DK1539746T3 - N-substituerede 1H-indol-5-propionsyre-forbindelser som PPAR-agonister der er nyttige til behandling af diabetes - Google Patents

N-substituerede 1H-indol-5-propionsyre-forbindelser som PPAR-agonister der er nyttige til behandling af diabetes

Info

Publication number: DK1539746T3
Authority: DK; Denmark
Prior art keywords: indole; diabetes; substituted; treatment; propionic acid
Prior art date: 2002-09-12

Application number

DK03747962T

Other languages

English (en)

Inventor

Hans Iding

Hans-Peter Maerki

Peter Mohr

Alfred Binggeli

Hans Hilpert

Beat Wirz

Uwe Grether

Roland Humm

Bernd Kuhn

Markus Meyer

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-12

Filing date

2003-09-04

Publication date

2007-03-26

2003-09-04 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2007-03-26 Application granted granted Critical

2007-03-26 Publication of DK1539746T3 publication Critical patent/DK1539746T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Diabetes (AREA)
Hematology (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Vascular Medicine (AREA)
Gastroenterology & Hepatology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Emergency Medicine (AREA)
Psychiatry (AREA)
Rheumatology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Indole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK03747962T 2002-09-12 2003-09-04 N-substituerede 1H-indol-5-propionsyre-forbindelser som PPAR-agonister der er nyttige til behandling af diabetes DK1539746T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP02020477		2002-09-12
PCT/EP2003/009819 WO2004024726A1 (en)	2002-09-12	2003-09-04	N-substituted-1h-indol-5-propionic acid compounds as ppar agonists useful for the treatment of diabetes

Publications (1)

Publication Number	Publication Date
DK1539746T3 true DK1539746T3 (da)	2007-03-26

Family

ID=31985028

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK03747962T DK1539746T3 (da)	2002-09-12	2003-09-04	N-substituerede 1H-indol-5-propionsyre-forbindelser som PPAR-agonister der er nyttige til behandling af diabetes

Country Status (29)

