[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

DK1955102T3 - Fremgangsmåde og indretning til konfokal billedbehandling - Google Patents

Fremgangsmåde og indretning til konfokal billedbehandling

Info

Publication number
DK1955102T3
DK1955102T3 DK06838184.7T DK06838184T DK1955102T3 DK 1955102 T3 DK1955102 T3 DK 1955102T3 DK 06838184 T DK06838184 T DK 06838184T DK 1955102 T3 DK1955102 T3 DK 1955102T3
Authority
DK
Denmark
Prior art keywords
confocal imaging
confocal
imaging
Prior art date
Application number
DK06838184.7T
Other languages
English (en)
Inventor
Theofilos Kotseroglou
Mark Wang
Alexander Triener
Diping Che
Robert Kain
Original Assignee
Illumina Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37808340&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1955102(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Illumina Inc filed Critical Illumina Inc
Application granted granted Critical
Publication of DK1955102T3 publication Critical patent/DK1955102T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0032—Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0036—Scanning details, e.g. scanning stages
    • G02B21/004—Scanning details, e.g. scanning stages fixed arrays, e.g. switchable aperture arrays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6421—Measuring at two or more wavelengths

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Microscoopes, Condenser (AREA)
DK06838184.7T 2005-11-23 2006-11-21 Fremgangsmåde og indretning til konfokal billedbehandling DK1955102T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/286,309 US7329860B2 (en) 2005-11-23 2005-11-23 Confocal imaging methods and apparatus
PCT/US2006/045058 WO2007062039A2 (en) 2005-11-23 2006-11-21 Confocal imaging methods and apparatus

Publications (1)

Publication Number Publication Date
DK1955102T3 true DK1955102T3 (da) 2013-05-13

Family

ID=37808340

Family Applications (2)

Application Number Title Priority Date Filing Date
DK06838184.7T DK1955102T3 (da) 2005-11-23 2006-11-21 Fremgangsmåde og indretning til konfokal billedbehandling
DK13155085.7T DK2594981T3 (da) 2005-11-23 2006-11-21 Fremgangsmåder og indretning til konfokal billedbehandling

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK13155085.7T DK2594981T3 (da) 2005-11-23 2006-11-21 Fremgangsmåder og indretning til konfokal billedbehandling

Country Status (9)

Country Link
US (6) US7329860B2 (da)
EP (2) EP2594981B1 (da)
JP (1) JP5055292B2 (da)
CN (1) CN101361015B (da)
CA (1) CA2632221C (da)
DK (2) DK1955102T3 (da)
ES (2) ES2407968T3 (da)
PL (1) PL2594981T3 (da)
WO (1) WO2007062039A2 (da)

