DK1933821T3 - Halevarianter af redox-aktive terapeutika til behandling af mitokondriesygdomme og andre tilstande og modulation af energibiomarkører - Google Patents
Halevarianter af redox-aktive terapeutika til behandling af mitokondriesygdomme og andre tilstande og modulation af energibiomarkører Download PDFInfo
- Publication number
- DK1933821T3 DK1933821T3 DK06814749.5T DK06814749T DK1933821T3 DK 1933821 T3 DK1933821 T3 DK 1933821T3 DK 06814749 T DK06814749 T DK 06814749T DK 1933821 T3 DK1933821 T3 DK 1933821T3
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- redox
- modulation
- treatment
- conditions
- energy biomarkers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
- A61K31/055—Phenols the aromatic ring being substituted by halogen
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
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- C07C37/07—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by conversion of non-aromatic six-membered rings or of such rings formed in situ into aromatic six-membered rings, e.g. by dehydrogenation with simultaneous reduction of C=O group in that ring
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- C—CHEMISTRY; METALLURGY
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/02—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with no unsaturation outside the aromatic ring
- C07C39/08—Dihydroxy benzenes; Alkylated derivatives thereof
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
- C07C46/02—Preparation of quinones by oxidation giving rise to quinoid structures
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
- C07C46/02—Preparation of quinones by oxidation giving rise to quinoid structures
- C07C46/06—Preparation of quinones by oxidation giving rise to quinoid structures of at least one hydroxy group on a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C50/00—Quinones
- C07C50/02—Quinones with monocyclic quinoid structure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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- C07C50/02—Quinones with monocyclic quinoid structure
- C07C50/06—Quinones with monocyclic quinoid structure with unsaturation outside the quinoid structure
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Psychology (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71767805P | 2005-09-15 | 2005-09-15 | |
| PCT/US2006/036052 WO2007035496A1 (en) | 2005-09-15 | 2006-09-15 | Tail variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1933821T3 true DK1933821T3 (da) | 2020-10-26 |
Family
ID=37637229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK06814749.5T DK1933821T3 (da) | 2005-09-15 | 2006-09-15 | Halevarianter af redox-aktive terapeutika til behandling af mitokondriesygdomme og andre tilstande og modulation af energibiomarkører |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7432305B2 (da) |
| EP (1) | EP1933821B1 (da) |
| JP (5) | JP2009508867A (da) |
| CA (1) | CA2622523C (da) |
| CY (1) | CY1123740T1 (da) |
| DK (1) | DK1933821T3 (da) |