Country	Link
US (1)	US6890947B2 (da)
EP (1)	EP1539746B1 (da)
JP (1)	JP4286782B2 (da)
KR (1)	KR100645684B1 (da)
CN (1)	CN100577660C (da)
AR (1)	AR041218A1 (da)
AT (1)	ATE345340T1 (da)
AU (1)	AU2003267041B2 (da)
BR (1)	BR0314261A (da)
CA (1)	CA2494601C (da)
DE (1)	DE60309719T2 (da)
DK (1)	DK1539746T3 (da)
ES (1)	ES2275105T3 (da)
GT (1)	GT200300194A (da)
HR (1)	HRP20050212A2 (da)
MX (1)	MXPA05002704A (da)
MY (1)	MY135646A (da)
NO (1)	NO20050667L (da)
NZ (1)	NZ537979A (da)
PA (1)	PA8581701A1 (da)
PE (1)	PE20050050A1 (da)
PL (1)	PL375878A1 (da)
PT (1)	PT1539746E (da)
RU (1)	RU2296759C2 (da)
SI (1)	SI1539746T1 (da)
TW (1)	TWI248933B (da)
UY (1)	UY27975A1 (da)
WO (1)	WO2004024726A1 (da)
ZA (1)	ZA200501273B (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10022925A1 (de) *	2000-05-11	2001-11-15	Basf Ag	Substituierte Indole als PARP-Inhibitoren
JP2006523698A (ja) *	2003-04-17	2006-10-19	カリプシス・インコーポレーテッド	Ｐｐａｒ変調薬としての（３−｛３−（２，４−ビス−トリフルオロメチル−ベンジル）−（５−エチル−ピリミジン−２−イル）−アミノ−プロポキシ｝−フェニル）−酢酸および関連化合物、ならびに代謝性障害の処置方法
WO2005060958A1 (en) *	2003-12-19	2005-07-07	Kalypsys, Inc.	(5- (2-phenyl)-thiazol-5-ylmethoxy)-indol-1-yl) -acetic acid derivatives and related compounds as modulators of the human ppar-delta receptor for the treatment of metabolic disorders such as type 2 diabetes
US7405236B2 (en) *	2004-08-16	2008-07-29	Hoffman-La Roche Inc.	Indole derivatives comprising an acetylene group
EP2025674A1 (de)	2007-08-15	2009-02-18	sanofi-aventis	Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
NO20083270L (no) *	2008-07-23	2010-01-25	Thia Medica As	Indolforbindelser
WO2011107494A1 (de)	2010-03-03	2011-09-09	Sanofi	Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
US8933024B2 (en)	2010-06-18	2015-01-13	Sanofi	Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US8530413B2 (en)	2010-06-21	2013-09-10	Sanofi	Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en)	2010-07-05	2012-06-01	Sanofi Sa	Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en)	2010-07-05	2012-04-16	Sanofi Aventis	Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en)	2010-07-05	2012-04-16	Sanofi Sa	(2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
EP2567959B1 (en)	2011-09-12	2014-04-16	Sanofi	6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013037390A1 (en)	2011-09-12	2013-03-21	Sanofi	6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en)	2011-09-27	2015-10-21	Sanofi	6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4011326A (en) *	1975-07-29	1977-03-08	Merck & Co., Inc.	2-Substituted oxazolo[4,5-b]pyridine anti-inflammatory agents
CA1247547A (en) *	1983-06-22	1988-12-28	Paul Hadvary	Leucine derivatives
CA1270837A (en)	1984-12-21	1990-06-26	Hoffmann-La Roche Limited	Oxetanones
CA1328881C (en)	1984-12-21	1994-04-26	Pierre Barbier	Process for the manufacture of oxetanones
CA2035972C (en)	1990-02-23	2006-07-11	Martin Karpf	Process for the preparation of oxetanones
US5089514A (en)	1990-06-14	1992-02-18	Pfizer Inc.	3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents
US5274143A (en)	1991-07-23	1993-12-28	Hoffmann-La Roche Inc.	Process for the preparation of (R)-3-hexyl-5,6-dihydro-4-hydroxy-6-undecyl-2H-pyran-2-one and (R)-5,6-dihydro-6-undecyl-2H-pyran-2,4(3H)-dione
RU2134686C1 (ru)	1992-07-03	1999-08-20	Смитклайн Бичам П.Л.С.	Гетероциклическое соединение, или его таутомерная форма, и/или фармацевтически приемлемая соль, и/или фармацевтически приемлемый сольват, фармацевтическая композиция, снижающая содержание глюкозы в крови, способ лечения и/или профилактики гипергликемии
GB9225386D0 (en)	1992-12-04	1993-01-27	Smithkline Beecham Plc	Novel compounds
DE4317320A1 (de) *	1993-05-25	1994-12-01	Boehringer Mannheim Gmbh	Neue Thiazolidindione und diese enthaltende Arzneimittel
GB9326171D0 (en)	1993-12-22	1994-02-23	Smithkline Beecham Plc	Novel compounds
IL117208A0 (en) *	1995-02-23	1996-06-18	Nissan Chemical Ind Ltd	Indole type thiazolidines
WO1996032379A1 (en) *	1995-04-10	1996-10-17	Fujisawa Pharmaceutical Co., Ltd.	INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS
JPH09176162A (ja) *	1995-12-22	1997-07-08	Toubishi Yakuhin Kogyo Kk	チアゾリジンジオン誘導体及びその製造法並びにそれを含む医薬組成物
GB9600464D0 (en)	1996-01-09	1996-03-13	Smithkline Beecham Plc	Novel method
EP0904079B1 (en) *	1996-02-02	2004-03-24	Merck & Co., Inc.	Antidiabetic agents
CN1152679C (zh) *	1996-12-10	2004-06-09	布里斯托尔-迈尔斯斯奎布公司	苯并二氧杂环戊烯、苯并呋喃、二氢苯并呋喃和苯并二噁烷类化合物褪黑激素能药剂
US6004996A (en) *	1997-02-05	1999-12-21	Hoffman-La Roche Inc.	Tetrahydrolipstatin containing compositions
DE19711616A1 (de) *	1997-03-20	1998-09-24	Boehringer Mannheim Gmbh	Verbessertes Verfahren zur Herstellung von Thiazolidindionen
US6121397A (en) *	1997-07-14	2000-09-19	Xerox Corporation	Polymerization processes using oligomeric compound, monomer and surfactant
HN1998000118A (es)	1997-08-27	1999-02-09	Pfizer Prod Inc	2 - aminopiridinas que contienen sustituyentes de anillos condensados.
EP0903343B1 (en)	1997-09-19	2003-05-28	SSP Co., Ltd.	Alpha-Substituted phenylpropionic acid derivative and medicine containing the same
EP1073643B1 (en)	1998-04-23	2004-12-29	Dr. Reddy's Laboratories Ltd.	New heterocyclic compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them
GB9817118D0 (en)	1998-08-07	1998-10-07	Glaxo Group Ltd	Pharmaceutical compounds
TR200100471T2 (tr)	1998-08-14	2001-07-23	F.Hoffmann-La Roche Ag	Lipaz inhibitörleri içeren farmasötik bileşimler
BR9912979B1 (pt)	1998-08-14	2010-09-21		composição farmacêutica administrável oralmente, tablete de mascar, cápsula e uso de chitosan.
GB9914977D0 (en)	1999-06-25	1999-08-25	Glaxo Group Ltd	Chemical compounds
DK1078923T3 (da) *	1999-08-02	2006-07-10	Hoffmann La Roche	Fremgangsmåde til fremstilling af benzothiophenderivater
CA2415742A1 (en) *	2000-07-25	2002-01-31	Merck & Co., Inc.	N-substituted indoles useful in the treatment of diabetes
EA200300286A1 (ru)	2000-08-23	2003-08-28	Эли Лилли Энд Компани	Агонисты активируемых пероксисомальным пролифератором рецепторов
DE10117090B4 (de) *	2001-04-06	2013-08-14	Dr. Ing. H.C. F. Porsche Aktiengesellschaft	Wassergekühlte, mehrzylindrige Brennkraftmaschine
WO2003005025A1 (en)	2001-07-03	2003-01-16	Biovitrum Ab	Methods for identifying compounds modulating the activity of ppar-gamma
WO2003040114A1 (en) *	2001-11-06	2003-05-15	Bristol-Myers Squibb Company	Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
WO2003053976A1 (en)	2001-12-20	2003-07-03	Biovitrum Ab	PIPAZOLO [1,5-a] PYRIMIDINE DERIVATIVES AS MODULATORS OF PPAR

