DK1539742T3 - Indolderivater, der er nyttige som histamin H3-antagonister - Google Patents

Indolderivater, der er nyttige som histamin H3-antagonister

Info

Publication number: DK1539742T3
Authority: DK; Denmark
Prior art keywords: histamine; antagonists; indole derivatives; derivatives useful; useful
Prior art date: 2002-06-24

Application number

DK03761216T

Other languages

Danish (da)

English (en)

Inventor

Robert G Aslanian

Michael Y Berlin

Pietro Mangiaracina

Kevin D Mccormick

Mwangi W Mutahi

Stuart B Rosenblum

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-06-24

Filing date

2003-06-20

Publication date

2006-12-27

2003-06-20 Application filed by Schering Corp filed Critical Schering Corp

2006-12-27 Application granted granted Critical

2006-12-27 Publication of DK1539742T3 publication Critical patent/DK1539742T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Pulmonology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Immunology (AREA)
Child & Adolescent Psychology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Ophthalmology & Optometry (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK03761216T 2002-06-24 2003-06-20 Indolderivater, der er nyttige som histamin H3-antagonister DK1539742T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US39098702P	2002-06-24	2002-06-24

Publications (1)

Publication Number	Publication Date
DK1539742T3 true DK1539742T3 (da)	2006-12-27

Family

ID=30000654

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK03761216T DK1539742T3 (da)	2002-06-24	2003-06-20	Indolderivater, der er nyttige som histamin H3-antagonister

Country Status (22)

Country	Link
US (1)	US6951871B2 (zh)
EP (2)	EP1539742B1 (zh)
JP (1)	JP4326468B2 (zh)
KR (1)	KR20050009757A (zh)
CN (1)	CN100497334C (zh)
AR (1)	AR039718A1 (zh)
AT (1)	ATE344798T1 (zh)
AU (1)	AU2003243709B2 (zh)
CA (1)	CA2489337C (zh)
CY (1)	CY1105986T1 (zh)
DE (1)	DE60309598T2 (zh)
DK (1)	DK1539742T3 (zh)
ES (1)	ES2271644T3 (zh)
HK (1)	HK1072259A1 (zh)
IL (1)	IL165863A0 (zh)
MX (1)	MXPA05000193A (zh)
MY (1)	MY135686A (zh)
NZ (1)	NZ537200A (zh)
PT (1)	PT1539742E (zh)
TW (1)	TW200400031A (zh)
WO (1)	WO2004000831A1 (zh)
ZA (1)	ZA200410213B (zh)