Families Citing this family (291)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040082863A1 (en) * 2002-03-15 2004-04-29 Mcgreevy James Device and method for the photodynamic diagnosis of tumor tissue
US20070057211A1 (en) 2005-05-25 2007-03-15 Karsten Bahlman Multifocal imaging systems and method
US7329860B2 (en) * 2005-11-23 2008-02-12 Illumina, Inc. Confocal imaging methods and apparatus
US7715001B2 (en) * 2006-02-13 2010-05-11 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US7995202B2 (en) 2006-02-13 2011-08-09 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US7813013B2 (en) * 2006-11-21 2010-10-12 Illumina, Inc. Hexagonal site line scanning method and system
EP2126766A2 (en) 2007-01-26 2009-12-02 Illumina Inc. Image data efficient genetic sequencing method and system
US8315817B2 (en) 2007-01-26 2012-11-20 Illumina, Inc. Independently removable nucleic acid sequencing system and method
US7687776B2 (en) * 2007-04-11 2010-03-30 General Monitors, Inc. Gas and/or flame imaging system with explosion proof housing
EP2201352B2 (en) 2007-09-28 2018-08-29 Illumina, Inc. Fluorescence excitation and detection system and method
JP5072688B2 (ja) * 2008-04-02 2012-11-14 キヤノン株式会社 走査型撮像装置
CN102084003A (zh) * 2008-04-04 2011-06-01 生命科技公司 用于成像和测序的扫描系统和方法
US8039817B2 (en) 2008-05-05 2011-10-18 Illumina, Inc. Compensator for multiple surface imaging
EP2291533B2 (en) 2008-07-02 2020-09-30 Illumina Cambridge Limited Using populations of beads for the fabrication of arrays on surfaces
US20100087325A1 (en) * 2008-10-07 2010-04-08 Illumina, Inc. Biological sample temperature control system and method
US7675045B1 (en) * 2008-10-09 2010-03-09 Los Alamos National Security, Llc 3-dimensional imaging at nanometer resolutions
JP2012505431A (ja) * 2008-10-09 2012-03-01 ジーイー・ヘルスケア・バイオサイエンス・コーポレイション イメージングシステムにおけるビームエクスパンダの調整システム及び方法
WO2010048337A2 (en) 2008-10-22 2010-04-29 Illumina, Inc. Preservation of information related to genomic dna methylation
KR101061004B1 (ko) * 2008-12-10 2011-09-01 한국전기연구원 광역학 치료 및 광 검출을 위한 장치
US20100157086A1 (en) 2008-12-15 2010-06-24 Illumina, Inc Dynamic autofocus method and system for assay imager
EP2425240A4 (en) 2009-04-30 2012-12-12 Good Start Genetics Inc METHOD AND COMPOSITION FOR EVALUATING GENETIC MARKERS
US12129514B2 (en) 2009-04-30 2024-10-29 Molecular Loop Biosolutions, Llc Methods and compositions for evaluating genetic markers
US8222589B2 (en) * 2009-05-29 2012-07-17 General Electric Company Solid-state photomultiplier module with improved signal-to-noise ratio
JP5568912B2 (ja) * 2009-07-22 2014-08-13 富士ゼロックス株式会社 発光素子ヘッドの特性計測装置および発光素子ヘッドの光量補正方法
US20110017915A1 (en) * 2009-07-23 2011-01-27 Palo Alto Research Center Incorporated Drift scanner for rare cell detection
EP2456892B1 (en) 2009-07-24 2014-10-01 Illumina, Inc. Method for sequencing a polynucleotide template
EP2293032A1 (en) * 2009-09-04 2011-03-09 Radisens Diagnostic Limited An Integrated Cytometric Sensor System and Method
KR101075155B1 (ko) 2009-10-07 2011-10-19 한국과학기술원 선주사 방식을 이용한 공초점 레이저 주사 현미경 시스템에 적용하기 위한 영상처리 장치 및 방법
FI20096067A0 (fi) * 2009-10-15 2009-10-15 Valtion Teknillinen Raman-säteilyn mittaus
DE102009057304A1 (de) * 2009-12-07 2011-06-09 Leica Microsystems Cms Gmbh Vorrichtung zum Untersuchen einer Probe umfassend ein Mikroskop
DE102009058295A1 (de) * 2009-12-10 2011-06-16 Biostep Gmbh Transilluminator
US8470733B2 (en) * 2009-12-22 2013-06-25 Zih Corp. Direct thermal media and registration sensor system and method for use in a color thermal printer
DK2531880T3 (da) 2010-02-01 2016-11-07 Illumina Inc Fokuseringsmetoder og optiske systemer samt anordninger dermed
WO2011112465A1 (en) 2010-03-06 2011-09-15 Illumina, Inc. Systems, methods, and apparatuses for detecting optical signals from a sample
US8532398B2 (en) 2010-03-26 2013-09-10 General Electric Company Methods and apparatus for optical segmentation of biological samples
ITRM20100286A1 (it) * 2010-05-28 2011-11-29 Consiglio Nazionale Ricerche Microscopio confocale spettrale in riflettanza a larga banda.
US9029103B2 (en) 2010-08-27 2015-05-12 Illumina Cambridge Limited Methods for sequencing polynucleotides
US8575071B2 (en) 2010-11-03 2013-11-05 Illumina, Inc. Reducing adapter dimer formation
US8773526B2 (en) 2010-12-17 2014-07-08 Mitutoyo Corporation Edge detection using structured illumination
US9163281B2 (en) 2010-12-23 2015-10-20 Good Start Genetics, Inc. Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction
US8951781B2 (en) 2011-01-10 2015-02-10 Illumina, Inc. Systems, methods, and apparatuses to image a sample for biological or chemical analysis
US10908403B2 (en) * 2011-02-14 2021-02-02 European Molecular Biology Laboratory (Embl) Light-pad microscope for high-resolution 3D fluorescence imaging and 2D fluctuation spectroscopy
US9291802B2 (en) * 2011-04-29 2016-03-22 Corning Incorporated Compact label free imaging system
US20120306998A1 (en) * 2011-06-01 2012-12-06 Merrill Ii Dennis E Macro Area Camera for an Infrared (IR) Microscope
US10378051B2 (en) 2011-09-29 2019-08-13 Illumina Cambridge Limited Continuous extension and deblocking in reactions for nucleic acids synthesis and sequencing
EP2768983A4 (en) 2011-10-17 2015-06-03 Good Start Genetics Inc METHODS OF IDENTIFYING MUTATIONS ASSOCIATED WITH DISEASES
EP3305400A3 (en) 2011-10-28 2018-06-06 Illumina, Inc. Microarray fabrication system and method
KR101302162B1 (ko) * 2011-11-04 2013-09-10 광주과학기술원 3차원 공초점 전계발광 분광 현미경 장치
CA2854023A1 (en) 2011-11-07 2013-05-16 Illumina, Inc. Integrated sequencing apparatuses and methods of use
CN103930816A (zh) * 2011-11-14 2014-07-16 皇家飞利浦有限公司 用于相关联的对象的扫描显微镜检查的光学显微镜检查探头
DK2788499T3 (da) 2011-12-09 2016-03-21 Illumina Inc Udvidet rod for polymer-tags
WO2013117595A2 (en) 2012-02-07 2013-08-15 Illumina Cambridge Limited Targeted enrichment and amplification of nucleic acids on a support
EP2816388A4 (en) * 2012-02-15 2015-07-22 Olympus Corp LASER SCANNING TYPE VISUALIZATION DEVICE
US20130250088A1 (en) * 2012-03-22 2013-09-26 Molecular Devices, Llc Multi-color confocal microscope and imaging methods
CN102638659B (zh) * 2012-03-28 2014-05-14 西安电子科技大学 基于cmos-tdi模式的高分辨率成像系统及方法
CA2867665C (en) 2012-04-03 2022-01-04 Illumina, Inc. Integrated optoelectronic read head and fluidic cartridge useful for nucleic acid sequencing
US8209130B1 (en) 2012-04-04 2012-06-26 Good Start Genetics, Inc. Sequence assembly
US8812422B2 (en) 2012-04-09 2014-08-19 Good Start Genetics, Inc. Variant database
US20130274148A1 (en) 2012-04-11 2013-10-17 Illumina, Inc. Portable genetic detection and analysis system and method
