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DK1670773T3 - Fremgangsmåde til fremstilling af benzoxazol-sulfonamidforbindelser og mellemprodukter deraf - Google Patents

Fremgangsmåde til fremstilling af benzoxazol-sulfonamidforbindelser og mellemprodukter deraf

Info

Publication number
DK1670773T3
DK1670773T3 DK04766869T DK04766869T DK1670773T3 DK 1670773 T3 DK1670773 T3 DK 1670773T3 DK 04766869 T DK04766869 T DK 04766869T DK 04766869 T DK04766869 T DK 04766869T DK 1670773 T3 DK1670773 T3 DK 1670773T3
Authority
DK
Denmark
Prior art keywords
benzoxazole
intermediates
preparation
sulfonamide compounds
sulfonamide
Prior art date
Application number
DK04766869T
Other languages
English (en)
Inventor
Kock Herman Augustinus De
Walter Ferdinand Mari Filliers
Wim Albert Alex Aelterman
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Application granted granted Critical
Publication of DK1670773T3 publication Critical patent/DK1670773T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK04766869T 2003-09-30 2004-09-30 Fremgangsmåde til fremstilling af benzoxazol-sulfonamidforbindelser og mellemprodukter deraf DK1670773T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03103630 2003-09-30
US50799603P 2003-10-02 2003-10-02
PCT/EP2004/052382 WO2005030739A1 (en) 2003-09-30 2004-09-30 Methods for the preparation of benzoxazole sulfonamide compounds and intermediates thereof

Publications (1)

Publication Number Publication Date
DK1670773T3 true DK1670773T3 (da) 2007-05-29

Family

ID=34395298

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04766869T DK1670773T3 (da) 2003-09-30 2004-09-30 Fremgangsmåde til fremstilling af benzoxazol-sulfonamidforbindelser og mellemprodukter deraf

Country Status (24)

Country Link
US (1) US20070123574A1 (da)
EP (1) EP1670773B1 (da)
JP (1) JP4919802B2 (da)
KR (1) KR101090102B1 (da)
CN (1) CN1860107B (da)
AP (1) AP1985A (da)
AT (1) ATE353323T1 (da)
AU (1) AU2004276017B2 (da)
BR (1) BRPI0414916A (da)
CA (1) CA2537877C (da)
DE (1) DE602004004674T2 (da)
DK (1) DK1670773T3 (da)
EA (1) EA011891B1 (da)
ES (1) ES2281828T3 (da)
IL (1) IL173891A0 (da)
IN (1) IN2012DN02301A (da)
MX (1) MXPA06003575A (da)
NO (1) NO20061951L (da)
NZ (1) NZ546279A (da)
PL (1) PL1670773T3 (da)
PT (1) PT1670773E (da)
SI (1) SI1670773T1 (da)
WO (1) WO2005030739A1 (da)
ZA (1) ZA200602603B (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR053845A1 (es) * 2005-04-15 2007-05-23 Tibotec Pharm Ltd 5-tiazolilmetil[(1s,2r)-3-[[(2-amino-6-benzoxazolil)sulfonil)](2-metilpropil)amino]-2-hidroxi-1-(fenilmetil)propil]carbamato como mejorador de farmacos metabolizados por el citocromo p450
US8575186B2 (en) 2009-10-05 2013-11-05 Albany Molecular Research, Inc. Epiminocycloalkyl[b] indole derivatives as serotonin sub-type 6 (5-HT6) modulators and uses thereof
CA2823955A1 (en) 2011-01-19 2012-07-26 Albany Molecular Research, Inc. Benzofuro[3,2-c] pyridines and related analogs as serotonin sub-type 6 (5-ht6) modulators for the treatment of obesity, metabolic syndrome, cognition and schizophrenia
WO2014194519A1 (en) 2013-06-07 2014-12-11 Merck Sharp & Dohme Corp. Imidazole derivatives and methods of use thereof for improving pharmacokinetics of drug

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5968942A (en) * 1992-08-25 1999-10-19 G. D. Searle & Co. α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
PT815124E (pt) * 1995-03-10 2003-04-30 Searle & Co Inibidores protease retroviral sulfonamida hidroxietilamino aminoacido heterociclocarbonilo
EP0861249A1 (en) * 1995-11-15 1998-09-02 G.D. Searle & Co. Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
CN1366524A (zh) * 2000-04-07 2002-08-28 三星电子株式会社 磺胺衍生物作为基质金属蛋白酶抑制剂
US6455738B1 (en) * 2000-07-13 2002-09-24 Rhodia Chimie Process for the sulfonation of an aromatic compound
SI1370543T1 (sl) * 2001-02-14 2007-04-30 Tibotec Pharm Ltd Sirokospektralni 2-(substituirani-amino)-benzotiazol sulfonamidni inhibitorji HIV proteaze
CZ304524B6 (cs) * 2001-05-11 2014-06-18 Tibotec Pharmaceuticals Ltd. Derivát 2-aminobenzoxazolsulfonamidu, farmaceutická kompozice s jeho obsahem a léčivo pro léčení infekce retroviry
TWI286476B (en) * 2001-12-12 2007-09-11 Tibotec Pharm Ltd Combination of cytochrome P450 dependent protease inhibitors
MY142238A (en) * 2002-03-12 2010-11-15 Tibotec Pharm Ltd Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors

Also Published As

Publication number Publication date
KR101090102B1 (ko) 2011-12-07
WO2005030739A1 (en) 2005-04-07
DE602004004674T2 (de) 2007-11-22
CN1860107A (zh) 2006-11-08
KR20060092224A (ko) 2006-08-22
IL173891A0 (en) 2006-07-05
CN1860107B (zh) 2013-08-21
IN2012DN02301A (da) 2015-08-14
AU2004276017B2 (en) 2010-08-19
PT1670773E (pt) 2007-05-31
EP1670773B1 (en) 2007-02-07
CA2537877C (en) 2015-03-17
SI1670773T1 (sl) 2007-06-30
AP1985A (en) 2009-03-30
ZA200602603B (en) 2008-05-28
ES2281828T3 (es) 2007-10-01
JP2007507468A (ja) 2007-03-29
EA011891B1 (ru) 2009-06-30
JP4919802B2 (ja) 2012-04-18
BRPI0414916A (pt) 2006-11-07
MXPA06003575A (es) 2006-06-05
CA2537877A1 (en) 2005-04-07
US20070123574A1 (en) 2007-05-31
NO20061951L (no) 2006-05-02
DE602004004674D1 (de) 2007-03-22
ATE353323T1 (de) 2007-02-15
PL1670773T3 (pl) 2007-06-29
EP1670773A1 (en) 2006-06-21
EA200600699A1 (ru) 2006-08-25
AP2006003603A0 (en) 2006-04-30
NZ546279A (en) 2008-09-26
AU2004276017A1 (en) 2005-04-07

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