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PE20020507A1 (es) *	2000-10-17	2002-06-25	Schering Corp	Compuestos no-imidazoles como antagonistas del receptor histamina h3
ES2300613T3 (es) *	2002-06-28	2008-06-16	Euro-Celtique S.A.	Derivados terapeuticos de piperacina utiles para tratar el dolor.
JP4613157B2 (ja)	2003-01-14	2011-01-12	サイトキネティクス・インコーポレーテッド	化合物、組成物および方法
PT1765327E (pt) *	2004-06-17	2014-11-24	Cytokinetics Inc	Compostos, composições e métodos
WO2005123716A1 (en)	2004-06-21	2005-12-29	F. Hoffmann-La Roche Ag	Indole derivatives as histamine receptor antagonists
US7176222B2 (en)	2004-07-27	2007-02-13	Cytokinetics, Inc.	Syntheses of ureas
FR2878849B1 (fr)	2004-12-06	2008-09-12	Aventis Pharma Sa	Indoles substitues, compositions les contenant, procede de fabrication et utilisation
JP2008532926A (ja) *	2004-12-06	2008-08-21	アバンテイス・フアルマ・エス・アー	置換インドール化合物、それを含有する組成物、この製造方法およびこの使用
MX2007008676A (es)	2005-01-19	2007-07-25	Hoffmann La Roche	Derivados de 5-aminoindol.
MX2007016523A (es) *	2005-06-20	2008-03-06	Schering Corp	Piperidinas sustituidas ligadas a carbono y derivados de las mismas utiles como antagonistas de hsitamina h3.
WO2007001975A1 (en) *	2005-06-20	2007-01-04	Schering Corporation	Piperidine derivatives useful as histamine h3 antagonists
WO2007016496A2 (en) *	2005-08-02	2007-02-08	Neurogen Corporation	Dipiperazinyl ketones and related analogues
US7538223B2 (en)	2005-08-04	2009-05-26	Cytokinetics, Inc.	Compounds, compositions and methods
JP4860700B2 (ja) *	2005-09-20	2012-01-25	シェーリングコーポレイション	ヒスタミンＨ３アンタゴニストとして有用な、１−［［１−［（２−アミノ−６−メチル−４−ピリジニル）メチル］−４−フルオロ−４−ピペリジニル］カルボニル］−４−［２−（２−ピリジニル）−３Ｈ−イミダゾ［４，５−ｂ］ピリジン−３−イル］ピペリジン
US7977359B2 (en)	2005-11-04	2011-07-12	Amira Pharmaceuticals, Inc.	5-lipdxygenase-activating protein (FLAP) inhibitors
GB2431927B (en) *	2005-11-04	2010-03-17	Amira Pharmaceuticals Inc	5-Lipoxygenase-activating protein (FLAP) inhibitors
JP2009515926A (ja)	2005-11-18	2009-04-16	エフ．ホフマン−ラロシュアーゲー	アザインドール−２−カルボキサミド誘導体
ATE466007T1 (de)	2005-11-30	2010-05-15	Hoffmann La Roche	5-substituierte indol-2-carbonsäureamidderivate
US7825120B2 (en) *	2005-12-15	2010-11-02	Cytokinetics, Inc.	Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas
WO2007070683A2 (en)	2005-12-15	2007-06-21	Cytokinetics, Inc.	Certain chemical entities, compositions and methods
US7718657B2 (en)	2005-12-16	2010-05-18	Cytokinetics, Inc.	Certain indanyl urea modulators of the cardiac sarcomere
WO2007078839A2 (en) *	2005-12-19	2007-07-12	Cytokinetics, Inc.	Compounds, compositions and methods
KR20080081321A (ko) *	2005-12-21	2008-09-09	쉐링 코포레이션	Ｈ3 길항제/역 작용제 및 식욕 억제제의 조합물
AU2006331882A1 (en) *	2005-12-21	2007-07-05	Schering Corporation	Phenoxypiperidines and analogs thereof useful as histamine H3 antagonists
MX2008008339A (es) *	2005-12-21	2008-09-03	Schering Corp	Derivados de anilina sustituida ùtiles como antagonistas de la histamina h3.
US7696229B2 (en) *	2006-02-17	2010-04-13	Memory Pharmaceuticals Corporation	Compounds having 5-HT6 receptor affinity
US7514433B2 (en) *	2006-08-03	2009-04-07	Hoffmann-La Roche Inc.	1H-indole-6-yl-piperazin-1-yl-methanone derivatives
US8148403B2 (en)	2006-10-27	2012-04-03	Boehringer Ingelheim International Gmbh	Substituted piperidyl-propane-thiols
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US8771643B2 (en) *	2008-01-04	2014-07-08	Schabar Research Associates Llc	Use of analgesic potentiating compounds to potentiate the analgesic properties of an analgesic compound
EA019819B1 (ru)	2008-05-23	2014-06-30	ПАНМИРА ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи	Кристаллическая полиморфная форма с ингибитора белка, активирующего 5-липоксигеназу, фармацевтическая композиция на ее основе и применение в лечении
US20100016297A1 (en) *	2008-06-24	2010-01-21	Memory Pharmaceuticals Corporation	Alkyl-substituted 3' compounds having 5-ht6 receptor affinity
WO2009158375A1 (en) *	2008-06-25	2009-12-30	Abbott Laboratories	Aza-cylic indole- 2 -carboxamides and methods of use thereof
AR072297A1 (es)	2008-06-27	2010-08-18	Novartis Ag	Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona.
EP2318387A1 (en) *	2008-07-23	2011-05-11	Schering Corporation	Bicyclic heterocycle derivatives as histamine h3 receptor antagonists
US20100029629A1 (en) *	2008-07-25	2010-02-04	Memory Pharmaceuticals Corporation	Acyclic compounds having 5-ht6 receptor affinity
US20100056531A1 (en) *	2008-08-22	2010-03-04	Memory Pharmaceuticals Corporation	Alkyl-substituted 3' compounds having 5-ht6 receptor affinity
WO2011124930A1 (en)	2010-04-08	2011-10-13	Respivert Limited	P38 map kinase inhibitors
CN103096893B (zh)	2010-06-04	2016-05-04	阿尔巴尼分子研究公司	甘氨酸转运体-1抑制剂、其制备方法及其用途
WO2013151982A1 (en)	2012-04-03	2013-10-10	Arena Pharmaceuticals, Inc.	Methods and compounds useful in treating pruritus, and methods for identifying such compounds
TWI748194B (zh)	2018-06-28	2021-12-01	德商菲尼克斯Ｆｘｒ有限責任公司	含有雙環核心部分之新穎lxr調節劑
EP3797769A1 (fr)	2019-09-25	2021-03-31	Fontès, M. Michel	Composition a usage therapeutique
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CN116194102A (zh)	2020-07-15	2023-05-30	沙巴研究联合有限责任公司	用于治疗急性疼痛和降低胃灼热的严重程度和/或风险的包含布洛芬和法莫替丁的单位口服剂量组合物

