindende fragment deraf med specificitet for interleukin-1 receptor-accessory-protein (IL1RAP) i påvisning af faste tumorer, hvor tumoren omfatter celler der udviser lige eller højere ekspressionsniveauer af IL1RAP end i den Philadelphia-positive cellelinje KU812 (ATCC 378) og hvor den faste tumor er valgt fra gruppen bestående af brystcancer, lungecancer, kolorektalcancer, melanomer, hjerne/CNS-cancer, lymfomer, og ovariecancer.
DK12705387.4T 2011-01-19 2012-01-19 Anti-il1rap-antistoffer og deres anvendelse til behandling af faste tumorer DK2665749T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161434040P 2011-01-19 2011-01-19
PCT/GB2012/050120 WO2012098407A1 (en) 2011-01-19 2012-01-19 Anti - il1rap antibodies and their use for treating human

Publications (1)

Publication Number Publication Date
DK2665749T3 true DK2665749T3 (da) 2016-03-21

Family

ID=45755402

Family Applications (2)

Application Number Title Priority Date Filing Date
DK15197139.7T DK3020730T3 (da) 2011-01-19 2012-01-19 Anti-il1rap-antistoffer og deres anvendelse til behandling af faste tumorer
DK12705387.4T DK2665749T3 (da) 2011-01-19 2012-01-19 Anti-il1rap-antistoffer og deres anvendelse til behandling af faste tumorer

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK15197139.7T DK3020730T3 (da) 2011-01-19 2012-01-19 Anti-il1rap-antistoffer og deres anvendelse til behandling af faste tumorer

Country Status (14)