2003
- 2003-09-04 SI SI200330631T patent/SI1539746T1/sl unknown
- 2003-09-04 EP EP03747962A patent/EP1539746B1/en not_active Expired - Lifetime
- 2003-09-04 DK DK03747962T patent/DK1539746T3/da active
- 2003-09-04 MX MXPA05002704A patent/MXPA05002704A/es active IP Right Grant
- 2003-09-04 BR BR0314261-2A patent/BR0314261A/pt not_active IP Right Cessation
- 2003-09-04 NZ NZ537979A patent/NZ537979A/en unknown
- 2003-09-04 AU AU2003267041A patent/AU2003267041B2/en not_active Ceased
- 2003-09-04 AT AT03747962T patent/ATE345340T1/de not_active IP Right Cessation
- 2003-09-04 ES ES03747962T patent/ES2275105T3/es not_active Expired - Lifetime
- 2003-09-04 PL PL03375878A patent/PL375878A1/xx not_active Application Discontinuation
- 2003-09-04 CA CA002494601A patent/CA2494601C/en not_active Expired - Fee Related
- 2003-09-04 JP JP2004535427A patent/JP4286782B2/ja not_active Expired - Fee Related
- 2003-09-04 CN CN03821483A patent/CN100577660C/zh not_active Expired - Fee Related
- 2003-09-04 KR KR1020057004166A patent/KR100645684B1/ko not_active IP Right Cessation
- 2003-09-04 RU RU2005110921/04A patent/RU2296759C2/ru not_active IP Right Cessation
- 2003-09-04 DE DE60309719T patent/DE60309719T2/de not_active Expired - Lifetime
- 2003-09-04 PT PT03747962T patent/PT1539746E/pt unknown
- 2003-09-04 WO PCT/EP2003/009819 patent/WO2004024726A1/en active IP Right Grant
- 2003-09-08 TW TW092124737A patent/TWI248933B/zh not_active IP Right Cessation
- 2003-09-09 PA PA20038581701A patent/PA8581701A1/es unknown
- 2003-09-10 AR ARP030103266A patent/AR041218A1/es unknown
- 2003-09-10 MY MYPI20033416A patent/MY135646A/en unknown
- 2003-09-10 US US10/659,664 patent/US6890947B2/en not_active Expired - Fee Related
- 2003-09-10 PE PE2003000917A patent/PE20050050A1/es not_active Application Discontinuation
- 2003-09-10 GT GT200300194A patent/GT200300194A/es unknown
- 2003-09-11 UY UY27975A patent/UY27975A1/es not_active Application Discontinuation
2005
- 2005-02-08 NO NO20050667A patent/NO20050667L/no not_active Application Discontinuation
- 2005-02-11 ZA ZA200501273A patent/ZA200501273B/en unknown
- 2005-03-04 HR HR20050212A patent/HRP20050212A2/hr not_active Application Discontinuation