| EA (1) | EA021818B1 (da) |
| ES (1) | ES2823728T3 (da) |
| HU (1) | HUE052377T2 (da) |
| LT (1) | LT1933821T (da) |
| PL (1) | PL1933821T3 (da) |
| PT (1) | PT1933821T (da) |
| SI (1) | SI1933821T1 (da) |
| WO (1) | WO2007035496A1 (da) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005033092A1 (en) | 2003-09-19 | 2005-04-14 | Galileo Pharmaceuticals, Inc. | Chroman derivatives |
| HUE033304T2 (en) | 2005-06-01 | 2017-11-28 | Bioelectron Tech Corp | Redoxactive therapeutic agents for the treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers |
| US9050005B2 (en) | 2005-08-25 | 2015-06-09 | Synapse Biomedical, Inc. | Method and apparatus for transgastric neurostimulation |
| EA019675B1 (ru) | 2006-02-22 | 2014-05-30 | Эдисон Фармасьютикалз, Инк. | Редокс-активные терапевтические средства для лечения митохондриальных заболеваний и модуляции биомаркера коэнзима q |
| EP1996284A2 (en) | 2006-03-09 | 2008-12-03 | Synapse Biomedical, Inc. | Ventilatory assist system and method to improve respiratory function |
| US20080097153A1 (en) * | 2006-08-24 | 2008-04-24 | Ignagni Anthony R | Method and apparatus for grasping an abdominal wall |
| WO2008098001A2 (en) * | 2007-02-05 | 2008-08-14 | Synapse Biomedical, Inc. | Removable intramuscular electrode |
| WO2008144578A1 (en) * | 2007-05-17 | 2008-11-27 | Synapse Biomedical, Inc. | Devices and methods for assessing motor point electromyogram as a biomarker |
| US8428726B2 (en) | 2007-10-30 | 2013-04-23 | Synapse Biomedical, Inc. | Device and method of neuromodulation to effect a functionally restorative adaption of the neuromuscular system |
| US8478412B2 (en) * | 2007-10-30 | 2013-07-02 | Synapse Biomedical, Inc. | Method of improving sleep disordered breathing |
| EP3018122B1 (en) | 2007-11-06 | 2018-10-10 | BioElectron Technology Corporation | 4-(p-quinonyl)-2-hydroxybutanamide derivatives for treatment of mitochondrial diseases |
| WO2009089224A1 (en) | 2008-01-08 | 2009-07-16 | Edison Pharmaceuticals, Inc. | (HET) ARYL-p-QUINONE DERIVATIVES FOR TREATMENT OF MITOCHONDRIAL DISEASES |
| JP5710277B2 (ja) | 2008-03-05 | 2015-04-30 | エジソン ファーマシューティカルズ， インコーポレイテッド | 酸化ストレス疾患の処置のための２−置換−ｐ−キノン誘導体 |
| CA2717741C (en) * | 2008-03-05 | 2018-04-03 | Edison Pharmaceuticals, Inc. | Treatment of hearing and balance impairments with redox-active therapeutics |
| US8716486B2 (en) * | 2008-06-25 | 2014-05-06 | Edison Pharmaceuticals, Inc. | 2-heterocyclylaminoalkyl-(p-quinone) derivatives for treatment of oxidative stress diseases |
| WO2010030607A1 (en) * | 2008-09-10 | 2010-03-18 | Edison Pharmaceuticals, Inc. | Treatment of pervasive developmental disorders with redox-active therapeutics |
| US8263094B2 (en) * | 2008-09-23 | 2012-09-11 | Eastman Chemical Company | Esters of 4,5-disubstituted-oxy-2-methyl-3,6-dioxo-cyclohexa-1,4-dienyl alkyl acids and preparation thereof |
| WO2010045220A1 (en) | 2008-10-14 | 2010-04-22 | Edison Pharmaceuticals, Inc. | Treatment of oxidative stress disorders including contrast nephropathy, radiation damage and disruptions in the function of red cells |