Country Link
US (4) US9403906B2 (da)
EP (3) EP3020730B1 (da)
JP (1) JP5940093B2 (da)
KR (1) KR101989134B1 (da)
CN (2) CN103459424B (da)
AU (1) AU2012208379B2 (da)
BR (1) BR112013018399B1 (da)
CA (1) CA2824719C (da)
DK (2) DK3020730T3 (da)
ES (2) ES2714716T3 (da)
MX (1) MX354450B (da)
PL (2) PL3020730T3 (da)
RU (1) RU2597831C2 (da)
WO (1) WO2012098407A1 (da)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2271673B1 (en) 2008-03-26 2016-02-24 Cellerant Therapeutics, Inc. Cytokine receptors associated with myelogenous haematological proliferative disorders and uses thereof
GB2472856B (en) 2009-08-21 2012-07-11 Cantargia Ab IL1-RAP modulators and uses thereof
PL3020730T3 (pl) 2011-01-19 2019-06-28 Cantargia Ab Przeciwciała anty-il1rap i ich zastosowanie do leczenia guzów litych
HUE039849T2 (hu) 2011-03-16 2019-02-28 Argenx Bvba CD70 elleni ellenanyagok
US9873918B2 (en) 2011-08-11 2018-01-23 Albert Einstein College Of Medicine, Inc. Treatment of acute myeloid leukemia and myelodysplastic syndromes
EA201691130A8 (ru) 2013-12-17 2018-08-31 Аимм Терапьютикс Б.В. Средства и способы противодействия миелопролиферативным или лимфопролиферативным расстройствам
GB201403875D0 (en) * 2014-03-05 2014-04-16 Cantargia Ab Novel antibodies and uses thereof
GB201413913D0 (en) * 2014-08-06 2014-09-17 Cantargia Ab Novel antibodies and uses thereof
US10391168B1 (en) 2014-08-22 2019-08-27 University Of Bern Anti-CD70 combination therapy
WO2016085832A1 (en) * 2014-11-24 2016-06-02 Albert Einstein College Of Medicine, Inc. Peptides for blocking il1rap protein-protein interaction and uses thereof for treatment of disease
WO2016207304A2 (en) 2015-06-26 2016-12-29 Mab Discovery Gmbh Monoclonal anti-il-1racp antibodies
CN108431042A (zh) * 2015-11-02 2018-08-21 詹森药业有限公司 抗-il1rap抗体，结合il1rap和cd3的双特异性抗原结合分子及其用途
EP3241845A1 (en) * 2016-05-06 2017-11-08 MAB Discovery GmbH Humanized anti-il-1r3 antibodies
EP3526247A4 (en) * 2016-10-16 2021-04-14 Cantargia AB ANTI-IL1 RAP ANTIBODIES
EP3548515A1 (en) 2016-12-01 2019-10-09 Regeneron Pharmaceuticals, Inc. Radiolabeled anti-pd-l1 antibodies for immuno-pet imaging
US10067409B2 (en) 2017-02-02 2018-09-04 James Harrison Elias Camera supporting base
EP3401332A1 (en) * 2017-05-08 2018-11-14 MAB Discovery GmbH Anti-il-1r3 antibodies for use in inflammatory conditions
KR102714600B1 (ko) * 2017-05-16 2024-10-08 비온디스 비.브이. 항-SIRPα 항체
USD951260S1 (en) 2017-05-19 2022-05-10 James Harrison Elias Electronic device mount
US11162632B2 (en) 2017-06-02 2021-11-02 James Harrison Elias Tripod stabilizing base
CA3066918A1 (en) 2017-06-12 2018-12-20 Bluefin Biomedicine, Inc. Anti-il1rap antibodies and antibody drug conjugates
US11370842B2 (en) 2017-08-01 2022-06-28 City Of Hope Anti-IL1RAP antibodies
GB201800649D0 (en) 2018-01-16 2018-02-28 Argenx Bvba CD70 Combination Therapy
US12209131B2 (en) 2018-08-16 2025-01-28 Cantargia Ab Anti-IL1RAP antibody compositions
TW202021618A (zh) 2018-08-17 2020-06-16 美商２３與我有限公司 抗ｉｌ１ｒａｐ抗體及其使用方法
EP3880707A1 (en) 2018-11-15 2021-09-22 Byondis B.V. HUMANIZED ANTI-SIRPa ANTIBODIES
USD888141S1 (en) 2018-11-29 2020-06-23 James Harrison Elias Tripod mount
USD888142S1 (en) 2018-11-29 2020-06-23 James Harrison Elias Tripod mount
USD888140S1 (en) 2018-11-29 2020-06-23 James Harrison Elias Tripod mount
USD896878S1 (en) 2018-11-29 2020-09-22 James Harrison Elias Tripod mount
USD897414S1 (en) 2018-11-29 2020-09-29 James Harrison Elias Tripod mount
USD888815S1 (en) 2018-11-29 2020-06-30 James Harrison Elias Tripod mount
USD900201S1 (en) 2018-11-29 2020-10-27 James Harrison Elias Tripod mount
USD888139S1 (en) 2018-11-29 2020-06-23 James Harrison Elias Tripod mount
USD896879S1 (en) 2018-11-30 2020-09-22 James Harrison Elias Tripod mount
USD896880S1 (en) 2018-11-30 2020-09-22 James Harrison Elias Tripod mount
USD888816S1 (en) 2018-11-30 2020-06-30 James Harrison Elias Tripod mount
USD888817S1 (en) 2018-11-30 2020-06-30 James Harrison Elias Tripod mount
TWI848030B (zh) 2018-12-18 2024-07-11 比利時商阿根思公司 Ｃｄ７０組合治療
MX2021015651A (es) 2019-06-26 2022-06-14 Glaxosmithkline Ip Dev Ltd Proteinas de union a la proteina accesoria del receptor de interleucina-1 (il1rap).
CN114599678A (zh) * 2019-08-12 2022-06-07 希望之城 Il1rap抗体
JP2023541627A (ja) 2020-09-14 2023-10-03 イシュノス サイエンシズ ソシエテ アノニム Ｉｌ１ｒａｐに結合する抗体及びその使用
MX2023007611A (es) 2020-12-23 2023-07-12 Cantargia Ab Anticuerpo anti-il1rap.
CN114736885A (zh) * 2022-05-27 2022-07-12 四川大学华西医院 一种携带bcr-abl1基因激酶区双位点突变的细胞株及其构建方法
TW202428613A (zh) 2022-09-21 2024-07-16 法商賽諾菲生物技術公司 人源化抗il-1r3抗體及使用方法
WO2024231251A1 (en) 2023-05-05 2024-11-14 Cantargia Ab Anti-il1rap antibodies
WO2025027529A1 (en) * 2023-07-31 2025-02-06 Advesya Anti-il-1rap antibody drug conjugates and methods of use thereof