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DK181190D0 (da)	1990-07-30	1990-07-30	Lundbeck & Co As H	3-aryl-indol- eller 3-aryl-indazolderivater
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2003
- 2003-06-20 US US10/600,674 patent/US6951871B2/en not_active Expired - Fee Related
- 2003-06-20 IL IL16586303A patent/IL165863A0/xx unknown
- 2003-06-20 ES ES03761216T patent/ES2271644T3/es not_active Expired - Lifetime
- 2003-06-20 TW TW092116874A patent/TW200400031A/zh unknown
- 2003-06-20 WO PCT/US2003/019619 patent/WO2004000831A1/en active IP Right Grant
- 2003-06-20 CA CA2489337A patent/CA2489337C/en not_active Expired - Fee Related
- 2003-06-20 JP JP2004516072A patent/JP4326468B2/ja not_active Expired - Fee Related
- 2003-06-20 AT AT03761216T patent/ATE344798T1/de not_active IP Right Cessation
- 2003-06-20 AU AU2003243709A patent/AU2003243709B2/en not_active Ceased
- 2003-06-20 DE DE60309598T patent/DE60309598T2/de not_active Expired - Lifetime
- 2003-06-20 DK DK03761216T patent/DK1539742T3/da active
- 2003-06-20 NZ NZ537200A patent/NZ537200A/en unknown
- 2003-06-20 EP EP03761216A patent/EP1539742B1/en not_active Expired - Lifetime
- 2003-06-20 CN CNB038147173A patent/CN100497334C/zh not_active Expired - Fee Related
- 2003-06-20 EP EP06020215A patent/EP1777223A1/en not_active Withdrawn
- 2003-06-20 AR ARP030102203A patent/AR039718A1/es unknown
- 2003-06-20 MX MXPA05000193A patent/MXPA05000193A/es active IP Right Grant
- 2003-06-20 KR KR10-2004-7020914A patent/KR20050009757A/ko not_active Application Discontinuation
- 2003-06-20 MY MYPI20032323A patent/MY135686A/en unknown
- 2003-06-20 PT PT03761216T patent/PT1539742E/pt unknown
2004
- 2004-12-17 ZA ZA200410213A patent/ZA200410213B/en unknown
2005
- 2005-06-18 HK HK05105092A patent/HK1072259A1/xx not_active IP Right Cessation
2007
- 2007-02-05 CY CY20071100153T patent/CY1105986T1/el unknown

Also Published As

Publication number	Publication date
AR039718A1 (es)	2005-03-09
EP1777223A1 (en)	2007-04-25
ZA200410213B (en)	2005-10-20
KR20050009757A (ko)	2005-01-25
CA2489337C (en)	2010-05-25
HK1072259A1 (en)	2005-08-19
JP4326468B2 (ja)	2009-09-09
EP1539742A1 (en)	2005-06-15
CA2489337A1 (en)	2003-12-31
AU2003243709A1 (en)	2004-01-06
WO2004000831A1 (en)	2003-12-31
PT1539742E (pt)	2007-01-31
IL165863A0 (en)	2006-01-15
JP2005531615A (ja)	2005-10-20
DE60309598T2 (de)	2007-09-13
MY135686A (en)	2008-06-30
ES2271644T3 (es)	2007-04-16
CN1662524A (zh)	2005-08-31
NZ537200A (en)	2007-09-28
MXPA05000193A (es)	2005-04-08
EP1539742B1 (en)	2006-11-08
CN100497334C (zh)	2009-06-10
ATE344798T1 (de)	2006-11-15
CY1105986T1 (el)	2011-04-06
TW200400031A (en)	2004-01-01
AU2003243709B2 (en)	2007-01-18
US20040019099A1 (en)	2004-01-29
US6951871B2 (en)	2005-10-04
DE60309598D1 (de)	2006-12-21

Publication	Publication Date	Title
DK1539742T3 (da)	2006-12-27	Indolderivater, der er nyttige som histamin H3-antagonister
DK1499316T3 (da)	2008-07-21	(1-4-piperidinyl)benzimidazolderivater anvendelige som histamin-H3-antagonister
DK1501787T3 (da)	2006-03-20	N-biphenylmethylaminocycloalkancarboxamid-derivater med en substituerent på methyl, der er nyttige som bradykininantagonister
CY2017032I2 (el)	2018-02-14	Παραγωγα (θειο)καρβαμοϋλ-κυκλοεξανιου ως ανταγωνιστες των υποδοχεων d3/d2
DK2279737T3 (da)	2013-02-11	Heterocycliske forbindelser, der er aktive som beta-lactamaseinhibitorer
DK1761519T3 (da)	2008-07-21	Indolderivater som histaminreceptorantagonister
DK1571145T3 (da)	2009-05-04	Substitueret piperidinforbindelser til anvendelse som H3 histaminreceptor-antagonister
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DK1175401T3 (da)	2005-11-14	Piperazinderivater, der er nyttige som CCR5-antagonister
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NO20044373L (no)	2004-10-14	Azetidinderivater som CCR-3-reseptorantagonister