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DK165620C - Frysetoerret farmaceutisk praeparat indeholdende anthracyclinglycosider og et cosolubiliserende middel og fremgangsmaade til fremstilling heraf, anvendelse af praeparatet til fremstilling af et tumormiddel samt fremgangsmaade til fremstilling af en rekonstitueret injicerbar oploesning af praeparatet - Google Patents

Frysetoerret farmaceutisk praeparat indeholdende anthracyclinglycosider og et cosolubiliserende middel og fremgangsmaade til fremstilling heraf, anvendelse af praeparatet til fremstilling af et tumormiddel samt fremgangsmaade til fremstilling af en rekonstitueret injicerbar oploesning af praeparatet

Info

Publication number
DK165620C
DK165620C DK481585A DK481585A DK165620C DK 165620 C DK165620 C DK 165620C DK 481585 A DK481585 A DK 481585A DK 481585 A DK481585 A DK 481585A DK 165620 C DK165620 C DK 165620C
Authority
DK
Denmark
Prior art keywords
preparation
anthracycliclycoside
annostation
cosolubilizing
freeze
Prior art date
Application number
DK481585A
Other languages
Danish (da)
English (en)
Other versions
DK481585A (da
DK165620B (da
DK481585D0 (da
Inventor
Gaetano Gatti
Diego Oldani
Carlo Confalonieri
Luciano Gambini
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of DK481585D0 publication Critical patent/DK481585D0/da
Publication of DK481585A publication Critical patent/DK481585A/da
Publication of DK165620B publication Critical patent/DK165620B/da
Application granted granted Critical
Publication of DK165620C publication Critical patent/DK165620C/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183Amino acids, e.g. glycine, EDTA or aspartame
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK481585A 1984-10-22 1985-10-21 Frysetoerret farmaceutisk praeparat indeholdende anthracyclinglycosider og et cosolubiliserende middel og fremgangsmaade til fremstilling heraf, anvendelse af praeparatet til fremstilling af et tumormiddel samt fremgangsmaade til fremstilling af en rekonstitueret injicerbar oploesning af praeparatet DK165620C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8426672 1984-10-22
GB848426672A GB8426672D0 (en) 1984-10-22 1984-10-22 Pharmaceutical compositions

Publications (4)

Publication Number Publication Date
DK481585D0 DK481585D0 (da) 1985-10-21
DK481585A DK481585A (da) 1986-04-23
DK165620B DK165620B (da) 1992-12-28
DK165620C true DK165620C (da) 1993-06-01

Family

ID=10568553

Family Applications (1)

Application Number Title Priority Date Filing Date
DK481585A DK165620C (da) 1984-10-22 1985-10-21 Frysetoerret farmaceutisk praeparat indeholdende anthracyclinglycosider og et cosolubiliserende middel og fremgangsmaade til fremstilling heraf, anvendelse af praeparatet til fremstilling af et tumormiddel samt fremgangsmaade til fremstilling af en rekonstitueret injicerbar oploesning af praeparatet

Country Status (35)

Country Link
US (4) US4675311A (es)
JP (1) JPH0611700B2 (es)
KR (1) KR920005813B1 (es)
CN (1) CN85107562B (es)
AT (1) AT401345B (es)
AU (1) AU572003B2 (es)
BE (1) BE903484A (es)
BG (1) BG60934B2 (es)
CA (1) CA1248453A (es)
CH (1) CH667594A5 (es)
CS (1) CS270421B2 (es)
DE (1) DE3536896C2 (es)
DK (1) DK165620C (es)
ES (1) ES8605374A1 (es)
FI (2) FI853913A (es)
FR (1) FR2571966B1 (es)
GB (2) GB8426672D0 (es)
GR (1) GR852549B (es)
HK (1) HK94390A (es)
HU (1) HU197988B (es)
IE (1) IE56992B1 (es)
IL (1) IL76732A (es)
IT (1) IT1186779B (es)
MY (1) MY103956A (es)
NL (1) NL191308C (es)
NO (1) NO170616C (es)
NZ (1) NZ213885A (es)
PH (1) PH23982A (es)
PT (1) PT81347B (es)
RU (2) RU1836088C (es)
SE (1) SE467520B (es)
SG (1) SG80290G (es)
UA (2) UA19169A (es)
YU (1) YU46160B (es)
ZA (1) ZA858033B (es)