| CA2741767C (en) | 2008-10-28 | 2017-09-12 | Kieron E. Wesson | Process for the production of alpha-tocotrienol and derivatives |
| PT2424495T (pt) | 2009-04-28 | 2018-03-13 | Bioelectron Tech Corp | Tratamento de neuropatia ótica hereditária de leber e atrofia ótica dominante com quinonas de tocotrienol |
| ES2663709T3 (es) * | 2009-08-26 | 2018-04-16 | Bioelectron Technology Corporation | Métodos para la prevención y el tratamiento de la isquemia cerebral |
| DK2701697T3 (da) | 2011-04-26 | 2020-06-29 | Retrotope Inc | Oxidative nethindesygdomme |
| US10154983B2 (en) | 2011-04-26 | 2018-12-18 | Retrotope, Inc. | Neurodegenerative disorders and muscle diseases implicating PUFAs |
| AU2012249918B2 (en) | 2011-04-26 | 2017-06-15 | Biojiva Llc | Impaired energy processing disorders and mitochondrial deficiency |
| AU2012249920B2 (en) | 2011-04-26 | 2017-06-15 | Biojiva Llc | Disorders implicating PUFA oxidation |
| EP2720689A4 (en) | 2011-06-14 | 2014-11-26 | Edison Pharmaceuticals Inc | CATÉCHOL DERIVATIVES FOR THE TREATMENT OF OXIDATIVE STRESS DISEASES |
| WO2013013078A1 (en) | 2011-07-19 | 2013-01-24 | Edison Pharmeceuticals, Inc. | Methods for selective oxidation of alpha tocotrienol in the presence of non-alpha tocotrienols |
| US20150216820A1 (en) * | 2012-09-07 | 2015-08-06 | Edison Pharmaceuticals, Inc. | Quinone derivatives for use in the modulation of redox status of individuals |
| US9670170B2 (en) | 2013-03-15 | 2017-06-06 | Bioelectron Technology Corporation | Resorufin derivatives for treatment of oxidative stress disorders |
| US9296712B2 (en) | 2013-03-15 | 2016-03-29 | Edison Pharmaceuticals, Inc. | Resorufin derivatives for treatment of oxidative stress disorders |
| US9868711B2 (en) | 2013-03-15 | 2018-01-16 | Bioelectron Technology Corporation | Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders |
| JP2016515526A (ja) | 2013-03-15 | 2016-05-30 | エジソン ファーマシューティカルズ， インコーポレイテッド | 酸化ストレス障害の処置のためのアルキル−ヘテロアリール置換されたキノン誘導体 |
| WO2015026708A2 (en) * | 2013-08-20 | 2015-02-26 | Wilson Robert B | Amelioration of the effects of friedriech's ataxia |
| CN106170206A (zh) | 2014-03-13 | 2016-11-30 | 乐巢拓普有限公司 | 视神经病变治疗和用稳定的多不饱和物质减少类固醇诱导的氧化应激 |
| CA2971252A1 (en) | 2014-12-16 | 2016-06-23 | Bioelectron Technology Corporation | Polymorphic and amorphous forms of (r)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide |
| WO2017106786A1 (en) | 2015-12-16 | 2017-06-22 | Bioelectron Technology Corporation | Improved methods for enriching alpha-tocotrienol from mixed tocol compositions |
| MX2018007389A (es) | 2015-12-17 | 2018-08-15 | Bioelectron Tech Corp | Derivados de fluoroalquil-, fluoroalcoxi-, fenoxi-, heteroariloxi-, alcoxi- y amina-1,4-benzoquinona para tratamiento de trastornos de estres oxidativo. |
| JP2018083799A (ja) | 2016-11-15 | 2018-05-31 | バイオエレクトロン テクノロジー コーポレイション | ２−置換アミノ−ナフト［１，２−ｄ］イミダゾール−５−オン化合物またはその製薬学上許容される塩 |
| JP7132630B2 (ja) | 2016-11-17 | 2022-09-07 | レトロトップ、 インコーポレイテッド | 同位体修飾成分及びその治療上の使用 |
