[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

DK2423331T3 - Fremgangsmåde til at bestemme reaktivitet af cancer på behandlinger målrettet mod epidermal vækstfaktor-receptor - Google Patents

Fremgangsmåde til at bestemme reaktivitet af cancer på behandlinger målrettet mod epidermal vækstfaktor-receptor Download PDF

Info

Publication number
DK2423331T3
DK2423331T3 DK11178200.9T DK11178200T DK2423331T3 DK 2423331 T3 DK2423331 T3 DK 2423331T3 DK 11178200 T DK11178200 T DK 11178200T DK 2423331 T3 DK2423331 T3 DK 2423331T3
Authority
DK
Denmark
Prior art keywords
reactivity
cancer
procedure
determining
growth factor
Prior art date
Application number
DK11178200.9T
Other languages
English (en)
Inventor
Daphne Winifred Bell
Daniel A Haber
Pasi Antero Janne
Bruce E Johnson
Matthew Meyerson
Juan Guillermo Paez
William R Sellers
Raffaella Sordella
Thomas J Lynch
Jeffrey E Settleman
Original Assignee
Massachusetts Gen Hospital
Dana Farber Cancer Inst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35064318&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2423331(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Massachusetts Gen Hospital, Dana Farber Cancer Inst Inc filed Critical Massachusetts Gen Hospital
Application granted granted Critical
Publication of DK2423331T3 publication Critical patent/DK2423331T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/118Prognosis of disease development
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/136Screening for pharmacological compounds
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/16Primer sets for multiplex assays
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475Assays involving growth factors
    • G01N2333/485Epidermal growth factor [EGF] (urogastrone)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
DK11178200.9T 2004-03-31 2005-03-31 Fremgangsmåde til at bestemme reaktivitet af cancer på behandlinger målrettet mod epidermal vækstfaktor-receptor DK2423331T3 (da)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US55821804P 2004-03-31 2004-03-31
US56109504P 2004-04-09 2004-04-09
US56598504P 2004-04-27 2004-04-27
US56575304P 2004-04-27 2004-04-27
US57403504P 2004-05-25 2004-05-25
US57791604P 2004-06-07 2004-06-07
US59228704P 2004-07-29 2004-07-29
EP05757467.5A EP1733056B1 (en) 2004-03-31 2005-03-31 Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments

Publications (1)

Publication Number Publication Date
DK2423331T3 true DK2423331T3 (da) 2019-07-29

Family

ID=35064318

Family Applications (5)

Application Number Title Priority Date Filing Date
DK11178202.5T DK2439285T3 (da) 2004-03-31 2005-03-31 Fremgangsmåde til at bestemme reaktivitet af cancer på behandlinger målrettet mod epidermal vækstfaktor-receptor
DK05757467.5T DK1733056T3 (da) 2004-03-31 2005-03-31 Fremgangsmåde til bestemmelse af responsiviteten af en tumor på behandlinger med den epidermale vækstfaktor-receptor som mål
DK11178194.4T DK2439284T3 (da) 2004-03-31 2005-03-31 Fremgangsmåde til at bestemme reaktivitet af cancer på behandlinger målrettet mod epidermal vækstfaktor-receptor
DK11178200.9T DK2423331T3 (da) 2004-03-31 2005-03-31 Fremgangsmåde til at bestemme reaktivitet af cancer på behandlinger målrettet mod epidermal vækstfaktor-receptor
DK11178198.5T DK2447375T3 (da) 2004-03-31 2005-03-31 Fremgangsmåde til bestemmelse af responsiviteten af en tumor på behandlinger med den epidermale vækstfaktor-receptor som mål

Family Applications Before (3)

Application Number Title Priority Date Filing Date
DK11178202.5T DK2439285T3 (da) 2004-03-31 2005-03-31 Fremgangsmåde til at bestemme reaktivitet af cancer på behandlinger målrettet mod epidermal vækstfaktor-receptor
DK05757467.5T DK1733056T3 (da) 2004-03-31 2005-03-31 Fremgangsmåde til bestemmelse af responsiviteten af en tumor på behandlinger med den epidermale vækstfaktor-receptor som mål
DK11178194.4T DK2439284T3 (da) 2004-03-31 2005-03-31 Fremgangsmåde til at bestemme reaktivitet af cancer på behandlinger målrettet mod epidermal vækstfaktor-receptor

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK11178198.5T DK2447375T3 (da) 2004-03-31 2005-03-31 Fremgangsmåde til bestemmelse af responsiviteten af en tumor på behandlinger med den epidermale vækstfaktor-receptor som mål

Country Status (14)

Country Link
US (8) US7294468B2 (da)
EP (6) EP2447375B1 (da)
JP (6) JP4350148B2 (da)
KR (3) KR101347613B1 (da)
CN (6) CN102586431B (da)
AU (4) AU2005228446B2 (da)
BR (1) BRPI0508286B8 (da)
CA (1) CA2556227C (da)
DK (5) DK2439285T3 (da)
ES (5) ES2425749T3 (da)
HK (4) HK1208250A1 (da)
PT (1) PT1733056E (da)
SI (1) SI1733056T1 (da)
WO (1) WO2005094357A2 (da)

