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DK1824775T3 - Debrideringssammensætning baseret på bromelain og fremgangsmåder til fremstilling deraf - Google Patents

Debrideringssammensætning baseret på bromelain og fremgangsmåder til fremstilling deraf

Info

Publication number
DK1824775T3
DK1824775T3 DK05804486.8T DK05804486T DK1824775T3 DK 1824775 T3 DK1824775 T3 DK 1824775T3 DK 05804486 T DK05804486 T DK 05804486T DK 1824775 T3 DK1824775 T3 DK 1824775T3
Authority
DK
Denmark
Prior art keywords
bromelain
preparation
methods
debridement composition
debridement
Prior art date
Application number
DK05804486.8T
Other languages
English (en)
Inventor
Marian Gorecki
Amir Toren
Original Assignee
Mediwound Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mediwound Ltd filed Critical Mediwound Ltd
Application granted granted Critical
Publication of DK1824775T3 publication Critical patent/DK1824775T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4873—Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK05804486.8T 2004-11-22 2005-11-22 Debrideringssammensætning baseret på bromelain og fremgangsmåder til fremstilling deraf DK1824775T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL16533404A IL165334A0 (en) 2004-11-22 2004-11-22 Debriding composition from bromelain and methods of producing same
PCT/IL2005/001236 WO2006054309A2 (en) 2004-11-22 2005-11-22 Debriding composition from bromelain

Publications (1)

Publication Number Publication Date
DK1824775T3 true DK1824775T3 (da) 2012-09-24

Family

ID=36407550

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05804486.8T DK1824775T3 (da) 2004-11-22 2005-11-22 Debrideringssammensætning baseret på bromelain og fremgangsmåder til fremstilling deraf

Country Status (18)

Country Link
US (2) US8119124B2 (da)
EP (1) EP1824775B1 (da)
JP (1) JP5053096B2 (da)
KR (1) KR101235544B1 (da)
CN (1) CN101297033B (da)
AU (1) AU2005305461B2 (da)
BR (1) BRPI0518050A (da)
CA (1) CA2587951C (da)
DK (1) DK1824775T3 (da)
ES (1) ES2389810T3 (da)
HK (1) HK1124639A1 (da)
IL (2) IL165334A0 (da)
MX (1) MX2007006074A (da)
NO (1) NO337096B1 (da)
PL (1) PL1824775T3 (da)
PT (1) PT1824775E (da)
WO (1) WO2006054309A2 (da)
ZA (1) ZA200704821B (da)

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RS62520B1 (sr) * 2010-06-25 2021-11-30 Shire Human Genetic Therapies Metode i kompozicije za isporuku cns iduronata-2-sulfataze
EP2707019B1 (en) 2011-05-12 2016-06-29 Smith & Nephew Orthopaedics AG Wound debridement compositions containing seaprose and methods of wound treatment using same
GB201110783D0 (en) * 2011-06-24 2011-08-10 Aqua Bio Technology Asa Methods and uses
GB201110777D0 (en) * 2011-06-24 2011-08-10 Aqua Bio Technology Asa Methods and uses
RU2625726C2 (ru) 2011-07-20 2017-07-18 Медиваунд Лтд. Экстракт бромелаина с протеолитической активностью для лечения заболеваний соединительных тканей
US10058596B2 (en) * 2011-12-20 2018-08-28 Kci Licensing, Inc. Composition for enzymatic debridement
CN104602700A (zh) 2012-05-11 2015-05-06 史密夫和内修公司 蜂蜜曲霉蛋白酶在用于去除细菌生物膜的用途
CA2890757C (en) * 2012-11-14 2021-10-26 Smith & Nephew, Inc. Stable thermolysin hydrogel
US20160101166A1 (en) 2014-10-10 2016-04-14 Rochal Industries, Llp Compositions and kits for treating pruritus and methods of using the same
LT6177B (lt) 2014-10-10 2015-07-27 Uab "Biocentras" Fermentų kompleksų išskyrimas iš steptomyces gougerotii 101, daugiafermentinių biopreparatų ruošimas bei taikymas
US10238719B2 (en) 2014-10-10 2019-03-26 Rochal Industries, Llc Compositions and kits for enzymatic debridement and methods of using the same
US9592280B2 (en) 2014-10-10 2017-03-14 Rochal Industries Llc Compositions and kits for enzymatic debridement and methods of using the same
CN104857187A (zh) * 2015-04-28 2015-08-26 李正 一种菠萝蛋白酶烧伤组织愈合药物
JP6952353B2 (ja) * 2016-01-31 2021-10-20 メディウーンド リミテッド 創傷を治療するためのデブリードマン組成物
BR112018071405A2 (pt) 2016-04-18 2019-02-05 Mediwound Ltd métodos de debridamento de ferimentos crônicos
CA3031866A1 (en) 2016-07-27 2018-02-01 Smith & Nephew, Inc. Use of thermolysin to reduce or eliminate bacterial biofilms from surfaces
CN107913401A (zh) * 2016-10-08 2018-04-17 江阴市本特塞缪森生命科学研究院有限公司 胰蛋白酶产品及治疗妇科炎症的应用
EP3573622B1 (en) 2017-01-30 2023-10-18 Smith & Nephew, Inc. Synergistic combination of thermolysin and an antibacterial agent to reduce or eliminate bacterial biofilms from surfaces
US10883084B2 (en) 2018-10-05 2021-01-05 Xenotherapeutics, Inc. Personalized cells, tissues, and organs for transplantation from a humanized, bespoke, designated-pathogen free, (non-human) donor and methods and products relating to same
EP3860336A1 (en) 2018-10-05 2021-08-11 Xenotherapeutics, Inc. Xenotransplantation products and methods
BR112021018788A2 (pt) 2019-03-25 2021-11-23 Xenotherapeutics Corp Células, tecidos e órgãos personalizados para transplante de um doador (não humano) humanizado, indivi-dualizado, designado livre de patógenos e métodos e produtos relacionados aos mesmos
EP4164677A4 (en) * 2020-06-16 2024-07-31 Anatara Lifesciences Ltd PROTEASE COMPOSITION
US20230255880A1 (en) * 2022-02-16 2023-08-17 Guild Associates Inc. Immobilized enzyme-based wound debridement