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US5977082A (en) * 1985-08-02 1999-11-02 Pharmacia & Upjohn Company Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5124317A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.P.A. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
FI91710C (fi) * 1986-12-05 1994-08-10 Erba Carlo Spa Menetelmä injektoitavan käyttövalmiin, säilytystä kestävän, steriilin antrasykliiniglykosidiliuoksen valmistamiseksi
JP2603480B2 (ja) * 1987-08-05 1997-04-23 住友製薬株式会社 安定化されたアンスラサイクリン系製剤
DE3801178A1 (de) * 1988-01-18 1989-07-27 Hoechst Ag Stabilisierte trockenzubereitung zytostatisch wirksamer anthracyclin-antibiotika und verfahren zu ihrer herstellung
US6300362B1 (en) 1990-07-25 2001-10-09 Novartis Ag (Formerly Sandoz Ltd.) Stabilized pharmaceutical compositions comprising acid donors
CA2628857C (en) 1996-12-30 2011-09-13 Batelle Memorial Institute Formulation and method for treating neoplasms by inhalation
US5942508A (en) * 1997-02-04 1999-08-24 Senju Pharmaceutical Co., Ltd. Method for solubilizing pyridonecarboxylic acid solubilizer thereof and aqueous solution containing solubilized pyridonecarboxylic acid
BRPI0307802B8 (pt) 2002-02-22 2021-05-25 Merck Sharp & Dohme formulação farmacêutica compreendendo temozolomida, processo para a produção da mesma, bem como artigo fabricado contendo pó liofilizado compreendendo temozolomida
DK1474995T3 (da) * 2003-05-06 2013-02-18 Gumlink As Fremgangsmåde til fremstilling af tyggegummigranulater, et gummisammensætningsekstruder- og granuleringssystem og et tyggegummiprodukt
US20090099346A1 (en) * 2003-07-02 2009-04-16 Victor Matvienko Thermally stable crystalline epirubicin hydrochloride
RU2341530C2 (ru) * 2003-07-02 2008-12-20 Солакс Корпорейшн Термостойкий кристаллический гидрохлорид эпирубицина и способ его получения
ATE471740T1 (de) * 2003-09-25 2010-07-15 Astellas Pharma Inc Antitumorales mittel mit einem histon-deacetylase-hemmer und einem topoisomerase-ii-hemmer
US7388083B2 (en) * 2005-03-07 2008-06-17 Solux Corporation Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
WO2006122309A2 (en) * 2005-05-11 2006-11-16 Sicor, Inc. Stable lyophilized anthracycline glycosides
AU2006270165B2 (en) 2005-07-14 2010-03-11 Neothetics, Inc. Sustained release enhanced lipolytic formulation for regional adipose tissue treatment
EP1976858B1 (en) * 2005-12-13 2016-01-06 Solux Corporation Method for preparing 4-demethyldaunorubicin
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
US8148338B2 (en) * 2006-02-22 2012-04-03 Supratek Pharma Inc. Doxorubicin formulations for anti-cancer use
US7470672B2 (en) * 2006-07-31 2008-12-30 Savvipharm Inc. Compositions and methods of reducing tissue levels of drugs when given as orotate derivatives
KR20100029764A (ko) * 2007-05-16 2010-03-17 케이티비 투머포슝스케쉘샤프트 엠비에이치 저점성 안트라사이클린 제제
ES2439497T3 (es) 2007-09-04 2014-01-23 Meiji Seika Pharma Co., Ltd. Preparación de una inyección, de una solución para inyección y de un kit de inyección
CA2703149A1 (en) * 2007-10-26 2009-04-30 Pfizer Products Inc. Idarubicin for the treatment of lymphoma in a dog
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
US9132084B2 (en) 2009-05-27 2015-09-15 Neothetics, Inc. Methods for administration and formulations for the treatment of regional adipose tissue
SG182485A1 (en) * 2010-01-15 2012-08-30 Lithera Inc Lyophilized cake formulations
AU2011336869B2 (en) 2010-11-24 2016-09-15 Neothetics, Inc. Selective, lipophilic, and long-acting beta agonist monotherapeutic formulations and methods for the cosmetic treatment of adiposity and contour bulging
DE102011103751A1 (de) 2011-05-31 2012-12-06 Heraeus Precious Metals Gmbh & Co. Kg Kristallisierung von Epirubicinhydrochlorid
DE102011111991A1 (de) * 2011-08-30 2013-02-28 Lead Discovery Center Gmbh Neue Cyclosporin-Derivate
DK2931042T3 (da) 2012-12-13 2021-06-07 Cytrx Corp Anthracyclinformuleringer
EP3003489B1 (en) 2013-06-05 2021-08-18 CytRx Corporation Cytotoxic agents for the treatment of cancer