| CA3097114A1 (en) | 2017-04-14 | 2018-10-18 | Bioelectron Technology Corporation | Methods and compositions for treatment of inflammation and oxidative stress |
| WO2020081879A2 (en) | 2018-10-17 | 2020-04-23 | Ptc Therapeutics, Inc. | 2,3,5-TRIMETHYL-6-NONYLCYCLOHEXA-2,5-DIENE-1,4-DIONE FOR SUPPRESSING AND TREATING α-SYNUCLEINOPATHIES, TAUOPATHIES, AND OTHER DISORDERS |
| US11471683B2 (en) | 2019-01-29 | 2022-10-18 | Synapse Biomedical, Inc. | Systems and methods for treating sleep apnea using neuromodulation |
| CN114746430A (zh) | 2019-10-04 | 2022-07-12 | 康德生物医疗有限公司 | 治疗线粒体异常疾病的伐替苯醌的醌-、氢醌-和萘醌-类似物 |
| WO2021077034A1 (en) | 2019-10-18 | 2021-04-22 | Ptc Therapeutics, Inc. | 2,3,5-trimethyl-6-nonylcyclohexa-2,5-diene-1,4-dione for suppressing and treating hemoglobinopathy, thalassemia, sickle cell disease and other disorders |
| JP2023520462A (ja) | 2020-04-03 | 2023-05-17 | ステルス バイオセラピューティクス インコーポレイテッド | フリードライヒ運動失調症を含むミトコンドリア病の予防および／または治療のための組成物および方法 |
| US12109194B2 (en) | 2021-02-05 | 2024-10-08 | Biojiva Llc | Synergistic combination therapy for treating ALS |
| EP4366700A1 (en) | 2021-07-08 | 2024-05-15 | PTC Therapeutics, Inc. | Pharmaceutical compositions comprising 2,3,5-trimethyl-6-nonylcyclohexa-2,5-diene-1,4-dione |
| WO2024050725A1 (en) * | 2022-09-07 | 2024-03-14 | Ptc Therapeutics, Inc. | Methods of producing 2, 3, 5, 6-alkyl-1, 4-benzoquinones |
Family Cites Families (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2856414A (en) * | 1958-10-14 | Oxidation of alpha-tocopherol | ||
| US2398418A (en) * | 1943-08-27 | 1946-04-16 | Louis F Fieser | Introduction of organic radicals into quinones |
| FR1201200A (fr) | 1958-08-08 | 1959-12-29 | Sogespar S A | Procédé de fabrication de l'alpha tocophéryl-quinone |
| US3071512A (en) * | 1959-01-26 | 1963-01-01 | Sogespar S A | New hypotensive pharmaceutical preparation containing alpha-tocopheryl-quinone |
| US3406188A (en) * | 1964-03-27 | 1968-10-15 | Sun Oil Co | Preparation of alpha-tocopherylquinone |
| FR5531M (da) | 1966-02-08 | 1967-11-13 | ||
| FR1536576A (fr) | 1967-08-29 | 1968-08-16 | Eastman Kodak Co | Procédés d'enrichissement et de fractionnement de mélanges à base de tocophérols |
| US3849453A (en) * | 1970-03-17 | 1974-11-19 | Takeda Chemical Industries Ltd | Quinone derivatives |
| US3705239A (en) * | 1970-10-16 | 1972-12-05 | Roy B Gregory | Pain removing compositions and methods |
| UST917001I4 (en) * | 1971-12-02 | 1973-12-04 | Defensive publication | |
| JPS5245698B2 (da) * | 1973-04-06 | 1977-11-17 | ||
| FR2235679B1 (da) * | 1973-07-02 | 1978-07-21 | Takeda Chemical Industries Ltd | |
| US3909376A (en) * | 1974-12-04 | 1975-09-30 | Basf Ag | Electrolytic manufacture of alkyl-substituted hydroquinones |
| LU77344A1 (da) * | 1977-05-16 | 1979-01-19 | ||
| US4153614A (en) * | 1978-05-12 | 1979-05-08 | Hoffmann-La Roche Inc. | Synthesis of (S)-(+)-6-hydroxy-2,5,7,8-tetramethylchroman-2-methanol and intermediates therein |
| US4201879A (en) * | 1977-05-16 | 1980-05-06 | Hoffmann-La Roche Inc. | Hydroquinones |