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
SE459005B (sv) 1985-07-12 1989-05-29 Aake Rikard Lindahl Saett att framstaella sfaeriska polymerpartiklar
US5094941A (en) * 1987-12-31 1992-03-10 Zymogenetics, Inc. Monoclonal antibodies to PDGF
CA1329119C (en) * 1988-03-29 1994-05-03 Milton David Goldenberg Cytotoxic therapy
US5120525A (en) * 1988-03-29 1992-06-09 Immunomedics, Inc. Radiolabeled antibody cytotoxic therapy of cancer
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
GB9314623D0 (en) * 1993-07-14 1993-08-25 Nordion Int Inc Localization and therapy with agents directed against prostate specific antigen in breast cancer
CN1169754A (zh) * 1995-01-23 1998-01-07 霍夫曼-拉罗奇有限公司 人白介素-1受体辅助蛋白
PE64396A1 (es) * 1995-01-23 1997-01-28 Hoffmann La Roche Proteina accesoria del receptor de la interleucina 1
CA2192782C (en) 1995-12-15 2008-10-14 Nobuyuki Takechi Production of microspheres
US6280955B1 (en) 1997-12-16 2001-08-28 Tularik Inc. Interleukin-1 receptor accessory proteins, nucleic acids and methods
US20030215453A1 (en) 2002-05-14 2003-11-20 Dedera Douglas A. Methods of therapy and diagnosis using immunotargeting of cells expressing VpreB1 protein
US20030026806A1 (en) 2000-10-27 2003-02-06 Amgen Inc. Antibodies and other selective IL-1 binding agents that allow binding to IL-1 receptor but not activation thereof
WO2002064630A2 (en) 2000-10-31 2002-08-22 Immunex Corporation Il-1 receptor accessory protein
US20030049255A1 (en) 2001-08-07 2003-03-13 Sims John E. Interleukin-1 receptors in the treatment of diseases
US20040224893A1 (en) 2003-05-06 2004-11-11 Li-Hsien Wang Methods of using IL-1 antagonists to treat neointimal hyperplasia
WO2005005601A2 (en) 2003-06-09 2005-01-20 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
CN1852974A (zh) * 2003-06-09 2006-10-25 密歇根大学董事会 用于治疗和诊断癌症的组合物和方法
RU2007130722A (ru) 2005-02-16 2009-03-27 Вайет (Us) Способы и устройства для диагностики, прогнозирования и выбора лечения лейкоза
WO2006110593A2 (en) 2005-04-07 2006-10-19 Macrogenics, Inc. Biological targets for the diagnosis, treatment and prevention of cancer
NZ612578A (en) 2005-08-19 2014-11-28 Abbvie Inc Dual variable domain immunoglobin and uses thereof
US7612181B2 (en) 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
US8014957B2 (en) 2005-12-15 2011-09-06 Fred Hutchinson Cancer Research Center Genes associated with progression and response in chronic myeloid leukemia and uses thereof
WO2007112097A2 (en) 2006-03-24 2007-10-04 Children's Medical Center Corporation Novel signature self renewal gene expression programs
US8207304B2 (en) 2006-10-19 2012-06-26 Csl Limited Antibody antagonists of interleukin-13 receptor α1
EP4160212B1 (en) 2008-01-15 2024-04-17 The Board of Trustees of the Leland Stanford Junior University Markers of acute myeloid leukemia stem cells
EP2271673B1 (en) 2008-03-26 2016-02-24 Cellerant Therapeutics, Inc. Cytokine receptors associated with myelogenous haematological proliferative disorders and uses thereof
EP2166021A1 (en) * 2008-09-16 2010-03-24 Ganymed Pharmaceuticals AG Monoclonal antibodies for treatment of cancer
GB0823445D0 (en) * 2008-12-23 2009-01-28 Univ Surrey Biomarker
GB2472856B (en) 2009-08-21 2012-07-11 Cantargia Ab IL1-RAP modulators and uses thereof
PL3020730T3 (pl) 2011-01-19 2019-06-28 Cantargia Ab Przeciwciała anty-il1rap i ich zastosowanie do leczenia guzów litych
GB201403875D0 (en) 2014-03-05 2014-04-16 Cantargia Ab Novel antibodies and uses thereof
GB201413913D0 (en) 2014-08-06 2014-09-17 Cantargia Ab Novel antibodies and uses thereof
WO2016207304A2 (en) 2015-06-26 2016-12-29 Mab Discovery Gmbh Monoclonal anti-il-1racp antibodies
CN108431042A (zh) 2015-11-02 2018-08-21 詹森药业有限公司 抗-il1rap抗体，结合il1rap和cd3的双特异性抗原结合分子及其用途
WO2018071910A2 (en) 2016-10-16 2018-04-19 Cellerant Therapeutics, Inc. Anti-il1-rap antibodies
EP3526247A4 (en) 2016-10-16 2021-04-14 Cantargia AB ANTI-IL1 RAP ANTIBODIES