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US4039663A (en) * 1975-03-19 1977-08-02 Societa' Farmaceutici Italia S.P.A. Daunomycins, process for their uses and intermediates
GB1506200A (en) * 1975-04-30 1978-04-05 Farmaceutici Italia Glycosides
GB1567456A (en) * 1976-11-16 1980-05-14 Farmaceutici Italia Daunomycin derivatives
US4177264A (en) * 1977-10-17 1979-12-04 Sri International N-benzyl anthracyclines
GB2007645B (en) * 1977-10-17 1982-05-12 Stanford Res Inst Int Benzyl anthracyclines and pharmaceutical compositions containing them
JPS563851A (en) * 1979-06-22 1981-01-16 Matsushita Electric Works Ltd Fireplace in floor
JPS5756494A (en) * 1980-09-22 1982-04-05 Microbial Chem Res Found New anthracyclin derivative
US4325947A (en) * 1981-05-12 1982-04-20 Farmitalia Carlo Erba S.P.A. 4-Demethoxy-4'-deoxydoxorubicin
IT1210476B (it) * 1981-05-28 1989-09-14 Erba Farmitalia Antracicline.
US4438105A (en) * 1982-04-19 1984-03-20 Farmaitalia Carlo Erba S.P.A 4'-Iododerivatives of anthracycline glycosides
DE3317702A1 (de) * 1982-05-24 1983-11-24 Farmitalia Carlo Erba S.p.A., 20159 Milano Anthracyclinglykoside, verfahren zu deren herstellung und arzneimittel, welche diese enthalten
US4464529A (en) * 1982-07-20 1984-08-07 Sri International Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin
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JPS5982395A (ja) * 1982-11-02 1984-05-12 Microbial Chem Res Found アントラサイクリン化合物、その製造法およびその用途
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JPS6092212A (ja) * 1983-10-26 1985-05-23 Kyowa Hakko Kogyo Co Ltd ドキソルビシン塩の製剤
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Also Published As

Publication number Publication date
AT401345B (de) 1996-08-26
ES8605374A1 (es) 1986-03-16
HU197988B (en) 1989-07-28
FR2571966A1 (fr) 1986-04-25
IE852593L (en) 1986-04-22
CS270421B2 (en) 1990-06-13
DK481585A (da) 1986-04-23
KR920005813B1 (ko) 1992-07-20
US4675311A (en) 1987-06-23
DE3536896C2 (de) 1996-11-14
CN85107562B (zh) 1988-06-01
IT1186779B (it) 1987-12-16
BG60934B2 (bg) 1996-06-28
SE8504945D0 (sv) 1985-10-21
NO854194L (no) 1986-04-23
YU164485A (en) 1987-10-31
PH23982A (en) 1990-02-09
UA19169A (uk) 1997-12-25
KR860003014A (ko) 1986-05-19
RU1836088C (ru) 1993-08-23
FI854035A0 (fi) 1985-10-16
RU2101018C1 (ru) 1998-01-10
IT8522507A0 (it) 1985-10-16
BE903484A (fr) 1986-04-21
ES547578A0 (es) 1986-03-16
CN85107562A (zh) 1986-07-23
AU572003B2 (en) 1988-04-28
NO170616B (no) 1992-08-03
NL191308C (nl) 1995-05-16
IL76732A (en) 1989-07-31
PT81347A (en) 1985-11-01
GB2165751A (en) 1986-04-23
US5091372A (en) 1992-02-25
HK94390A (en) 1990-11-23
DE3536896A1 (de) 1986-04-24
DK165620B (da) 1992-12-28
FI86252B (fi) 1992-04-30
SG80290G (en) 1990-11-23
PT81347B (pt) 1987-11-11
CH667594A5 (de) 1988-10-31
FI853913A0 (fi) 1985-10-08
UA34419C2 (uk) 2001-03-15
FI854035L (fi) 1986-04-23
YU46160B (sh) 1993-05-28
GR852549B (es) 1986-02-24
SE467520B (sv) 1992-08-03
GB2165751B (en) 1988-08-17
GB8426672D0 (en) 1984-11-28
NO170616C (no) 1992-11-11
JPH0611700B2 (ja) 1994-02-16
IL76732A0 (en) 1986-02-28
FR2571966B1 (fr) 1988-04-15
GB8525709D0 (en) 1985-11-20
NL191308B (nl) 1994-12-16
FI853913A (fi) 1986-04-23
ATA303285A (de) 1996-01-15
DK481585D0 (da) 1985-10-21
MY103956A (en) 1993-10-30
IE56992B1 (en) 1992-02-26
AU4880585A (en) 1986-05-01
ZA858033B (en) 1986-06-25
JPS61246129A (ja) 1986-11-01
FI86252C (fi) 1992-08-10
US5091373A (en) 1992-02-25
CS756585A2 (en) 1989-11-14
HUT40759A (en) 1987-02-27
NL8502869A (nl) 1986-05-16
NZ213885A (en) 1988-05-30
CA1248453A (en) 1989-01-10
SE8504945L (sv) 1986-04-23
US4840938A (en) 1989-06-20

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