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DK2173770T3 - Fremgangsmåde til fjernelse af endotoxin fra proteiner - Google Patents

Fremgangsmåde til fjernelse af endotoxin fra proteiner Download PDF

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Publication number
DK2173770T3
DK2173770T3 DK08826178.9T DK08826178T DK2173770T3 DK 2173770 T3 DK2173770 T3 DK 2173770T3 DK 08826178 T DK08826178 T DK 08826178T DK 2173770 T3 DK2173770 T3 DK 2173770T3
Authority
DK
Denmark
Prior art keywords
proteins
removing endotoxin
endotoxin
Prior art date
Application number
DK08826178.9T
Other languages
English (en)
Inventor
Loren Ward
Stan Wrobel
Kevin Thomson
Vincent Anita Lind
Original Assignee
Glanbia Nutritionals Ireland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40229071&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2173770(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glanbia Nutritionals Ireland Ltd filed Critical Glanbia Nutritionals Ireland Ltd
Application granted granted Critical
Publication of DK2173770T3 publication Critical patent/DK2173770T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/362—Cation-exchange
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/40—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK08826178.9T 2007-07-10 2008-07-10 Fremgangsmåde til fjernelse af endotoxin fra proteiner DK2173770T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94883907P 2007-07-10 2007-07-10
PCT/US2008/069713 WO2009009706A1 (en) 2007-07-10 2008-07-10 Method for removing endotoxin from proteins

Publications (1)

Publication Number Publication Date
DK2173770T3 true DK2173770T3 (da) 2015-06-08

Family

ID=40229071

Family Applications (2)

Application Number Title Priority Date Filing Date
DK15156532.2T DK2902409T3 (da) 2007-07-10 2008-07-10 Fremgangsmåde til fjernelse af endotoxin fra proteiner
DK08826178.9T DK2173770T3 (da) 2007-07-10 2008-07-10 Fremgangsmåde til fjernelse af endotoxin fra proteiner

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK15156532.2T DK2902409T3 (da) 2007-07-10 2008-07-10 Fremgangsmåde til fjernelse af endotoxin fra proteiner

Country Status (10)

Country Link
US (4) US7919589B2 (da)
EP (3) EP2902409B1 (da)
JP (2) JP2010533201A (da)
AU (1) AU2008274969B2 (da)
CA (1) CA2696145C (da)
DK (2) DK2902409T3 (da)
ES (1) ES2518290T3 (da)
NZ (1) NZ583234A (da)
PL (1) PL2650302T3 (da)
WO (1) WO2009009706A1 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2941374B1 (fr) * 2009-01-28 2011-03-11 Alaxia Utilisation d'une association synergique d'ions hypothiocyanites et/ou hypohalites et de lactoferrine pour la preparation pour le traitement de la mucoviscidose
CN102348387B (zh) * 2009-01-28 2014-12-31 让-保罗·佩罗丹 生产乳转铁蛋白的方法
US9359426B2 (en) 2009-04-24 2016-06-07 Westland Co-Operative Diary Company Limited Method of preparing low-iron lactoferrin
US10448889B2 (en) * 2011-04-29 2019-10-22 Medtronic, Inc. Determining nerve location relative to electrodes
US9358256B2 (en) 2013-07-11 2016-06-07 Links Medical Products, Inc. Gap-patterned foam dressing and method of making same
US20170224268A1 (en) * 2016-02-10 2017-08-10 Bloom Technologies NV Systems and methods for detecting a labor condition
FR3115037A1 (fr) 2020-10-12 2022-04-15 Compagnie Laitiere Europeenne Procédé de purification de fraction de protéines cationiques et fraction ainsi obtenue