Families Citing this family (173)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7219016B2 (en) 2001-04-20 2007-05-15 Yale University Systems and methods for automated analysis of cells and tissues
US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
DK2163256T3 (da) 2001-05-11 2015-12-07 Ludwig Inst For Cancer Res Ltd Specifikke bindende proteiner og anvendelse deraf
CN102586431B (zh) * 2004-03-31 2015-04-22 综合医院公司 测定癌症对表皮生长因子受体靶向性治疗反应性的方法
WO2005118876A2 (en) * 2004-06-04 2005-12-15 Genentech, Inc. Egfr mutations
TW200617396A (en) * 2004-10-06 2006-06-01 Astrazeneca Ab Method
DK1805199T3 (da) * 2004-10-18 2011-04-26 Univ Brandeis Fremgangsmåder til nucleinsyreamplifikation
JPWO2006070667A1 (ja) * 2004-12-28 2008-06-12 タカラバイオ株式会社 Egfr遺伝子変異の検出法ならびに検出キット
CN113952459A (zh) 2005-02-03 2022-01-21 综合医院公司 治疗吉非替尼耐药性癌症的方法
ES2586410T3 (es) 2005-02-11 2016-10-14 Memorial Sloan-Kettering Cancer Center Procedimientos y composiciones de detección de un mutante de EGFR resistente a fármacos
BRPI0607235A2 (pt) 2005-02-24 2009-08-25 Amgen Inc mutações do receptor do fator de crescimento epidérmico
GB0506670D0 (en) * 2005-04-01 2005-05-11 Astrazeneca Ab Method
GB2424886A (en) * 2005-04-04 2006-10-11 Dxs Ltd Polynucleotide primers against epidermal growth factor receptor and method of detecting gene mutations
EP1874920A4 (en) 2005-04-05 2009-11-04 Cellpoint Diagnostics DEVICES AND METHODS FOR ENRICHING AND MODIFYING CIRCULATING TUMOR CELLS AND OTHER PARTICLES
CA2646257A1 (en) * 2005-04-14 2006-10-26 Wyeth Use of an epidermal growth factor receptor kinase inhibitor (egfr) in gefitinib resistant patients
CA2612183C (en) * 2005-06-28 2015-08-11 Genentech, Inc. Egfr and kras mutations
ZA200802854B (en) * 2005-10-05 2009-06-24 Astrazeneca Ltd Method to predict or monitor the response of a patient to an ErbB receptor drug
EP3488866A1 (en) 2005-11-04 2019-05-29 Wyeth LLC Antineoplastic combinations with mtor inhibitor, herceptin, and/or hki-272
JP5688877B2 (ja) 2005-11-11 2015-03-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 癌疾患の治療用キナゾリン誘導体
SI1948180T1 (sl) * 2005-11-11 2013-06-28 Boehringer Ingelheim International Gmbh Kombinacijsko zdravljenje raka, ki obsega EGFR/HER2 inhibitorje
EP1988164A4 (en) * 2006-02-23 2009-04-22 Univ Kanazawa Nat Univ Corp METHOD FOR TESTING THE SENSITIVITY OF SOLIC CANCER AGAINST A TYROSINE KINASE INHIBITOR AND CORRESPONDING TEST REQUIREMENTS
US7867775B2 (en) * 2006-03-31 2011-01-11 Biodesix, Inc. Selection of head and neck cancer patients for treatment with drugs targeting EGFR pathway
US7736905B2 (en) * 2006-03-31 2010-06-15 Biodesix, Inc. Method and system for determining whether a drug will be effective on a patient with a disease
US7906342B2 (en) 2006-03-31 2011-03-15 Biodesix, Inc. Monitoring treatment of cancer patients with drugs targeting EGFR pathway using mass spectrometry of patient samples
US8367351B2 (en) 2006-05-05 2013-02-05 Historx, Inc. Methods for determining signal transduction activity in tumors
EP3399450A1 (en) * 2006-05-18 2018-11-07 Caris MPI, Inc. System and method for determining individualized medical intervention for a disease state
US8768629B2 (en) * 2009-02-11 2014-07-01 Caris Mpi, Inc. Molecular profiling of tumors
EP2589668A1 (en) 2006-06-14 2013-05-08 Verinata Health, Inc Rare cell analysis using sample splitting and DNA tags
WO2007147079A2 (en) 2006-06-14 2007-12-21 Living Microsystems, Inc. Rare cell analysis using sample splitting and dna tags
US7709222B2 (en) * 2006-07-13 2010-05-04 Yale University Methods for making cancer prognoses based on subcellular localization of biomarkers
ATE552835T1 (de) * 2006-09-18 2012-04-15 Boehringer Ingelheim Int Verfahren zur behandlung von tumoren mit egfr- mutationen
JPWO2008038812A1 (ja) * 2006-09-28 2010-01-28 株式会社島津製作所 マトリックス支援レーザー脱離イオン化質量分析用サンプル調製法及びマトリックス支援レーザー脱離イオン化質量分析法
JP4795203B2 (ja) * 2006-11-13 2011-10-19 シスメックス株式会社 アンスラサイクリン系抗癌剤の感受性判定方法及びそのシステム
MX2009007987A (es) 2007-01-25 2010-03-01 Dana Farber Cancer Inst Inc Uso de anticuerpos anti-egfr en el tratamiento de enfermedad mediada por egfr mutante.
WO2008100624A2 (en) * 2007-02-16 2008-08-21 Merrimack Pharmaceuticals, Inc. Antibodies against erbb3 and uses thereof
PT2465950T (pt) 2007-03-13 2017-10-17 Amgen Inc Mutações de k-ras e terapia de anticorpo anti-egfr
WO2008112274A2 (en) * 2007-03-13 2008-09-18 Amgen Inc. K-ras and b-raf mutations and anti-egfr antibody therapy
WO2008115404A1 (en) 2007-03-15 2008-09-25 Ludwing Institute For Cancer Research Treatment method using egfr antibodies and src inhibitors and related formulations
US8642067B2 (en) 2007-04-02 2014-02-04 Allergen, Inc. Methods and compositions for intraocular administration to treat ocular conditions
US8999634B2 (en) * 2007-04-27 2015-04-07 Quest Diagnostics Investments Incorporated Nucleic acid detection combining amplification with fragmentation
BRPI0811156A2 (pt) * 2007-05-11 2019-09-24 Enzon Pharmaceuticals Inc compostos antagonistas de rna para a modulação de her3
WO2009005715A1 (en) * 2007-06-29 2009-01-08 Yale University Methods for a predictive diagnostic test for tamoxifen