US10227635B2 (en) 2012-04-16 2019-03-12 Molecular Loop Biosolutions, Llc Capture reactions
RU2616653C2 (ru) * 2012-06-05 2017-04-18 Хайпермед Имэджинг, Инк. Способы и устройство для соосного формирования изображения с множеством длин волн
NL2017959B1 (en) 2016-12-08 2018-06-19 Illumina Inc Cartridge assembly
CA3040684C (en) 2012-08-20 2023-02-07 Hod Finkelstein Method and system for fluorescence lifetime based sequencing
US9116139B2 (en) 2012-11-05 2015-08-25 Illumina, Inc. Sequence scheduling and sample distribution techniques
WO2014074611A1 (en) 2012-11-07 2014-05-15 Good Start Genetics, Inc. Methods and systems for identifying contamination in samples
JP5388078B1 (ja) 2012-11-14 2014-01-15 レーザーテック株式会社 解析装置及び解析方法
US9426400B2 (en) * 2012-12-10 2016-08-23 Kla-Tencor Corporation Method and apparatus for high speed acquisition of moving images using pulsed illumination
US20140168402A1 (en) * 2012-12-13 2014-06-19 Vala Sciences, Inc. Continuous-Scanning Image Acquisition in Automated Microscopy Using Reflective Autofocus
CN103018911B (zh) * 2012-12-14 2015-06-24 清华大学 基于波分复用的光纤激光合成装置
US9805407B2 (en) 2013-01-25 2017-10-31 Illumina, Inc. Methods and systems for using a cloud computing environment to configure and sell a biological sample preparation cartridge and share related data
US8842273B2 (en) 2013-02-14 2014-09-23 United Sciences, Llc Optical measurement of drilled holes
EP2971159B1 (en) 2013-03-14 2019-05-08 Molecular Loop Biosolutions, LLC Methods for analyzing nucleic acids
US9193998B2 (en) 2013-03-15 2015-11-24 Illumina, Inc. Super resolution imaging
US20140274747A1 (en) 2013-03-15 2014-09-18 Illumina, Inc. Super resolution imaging
CN103257438B (zh) * 2013-05-29 2015-02-18 哈尔滨工业大学 一种基于自动控制电动平移台的平面二维矩形扫描装置及其扫描方法
EP3005200A2 (en) 2013-06-03 2016-04-13 Good Start Genetics, Inc. Methods and systems for storing sequence read data
WO2015002789A1 (en) 2013-07-03 2015-01-08 Illumina, Inc. Sequencing by orthogonal synthesis
US9324900B2 (en) * 2013-08-01 2016-04-26 Teledyne Scientific & Imaging, Llc Method of fabricating a superlattice structure
US9116866B2 (en) 2013-08-21 2015-08-25 Seven Bridges Genomics Inc. Methods and systems for detecting sequence variants
US9898575B2 (en) 2013-08-21 2018-02-20 Seven Bridges Genomics Inc. Methods and systems for aligning sequences
US9188775B2 (en) * 2013-08-28 2015-11-17 United Sciences, Llc Optical scanning and measurement
DK3039409T3 (da) 2013-08-28 2018-01-29 Illumina Inc Optisk opretningsværktøj
WO2015031849A1 (en) 2013-08-30 2015-03-05 Illumina, Inc. Manipulation of droplets on hydrophilic or variegated-hydrophilic surfaces
US9352315B2 (en) 2013-09-27 2016-05-31 Taiwan Semiconductor Manufacturing Company, Ltd. Method to produce chemical pattern in micro-fluidic structure
WO2015058097A1 (en) 2013-10-18 2015-04-23 Seven Bridges Genomics Inc. Methods and systems for identifying disease-induced mutations
JP2017500004A (ja) 2013-10-18 2017-01-05 セブン ブリッジズ ジェノミクス インコーポレイテッド 遺伝子試料について遺伝子型解析するための方法およびシステム
US10832797B2 (en) 2013-10-18 2020-11-10 Seven Bridges Genomics Inc. Method and system for quantifying sequence alignment
WO2015057565A1 (en) 2013-10-18 2015-04-23 Good Start Genetics, Inc. Methods for assessing a genomic region of a subject
US11049587B2 (en) 2013-10-18 2021-06-29 Seven Bridges Genomics Inc. Methods and systems for aligning sequences in the presence of repeating elements
US10851414B2 (en) 2013-10-18 2020-12-01 Good Start Genetics, Inc. Methods for determining carrier status
US9092402B2 (en) 2013-10-21 2015-07-28 Seven Bridges Genomics Inc. Systems and methods for using paired-end data in directed acyclic structure
US10540783B2 (en) 2013-11-01 2020-01-21 Illumina, Inc. Image analysis useful for patterned objects
JP6596001B2 (ja) * 2013-12-24 2019-10-23 ティシュヴィジョン、インコーポレーテッド 多焦点多光子イメージングシステム及び方法
WO2015103225A1 (en) 2013-12-31 2015-07-09 Illumina, Inc. Addressable flow cell using patterned electrodes
CN106068330B (zh) 2014-01-10 2020-12-29 七桥基因公司 将已知等位基因用于读数映射中的系统和方法
US9817944B2 (en) 2014-02-11 2017-11-14 Seven Bridges Genomics Inc. Systems and methods for analyzing sequence data
US10767219B2 (en) 2014-03-11 2020-09-08 Illumina, Inc. Disposable, integrated microfluidic cartridge and methods of making and using same
KR101476820B1 (ko) * 2014-04-07 2014-12-29 주식회사 썸텍 3ｄ 비디오 현미경 장치
FR3019901B1 (fr) 2014-04-09 2020-10-30 Bio Rad Innovations Marqueur de controle pour la mise en oeuvre de procedes d'analyse sur spots
US11053548B2 (en) 2014-05-12 2021-07-06 Good Start Genetics, Inc. Methods for detecting aneuploidy
WO2015175832A1 (en) 2014-05-16 2015-11-19 Illumina, Inc. Nucleic acid synthesis techniques
CA3127071A1 (en) 2014-05-27 2015-12-03 Alex Aravanis Systems and methods for biochemical analysis including a base instrument and a removable cartridge
GB201409777D0 (en) 2014-06-02 2014-07-16 Illumina Cambridge Ltd Methods of reducing density-dependent GC bias in isothermal amplification
JP6408796B2 (ja) * 2014-06-11 2018-10-17 オリンパス株式会社 レーザ顕微鏡装置
US9261358B2 (en) 2014-07-03 2016-02-16 Align Technology, Inc. Chromatic confocal system
US9439568B2 (en) * 2014-07-03 2016-09-13 Align Technology, Inc. Apparatus and method for measuring surface topography optically
WO2016040446A1 (en) 2014-09-10 2016-03-17 Good Start Genetics, Inc. Methods for selectively suppressing non-target sequences
ES2803079T3 (es) 2014-09-12 2021-01-22 Illumina Inc Métodos para detectar la presencia de subunidades de polímeros usando quimioluminiscencia
CA2999708A1 (en) 2014-09-24 2016-03-31 Good Start Genetics, Inc. Process control for increased robustness of genetic assays
BR112017005038B1 (pt) 2014-10-09 2022-01-25 Illumina, Inc Método e dispositivo para separar líquidos imiscíveis para isolar efetivamente pelo menos um dos líquidos
CN107408043A (zh) 2014-10-14 2017-11-28 七桥基因公司 用于序列流水线中的智能工具的系统和方法
US9897791B2 (en) 2014-10-16 2018-02-20 Illumina, Inc. Optical scanning systems for in situ genetic analysis
JP2017530720A (ja) 2014-10-17 2017-10-19 グッド スタート ジェネティクス， インコーポレイテッド 着床前遺伝子スクリーニングおよび異数性検出
US10000799B2 (en) 2014-11-04 2018-06-19 Boreal Genomics, Inc. Methods of sequencing with linked fragments
TWI569912B (zh) * 2014-12-08 2017-02-11 國立高雄應用科技大學 雷射聚焦光學模組及雷射聚焦方法
EP3271480B8 (en) 2015-01-06 2022-09-28 Molecular Loop Biosciences, Inc. Screening for structural variants
CN104568710B (zh) * 2015-01-22 2017-03-08 福建师范大学 一种高时空分辨光学检测与显微成像方法与装置
JP6622723B2 (ja) * 2015-01-30 2019-12-18 国立研究開発法人科学技術振興機構 多焦点分光計測装置、及び多焦点分光計測装置用光学系
JP6375239B2 (ja) 2015-02-05 2018-08-15 オリンパス株式会社 レーザ顕微鏡装置
WO2016141294A1 (en) 2015-03-05 2016-09-09 Seven Bridges Genomics Inc. Systems and methods for genomic pattern analysis