| US4201726A (en) * | 1977-05-17 | 1980-05-06 | Hoffmann-La Roche Inc. | Synthesis of Vitamin E |
| US4310465A (en) * | 1977-05-17 | 1982-01-12 | Hoffmann-La Roche Inc. | Synthesis of vitamin E and quinone intermediates |
| US4185154A (en) * | 1977-05-17 | 1980-01-22 | Hoffmann-La Roche, Inc. | Synthesis of vitamin E |
| US4243598A (en) * | 1977-05-17 | 1981-01-06 | Hoffmann-La Roche Inc. | Synthesis of vitamin E |
| US4127608A (en) * | 1977-05-17 | 1978-11-28 | Hoffmann-La Roche Inc. | Synthesis of Vitamin E |
| JPS5640651A (en) * | 1979-09-12 | 1981-04-16 | Takeda Chem Ind Ltd | Quinone compound and its preparation |
| JPS567734A (en) * | 1979-06-28 | 1981-01-27 | Takeda Chem Ind Ltd | Preparation of quinone derivative |
| JPS56147746A (en) * | 1980-04-15 | 1981-11-16 | Takeda Chem Ind Ltd | Quinones and their preparation |
| JPS567737A (en) * | 1979-07-02 | 1981-01-27 | Takeda Chem Ind Ltd | Physiologically active quinone and its preparation |
| JPS5697223A (en) * | 1979-12-30 | 1981-08-05 | Takeda Chem Ind Ltd | Tissue metabolism activator |
| JPS56140943A (en) | 1980-04-07 | 1981-11-04 | Takeda Chem Ind Ltd | Preparation of organic compound |
| JPH0193554A (ja) | 1980-04-07 | 1989-04-12 | Takeda Chem Ind Ltd | 有機化合物 |
| US4393075A (en) * | 1980-04-14 | 1983-07-12 | Takeda Chemical Industries, Ltd. | Quinone compounds and their use in suppressing the production of SRS-A in mammals |
| JPS5750935A (en) | 1980-09-12 | 1982-03-25 | Otsuka Pharmaceut Co Ltd | 1,4-benzoquinone derivative |
| JPS57131735A (en) * | 1981-02-09 | 1982-08-14 | Takeda Chem Ind Ltd | Preparation of quinones |
| JPS5883698A (ja) | 1981-11-13 | 1983-05-19 | Takeda Chem Ind Ltd | キノン化合物およびその製造法 |
| JPS58193689A (ja) | 1982-05-10 | 1983-11-11 | Shiseido Co Ltd | テストステロン−５α−レダクタ−ゼ阻害剤 |
| CH655005A5 (it) * | 1983-02-16 | 1986-03-27 | Sigma Tau Ind Farmaceuti | Composizione farmaceutica ad azione metabolica ed energetica utilizzabile in terapia cardiaca e vascolare. |
| JPS59163316A (ja) * | 1983-03-08 | 1984-09-14 | Eisai Co Ltd | けいれんの治療・予防剤 |
| JPS6028919A (ja) | 1983-07-28 | 1985-02-14 | Shiseido Co Ltd | 皮膚外用剤 |
| EP0134198A1 (de) * | 1983-08-10 | 1985-03-13 | Ciba-Geigy Ag | Verwendung von Chinonderivaten zum Schützen von Kulturpflanzen vor der phytotoxischen Wirkung von Herbiziden |
| MX9203040A (es) * | 1984-08-01 | 1992-07-31 | Takeda Chemical Industries Ltd | Derivados de quinona y composicion farmaceutica que los contiene. |
| US5304658A (en) * | 1984-08-01 | 1994-04-19 | Takeda Chemical Industries, Ltd. | Quinone derivatives, their production and use |
| JPS6140236A (ja) | 1984-08-02 | 1986-02-26 | Yamanouchi Pharmaceut Co Ltd | ハイドロキノン誘導体 |
| US4592867A (en) * | 1984-10-19 | 1986-06-03 | Energy Conversion Devices, Inc. | Synthesis method for reductant precursor |
| EP0183869B1 (en) * | 1984-12-06 | 1991-04-17 | Kuraray Co., Ltd. | Chroman compounds and their use |
| US5229385A (en) * | 1986-01-30 | 1993-07-20 | Takeda Chemical Industries, Ltd. | Quinone derivatives, their production and use |