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1563100A (en) 1975-11-26 1980-03-19 Atomic Energy Authority Uk Separation of macromolecules
FR2505615A1 (fr) 1981-05-15 1982-11-19 Elf Aquitaine Procede d'extraction de lactoferrine et d'immunoglobulines du lait
JPS61145200A (ja) 1984-12-19 1986-07-02 Snow Brand Milk Prod Co Ltd ウシラクトフェリンの分離精製法
BE901672A (fr) 1985-02-07 1985-08-07 Oleofina Sa Procede de purification de proteines du lait et de ses derives.
IE61701B1 (en) 1986-07-17 1994-11-30 Morinaga Milk Industry Co Ltd Process for producing bovine lactoferrin in high purity
JPH0725800B2 (ja) 1987-04-10 1995-03-22 雪印乳業株式会社 硫酸エステル化物を用いて乳からラクトフエリンを分離、精製する方法
SE458818B (sv) 1987-11-27 1989-05-16 Svenska Mejeriernas Riksforeni Foerfarande foer utvinning av rena fraktioner av laktoperoxidas och laktoferrin ur mjoelkserum
NZ230031A (en) 1988-07-27 1991-10-25 Snow Brand Milk Products Co Ltd Separation of proteins (e.g. lactoferrin) using affinity gel carrier in a rotary column
US5169936A (en) 1989-04-14 1992-12-08 Biogen, Inc. Protein purification on immobilized metal affinity resins effected by elution using a weak ligand
US6066469A (en) 1990-03-08 2000-05-23 Ferro Dynamics, Inc. Cloning, expression, and uses of human lactoferrin
JP2974434B2 (ja) 1990-03-15 1999-11-10 雪印乳業株式会社 分泌性コンポネント含有組成物
ES2089797T3 (es) 1992-01-15 1996-10-01 Campina Melkunie Bv Procedimiento para aislar la lactoferrina y la lactoperoxidasa de la leche y de los productos lacteos.
JPH05202098A (ja) 1992-01-29 1993-08-10 Snow Brand Milk Prod Co Ltd 乳質原料から生理活性物質の製造法
ZA932568B (en) 1992-04-24 1993-11-12 Baylor College Midecine A Non Production of recombinant human lactoferrin
US6096870A (en) 1994-01-05 2000-08-01 Sepragen Corporation Sequential separation of whey
US5756680A (en) 1994-01-05 1998-05-26 Sepragen Corporation Sequential separation of whey proteins and formulations thereof
JPH09509165A (ja) 1994-02-16 1997-09-16 ファーミング ベスローテン フェンノートシャップ ミルクからのラクトフェリンの分離
US6268487B1 (en) 1996-05-13 2001-07-31 Genzyme Transgenics Corporation Purification of biologically active peptides from milk
NL1005677C2 (nl) 1997-03-27 1998-09-29 Campina Melkunie Bv Werkwijze voor het winnen van groeifactoren, of een samenstelling die één of meer groeifactoren bevat, uit melk of een derivaat daarvan.
US6172040B1 (en) 1999-05-28 2001-01-09 A. Satyanarayan Naidu Immobilized lactoferrin antimicrobial agents and the use thereof
KR100356738B1 (ko) * 2000-09-07 2002-10-18 주식회사 삼양제넥스 염기성 단백질로부터 엔도톡신을 제거하는 방법
US20030191193A1 (en) * 2002-04-03 2003-10-09 Jillian Cornish Lactoferrin
DE602004020473D1 (de) * 2003-06-24 2009-05-20 Organon Nv Abtrennung von lipopolysacchariden aus lipopolysaccharidkomplexen mit hilfe von nicht-entzündbaren lösungsmitteln
US7125963B2 (en) 2004-03-03 2006-10-24 En N Tech Inc Treatments for contaminant reduction in lactoferrin preparations and lactoferrin containing compositions
WO2006047744A2 (en) * 2004-10-26 2006-05-04 Agennix Incorporated Compositions of lactoferrin related peptides and uses thereof
FR2889068B1 (fr) * 2005-07-29 2012-03-02 Cie Laitiere Europeenne Nouvelles fractions proteiques laitieres et leur utilisation pour la prevention ou le traitement des maladies inflammatoires chroniques
ES2526640T3 (es) * 2005-11-18 2015-01-14 Glanbia Nutritionals (Ireland) Limited Composiciones para romper e inhibir la reconstitución de la biopelícula de heridas

Also Published As

Publication number Publication date
EP2173770B1 (en) 2015-05-27
US8138150B2 (en) 2012-03-20
US8778662B2 (en) 2014-07-15
JP5989723B2 (ja) 2016-09-07
AU2008274969A1 (en) 2009-01-15
EP2173770A4 (en) 2010-09-08
US7919589B2 (en) 2011-04-05
ES2518290T3 (es) 2014-11-04
EP2902409A1 (en) 2015-08-05
CA2696145A1 (en) 2009-01-15
CA2696145C (en) 2016-12-20
JP2015017098A (ja) 2015-01-29
US20140322797A1 (en) 2014-10-30
NZ583234A (en) 2012-06-29
US20130035477A1 (en) 2013-02-07
AU2008274969B2 (en) 2014-04-24
DK2902409T3 (da) 2018-04-16
JP2010533201A (ja) 2010-10-21
EP2173770A1 (en) 2010-04-14
EP2650302B1 (en) 2014-10-08
EP2650302A1 (en) 2013-10-16
PL2650302T3 (pl) 2015-01-30
US20090029921A1 (en) 2009-01-29
US20120028882A1 (en) 2012-02-02
EP2902409B1 (en) 2018-01-17
US9738882B2 (en) 2017-08-22
WO2009009706A1 (en) 2009-01-15

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