EP3268715B1 (en) 2015-03-11 2024-09-25 TissueVision, Inc. System and methods for serial staining and imaging
EP3271073B1 (en) 2015-03-20 2019-06-12 Illumina, Inc. Fluidics cartridge for use in the vertical or substantially vertical position
WO2016154193A1 (en) 2015-03-24 2016-09-29 Illumina, Inc. Methods, carrier assemblies, and systems for imaging samples for biological or chemical analysis
US10275567B2 (en) 2015-05-22 2019-04-30 Seven Bridges Genomics Inc. Systems and methods for haplotyping
US10214772B2 (en) 2015-06-22 2019-02-26 Fluxergy, Llc Test card for assay and method of manufacturing same
WO2016209734A1 (en) 2015-06-22 2016-12-29 Fluxergy, Llc Device for analyzing a fluid sample and use of test card with same
WO2016209735A1 (en) 2015-06-22 2016-12-29 Fluxergy, Llc Camera imaging system for a fluid sample assay and method of using same
ES2925724T3 (es) * 2015-06-22 2022-10-19 Fluxergy Llc Sistema de obtención de imágenes de cámara para un ensayo de muestra de fluido y método para usar el mismo
WO2017007757A1 (en) 2015-07-06 2017-01-12 Illumina, Inc. Balanced ac modulation for driving droplet operations electrodes
WO2017011660A1 (en) 2015-07-14 2017-01-19 Personal Genome Diagnostics, Inc. Neoantigen analysis
CN108350500A (zh) 2015-07-29 2018-07-31 普罗格尼迪公司 用于检测染色体异常的核酸和方法
JP6712606B2 (ja) 2015-07-30 2020-06-24 イラミーナ インコーポレーテッド ヌクレオチドのオルトゴナルな脱ブロッキング
US10793895B2 (en) 2015-08-24 2020-10-06 Seven Bridges Genomics Inc. Systems and methods for epigenetic analysis
US10724110B2 (en) 2015-09-01 2020-07-28 Seven Bridges Genomics Inc. Systems and methods for analyzing viral nucleic acids
US10584380B2 (en) 2015-09-01 2020-03-10 Seven Bridges Genomics Inc. Systems and methods for mitochondrial analysis
CN106541132B (zh) * 2015-09-18 2018-09-25 广东汉邦激光科技有限公司 激光3d打印机及其调焦系统及方法
DE102015116598B4 (de) 2015-09-30 2024-10-24 Carl Zeiss Microscopy Gmbh Verfahren und Mikroskop zur hochauflösenden Abbildung mittels SIM
US10577643B2 (en) 2015-10-07 2020-03-03 Illumina, Inc. Off-target capture reduction in sequencing techniques
US20180300449A1 (en) 2015-10-10 2018-10-18 Guardant Health, Inc. Methods and applications of gene fusion detection in cell-free dna analysis
US11347704B2 (en) 2015-10-16 2022-05-31 Seven Bridges Genomics Inc. Biological graph or sequence serialization
CA3005101A1 (en) 2015-11-16 2017-05-26 Progenity, Inc. Nucleic acids and methods for detecting methylation status
US10377538B2 (en) 2015-12-01 2019-08-13 Illumina, Inc. Liquid storage and delivery mechanisms and methods
CN108473927B (zh) 2015-12-01 2021-10-22 亿明达股份有限公司 用于单细胞分离和分析物表征的数字微流体系统
CN117174167A (zh) 2015-12-17 2023-12-05 夸登特健康公司 通过分析无细胞dna确定肿瘤基因拷贝数的方法
US20170199960A1 (en) 2016-01-07 2017-07-13 Seven Bridges Genomics Inc. Systems and methods for adaptive local alignment for graph genomes
US10364468B2 (en) 2016-01-13 2019-07-30 Seven Bridges Genomics Inc. Systems and methods for analyzing circulating tumor DNA
US10460829B2 (en) 2016-01-26 2019-10-29 Seven Bridges Genomics Inc. Systems and methods for encoding genetic variation for a population
US10262102B2 (en) 2016-02-24 2019-04-16 Seven Bridges Genomics Inc. Systems and methods for genotyping with graph reference
WO2017168332A1 (en) 2016-03-28 2017-10-05 Boreal Genomics, Inc. Linked duplex target capture
EP3831484B1 (en) 2016-03-28 2024-05-01 Illumina, Inc. Multi-plane microarrays
US10961573B2 (en) 2016-03-28 2021-03-30 Boreal Genomics, Inc. Linked duplex target capture
ES2786974T3 (es) 2016-04-07 2020-10-14 Illumina Inc Métodos y sistemas para la construcción de bibliotecas de ácidos nucleicos normalizadas
CN108885260B (zh) * 2016-04-08 2022-06-03 苹果公司 具有单轴扫描的渡越时间探测器
EP3974815A1 (en) * 2016-05-27 2022-03-30 Verily Life Sciences LLC Systems and methods for 4-d hyperspectrial imaging
CN109477956B (zh) * 2016-05-30 2022-01-14 纽约市哥伦比亚大学理事会 使用扫掠、共焦对准的平面激发的三维成像
US11250931B2 (en) 2016-09-01 2022-02-15 Seven Bridges Genomics Inc. Systems and methods for detecting recombination
MX2019003344A (es) 2016-09-22 2019-09-04 Illumina Inc Deteccion de variacion de numero de copias somaticas.
WO2018064116A1 (en) 2016-09-28 2018-04-05 Illumina, Inc. Methods and systems for data compression
US10955652B2 (en) 2016-09-30 2021-03-23 The Trustees Of Columbia University In The City Of New York Three-dimensional imaging using swept, confocally aligned planar excitation with a Powell lens and/or deliberate misalignment
DE102016119268B3 (de) * 2016-10-10 2017-12-21 Leica Microsystems Cms Gmbh Schiefebenenmikroskop
EP4439045A2 (en) 2016-10-14 2024-10-02 Illumina, Inc. Cartridge assembly
CA3042434A1 (en) 2016-11-15 2018-05-24 Personal Genome Diagnostics Inc. Non-unique barcodes in a genotyping assay
JP7197477B2 (ja) 2016-11-18 2022-12-27 ティシュヴィジョン、インコーポレーテッド 自動化された組織切片の捕捉、指標付けおよび保管システム
KR101936120B1 (ko) * 2016-11-30 2019-01-08 부경대학교 산학협력단 광음향 단층촬영을 위한 프로브 및 실시간 광음향 단층촬영 장치
EP3551769A4 (en) 2016-12-09 2020-10-28 Boreal Genomics, Inc. LINKED LIGATURE
GB201704771D0 (en) * 2017-01-05 2017-05-10 Illumina Inc Modular optical analytic systems and methods
TWI773721B (zh) * 2017-01-20 2022-08-11 日商東京威力科創股份有限公司 異物檢測裝置、異物檢測方法及記憶媒體
CA3037799A1 (en) * 2017-01-26 2018-08-02 Azure Biosystems, Inc. Devices and methods for imaging biomolecules
US11896944B2 (en) 2017-02-01 2024-02-13 Illumina, Inc. System and method with fiducials responding to multiple excitation frequencies
GB201701689D0 (en) 2017-02-01 2017-03-15 Illumia Inc System and method with fiducials of non-closed shapes
GB201701688D0 (en) * 2017-02-01 2017-03-15 Illumia Inc System and method with fiducials in non-recliner layouts
GB201701686D0 (en) 2017-02-01 2017-03-15 Illunina Inc System & method with fiducials having offset layouts
GB201701691D0 (en) 2017-02-01 2017-03-15 Illumina Inc System and method with reflective fiducials
EP4462437A2 (en) 2017-03-30 2024-11-13 Illumina, Inc. Genomic data analysis system and method
US10737267B2 (en) 2017-04-04 2020-08-11 Omniome, Inc. Fluidic apparatus and methods useful for chemical and biological reactions
US10161003B2 (en) 2017-04-25 2018-12-25 Omniome, Inc. Methods and apparatus that increase sequencing-by-binding efficiency
SG11202000964UA (en) 2017-08-15 2020-02-27 Omniome Inc Scanning apparatus and methods useful for detection of chemical and biological analytes
IL313470A (en) 2017-11-06 2024-08-01 Illumina Inc A method for developing nucleic acids
CN111065521B (zh) 2017-11-14 2021-09-10 伊鲁米纳公司 液滴分配
KR102402002B1 (ko) 2017-11-16 2022-05-25 일루미나, 인코포레이티드 미세부수체 불안정성을 결정하기 위한 시스템 및 방법