US9283276B2 (en) 2007-08-14 2016-03-15 Ludwig Institute For Cancer Research Ltd. Monoclonal antibody 175 targeting the EGF receptor and derivatives and uses thereof
US8022216B2 (en) 2007-10-17 2011-09-20 Wyeth Llc Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
SG190670A1 (en) 2008-02-01 2013-06-28 Gen Hospital Corp Use of microvesicles in diagnosis, prognosis and treatment of medical diseases and conditions
AU2009231582B2 (en) * 2008-04-03 2015-02-26 iRepertoire, Inc. Amplicon rescue multiplex polymerase chain reaction for amplificaton of multiple targets
US8137919B2 (en) * 2008-04-10 2012-03-20 Montefiore Medical Center Method of determining the sensitivity of cancer cells to EGFR inhibitors including cetuximab, panitumumab and erlotinib
CN101445829B (zh) * 2008-04-23 2013-06-05 广州益善生物技术有限公司 Egfr基因突变位点的检测探针、液相芯片及其检测方法
ES2431355T3 (es) 2008-06-17 2013-11-26 Wyeth Llc Combinaciones antineoplásicas que contienen HKI-272 y vinorelbina
CN105147713A (zh) 2008-08-04 2015-12-16 惠氏有限责任公司 4-苯胺基-3-氰基喹啉和卡培他滨的抗肿瘤组合
JP2012500008A (ja) * 2008-08-15 2012-01-05 メリマック ファーマシューティカルズ インコーポレーティッド 治療薬に対する細胞の応答を予測するための方法およびシステム
GB2467691A (en) 2008-09-05 2010-08-11 Aueon Inc Methods for stratifying and annotating cancer drug treatment options
US12090480B2 (en) 2008-09-23 2024-09-17 Bio-Rad Laboratories, Inc. Partition-based method of analysis
US8633015B2 (en) 2008-09-23 2014-01-21 Bio-Rad Laboratories, Inc. Flow-based thermocycling system with thermoelectric cooler
US9492797B2 (en) 2008-09-23 2016-11-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
US8709762B2 (en) 2010-03-02 2014-04-29 Bio-Rad Laboratories, Inc. System for hot-start amplification via a multiple emulsion
US9764322B2 (en) 2008-09-23 2017-09-19 Bio-Rad Laboratories, Inc. System for generating droplets with pressure monitoring
US9598725B2 (en) 2010-03-02 2017-03-21 Bio-Rad Laboratories, Inc. Emulsion chemistry for encapsulated droplets
US8951939B2 (en) 2011-07-12 2015-02-10 Bio-Rad Laboratories, Inc. Digital assays with multiplexed detection of two or more targets in the same optical channel
US11130128B2 (en) 2008-09-23 2021-09-28 Bio-Rad Laboratories, Inc. Detection method for a target nucleic acid
US9417190B2 (en) 2008-09-23 2016-08-16 Bio-Rad Laboratories, Inc. Calibrations and controls for droplet-based assays
US10512910B2 (en) 2008-09-23 2019-12-24 Bio-Rad Laboratories, Inc. Droplet-based analysis method
US9132394B2 (en) 2008-09-23 2015-09-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
CA2739675C (en) * 2008-10-14 2020-12-01 Caris Mpi, Inc. Gene and gene expressed protein targets depicting biomarker patterns and signature sets by tumor type
ES2805347T3 (es) * 2009-02-11 2021-02-11 Caris Mpi Inc Perfilado molecular de tumores
WO2010101916A1 (en) * 2009-03-02 2010-09-10 Trackfive Diagnostics Inc Methods for predicting cancer response to egfr inhibitors
KR20180056796A (ko) 2009-04-06 2018-05-29 와이어쓰 엘엘씨 네라티닙을 이용한 유방암의 치료법
DK2451445T3 (da) 2009-07-06 2019-06-24 Boehringer Ingelheim Int Fremgangsmåde til at tørre bibw2992, dets salte og faste farmaceutiske formuleringer omfattende denne aktive ingrediens
CA2767056C (en) 2009-09-02 2018-12-04 Bio-Rad Laboratories, Inc. System for mixing fluids by coalescence of multiple emulsions
EP2475989A4 (en) 2009-09-09 2013-02-27 Gen Hospital Corp USE OF MICROVESICLES IN THE ANALYSIS OF KRAS MUTATIONS
WO2011031982A1 (en) * 2009-09-10 2011-03-17 Myriad Genetics, Inc. Methods and compositions for predicting cancer therapy response
US8323883B1 (en) 2009-10-09 2012-12-04 Cold Spring Harbor Laboratory Methods of assessing therapeutic benefits of patients having cancers resistant to epidermal growth factor receptor kinase inhibitors
US7947653B1 (en) 2009-10-09 2011-05-24 Cold Spring Harbor Laboratory Methods for treating epidermal growth factor receptor tyrosine kinase inhibitor-resistant cancers
CN107308130B (zh) 2009-11-09 2021-06-15 惠氏有限责任公司 包衣药物球状体及消除或减少病症如呕吐和腹泻的用途
CA2780875A1 (en) 2009-11-13 2011-05-19 Pangaea Biotech, S.L. Molecular biomarkers for predicting response to tyrosine kinase inhibitors in lung cancer
WO2011063416A2 (en) 2009-11-23 2011-05-26 The General Hospital Corporation Microfluidic devices for the capture of biological sample components
US10731221B2 (en) 2009-12-11 2020-08-04 Dignity Health Diagnosing IDH1 related subgroups and treatment of cancer
WO2011072258A1 (en) * 2009-12-11 2011-06-16 Catholic Healthcare West Pi3k/akt pathway subgroups in cancer: methods of using biomarkers for diagnosis and therapy
TWI405566B (zh) * 2010-02-11 2013-08-21 Univ Nat Taiwan 薑黃素或其類似物於使用上皮細胞生長因子接受器酪胺酸激酶抑制劑之癌症醫療之用途
MX344355B (es) 2010-03-11 2016-12-14 Merrimack Pharmaceuticals Inc * Uso de inhibidores de erbb3 en el tratamiento de canceres de mama triple negativos y de tipo basal.
EP2548027A2 (en) * 2010-03-18 2013-01-23 Institut National de la Santé et de la Recherche Médicale Method for predicting the responsiveness to chemotherapy
EP2550528B1 (en) 2010-03-25 2019-09-11 Bio-Rad Laboratories, Inc. Droplet generation for droplet-based assays