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US4307081A (en) 1974-01-08 1981-12-22 Gerold K. V. Klein Enzyme mixture
US4226854A (en) 1974-01-08 1980-10-07 Gerold K. V. Klein Debridement of devitalized tissue with hydrolytic enzyme product
US4197291A (en) 1974-01-08 1980-04-08 Gerold K. V. Klein Hydrolytic enzyme material
US4329430A (en) * 1979-06-04 1982-05-11 Klein Gerold K V Enzyme mixture
US4320120A (en) 1979-10-22 1982-03-16 Zenyaku Kogyo Kabushiki Kaisha Extracts of Marsdenia cundurango Reichenbach fil
EP0039726A4 (en) 1979-11-05 1982-09-27 Riker Laboratories Inc ENZYMATIC DEBRIDING PROCESS.
US4361551A (en) 1979-11-05 1982-11-30 Riker Laboratories, Inc. Method of enzymatic debridement
US4286064A (en) * 1979-11-05 1981-08-25 Riker Laboratories, Inc. Process for isolating active debriding agent from bromelain
GB8724728D0 (en) 1987-10-22 1987-11-25 Genzyme Corp Cysteine proteinase
CA2046802C (en) 1990-08-15 2007-05-22 Donald Zane Fortney Compositions containing protease produced by vibrio and method of use in debridement and wound healing
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JP3255643B2 (ja) 1991-12-03 2002-02-12 クライン，マーガレット エル． エスカラーゼを含む蛋白質分解混合物およびその分離方法
SG42846A1 (en) * 1992-06-30 1997-10-17 Cortecs Ltd Use of enzymes especially bromelain in the treatment of diarrhoea
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US5858964A (en) 1995-04-14 1999-01-12 Yeda Research And Development Co. Ltd. Pharmaceutical compositions comprising synthetic peptide copolymer for prevention of GVHD
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US20020102253A1 (en) * 1997-02-25 2002-08-01 Mynott Tracey Lehanne Component of bromelain
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GB9819138D0 (en) * 1998-09-02 1998-10-28 Cortecs Uk Ltd Nucleic acids and proteins from pineapple stem
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WO2008021543A2 (en) * 2006-08-17 2008-02-21 Monsanto Technology, Llc Transgenic plants with enhanced agronomic traits
EP2036978A1 (en) * 2007-09-14 2009-03-18 URSAPHARM Arzneimittel GmbH & Co. KG Recombinant preparation of selected bromelain fractions

Also Published As

Publication number Publication date
PT1824775E (pt) 2012-09-19
JP5053096B2 (ja) 2012-10-17
NO337096B1 (no) 2016-01-18
KR20070091285A (ko) 2007-09-10
CN101297033B (zh) 2012-05-30
IL165334A0 (en) 2006-01-15
EP1824775A2 (en) 2007-08-29
PL1824775T3 (pl) 2012-12-31
US20120171187A1 (en) 2012-07-05
EP1824775A4 (en) 2011-01-26
ZA200704821B (en) 2008-11-26
BRPI0518050A (pt) 2008-10-28
KR101235544B1 (ko) 2013-02-21
US20090148429A1 (en) 2009-06-11
IL183184A (en) 2015-09-24
NO20073115L (no) 2007-08-13
MX2007006074A (es) 2007-10-04
EP1824775B1 (en) 2012-06-13
JP2008520651A (ja) 2008-06-19
WO2006054309A3 (en) 2009-04-30
IL183184A0 (en) 2007-09-20
ES2389810T3 (es) 2012-10-31
CA2587951A1 (en) 2006-05-26
US8540983B2 (en) 2013-09-24
HK1124639A1 (en) 2009-07-17
AU2005305461B2 (en) 2011-01-27
US8119124B2 (en) 2012-02-21
AU2005305461A1 (en) 2006-05-26
CA2587951C (en) 2015-03-31
WO2006054309A2 (en) 2006-05-26
CN101297033A (zh) 2008-10-29

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