AU2018375785A1 (en) 2017-11-30 2019-12-12 Illumina, Inc. Validation methods and systems for sequence variant calls
EP3717520A4 (en) 2017-12-01 2021-08-18 Personal Genome Diagnostics Inc. PROCESS FOR DETECTING MICROSATELLITE INSTABILITY
CN108519329B (zh) * 2018-03-26 2021-01-15 华中科技大学 一种多路扫描与探测的线共聚焦成像装置
WO2019203986A1 (en) 2018-04-19 2019-10-24 Omniome, Inc. Improving accuracy of base calls in nucleic acid sequencing methods
EP3784800B1 (en) 2018-04-26 2023-05-03 Pacific Biosciences of California, Inc. Methods and compositions for stabilizing nucleic acid-nucleotide-polymerase complexes
EP3802874A1 (en) 2018-05-31 2021-04-14 Omniome, Inc. Increased signal to noise in nucleic acid sequencing
US10753734B2 (en) 2018-06-08 2020-08-25 Dentsply Sirona Inc. Device, method and system for generating dynamic projection patterns in a confocal camera
NL2021377B1 (en) 2018-07-03 2020-01-08 Illumina Inc Interposer with first and second adhesive layers
AU2019312152A1 (en) 2018-07-24 2021-02-18 Pacific Biosciences Of California, Inc. Serial formation of ternary complex species
WO2020039261A1 (en) 2018-08-23 2020-02-27 Boreal Genomics, Inc. Linked target capture and ligation
US12032147B2 (en) 2018-10-01 2024-07-09 Hewlett-Packard Development Company, L.P. Microscopy systems
CN113166805B (zh) 2018-12-04 2024-07-16 加利福尼亚太平洋生物科学股份有限公司 用于核酸测序和其他分析测定的混合相流体
EP3894598B1 (en) 2018-12-14 2024-01-03 Illumina Cambridge Limited Decreasing phasing with unlabeled nucleotides during sequencing
WO2020126593A1 (en) 2018-12-17 2020-06-25 Illumina Cambridge Limited Compositions for use in polyunucleotide sequencing
KR20210104555A (ko) 2018-12-17 2021-08-25 일루미나 케임브리지 리미티드 서열분석을 위한 프라이머 올리고뉴클레오타이드
US11041199B2 (en) 2018-12-20 2021-06-22 Omniome, Inc. Temperature control for analysis of nucleic acids and other analytes
US11473136B2 (en) 2019-01-03 2022-10-18 Ncan Genomics, Inc. Linked target capture
WO2020146741A1 (en) 2019-01-10 2020-07-16 Selim Olcum Calibration of a functional biomarker instrument
US11499189B2 (en) 2019-02-14 2022-11-15 Pacific Biosciences Of California, Inc. Mitigating adverse impacts of detection systems on nucleic acids and other biological analytes
EP3927467A4 (en) 2019-02-20 2022-12-14 Pacific Biosciences of California, Inc. SCANNING APPARATUS AND METHODS FOR DETECTING CHEMICAL OR BIOLOGICAL ANALYTES
WO2020205296A1 (en) 2019-03-21 2020-10-08 Illumina, Inc. Artificial intelligence-based generation of sequencing metadata
US11210554B2 (en) 2019-03-21 2021-12-28 Illumina, Inc. Artificial intelligence-based generation of sequencing metadata
NL2023316B1 (en) 2019-03-21 2020-09-28 Illumina Inc Artificial intelligence-based sequencing
NL2023310B1 (en) 2019-03-21 2020-09-28 Illumina Inc Training data generation for artificial intelligence-based sequencing
NL2023312B1 (en) 2019-03-21 2020-09-28 Illumina Inc Artificial intelligence-based base calling
NL2023311B9 (en) 2019-03-21 2021-03-12 Illumina Inc Artificial intelligence-based generation of sequencing metadata
NL2023314B1 (en) 2019-03-21 2020-09-28 Illumina Inc Artificial intelligence-based quality scoring
WO2020206170A1 (en) 2019-04-02 2020-10-08 Progenity, Inc. Methods, systems, and compositions for counting nucleic acid molecules
WO2020223713A1 (en) * 2019-05-02 2020-11-05 Duke University Devices and methods for imaging microarray chips
US11644406B2 (en) 2019-06-11 2023-05-09 Pacific Biosciences Of California, Inc. Calibrated focus sensing
KR20220024561A (ko) * 2019-06-19 2022-03-03 라이프 테크놀로지스 홀딩스 프리베이트 리미티드 생물학적 분석 디바이스 및 시스템
DE102019004870B4 (de) * 2019-07-11 2023-03-09 Particle Metrix Gmbh Vorrichtung und Verfahren zur Reduzierung der Intensitätsminderung des Fluoreszenzfarbstoffes durch Laserlicht bei der Bestimmung der Fluoreszenz und der Anzahl von Antikörpern auf Exosomen.
US10656368B1 (en) 2019-07-24 2020-05-19 Omniome, Inc. Method and system for biological imaging using a wide field objective lens
TW202124406A (zh) 2019-09-10 2021-07-01 美商歐姆尼歐美公司 核苷酸之可逆修飾
WO2021076152A1 (en) 2019-10-18 2021-04-22 Omniome, Inc. Methods and compositions for capping nucleic acids
AU2020418180A1 (en) * 2019-12-31 2022-01-06 Illumina, Inc. Autofocus functionality in optical sample analysis
CN115698282A (zh) 2020-01-13 2023-02-03 福路伦特生物科学公司 单细胞测序
EP4100161B1 (en) 2020-02-04 2024-07-10 Pacific Biosciences of California, Inc. Flow cells and methods for their use
US20210265018A1 (en) 2020-02-20 2021-08-26 Illumina, Inc. Knowledge Distillation and Gradient Pruning-Based Compression of Artificial Intelligence-Based Base Caller
CA3173798A1 (en) 2020-03-03 2021-09-10 Pacific Biosciences Of California, Inc. Methods and compositions for sequencing double stranded nucleic acids
CA3175931A1 (en) 2020-03-16 2021-09-23 Fluent Biosciences Inc. Multi-omic analysis in monodisperse droplets
US11188778B1 (en) 2020-05-05 2021-11-30 Illumina, Inc. Equalization-based image processing and spatial crosstalk attenuator
US20230183798A1 (en) 2020-05-05 2023-06-15 Pacific Biosciences Of California, Inc. Compositions and methods for modifying polymerase-nucleic acid complexes
US20230203592A1 (en) 2020-05-05 2023-06-29 Akershus Universitetssykehus Hf Compositions and methods for characterizing bowel cancer
CA3174298A1 (en) 2020-05-08 2021-11-11 Sven BILKE Genome sequencing and detection techniques
WO2021252800A1 (en) 2020-06-11 2021-12-16 Nautilus Biotechnology, Inc. Methods and systems for computational decoding of biological, chemical, and physical entities
WO2021262285A1 (en) 2020-06-26 2021-12-30 Becton, Dickinson And Company Dual excitation beams for irradiating a sample in a flow stream and methods for using same
WO2022029495A1 (en) 2020-08-06 2022-02-10 Agendia NV Systems and methods of scoring risk and residual disease from passenger mutations
WO2022029484A1 (en) 2020-08-06 2022-02-10 Agendia NV Methods of assessing breast cancer using circulating hormone receptor transcripts
WO2022029489A1 (en) 2020-08-06 2022-02-10 Agendia NV Systems and methods of using cell-free nucleic acids to tailor cancer treatment
US20220042108A1 (en) 2020-08-06 2022-02-10 Agendia NV Systems and methods of assessing breast cancer
JP7431699B2 (ja) 2020-08-20 2024-02-15 株式会社東芝 光検出器、光検出システム、ライダー装置、及び車
JP2023541449A (ja) 2020-09-14 2023-10-02 シンギュラー・ゲノミクス・システムズ・インコーポレイテッド 多次元撮像のための方法およびシステム
JP2023549350A (ja) 2020-11-11 2023-11-24 ノーティラス・サブシディアリー・インコーポレイテッド 向上した結合及び検出特徴を有する親和性試薬
AU2021391422A1 (en) 2020-12-02 2022-11-03 Illumina Software, Inc. System and method for detection of genetic alterations
WO2022120595A1 (zh) * 2020-12-08 2022-06-16 深圳华大智造科技股份有限公司 超分辨检测系统及超分辨检测方法
EP4264231A4 (en) 2020-12-16 2024-11-13 Singular Genomics Systems Inc KINEMATIC IMAGING SYSTEM