JP2013524169A (ja) 2010-03-25 2013-06-17 クァンタライフ・インコーポレーテッド 液滴によるアッセイ用の検出システム
JP6155419B2 (ja) 2010-03-25 2017-07-05 バイオ−ラッド・ラボラトリーズ・インコーポレーテッド 検出用の液滴輸送システム
CN102234683B (zh) * 2010-04-23 2013-07-17 广州益善生物技术有限公司 一种egfr基因突变检测液相芯片
CN101858909B (zh) * 2010-05-28 2013-07-03 广州瑞博奥生物科技有限公司 检测磷酸化表皮生长因子受体的试剂盒及其制备方法
EP3572528A1 (en) 2010-09-24 2019-11-27 The Board of Trustees of the Leland Stanford Junior University Direct capture, amplification and sequencing of target dna using immobilized primers
US9238812B2 (en) 2010-09-30 2016-01-19 Lsip, Llc Agent for suppressing expression of dominant mutant gene
WO2012058592A2 (en) 2010-10-29 2012-05-03 Immunogen, Inc. Non-antagonistic egfr-binding molecules and immunoconjugates thereof
CN103298489A (zh) 2010-10-29 2013-09-11 伊缪诺金公司 新型egfr结合分子及其免疫偶联物
DE202011110979U1 (de) 2010-11-01 2017-12-04 Bio-Rad Laboratories, Inc. System zum Bilden von Emulsionen
WO2012065071A2 (en) * 2010-11-12 2012-05-18 The Broad Institute Of Mit And Harvard Methods of predicting response to egfr antibody therapy
WO2012065705A1 (en) 2010-11-19 2012-05-24 Roche Diagnostics Gmbh Novel complex mutation in the epidermal growth factor receptor kinase domain
US20120164641A1 (en) 2010-12-22 2012-06-28 Roche Molecular Systems, Inc. Methods and Compositions for Detecting Mutation in the Human Epidermal Growth Factor Receptor Gene
CN102140518B (zh) * 2011-01-18 2013-02-06 杭州迪安医学检验中心有限公司 肺癌相关表皮生长因子受体egfr外显子突变定量检测试剂盒及方法
WO2012103442A2 (en) 2011-01-28 2012-08-02 The Broad Institute, Inc. Paired end bead amplification and high throughput sequencing
CN103339509A (zh) 2011-01-28 2013-10-02 佰欧迪塞克斯公司 针对激素和联合疗法选择转移性乳腺癌病人的预测性测试
US9556473B2 (en) 2011-02-15 2017-01-31 Leica Biosystems Newcastle Ltd Methods for identifying nucleic acid sequences
EP2675916B1 (en) 2011-02-15 2016-08-24 Leica Biosystems Newcastle Limited METHOD FOR LOCALIZED IN SITU DETECTION OF mRNA
US12097495B2 (en) 2011-02-18 2024-09-24 Bio-Rad Laboratories, Inc. Methods and compositions for detecting genetic material
EP2492688A1 (en) 2011-02-23 2012-08-29 Pangaea Biotech, S.A. Molecular biomarkers for predicting response to antitumor treatment in lung cancer
WO2012129145A1 (en) 2011-03-18 2012-09-27 OSI Pharmaceuticals, LLC Nscle combination therapy
JP2014509865A (ja) 2011-03-18 2014-04-24 バイオ−ラッド・ラボラトリーズ・インコーポレーテッド シグナルの組合せ使用による多重化デジタルアッセイ
JP2014512826A (ja) 2011-04-25 2014-05-29 バイオ−ラド ラボラトリーズ インコーポレイテッド 核酸分析のための方法および組成物
JP5930825B2 (ja) * 2011-05-06 2016-06-08 アークレイ株式会社 Egfrエクソン19多型検出試験用試薬キット及びその用途
WO2013019751A1 (en) 2011-07-29 2013-02-07 Bio-Rad Laboratories, Inc., Library characterization by digital assay
EP2739587B1 (en) 2011-08-01 2020-05-27 Denovo Sciences Cell capture system
US9174216B2 (en) 2013-03-13 2015-11-03 DeNovo Science, Inc. System for capturing and analyzing cells
US10466160B2 (en) 2011-08-01 2019-11-05 Celsee Diagnostics, Inc. System and method for retrieving and analyzing particles
US9404864B2 (en) 2013-03-13 2016-08-02 Denovo Sciences, Inc. System for imaging captured cells
WO2013022961A1 (en) 2011-08-08 2013-02-14 3The Broad Institute Compositions and methods for co-amplifying subsequences of a nucleic acid fragment sequence
US9738935B2 (en) 2011-11-10 2017-08-22 Roche Molecular Systems, Inc. Complex mutations in the epidermal growth factor receptor kinase domain
EP2794010A4 (en) * 2011-11-21 2015-10-21 Immunogen Inc METHOD OF TREATING TUMORS RESISTANT TO EGFR THERAPIES BY A CYTOTOXIC EGFR-AGENT ANTIBODY CONJUGATE
US9260714B2 (en) 2011-12-02 2016-02-16 Roche Molecular Systems, Inc. Suppression of non-specific amplification with high-homology oligonucleotides
KR101963230B1 (ko) 2011-12-26 2019-03-29 삼성전자주식회사 복수개의 단일 항체를 포함하는 단백질 복합체
WO2013155531A2 (en) 2012-04-13 2013-10-17 Bio-Rad Laboratories, Inc. Sample holder with a well having a wicking promoter
EP2653558B1 (en) 2012-04-18 2015-10-07 Roche Diagniostics GmbH A method of detecting nucleic acid targets using a statistical classifier
CN102732636B (zh) * 2012-07-17 2014-01-15 海南医学院 一种检测肿瘤细胞egfr基因突变的芯片
CN102851375B (zh) * 2012-09-11 2014-02-19 上海源奇生物医药科技有限公司 检测egfr基因突变的引物、探针及其试剂盒和使用方法
KR101911438B1 (ko) * 2012-10-31 2018-10-24 삼성전자주식회사 이중 특이 항원 결합 단백질 복합체 및 이중 특이 항체의 제조 방법
US20140341884A1 (en) * 2012-12-04 2014-11-20 Roche Molecular Systems, Inc. Novel Complex Mutations in the Epidermal Growth Factor Receptor Kinase Domain
US9606102B2 (en) 2013-01-26 2017-03-28 Denovo Sciences, Inc. System and method for capturing and analyzing cells
KR101645112B1 (ko) 2013-03-06 2016-08-02 아스트라제네카 아베 표피 성장 인자 수용체의 활성화 돌연변이체 형태의 퀴나졸린 억제제
US20140287417A1 (en) 2013-03-08 2014-09-25 Roche Molecular Systems, Inc. EGFR Blood Monitoring
US9873913B2 (en) 2013-03-08 2018-01-23 Roche Molecular Systems, Inc. Mutation testing
US9707562B2 (en) 2013-03-13 2017-07-18 Denovo Sciences, Inc. System for capturing and analyzing cells
US9856535B2 (en) 2013-05-31 2018-01-02 Denovo Sciences, Inc. System for isolating cells
US10391490B2 (en) 2013-05-31 2019-08-27 Celsee Diagnostics, Inc. System and method for isolating and analyzing cells