| GB8626344D0 (en) * | 1986-11-04 | 1986-12-03 | Zyma Sa | Bicyclic compounds |
| US5057514A (en) * | 1987-02-03 | 1991-10-15 | Suntory Limited | Compounds effective as cerebral schemia treating agents |
| US5292768A (en) * | 1987-12-22 | 1994-03-08 | Suntory Limited | Compound effective as cerebral insufficiency improver |
| US5179092A (en) * | 1987-12-22 | 1993-01-12 | Suntory Limited | Compound effective as cerebral insufficiency improver |
| JPH01209445A (ja) | 1988-02-17 | 1989-08-23 | Fuji Photo Film Co Ltd | 放射線感応性材料 |
| DE3818696C1 (en) | 1988-06-01 | 1989-03-30 | Ems-Inventa Ag, Zuerich, Ch | Process for the preparation of hydroquinone and its alkyl derivatives |
| JPH08768B2 (ja) * | 1989-08-24 | 1996-01-10 | 武田薬品工業株式会社 | 神経成長因子分泌誘導剤 |
| FI102273B (fi) * | 1989-09-11 | 1998-11-13 | Eisai Co Ltd | Kinonijohdannaiset, niiden valmistaminen ja niiden farmakologinen käyt tö |
| JP3086284B2 (ja) | 1991-07-05 | 2000-09-11 | 京セラミタ株式会社 | 電子写真感光体 |
| PT643775E (pt) * | 1992-05-28 | 2004-10-29 | Ct For Molecular Biology And M | Derivados da quinona para aumentar a bioenergia celular |
| CN1093360A (zh) | 1992-10-02 | 1994-10-12 | 武田药品工业株式会社 | 2-o-烷基抗坏血酸的锂盐 |
| US5600029A (en) * | 1994-03-09 | 1997-02-04 | Takeda Chemical Industries, Ltd. | Process for producing DL-tocopherols and intermediates therefor |
| AU3192795A (en) * | 1994-08-12 | 1996-03-07 | Takeda Chemical Industries Ltd. | Use of quinone and hydroquinone derivatives for the teatment of cachexia |
| US6150402A (en) * | 1994-08-15 | 2000-11-21 | Loma Linda University Medical Center | Natriuretic compounds |
| JPH0892151A (ja) | 1994-09-29 | 1996-04-09 | Sagami Chem Res Center | アリルキノンの製造方法 |
| US5547827A (en) * | 1994-12-22 | 1996-08-20 | Eastman Kodak Company | Iodochloride emulsions containing quinones having high sensitivity and low fog |
| EP0719552A3 (en) | 1994-12-26 | 1997-08-20 | Takeda Chemical Industries Ltd | Pharmaceutical composition containing a quinone derivative or the hydroquinone thereof for the treatment of dermatitis |
| CA2227985A1 (en) * | 1995-08-21 | 1997-02-27 | Takeda Chemical Industries, Ltd. | Quinone compound, its production and use |
| DK0842165T3 (da) * | 1996-03-25 | 2001-08-06 | Alcon Lab Inc | Thiazolidin-4-carboxylsyrederivater som cytobeskyttende midler |
| AU3458997A (en) * | 1996-07-11 | 1998-02-09 | Takeda Chemical Industries Ltd. | Anti-beta-amyloid protein-induced cytotoxicity composition |
| GB9702310D0 (en) | 1997-02-05 | 1997-03-26 | Univ Hertfordshire | Invention |
| GB9722361D0 (en) * | 1997-10-24 | 1997-12-17 | Pharma Nord Uk Ltd | Pharmaceutical formulation for treating liver disorders |
| US6331532B1 (en) * | 1998-11-25 | 2001-12-18 | University Of Otago | Mitochondrially targeted antioxidants |
| US6433199B1 (en) * | 1998-05-22 | 2002-08-13 | Shionogi Bioresearch Corporation | Quinone derivatives |
| US5969133A (en) * | 1998-05-22 | 1999-10-19 | Shiongi Bioresearch Corp. | Bioreductive cytotoxic agents |
| EP1101759A4 (en) * | 1998-07-31 | 2001-12-12 | Nippon Soda Co | PHENYLAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICATIONS FOR HYPERLIPEMY |