WO2022140291A1 (en) 2020-12-21 2022-06-30 Singular Genomics Systems, Inc. Systems and methods for multicolor imaging
JP7515422B2 (ja) 2021-01-14 2024-07-12 株式会社東芝 光検出器、光検出システム、ライダー装置、及び移動体
WO2022159663A1 (en) 2021-01-21 2022-07-28 Nautilus Biotechnology, Inc. Systems and methods for biomolecule preparation
US11505796B2 (en) 2021-03-11 2022-11-22 Nautilus Biotechnology, Inc. Systems and methods for biomolecule retention
KR20230165273A (ko) 2021-03-31 2023-12-05 일루미나 케임브리지 리미티드 어댑터 이량체 검출을 갖는 핵산 라이브러리 서열분석 기술
KR20240004473A (ko) 2021-04-29 2024-01-11 일루미나, 인코포레이티드 핵산 특성화를 위한 증폭 기법
WO2022240766A1 (en) 2021-05-10 2022-11-17 Pacific Biosciences Of California, Inc. Dna amplification buffer replenishment during rolling circle amplification
US20220356519A1 (en) 2021-05-10 2022-11-10 Pacific Biosciences Of California, Inc. Single-molecule seeding and amplification on a surface
US20220403450A1 (en) 2021-06-03 2022-12-22 Illumina Software, Inc. Systems and methods for sequencing nucleotides using two optical channels
EP4359129A1 (en) 2021-06-25 2024-05-01 Illumina, Inc. Linear fourier fiducial
US20220414853A1 (en) 2021-06-25 2022-12-29 Illumina, Inc. Fiducials for use in registration of a patterned surface
EP4374343A1 (en) 2021-07-19 2024-05-29 Illumina, Inc. Intensity extraction with interpolation and adaptation for base calling
US11455487B1 (en) 2021-10-26 2022-09-27 Illumina Software, Inc. Intensity extraction and crosstalk attenuation using interpolation and adaptation for base calling
EP4373968A1 (en) * 2021-07-21 2024-05-29 Element Biosciences, Inc. Optical systems for nucleic acid sequencing and methods thereof
CN113780521B (zh) * 2021-08-24 2022-03-04 中国人民解放军93114部队 一种基于深度学习的辐射源个体识别方法
EP4396376A1 (en) 2021-09-01 2024-07-10 Illumina, Inc. Amplitude modulation for accelerated base calling
WO2023038859A1 (en) 2021-09-09 2023-03-16 Nautilus Biotechnology, Inc. Characterization and localization of protein modifications
US20230088338A1 (en) 2021-09-10 2023-03-23 Illumina, Inc. Sequencer focus quality metrics and focus tracking for periodically patterned surfaces
AU2022352593A1 (en) 2021-09-22 2024-02-15 Nautilus Subsidiary, Inc. Methods and systems for determining polypeptide interactions
WO2023049212A2 (en) 2021-09-22 2023-03-30 Illumina, Inc. State-based base calling
US20230096386A1 (en) 2021-09-30 2023-03-30 Illumina Cambridge Limited Polynucleotide sequencing
EP4416731A1 (en) 2021-10-11 2024-08-21 Nautilus Subsidiary, Inc. Highly multiplexable analysis of proteins and proteomes
CN114035199B (zh) * 2021-10-15 2024-04-12 中国人民解放军91977部队 一种基于雪崩二极管成像器件的光电搜索跟踪装置
US20230149883A1 (en) 2021-11-03 2023-05-18 Nautilus Biotechnology, Inc. Systems and methods for surface structuring
WO2023081485A1 (en) 2021-11-08 2023-05-11 Pacific Biosciences Of California, Inc. Stepwise sequencing of a polynucleotide with a homogenous reaction mixture
WO2023107622A1 (en) 2021-12-10 2023-06-15 Illumina, Inc. Parallel sample and index sequencing
KR102645654B1 (ko) * 2021-12-22 2024-03-13 (주)얼라인드제네틱스 고효율 다중 스펙트럼 검출을 위한 라인 공초점 세포 계수기
WO2023122363A1 (en) 2021-12-23 2023-06-29 Illumina Software, Inc. Dynamic graphical status summaries for nucelotide sequencing
US20230215515A1 (en) 2021-12-23 2023-07-06 Illumina Software, Inc. Facilitating secure execution of external workflows for genomic sequencing diagnostics
WO2023129764A1 (en) 2021-12-29 2023-07-06 Illumina Software, Inc. Automatically switching variant analysis model versions for genomic analysis applications
WO2023158809A1 (en) 2022-02-17 2023-08-24 Illumina, Inc. Ai-driven enhancement of motion blurred sequencing images
US20230296516A1 (en) 2022-02-17 2023-09-21 Illumina, Inc. Ai-driven signal enhancement of sequencing images
US11639499B1 (en) 2022-03-08 2023-05-02 Watchmaker Genomics, Inc. Reverse transcriptase variants
WO2023175029A1 (en) 2022-03-15 2023-09-21 Illumina, Inc. Concurrent sequencing of hetero n-mer polynucleotides
WO2023183937A1 (en) 2022-03-25 2023-09-28 Illumina, Inc. Sequence-to-sequence base calling
WO2023192917A1 (en) 2022-03-29 2023-10-05 Nautilus Subsidiary, Inc. Integrated arrays for single-analyte processes
US20240287583A1 (en) 2022-04-08 2024-08-29 Illumina, Inc. Aptamer dynamic range compression and detection techniques
US20230360732A1 (en) 2022-04-25 2023-11-09 Nautilus Subsidiary, Inc. Systems and methods for assessing and improving the quality of multiplex molecular assays
WO2023239917A1 (en) 2022-06-09 2023-12-14 Illumina, Inc. Dependence of base calling on flow cell tilt
WO2023250364A1 (en) 2022-06-21 2023-12-28 Nautilus Subsidiary, Inc. Method for detecting analytes at sites of optically non-resolvable distances
WO2024025806A1 (en) 2022-07-27 2024-02-01 Illumina, Inc. Motion feedback using patterned flowcells
WO2024059655A1 (en) 2022-09-15 2024-03-21 Nautilus Subsidiary, Inc. Characterizing accessibility of macromolecule structures
WO2024072799A1 (en) 2022-09-26 2024-04-04 Illumina, Inc. Flow cell based motion system calibration and control methods
US20240118203A1 (en) 2022-09-28 2024-04-11 Illumina, Inc. Method for reducing vibration using segmented acceleration
WO2024073599A1 (en) 2022-09-29 2024-04-04 Nautilus Subsidiary, Inc. Preparation of array surfaces for single-analyte processes
WO2024124073A1 (en) 2022-12-09 2024-06-13 Nautilus Subsidiary, Inc. A method comprising performing on a single-analyte array at least 50 cycles of a process
WO2024130000A1 (en) 2022-12-15 2024-06-20 Nautilus Subsidiary, Inc. Inhibition of photon phenomena on single molecule arrays
US20240241110A1 (en) 2023-01-12 2024-07-18 Nautilus Subsidiary, Inc. Characterization of glycans and glycoconjugates
US20240257320A1 (en) 2023-01-27 2024-08-01 Illumina, Inc. Jitter correction image analysis
WO2024173265A1 (en) 2023-02-13 2024-08-22 Guardant Health, Inc. Characterization of whole genome duplication in a genomic cohort of over 14000 cell free dna samples
WO2024191806A1 (en) 2023-03-10 2024-09-19 Illumina, Inc. Aptamer detection techniques
US20240344116A1 (en) 2023-03-24 2024-10-17 Nautilus Subsidiary, Inc. Transfer of nanoparticles to array surfaces
DE102023108014A1 (de) 2023-03-29 2024-10-02 Technische Hochschule Rosenheim, Körperschaft des öffentlichen Rechts Inspektionsvorrichtung und Verfahren zur optischen Erfassung von Eigenschaften eines auf einer Fördereinrichtung in eine Transportrichtung transportierten Objektes mittels Fluoreszenzanregung
WO2024220594A1 (en) 2023-04-17 2024-10-24 Personal Genome Diagnostics, Inc. Cancer detection through integrated analysis of whole genome sequencing