CN103333963A (zh) * 2013-06-09 2013-10-02 中国人民解放军第四军医大学 Egfr突变检测引物组及其用途
JP6463675B2 (ja) * 2013-06-19 2019-02-06 学校法人 久留米大学 上皮成長因子受容体チロシンキナーゼ阻害薬の治療効果を予測する方法
EP3019491A4 (en) 2013-07-09 2016-12-21 Dana Farber Cancer Inst Inc KINASE INHIBITORS FOR THE TREATMENT OF DISEASE
WO2015100459A2 (en) 2013-12-27 2015-07-02 Merrimack Pharmaceuticals, Inc. Biomarker profiles for predicting outcomes of cancer therapy with erbb3 inhibitors and/or chemotherapies
US9242965B2 (en) 2013-12-31 2016-01-26 Boehringer Ingelheim International Gmbh Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors
CN103923975B (zh) * 2014-01-27 2016-01-20 上海涌泰生物医药科技有限公司 一种检测egfr基因外显子19缺失突变的试剂盒和方法
US9211314B2 (en) 2014-04-04 2015-12-15 Biodesix, Inc. Treatment selection for lung cancer patients using mass spectrum of blood-based sample
CN106573967B (zh) * 2014-07-28 2022-02-18 玛尔医学研究所基金会 表皮生长因子受体基因的胞外域iii中的突变
CA2961437C (en) 2014-10-09 2019-01-15 F. Hoffmann-La Roche Ag Mutations in the epidermal growth factor receptor kinase domain
KR101692044B1 (ko) * 2014-12-05 2017-01-04 사회복지법인 삼성생명공익재단 교모세포종에서 표피 성장인자 수용체 억제제의 치료 효과를 예측하는 방법
US20160333087A1 (en) * 2015-05-12 2016-11-17 Bioven 3 Limited Methods and compositions for inhibition of egf/egfr pathway in combination with tyrosine kinase inhibitors
US10184006B2 (en) 2015-06-04 2019-01-22 Merrimack Pharmaceuticals, Inc. Biomarkers for predicting outcomes of cancer therapy with ErbB3 inhibitors
CA3014252A1 (en) * 2016-02-12 2017-08-17 Nantomics, Llc High-throughput identification of patient-specific neoepitopes as therapeutic targets for cancer immunotherapies
CN105624309B (zh) * 2016-02-23 2020-04-21 深圳华大生命科学研究院 检测EGFR和/或K-ras基因突变的引物、探针及试剂盒
CN105866217B (zh) * 2016-03-21 2018-04-10 杭州市红十字会医院 三尖杉酯碱癌症治疗效果检测装置及方法
US11261482B2 (en) * 2016-05-25 2022-03-01 Gencurix Inc Composition for detecting epidermal cell growth factor receptor gene mutation, and kit comprising same
AU2018256436A1 (en) 2017-04-19 2019-11-07 Board Of Regents, The University Of Texas System Immune cells expressing engineered antigen receptors
WO2018201584A1 (zh) * 2017-05-03 2018-11-08 华为技术有限公司 基于竞争的传输方法和设备
US10299039B2 (en) 2017-06-02 2019-05-21 Apple Inc. Audio adaptation to room
US10391492B2 (en) 2017-08-29 2019-08-27 Celsee Diagnostics, Inc. System and method for isolating and analyzing cells
WO2019074920A1 (en) * 2017-10-10 2019-04-18 Oncocyte Corporation METHODS AND COMPOSITIONS FOR THE DETECTION AND DIAGNOSIS OF BREAST CANCER
CN109722476A (zh) * 2017-10-31 2019-05-07 北京雅康博生物科技有限公司 用于检测egfr基因2237-2257位突变的引物、探针及试剂盒
US20210115108A1 (en) * 2018-05-01 2021-04-22 The United States Of America,As Represented By The Secretary,Department Of Health And Human Services T cell receptors which recognize mutated egfr
WO2020080871A2 (ko) * 2018-10-18 2020-04-23 (주)신테카바이오 암 약물 반응성 판단을 위한 바이오 마커 조성물, 바이오 마커 조성물을 이용한 암 약물 반응성 판단 방법 및 암 약물 반응성 판단을 위한 바이오 마커 조성물 검출용 진단칩
KR20210132117A (ko) 2019-02-26 2021-11-03 얀센 바이오테크 인코포레이티드 이중특이성 항-EGFR/c-Met 항체를 사용한 병용 요법 및 환자 계층화
US10633693B1 (en) 2019-04-16 2020-04-28 Celsee Diagnostics, Inc. System and method for leakage control in a particle capture system
US10900032B2 (en) 2019-05-07 2021-01-26 Bio-Rad Laboratories, Inc. System and method for automated single cell processing
US11273439B2 (en) 2019-05-07 2022-03-15 Bio-Rad Laboratories, Inc. System and method for target material retrieval from microwells
WO2020230091A1 (en) 2019-05-14 2020-11-19 Janssen Biotech, Inc. Combination therapies with bispecific anti-egfr/c-met antibodies and third generation egfr tyrosine kinase inhibitors
US11724256B2 (en) 2019-06-14 2023-08-15 Bio-Rad Laboratories, Inc. System and method for automated single cell processing and analyses
CN118834950A (zh) 2019-11-06 2024-10-25 斯坦福大学托管董事会 用于分析核酸分子的方法和系统
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
CN111154881A (zh) * 2020-03-09 2020-05-15 南京实践医学检验有限公司 一种急性髓系白血病中基因突变的检测试剂盒及应用
US11504719B2 (en) 2020-03-12 2022-11-22 Bio-Rad Laboratories, Inc. System and method for receiving and delivering a fluid for sample processing
US20220025453A1 (en) * 2020-07-23 2022-01-27 Michael Y Sha Xenonucleic acid-mediated multiplex qpcr clamping technology for lung cancer mutation detection
CN114107449B (zh) * 2020-08-31 2024-04-09 中山大学孙逸仙纪念医院 一种单细胞内原位qPCR方法
CN111996193B (zh) * 2020-09-11 2024-02-20 北京键凯科技股份有限公司 一种有效抑制表皮生长因子受体表达的siRNA序列
US11783912B2 (en) 2021-05-05 2023-10-10 The Board Of Trustees Of The Leland Stanford Junior University Methods and systems for analyzing nucleic acid molecules
CN113564255A (zh) * 2021-08-13 2021-10-29 河北医科大学第四医院 一种lncRNA NEAT1_1的应用
DE102021126650A1 (de) 2021-10-14 2023-04-20 Rheinische Friedrich-Wilhelms-Universität Bonn, Körperschaft des öffentlichen Rechts Verfahren zur bestimmung der ansprechwahrscheinlichkeit einer malignen erkrankung auf eine behandlung mit einem pharmazeutischen hemmwirkstoff
CN114113265B (zh) * 2021-12-14 2023-08-08 郑州轻工业大学 一种适配体传感器及其制备方法
WO2023190967A1 (ja) * 2022-03-31 2023-10-05 Chordia Therapeutics株式会社 イミダゾ[4,5-b]ピリジン誘導体による固形癌治療のためのバイオマーカー