| IT1304406B1 (it) * | 1998-10-21 | 2001-03-19 | Danital Italia S R L | Preparazione per la veicolazione di principi attivi basata su acidigrassi polinsaturi del gruppo omega 3. |
| US6133322A (en) * | 1998-10-29 | 2000-10-17 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Quinone derivatives for treating or preventing diseases associated with iron overload |
| JP2000202297A (ja) | 1999-01-20 | 2000-07-25 | Chemiprokasei Kaisha Ltd | 新規な酸化反応用触媒およびそれを用いたｐ―ベンゾキノン類の製造方法 |
| IL144964A0 (en) * | 1999-02-23 | 2002-06-30 | Pro Neuron Inc | Methods of treatment of mitochondrial disorders |
| US6045826A (en) * | 1999-04-02 | 2000-04-04 | National Research Council Of Canada | Water-soluble compositions of bioactive lipophilic compounds |
| US6632443B2 (en) * | 2000-02-23 | 2003-10-14 | National Research Council Of Canada | Water-soluble compositions of bioactive lipophilic compounds |
| DE19916801A1 (de) | 1999-04-14 | 2000-11-02 | Bosch Gmbh Robert | Spritzdüse für eine Scheibenwaschanlage |
| US6426362B1 (en) * | 1999-10-08 | 2002-07-30 | Galileo Laboratories, Inc. | Formulations of tocopherols and methods of making and using them |
| US8753675B1 (en) | 2000-01-20 | 2014-06-17 | Raj K. Chopra | Reduced form of Coenzyme Q in high bioavailability stable dosage forms and related applications |
| US6740338B1 (en) * | 2000-01-20 | 2004-05-25 | Raj K. Chopra | Reduced form of Cenzyme Q in high bioavailability stable oral dosage form |
| WO2001092215A2 (en) | 2000-06-02 | 2001-12-06 | Us Health | Superoxide-generating diazeniumdiolates, compositions comprising same, and methods for using same |
| DE10034233A1 (de) * | 2000-07-14 | 2002-01-24 | Basf Ag | Tocotrienolchinon-Cyclisierungsprodukte |
| US6545184B1 (en) * | 2000-08-15 | 2003-04-08 | The Regents Of The University Of California | Practical, cost-effective synthesis of COQ10 |
| US6300377B1 (en) * | 2001-02-22 | 2001-10-09 | Raj K. Chopra | Coenzyme Q products exhibiting high dissolution qualities |
| US6764768B2 (en) * | 2001-02-28 | 2004-07-20 | Arch Development Corporation | Controlled release composition |
| US6964969B2 (en) * | 2001-04-19 | 2005-11-15 | Mccleary Edward Larry | Composition and method for treating impaired or deteriorating neurological function |
| JP2003064017A (ja) | 2001-06-12 | 2003-03-05 | Hokko Chem Ind Co Ltd | オキシスチレン誘導体の蒸留方法 |
| US7172905B2 (en) * | 2001-08-07 | 2007-02-06 | The University Of Chicago | Polypeptide immobilization |
| NZ513547A (en) * | 2001-08-13 | 2002-09-27 | Antipodean Biotechnology Ltd | Synthesis of triphenylphosphonium quinols (e.g. mitoquinol) and/or quinones (e.g. mitoquinone) |
| JP2003137716A (ja) | 2001-10-30 | 2003-05-14 | Eau De Faveur:Kk | 皮膚の外用剤 |
| EP1378753B1 (en) | 2002-07-01 | 2006-05-31 | Santhera Pharmaceuticals (Schweiz) GmbH | A screening method and compounds for treating Friedreich Ataxia |
| US6953331B2 (en) * | 2002-08-30 | 2005-10-11 | Extreme Components L.P. | Positioning device with bearing mechanism |