Also Published As

Publication number	Publication date
RU2005110921A (ru)	2006-01-20
TW200418845A (en)	2004-10-01
MXPA05002704A (es)	2005-05-05
AU2003267041B2 (en)	2007-03-29
PT1539746E (pt)	2007-02-28
US6890947B2 (en)	2005-05-10
ZA200501273B (en)	2006-08-30
EP1539746A1 (en)	2005-06-15
PL375878A1 (en)	2005-12-12
NZ537979A (en)	2007-08-31
DE60309719D1 (de)	2006-12-28
EP1539746B1 (en)	2006-11-15
GT200300194A (es)	2004-04-15
SI1539746T1 (sl)	2007-04-30
JP4286782B2 (ja)	2009-07-01
JP2006503029A (ja)	2006-01-26
ES2275105T3 (es)	2007-06-01
CN1681808A (zh)	2005-10-12
KR20050042809A (ko)	2005-05-10
US20040053979A1 (en)	2004-03-18
HRP20050212A2 (en)	2006-05-31
CN100577660C (zh)	2010-01-06
AU2003267041A1 (en)	2004-04-30
MY135646A (en)	2008-06-30
UY27975A1 (es)	2004-03-31
PE20050050A1 (es)	2005-02-18
KR100645684B1 (ko)	2006-11-15
ATE345340T1 (de)	2006-12-15
TWI248933B (en)	2006-02-11
BR0314261A (pt)	2005-07-26
RU2296759C2 (ru)	2007-04-10
AR041218A1 (es)	2005-05-11
WO2004024726A1 (en)	2004-03-25
PA8581701A1 (es)	2004-04-23
DE60309719T2 (de)	2007-09-20
CA2494601C (en)	2009-09-29
CA2494601A1 (en)	2004-03-25
NO20050667L (no)	2005-06-08

Publication	Publication Date	Title
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DK1620437T3 (da)	2009-08-24	5,7-diaminopyrazolo-4,3-d-pyrimidiner, der er anvendelige til behandling af hypertension
DK1756084T3 (da)	2009-03-23	Substituerede aryl- og heteroarylderivater som modulatorer af metabolisme og forebyggelse og behandling af forstyrrelser beslægtet dermed
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DK1492785T3 (da)	2009-03-02	2-hydroxy-3-heteroarylindol-derivater som GSK3-inhibitorer
DE602004026320D1 (de)	2010-05-12	Nichtwässrige flüssige zahnbleichzusammensetzung
DK1803718T3 (da)	2008-10-27	4-Tetrazolyl-4-phenylpiperidin-derivater til behandling af smerter
DK1954690T3 (da)	2013-07-29	Benzamidforbindelser, der er anvendelige som inhibitorer af histondeacetylase
DK1954668T3 (da)	2012-01-23	Homo- og heterocykliske forbindelser, der er egnede som CETP-inhibitorer
NO20050665L (no)	2005-04-18	Pyrrolidonderivater som MAOE inhibitoere
DK1617834T3 (da)	2007-02-05	Anvendelse af en farmaceutisk sammensætning indeholdende mælkesyre eller lactat og kalium til behandling af hjerneödem eller hjerneskade
DK1720848T3 (da)	2008-03-25	Derivater af alkylpiperazin- og alkylhomopiperazincarboxylater, fremgangsmåde til fremstilling heraf og anvendelse heraf som inhibitorer af enzymet FAAH
DK1599452T3 (da)	2007-10-01	3- (2-phenyloxazol- 4-ylmethoxy) - cyclohexylmethoxyeddikesyrederivater og beslægtede forbindelser som PPAR modulatorer til behandling af type 2 diabetes og atherosklerosw
IS7858A (is)	2005-05-23	Samsetning til notkunar í meðferð á athyglisbresti með ofvirkni (ADHD)
DK1551814T3 (da)	2008-10-27	Chirale oxazol-arylpropionsyrederivater og anvendelse deraf som ppar-agnister
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