Family Cites Families (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4204230A (en) 1978-10-25 1980-05-20 Xerox Corporation High resolution input scanner using a two dimensional detector array
US4382267A (en) 1981-09-24 1983-05-03 Rca Corporation Digital control of number of effective rows of two-dimensional charge-transfer imager array
US4700298A (en) 1984-09-14 1987-10-13 Branko Palcic Dynamic microscope image processing scanner
US4826299A (en) 1987-01-30 1989-05-02 Canadian Patents And Development Limited Linear deiverging lens
US4845552A (en) 1987-08-20 1989-07-04 Bruno Jaggi Quantitative light microscope using a solid state detector in the primary image plane
US4877326A (en) 1988-02-19 1989-10-31 Kla Instruments Corporation Method and apparatus for optical inspection of substrates
GB8822228D0 (en) 1988-09-21 1988-10-26 Southern E M Support-bound oligonucleotides
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
DE3924454A1 (de) 1989-07-24 1991-02-07 Cornelis P Prof Dr Hollenberg Die anwendung von dna und dna-technologie fuer die konstruktion von netzwerken zur verwendung in der chip-konstruktion und chip-produktion (dna chips)
US5252743A (en) 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
US5159199A (en) 1991-08-12 1992-10-27 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Integrated filter and detector array for spectral imaging
ATE148889T1 (de) 1991-09-18 1997-02-15 Affymax Tech Nv Verfahren zur synthese der verschiedenen sammlungen von oligomeren
JP3939338B2 (ja) 1991-11-22 2007-07-04 アフィメトリックス， インコーポレイテッド ポリマー合成に対する組合わせの戦略
US5324633A (en) 1991-11-22 1994-06-28 Affymax Technologies N.V. Method and apparatus for measuring binding affinity
US5173748A (en) 1991-12-05 1992-12-22 Eastman Kodak Company Scanning multichannel spectrometry using a charge-coupled device (CCD) in time-delay integration (TDI) mode
AU3728093A (en) 1992-02-19 1993-09-13 Public Health Research Institute Of The City Of New York, Inc., The Novel oligonucleotide arrays and their use for sorting, isolating, sequencing, and manipulating nucleic acids
US5583211A (en) 1992-10-29 1996-12-10 Beckman Instruments, Inc. Surface activated organic polymers useful for location - specific attachment of nucleic acids, peptides, proteins and oligosaccharides
US5491074A (en) 1993-04-01 1996-02-13 Affymax Technologies Nv Association peptides
US5858659A (en) 1995-11-29 1999-01-12 Affymetrix, Inc. Polymorphism detection
US5472672A (en) 1993-10-22 1995-12-05 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and method for polymer synthesis using arrays
US5429807A (en) 1993-10-28 1995-07-04 Beckman Instruments, Inc. Method and apparatus for creating biopolymer arrays on a solid support surface
US6309601B1 (en) 1993-11-01 2001-10-30 Nanogen, Inc. Scanning optical detection system
US6090555A (en) 1997-12-11 2000-07-18 Affymetrix, Inc. Scanned image alignment systems and methods
US6741344B1 (en) 1994-02-10 2004-05-25 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
US5578832A (en) 1994-09-02 1996-11-26 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
DE69503126T2 (de) 1994-05-05 1998-11-12 Beckman Instruments Inc Repetitive oligonukleotide matrix
US5782770A (en) 1994-05-12 1998-07-21 Science Applications International Corporation Hyperspectral imaging methods and apparatus for non-invasive diagnosis of tissue for cancer
US5571639A (en) 1994-05-24 1996-11-05 Affymax Technologies N.V. Computer-aided engineering system for design of sequence arrays and lithographic masks
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US5795716A (en) 1994-10-21 1998-08-18 Chee; Mark S. Computer-aided visualization and analysis system for sequence evaluation
EP0746865B1 (en) 1994-12-08 2003-03-26 Molecular Dynamics, Inc. Fluorescence imaging system employing a macro scanning objective
US5599695A (en) 1995-02-27 1997-02-04 Affymetrix, Inc. Printing molecular library arrays using deprotection agents solely in the vapor phase
US5624711A (en) 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
US5578818A (en) 1995-05-10 1996-11-26 Molecular Dynamics LED point scanning system
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
US5528050A (en) 1995-07-24 1996-06-18 Molecular Dynamics, Inc. Compact scan head with multiple scanning modalities
US5968740A (en) 1995-07-24 1999-10-19 Affymetrix, Inc. Method of Identifying a Base in a Nucleic Acid
US5585639A (en) 1995-07-27 1996-12-17 Hewlett-Packard Company Optical scanning apparatus
US5658734A (en) 1995-10-17 1997-08-19 International Business Machines Corporation Process for synthesizing chemical compounds
US5629808A (en) 1995-12-15 1997-05-13 National Research Council Of Canada D-shape laser beam projector
US6022963A (en) 1995-12-15 2000-02-08 Affymetrix, Inc. Synthesis of oligonucleotide arrays using photocleavable protecting groups
GB9526183D0 (en) * 1995-12-21 1996-02-21 Stc Submarine Systems Ltd Dispersion slope equalisaion for wdm systems wih branches
US5847400A (en) 1996-02-01 1998-12-08 Molecular Dynamics, Inc. Fluorescence imaging system having reduced background fluorescence
US7244622B2 (en) * 1996-04-03 2007-07-17 Applera Corporation Device and method for multiple analyte detection
EP0902885A4 (en) 1996-05-16 2006-09-27 Affymetrix Inc SYSTEMS AND METHODS FOR DETECTION OF BRANDED PRODUCTS
US5754291A (en) 1996-09-19 1998-05-19 Molecular Dynamics, Inc. Micro-imaging system
DE69720041T2 (de) 1996-11-14 2004-01-08 Affymetrix, Inc., Santa Clara Chemische amplifizierung zur synthese von musterordnungen
US6297006B1 (en) 1997-01-16 2001-10-02 Hyseq, Inc. Methods for sequencing repetitive sequences and for determining the order of sequence subfragments
JP3438855B2 (ja) 1997-01-23 2003-08-18 横河電機株式会社 共焦点装置
US5837475A (en) 1997-01-30 1998-11-17 Hewlett-Packard Co. Apparatus and method for scanning a chemical array
DE19707227A1 (de) 1997-02-24 1998-08-27 Bodenseewerk Perkin Elmer Co Lichtabtastvorrichtung
US6327410B1 (en) 1997-03-14 2001-12-04 The Trustees Of Tufts College Target analyte sensors utilizing Microspheres
US6023540A (en) 1997-03-14 2000-02-08 Trustees Of Tufts College Fiber optic sensor with encoded microspheres
US6008892A (en) 1997-05-23 1999-12-28 Molecular Dynamics, Inc. Optical substrate for enhanced detectability of fluorescence
JP2002508664A (ja) 1997-06-25 2002-03-19 オーキッド・バイオサイエンシーズ・インコーポレイテッド 複数の単一ヌクレオチド多型を単一の反応で検出する方法
US6043506A (en) 1997-08-13 2000-03-28 Bio-Rad Laboratories, Inc. Multi parameter scanner
US6043880A (en) 1997-09-15 2000-03-28 Becton Dickinson And Company Automated optical reader for nucleic acid assays
DE69829402T2 (de) 1997-10-31 2006-04-13 Affymetrix, Inc. (a Delaware Corp.), Santa Clara Expressionsprofile in adulten und fötalen organen
US5998796A (en) 1997-12-22 1999-12-07 Spectrumedix Corporation Detector having a transmission grating beam splitter for multi-wavelength sample analysis
US6087102A (en) 1998-01-07 2000-07-11 Clontech Laboratories, Inc. Polymeric arrays and methods for their use in binding assays
US6428752B1 (en) 1998-05-14 2002-08-06 Affymetrix, Inc. Cleaning deposit devices that form microarrays and the like
US6287776B1 (en) 1998-02-02 2001-09-11 Signature Bioscience, Inc. Method for detecting and classifying nucleic acid hybridization
WO1999039817A1 (en) 1998-02-06 1999-08-12 Affymetrix, Inc. Method of quality control in manufacturing processes
JP3944996B2 (ja) 1998-03-05 2007-07-18 株式会社日立製作所 Ｄｎａプローブアレー
US6388788B1 (en) 1998-03-16 2002-05-14 Praelux, Inc. Method and apparatus for screening chemical compounds
KR100618502B1 (ko) * 1998-03-16 2006-09-01 지이 헬스케어 바이오-사이언시즈 코프. 공초점 마이크로스코피 영상 시스템에서 사용하기 위한 전자기 방출의 집속 시스템 및 방법
WO1999047041A1 (en) * 1998-03-19 1999-09-23 Board Of Regents, The University Of Texas System Fiber-optic confocal imaging apparatus and methods of use
US6031078A (en) 1998-06-16 2000-02-29 Millennium Pharmaceuticals, Inc. MTbx protein and nucleic acid molecules and uses therefor
US6160618A (en) 1998-06-19 2000-12-12 Board Of Regents, The University Of Texas System Hyperspectral slide reader
US6678048B1 (en) 1998-07-20 2004-01-13 Sandia Corporation Information-efficient spectral imaging sensor with TDI
US6245507B1 (en) 1998-08-18 2001-06-12 Orchid Biosciences, Inc. In-line complete hyperspectral fluorescent imaging of nucleic acid molecules
AU749690B2 (en) * 1998-08-21 2002-07-04 Surromed, Inc. Novel optical architectures for microvolume laser-scanning cytometers
US6277628B1 (en) 1998-10-02 2001-08-21 Incyte Genomics, Inc. Linear microarrays
AT410718B (de) 1998-10-28 2003-07-25 Schindler Hansgeorg Dr Vorrichtung zur visualisierung von molekülen
US6545264B1 (en) 1998-10-30 2003-04-08 Affymetrix, Inc. Systems and methods for high performance scanning
US6134002A (en) 1999-01-14 2000-10-17 Duke University Apparatus and method for the rapid spectral resolution of confocal images
US6355934B1 (en) 1999-02-26 2002-03-12 Packard Biochip Technologies Imaging system for an optical scanner
US20030215821A1 (en) 1999-04-20 2003-11-20 Kevin Gunderson Detection of nucleic acid reactions on bead arrays
US20030108867A1 (en) 1999-04-20 2003-06-12 Chee Mark S Nucleic acid sequencing using microsphere arrays
US6355431B1 (en) 1999-04-20 2002-03-12 Illumina, Inc. Detection of nucleic acid amplification reactions using bead arrays
WO2000063437A2 (en) 1999-04-20 2000-10-26 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US6371370B2 (en) 1999-05-24 2002-04-16 Agilent Technologies, Inc. Apparatus and method for scanning a surface
US6222664B1 (en) 1999-07-22 2001-04-24 Agilent Technologies Inc. Background reduction apparatus and method for confocal fluorescence detection systems
WO2001037025A1 (en) 1999-11-16 2001-05-25 Agilent Technologies, Inc. Confocal imaging
US7611869B2 (en) 2000-02-07 2009-11-03 Illumina, Inc. Multiplexed methylation detection methods
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US6770441B2 (en) 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
US6687000B1 (en) 2000-06-26 2004-02-03 Wisconsin Alumni Research Foundation Photon-sorting spectroscopic microscope system
US6818907B2 (en) * 2000-10-17 2004-11-16 The President And Fellows Of Harvard College Surface plasmon enhanced illumination system
JP3590765B2 (ja) * 2000-12-21 2004-11-17 Ｓｍｃ株式会社 電磁弁
TW555954B (en) * 2001-02-28 2003-10-01 Olympus Optical Co Confocal microscope, optical height-measurement method, automatic focusing method
GB0106342D0 (en) 2001-03-15 2001-05-02 Renishaw Plc Spectroscopy apparatus and method
US6650411B2 (en) 2001-04-26 2003-11-18 Affymetrix, Inc. System, method, and product for pixel clocking in scanning of biological materials
US7105795B2 (en) * 2001-07-06 2006-09-12 Palantyr Research, Llc Imaging system, methodology, and applications employing reciprocal space optical design
US7248716B2 (en) * 2001-07-06 2007-07-24 Palantyr Research, Llc Imaging system, methodology, and applications employing reciprocal space optical design
JP2003028798A (ja) * 2001-07-11 2003-01-29 Olympus Optical Co Ltd 蛍光取得装置
US20080099667A1 (en) * 2001-08-14 2008-05-01 President And Fellows Of Harvard College Methods and apparatus for sensing a physical substance
JP3616999B2 (ja) 2001-12-04 2005-02-02 レーザーテック株式会社 コンフォーカル顕微鏡
CN1435684A (zh) * 2002-01-30 2003-08-13 无锡市朗珈生物医学工程有限公司 生物芯片荧光检测扫描装置
US6825930B2 (en) 2002-06-04 2004-11-30 Cambridge Research And Instrumentation, Inc. Multispectral imaging system
US20050227252A1 (en) 2002-08-20 2005-10-13 Moon John A Diffraction grating-based encoded articles for multiplexed experiments
AU2003267192A1 (en) 2002-09-12 2004-04-30 Cyvera Corporation Method and apparatus for aligning elongated microbeads in order to interrogate the same
US6813018B2 (en) 2002-11-07 2004-11-02 The Boeing Company Hyperspectral imager
US20040140417A1 (en) * 2002-12-27 2004-07-22 Accretech (Israel) Ltd. Image sensor for confocal microscopy
US20050181394A1 (en) 2003-06-20 2005-08-18 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
JP4235046B2 (ja) * 2003-07-08 2009-03-04 新日本製鐵株式会社 鋼板表面の検査方法、システム、画像処理装置、及びコンピュータプログラム
US7218446B2 (en) * 2003-08-27 2007-05-15 Biomedical Photometrics Inc. Imaging system having a fine focus
CA2559801A1 (en) 2003-10-01 2005-04-14 Cyvera Corporation Optical reader for diffraction grating-based encoded optical identification elements
WO2005043197A2 (en) * 2003-10-28 2005-05-12 University Of Maryland, Baltimore Spatial light modulator apparatus and method
US7227113B2 (en) * 2003-11-21 2007-06-05 Olympus Corporation Confocal laser scanning microscope
JP4589101B2 (ja) * 2003-12-25 2010-12-01 昭和電工株式会社 表面検査方法および同装置
JP4635145B2 (ja) 2004-03-17 2011-02-16 レーザーテック株式会社 コンフォーカル顕微鏡及び膜厚測定装置
US20050225849A1 (en) * 2004-04-05 2005-10-13 Fujifilm Electronic Imaging Ltd. Slit confocal microscope and method
KR20070034613A (ko) 2004-06-30 2007-03-28 아노토 아베 전자 펜에서의 데이터 처리
US7329860B2 (en) * 2005-11-23 2008-02-12 Illumina, Inc. Confocal imaging methods and apparatus
US7791013B2 (en) * 2006-11-21 2010-09-07 Illumina, Inc. Biological microarray line scanning method and system