| WO2005033092A1 (en) * | 2003-09-19 | 2005-04-14 | Galileo Pharmaceuticals, Inc. | Chroman derivatives |
| US7022441B2 (en) * | 2004-02-25 | 2006-04-04 | Eastman Kodak Company | Silver-free black-and-white thermographic materials containing a benzoquinone and methods of imaging |
| DE102004032837A1 (de) * | 2004-07-02 | 2006-02-09 | Beiersdorf Ag | Verwendung von Wirkstoffkombinationen aus einem oder mehreren Biochinonen und einem oder mehreren Isoflavonen zur Verbesserung der Hautkonturen |
| HUE033304T2 (en) * | 2005-06-01 | 2017-11-28 | Bioelectron Tech Corp | Redoxactive therapeutic agents for the treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers |
-
2006
- 2006-09-15 PL PL06814749T patent/PL1933821T3/pl unknown
- 2006-09-15 EA EA200800819A patent/EA021818B1/ru not_active IP Right Cessation
- 2006-09-15 PT PT68147495T patent/PT1933821T/pt unknown
- 2006-09-15 CA CA2622523A patent/CA2622523C/en active Active
- 2006-09-15 EP EP06814749.5A patent/EP1933821B1/en active Active
- 2006-09-15 ES ES06814749T patent/ES2823728T3/es active Active
- 2006-09-15 DK DK06814749.5T patent/DK1933821T3/da active
- 2006-09-15 HU HUE06814749A patent/HUE052377T2/hu unknown
- 2006-09-15 JP JP2008531360A patent/JP2009508867A/ja not_active Withdrawn
- 2006-09-15 WO PCT/US2006/036052 patent/WO2007035496A1/en active Application Filing
- 2006-09-15 SI SI200632388T patent/SI1933821T1/sl unknown
- 2006-09-15 US US11/521,887 patent/US7432305B2/en active Active
- 2006-09-15 LT LTEP06814749.5T patent/LT1933821T/lt unknown
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2013
- 2013-05-08 JP JP2013098528A patent/JP5999816B2/ja active Active
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2014
- 2014-12-17 JP JP2014254928A patent/JP2015078224A/ja not_active Withdrawn
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2015
- 2015-11-16 JP JP2015223653A patent/JP2016040311A/ja active Pending
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2017
- 2017-07-03 JP JP2017130267A patent/JP2017193570A/ja not_active Withdrawn
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2020
- 2020-10-29 CY CY20201101024T patent/CY1123740T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20070072943A1 (en) | 2007-03-29 |
| LT1933821T (lt) | 2020-11-10 |
| US7432305B2 (en) | 2008-10-07 |
| CY1123740T1 (el) | 2022-03-24 |
| EA200800819A1 (ru) | 2008-08-29 |
| PL1933821T3 (pl) | 2021-01-11 |
| EP1933821A1 (en) | 2008-06-25 |
| JP2013155194A (ja) | 2013-08-15 |
| JP2016040311A (ja) | 2016-03-24 |
| JP2015078224A (ja) | 2015-04-23 |
| CA2622523A1 (en) | 2007-03-29 |
| JP2009508867A (ja) | 2009-03-05 |
| SI1933821T1 (sl) | 2020-11-30 |
| JP5999816B2 (ja) | 2016-09-28 |
| EA021818B1 (ru) | 2015-09-30 |
| HUE052377T2 (hu) | 2021-04-28 |
| EP1933821B1 (en) | 2020-07-29 |
| ES2823728T3 (es) | 2021-05-10 |
| WO2007035496A1 (en) | 2007-03-29 |
| CA2622523C (en) | 2014-02-18 |
| PT1933821T (pt) | 2020-10-15 |
| JP2017193570A (ja) | 2017-10-26 |
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