Also Published As

Publication number Publication date
CN103459424A (zh) 2013-12-18
US20180334506A1 (en) 2018-11-22
US20210261674A1 (en) 2021-08-26
CN107929730A (zh) 2018-04-20
RU2597831C2 (ru) 2016-09-20
JP2014511348A (ja) 2014-05-15
EP2665749B1 (en) 2016-01-13
PL2665749T3 (pl) 2016-06-30
BR112013018399B1 (pt) 2022-11-01
RU2013138439A (ru) 2015-02-27
BR112013018399A2 (pt) 2017-08-01
ES2714716T3 (es) 2019-05-29
PL3020730T3 (pl) 2019-06-28
MX354450B (es) 2018-03-05
MX2013008375A (es) 2013-08-12
KR101989134B1 (ko) 2019-06-13
US10005841B2 (en) 2018-06-26
EP2665749A1 (en) 2013-11-27
US9403906B2 (en) 2016-08-02
KR20140003550A (ko) 2014-01-09
EP3020730B1 (en) 2018-12-26
US10995144B2 (en) 2021-05-04
JP5940093B2 (ja) 2016-06-29
US20170081414A1 (en) 2017-03-23
CA2824719A1 (en) 2012-07-26
AU2012208379B2 (en) 2017-04-20
WO2012098407A1 (en) 2012-07-26
CA2824719C (en) 2020-06-02
CN103459424B (zh) 2017-11-10
US20140017167A1 (en) 2014-01-16
EP3508498A1 (en) 2019-07-10
ES2566538T3 (es) 2016-04-13
EP3020730A1 (en) 2016-05-18
DK3020730T3 (da) 2019-04-15
US11773174B2 (en) 2023-10-03

Similar Documents

Publication Publication Date Title
US11773174B2 (en) Anti-IL1RAP antibodies and their use for treating humans
US10878703B2 (en) Method of treatment of leukemia with anti-IL1RAP antibodies
AU2012208379A1 (en) Anti - IL1RAP antibodies and their use for treating human
EP3188758A1 (en) Sirp alpha-antibody fusion proteins
KR102312222B1 (ko) Ｃｄ43의 독특한 시알로글리코실화된 암-연관 에피토프를 표적으로 하는 모노클로날 항체
JP2024509501A (ja) 新規活性を持つｈｈｌａ２結合剤