Also Published As

Publication number Publication date
US20150069267A1 (en) 2015-03-12
EP2594981A3 (en) 2013-06-19
US20080290263A1 (en) 2008-11-27
US9816929B2 (en) 2017-11-14
US20120168644A1 (en) 2012-07-05
EP1955102A2 (en) 2008-08-13
JP2009517662A (ja) 2009-04-30
US7329860B2 (en) 2008-02-12
US8158926B2 (en) 2012-04-17
CN101361015A (zh) 2009-02-04
CA2632221A1 (en) 2007-05-31
EP1955102B1 (en) 2013-04-24
ES2407968T3 (es) 2013-06-17
US7589315B2 (en) 2009-09-15
EP2594981A2 (en) 2013-05-22
EP2594981B1 (en) 2017-05-10
PL2594981T3 (pl) 2017-10-31
JP5055292B2 (ja) 2012-10-24
US8884211B2 (en) 2014-11-11
US20110204212A1 (en) 2011-08-25
US20070114362A1 (en) 2007-05-24
CN101361015B (zh) 2012-11-21
US20100012825A1 (en) 2010-01-21
CA2632221C (en) 2013-08-27
WO2007062039A2 (en) 2007-05-31
ES2635094T3 (es) 2017-10-02
WO2007062039A3 (en) 2007-07-19
DK2594981T3 (da) 2017-08-21
US7960685B2 (en) 2011-06-14

Similar Documents

Publication Publication Date Title
DK1955102T3 (da) Fremgangsmåde og indretning til konfokal billedbehandling
DE602006009191D1 (de) Bildaufnahmegerät und -verfahren
DK1937137T3 (da) Fremgangsmåde og indretning til optisk billeddannelse via spektral kodning
BRPI0607526A2 (pt) Dispositivo e método para suporte de câmara
DE602006020651D1 (de) Kalibrierverfahren und -vorrichtung
DE602006008682D1 (de) Bildgebungsanordnung und Prüfverfahren
FI20060449A0 (fi) Mammografiamenetelmä ja mammografialaite
DE602006003491D1 (de) Beobachtungsvorrichtung und Beobachtungsverfahren
DK1997291T3 (da) Metode og anordning til sikker godkendelse
DE602006016186D1 (de) Anzeigevorrichtung und Anzeigeverfahren
DE602006020556D1 (de) Bilddecodierungsvorrichtung und bilddecodierungsverfahren
DK2079355T3 (da) Fremgangsmåde og system til brilleordination
DE602006011416D1 (de) Bilderzeugungsvorrichtung
DE602006011600D1 (de) Audiocodierungseinrichtung und audiocodierungsverfahren
DE602006016536D1 (de) Bildaufnahmegerät
DE602006014957D1 (de) Audiocodierungseinrichtung und audiocodierungsverfahren
DK1966594T3 (da) Anordning og fremsgangsmåde til påvisning af mykotoxiner
NL1032239A1 (nl) Sequentieel veldweergave-inrichting en werkwijze daarvoor.
DK2131939T3 (da) Filteranordning og fremgangsmåde
DE602005022691D1 (de) Bilderzeugungsvorrichtung
DK1937332T3 (da) Infusionsapparat og aktuator hertil
EP1744554A4 (en) PICTURE DEVICE AND METHOD
DE602006006130D1 (de) Bildaufnahmevorrichtung
DE602006006244D1 (de) Bildaufzeichnungsgerät und Verfahren
DE602006020989D1 (de) Bildverarbeitungseinrichtung und bildverarbeitungsverfahren