Family Cites Families (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5811A (en) 1848-09-26 Improvement in hemp-brakes
US234A (en) 1837-06-14 Improvement in machines for breaking hemp and flax
US3625214A (en) 1970-05-18 1971-12-07 Alza Corp Drug-delivery device
GB1541435A (en) 1975-02-04 1979-02-28 Searle & Co Immunological materials
US4046784A (en) 1975-04-04 1977-09-06 Texaco Development Corporation Boride catalyst for epoxidizing olefinic compounds
US4361544A (en) 1980-03-03 1982-11-30 Goldenberg Milton David Tumor localization and therapy with labeled antibodies specific to intracellular tumor-associated markers
US4444744A (en) 1980-03-03 1984-04-24 Goldenberg Milton David Tumor localization and therapy with labeled antibodies to cell surface antigens
US4460561A (en) 1980-03-03 1984-07-17 Goldenberg M David Tumor localization and therapy with labeled antibodies specific to intracellular tumor-associated markers
US4348376A (en) 1980-03-03 1982-09-07 Goldenberg Milton David Tumor localization and therapy with labeled anti-CEA antibody
US4331647A (en) 1980-03-03 1982-05-25 Goldenberg Milton David Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers
US4468457A (en) 1981-06-01 1984-08-28 David M. Goldenberg Method for producing a CSAp tryptic peptide and anti-CSAp antibodies
US4671958A (en) 1982-03-09 1987-06-09 Cytogen Corporation Antibody conjugates for the delivery of compounds to target sites
US4818709A (en) 1983-01-21 1989-04-04 Primus Frederick J CEA-family antigens, Anti-CEA antibodies and CEA immunoassay
US4460459A (en) 1983-02-16 1984-07-17 Anschutz Mining Corporation Sequential flotation of sulfide ores
US4906474A (en) 1983-03-22 1990-03-06 Massachusetts Institute Of Technology Bioerodible polyanhydrides for controlled drug delivery
US4624846A (en) 1983-07-29 1986-11-25 Immunomedics, Inc. Method for enhancing target specificity of antibody localization and clearance of non-target diagnostic and therapeutic principles
US4736866B1 (en) 1984-06-22 1988-04-12 Transgenic non-human mammals
IL73883A (en) 1984-12-20 1990-12-23 Yeda Res & Dev Monoclonal antibodies against tnf-alpha,hybridomas producing them and method for the purification of tnf-alpha
US4789734A (en) 1985-08-06 1988-12-06 La Jolla Cancer Research Foundation Vitronectin specific cell receptor derived from mammalian mesenchymal tissue
WO1988001213A1 (en) 1986-08-18 1988-02-25 Clinical Technologies Associates, Inc. Delivery systems for pharmacological agents
US4932412A (en) 1986-12-18 1990-06-12 Immunomedics, Inc. Intraoperative and endoscopic tumor detection and therapy
US5541297A (en) 1988-04-01 1996-07-30 Immunomedics, Inc. Therapeutic conjugates of toxins and drugs
US4925648A (en) 1988-07-29 1990-05-15 Immunomedics, Inc. Detection and treatment of infectious and inflammatory lesions
US5175383A (en) 1989-02-17 1992-12-29 President And Fellows Of Harvard College Animal model for benign prostatic disease
US5459039A (en) 1989-05-12 1995-10-17 Duke University Methods for mapping genetic mutations
US5332567A (en) 1989-08-24 1994-07-26 Immunomedics Detection and treatment of infections with immunoconjugates
ATE135373T1 (de) * 1989-09-08 1996-03-15 Univ Johns Hopkins Modifikationen der struktur des egf-rezeptor-gens in menschlichen glioma
KR0162259B1 (ko) 1989-12-05 1998-12-01 아미 펙터 감염성 병변 및 염증성 병변을 검출 및 치료하기 위한 키메라 항체
US5567588A (en) 1990-06-11 1996-10-22 University Research Corporation Systematic evolution of ligands by exponential enrichment: Solution SELEX
US5763177A (en) 1990-06-11 1998-06-09 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex
US5660985A (en) 1990-06-11 1997-08-26 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands containing modified nucleotides
US5580737A (en) 1990-06-11 1996-12-03 Nexstar Pharmaceuticals, Inc. High-affinity nucleic acid ligands that discriminate between theophylline and caffeine
US5707796A (en) 1990-06-11 1998-01-13 Nexstar Pharmaceuticals, Inc. Method for selecting nucleic acids on the basis of structure
US5410016A (en) 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5217889A (en) 1990-10-19 1993-06-08 Roninson Igor B Methods and applications for efficient genetic suppressor elements
ES2289997T3 (es) 1991-03-18 2008-02-16 New York University Anticuerpos monoclonales y quimericos especificos para el factor de necrosis tumoral humano.
NZ243082A (en) 1991-06-28 1995-02-24 Ici Plc 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof
DE4129533A1 (de) 1991-09-05 1993-03-11 Max Planck Gesellschaft Mutierter wachstumsfaktorrezeptor als arzneimittel und seine verwendung zur behandlung von krebs
GB9300059D0 (en) 1992-01-20 1993-03-03 Zeneca Ltd Quinazoline derivatives
AU683893B2 (en) 1993-05-17 1997-11-27 Immunomedics Inc. Improved detection and therapy of lesions with biotin/avidin-metal chelating protein conjugates
US5837832A (en) 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US5593688A (en) 1993-06-25 1997-01-14 Nexstar Pharmaceuticals, Inc. Liposomal targeting of ischemic tissue
US5443953A (en) 1993-12-08 1995-08-22 Immunomedics, Inc. Preparation and use of immunoconjugates
DE69320824T2 (de) 1993-12-09 1999-05-12 Stmicroelectronics S.R.L., Agrate Brianza, Mailand/Milano Integrierte Schaltung zur Überwachung der Benutzung von Redunanzspeicherbauelementen in einer Halbleiterspeichereinrichtung
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5686578A (en) 1994-08-05 1997-11-11 Immunomedics, Inc. Polyspecific immunoconjugates and antibody composites for targeting the multidrug resistant phenotype
AU3272695A (en) 1994-08-12 1996-03-07 Immunomedics Inc. Immunoconjugates and humanized antibodies specific for b-cell lymphoma and leukemia cells
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US5599695A (en) 1995-02-27 1997-02-04 Affymetrix, Inc. Printing molecular library arrays using deprotection agents solely in the vapor phase
DK0817775T3 (da) 1995-03-30 2001-11-19 Pfizer Quinazolinderivater
US5624711A (en) 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
DE69613367T2 (de) 1995-04-27 2002-04-18 Astrazeneca Ab, Soedertaelje Chinazolin derivate
GB9508538D0 (en) 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
GB9508565D0 (en) 1995-04-27 1995-06-14 Zeneca Ltd Quiazoline derivative
US6699843B2 (en) 1995-06-07 2004-03-02 Gilead Sciences, Inc. Method for treatment of tumors using nucleic acid ligands to PDGF
WO1997014709A1 (en) 1995-10-13 1997-04-24 F. Hoffmann-La Roche Ag Antisense oligomers
BR9708640B1 (pt) 1996-04-12 2013-06-11 inibidores irreversÍveis de tirosina-cinases e composiÇço farmacÊutica compreendendo os mesmo.
US6015670A (en) 1996-05-17 2000-01-18 Hexagen Technology Limited Methods for identifying a mutation in a gene of interest without a phenotypic guide using ES cells
US5861251A (en) * 1996-10-15 1999-01-19 Bioneer Corporation Lyophilized reagent for polymerase chain reaction
US5814500A (en) 1996-10-31 1998-09-29 The Johns Hopkins University School Of Medicine Delivery construct for antisense nucleic acids and methods of use
UA73073C2 (uk) 1997-04-03 2005-06-15 Уайт Холдінгз Корпорейшн Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція
US6011577A (en) 1997-06-30 2000-01-04 Polaroid Corporation Modular optical print head assembly
ZA986732B (en) 1997-07-29 1999-02-02 Warner Lambert Co Irreversible inhibitiors of tyrosine kinases
ZA986729B (en) 1997-07-29 1999-02-02 Warner Lambert Co Irreversible inhibitors of tyrosine kinases
TW436485B (en) 1997-08-01 2001-05-28 American Cyanamid Co Substituted quinazoline derivatives
CA2335649A1 (en) 1998-07-20 2000-01-27 Variagenics, Inc. Gene sequence variances with utility in determining the treatment of disease
US6821724B1 (en) * 1998-09-17 2004-11-23 Affymetrix, Inc. Methods of genetic analysis using nucleic acid arrays
US20040063906A1 (en) 2000-11-24 2004-04-01 Nielsen Peter E. Pna analogues
EP2322627A3 (en) 2001-06-14 2011-10-12 The Regents of the University of California Mutations in the BCR-abl tyrosine kinase associated with resistance to STI-571
US20030198627A1 (en) 2001-09-01 2003-10-23 Gert-Jan Arts siRNA knockout assay method and constructs
US7250289B2 (en) * 2002-11-20 2007-07-31 Affymetrix, Inc. Methods of genetic analysis of mouse
WO2005006940A2 (en) * 2003-06-19 2005-01-27 University Of Medicine And Dentistry Of New Jersey Detection of mutations in nucleic acid sequences
EP1648516A2 (en) 2003-08-01 2006-04-26 Wyeth Holdings Corporation Use of combination of an epidermal growth factor receptor kinase inhibitor and cytotoxic agents for treatment and inhibition of cancer
WO2005079434A2 (en) 2004-02-17 2005-09-01 The University Of North Carolina At Chapel Hill Modulation of epidermal growth factor heterodimer activity
CN102586431B (zh) * 2004-03-31 2015-04-22 综合医院公司 测定癌症对表皮生长因子受体靶向性治疗反应性的方法
WO2005118876A2 (en) * 2004-06-04 2005-12-15 Genentech, Inc. Egfr mutations

Also Published As

Publication number Publication date
KR20070031894A (ko) 2007-03-20
AU2015201692B2 (en) 2017-03-02
CN102586431B (zh) 2015-04-22
CN107794302B (zh) 2022-03-15
US20210017604A1 (en) 2021-01-21
US8105769B2 (en) 2012-01-31
EP1733056A2 (en) 2006-12-20
ES2741546T3 (es) 2020-02-11
EP1733056B1 (en) 2013-05-22
ES2425749T3 (es) 2013-10-17
CN102586431A (zh) 2012-07-18
US20080207615A1 (en) 2008-08-28
ES2741547T3 (es) 2020-02-11
WO2005094357A2 (en) 2005-10-13
US20060147959A1 (en) 2006-07-06
HK1208250A1 (en) 2016-02-26
EP2439285A1 (en) 2012-04-11
US10000815B2 (en) 2018-06-19
CN101501211A (zh) 2009-08-05
CN104480200B (zh) 2017-12-29
AU2012202668B2 (en) 2015-02-05
US20130316935A1 (en) 2013-11-28
JP5449943B2 (ja) 2014-03-19
DK2439285T3 (da) 2019-07-29
EP2447375A3 (en) 2012-08-22
AU2005228446B2 (en) 2007-02-22
EP2439284A1 (en) 2012-04-11
ES2741574T3 (es) 2020-02-11
BRPI0508286B8 (pt) 2021-05-25
JP2009171965A (ja) 2009-08-06
AU2012202668A1 (en) 2012-05-31
EP2439285B1 (en) 2019-05-08
CN107988363A (zh) 2018-05-04
HK1254906A1 (zh) 2019-08-02
AU2012202668B9 (en) 2015-02-12
ES2741573T3 (es) 2020-02-11
US9035036B2 (en) 2015-05-19
DK2439284T3 (da) 2019-07-29
US20080234264A1 (en) 2008-09-25
EP2447375B1 (en) 2019-05-08
SI1733056T1 (sl) 2013-10-30
EP2423331A2 (en) 2012-02-29
AU2007202288B2 (en) 2012-02-09
JP2013059339A (ja) 2013-04-04
EP2439284B1 (en) 2019-05-08
US7294468B2 (en) 2007-11-13
KR101368446B1 (ko) 2014-02-28
HK1252399A1 (zh) 2019-05-24
US7964349B2 (en) 2011-06-21
KR20130008075A (ko) 2013-01-21
US8465916B2 (en) 2013-06-18
CN107794302A (zh) 2018-03-13
DK1733056T3 (da) 2013-08-26
AU2005228446C1 (en) 2005-10-13
EP1733056A4 (en) 2009-08-12
CA2556227C (en) 2013-03-19
EP2423331B1 (en) 2019-05-08
US12006555B2 (en) 2024-06-11
EP2447375A2 (en) 2012-05-02
AU2007202288A1 (en) 2007-06-14
PT1733056E (pt) 2013-08-29
JP4468475B2 (ja) 2010-05-26
US10669589B2 (en) 2020-06-02
HK1212397A1 (en) 2016-06-10
CN104774931A (zh) 2015-07-15
JP5688399B2 (ja) 2015-03-25
KR101289774B1 (ko) 2013-08-07
KR20120087880A (ko) 2012-08-07
EP2423331A3 (en) 2012-06-27
US20150176081A1 (en) 2015-06-25
JP2015023865A (ja) 2015-02-05
CA2556227A1 (en) 2005-10-13
BRPI0508286A (pt) 2007-07-31
DK2447375T3 (da) 2019-07-29
US20180251860A1 (en) 2018-09-06
JP2007531525A (ja) 2007-11-08
JP6557646B2 (ja) 2019-08-07
WO2005094357A3 (en) 2008-12-24
CN104480200A (zh) 2015-04-01
US20080096212A1 (en) 2008-04-24
JP2010051316A (ja) 2010-03-11
JP2017074048A (ja) 2017-04-20
JP4350148B2 (ja) 2009-10-21
CN104774931B (zh) 2017-11-10
BRPI0508286B1 (pt) 2020-12-29
AU2005228446A1 (en) 2005-10-13
AU2015201692A1 (en) 2015-04-23
KR101347613B1 (ko) 2014-01-06
EP3611273A1 (en) 2020-02-19

Similar Documents

Publication Publication Date Title
DK2439285T3 (da) Fremgangsmåde til at bestemme reaktivitet af cancer på behandlinger målrettet mod epidermal vækstfaktor-receptor
DK1948693T3 (da) Monoklonale antistoffer mod claudin-18 til behandling af cancer
DK2068874T3 (da) Fremgangsmåder til behandling af multiple myelom med anvendelse af kombinationsterapier baseret på anti-cs1 antistoffer
LTC1735348I2 (lt) Antikūnas prieš žmogaus epiderminio augimo faktoriaus receptorių
DK3401334T5 (da) Monoklonale antistoffer mod claudin-18 til cancerbehandling
DK1765391T3 (da) Bakterielle præparater til behandlingen af cancer
DK3403657T3 (da) Anvendelse af oligouronater til behandling af slimhyperviskositet
DK1781604T3 (da) Bis(thio-hydrazid-amid)-salte til behandling af cancere
DK1948180T3 (da) Kombinationsbehandling af cancer omfattende EGFR/HER2 inhibitorer
NL1029015A1 (nl) Therapeutische verbindingen.
DK1893649T3 (da) Fremgangsmåde til forstærkning af opioide analgetikas virkninger på smerte
DE502005008677D1 (de) Bestrahlungseinrichtung
DK1499730T3 (da) Immunokonjugater til behandling af tumorer
DE602005023972D1 (de) Vereinfachte wafer-ausrichtung
DK1727782T3 (da) Fremgangsmåde til fremstilling af aminophenolforbindelser
DE602005017683D1 (de) Winkelverstellvorrichtung
DK1814555T3 (da) S-mirtazapin til behandling af hedeture
DK3332789T3 (da) Cladribinkur til behandling af multipel sklerose
ATE424367T1 (de) Stelleinrichtung
NO20072717L (no) Sporingsanordning
FR2867058B1 (fr) Appareil de positionnement lingual
SE0400530L (sv) Förfarande
DK2301576T3 (da) Terapeutisk anvendelse af anti-CS1-antistoffer
DK1567524T3 (da) Thia-epothilonderivater til behandling af cancer
DE502004003403D1 (de) Nicht-invasive Navigationsreferenz-Fixierung