DK155525C - Fremgangsmaade til fremstilling af (6r,7r)-7-oe(z)-2-(2-aminotiazol-4-yl)-2-(2-karboxyprop-2-oxyimino)-acetamidoaa-3-(1-pyridiniummetyl)-ceph-3-em-4-karboxylat-pentahydrat - Google Patents

Fremgangsmaade til fremstilling af (6r,7r)-7-oe(z)-2-(2-aminotiazol-4-yl)-2-(2-karboxyprop-2-oxyimino)-acetamidoaa-3-(1-pyridiniummetyl)-ceph-3-em-4-karboxylat-pentahydrat

Info

Publication number: DK155525C
Authority: DK; Denmark
Prior art keywords: acetamidoaa; aminotiazol; carboxyprop; ceph; oxyimino
Prior art date: 1979-10-02

Application number

DK414780A

Other languages

Danish (da)

English (en)

Other versions

DK155525B (da

DK414780A (da

Inventor

Alastair Couper Brodie

Lewis Aubrey Wetherill

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-10-02

Filing date

1980-10-01

Publication date

1989-09-04

1980-10-01 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

1981-04-03 Publication of DK414780A publication Critical patent/DK414780A/da

1989-04-17 Publication of DK155525B publication Critical patent/DK155525B/da

1989-09-04 Application granted granted Critical

1989-09-04 Publication of DK155525C publication Critical patent/DK155525C/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK414780A 1979-10-02 1980-10-01 Fremgangsmaade til fremstilling af (6r,7r)-7-oe(z)-2-(2-aminotiazol-4-yl)-2-(2-karboxyprop-2-oxyimino)-acetamidoaa-3-(1-pyridiniummetyl)-ceph-3-em-4-karboxylat-pentahydrat DK155525C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB7934204		1979-10-02
GB7934204		1979-10-02

Publications (3)

Publication Number	Publication Date
DK414780A DK414780A (da)	1981-04-03
DK155525B DK155525B (da)	1989-04-17
DK155525C true DK155525C (da)	1989-09-04

Family

ID=10508246

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK414780A DK155525C (da)	1979-10-02	1980-10-01	Fremgangsmaade til fremstilling af (6r,7r)-7-oe(z)-2-(2-aminotiazol-4-yl)-2-(2-karboxyprop-2-oxyimino)-acetamidoaa-3-(1-pyridiniummetyl)-ceph-3-em-4-karboxylat-pentahydrat

Country Status (36)

Country	Link
US (1)	US4329453A (ro)
JP (1)	JPS5657791A (ro)
KR (1)	KR840001776B1 (ro)
AT (1)	AT368161B (ro)
AU (1)	AU539519B2 (ro)
BE (1)	BE885489A (ro)
BG (1)	BG33586A3 (ro)
CA (1)	CA1142919A (ro)
CH (1)	CH645118A5 (ro)
CS (1)	CS214721B2 (ro)
CY (1)	CY1338A (ro)
DD (1)	DD153376A5 (ro)
DE (1)	DE3037102C2 (ro)
DK (1)	DK155525C (ro)
EC (1)	ECSP941099A (ro)
ES (1)	ES8106908A1 (ro)
FI (1)	FI71157C (ro)
FR (1)	FR2466467A1 (ro)
GB (1)	GB2063871B (ro)
GR (1)	GR69123B (ro)
HK (1)	HK78686A (ro)
HU (1)	HU184835B (ro)
IT (1)	IT1144006B (ro)
KE (1)	KE3641A (ro)
MX (1)	MX6545E (ro)
MY (1)	MY8500315A (ro)
NL (1)	NL190329C (ro)
NO (1)	NO156246C (ro)
PL (1)	PL126606B1 (ro)
PT (1)	PT71860B (ro)
RO (1)	RO82721B (ro)
SE (1)	SE449614B (ro)
SU (1)	SU942599A3 (ro)
UA (1)	UA7208A1 (ro)
YU (1)	YU42357B (ro)
ZA (1)	ZA806081B (ro)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4443444A (en) *	1980-08-11	1984-04-17	Fujisawa Pharmaceutical Co., Ltd.	Cephem compounds
US4427677A (en)	1980-12-31	1984-01-24	Fujisawa Pharmaceutical Co., Ltd.	Cephem compounds
US4394503A (en)	1981-12-07	1983-07-19	Bristol-Myers Company	Cephalosporin derivatives
US4474954A (en) *	1981-12-07	1984-10-02	Bristol-Myers Company	Intermediates for cephalosporin derivatives
JPS58198489A (ja) *	1982-05-14	1983-11-18	Meiji Seika Kaisha Ltd	７β−（２Ｄ−２−アミノ−２−カルボキシエチルチオアセトアミド）−７α−メトキシ−３−（１−メチル−１Ｈ−テトラゾ−ル−５−イル）−チオメチル−３−セフエム−４−カルボン酸ナトリウム塩の七水和物及びその製造方法
ES8502863A1 (es) *	1982-09-10	1985-02-01	Glaxo Group Ltd	Un procedimiento para la produccion de un recipiente hermeticamente cerrado que contiene al menos un antibiotico de beta-lactama.
DE3313818A1 (de) *	1983-04-16	1984-10-18	Hoechst Ag, 6230 Frankfurt	Neue kristallmodifikation von ceftazidim
DE3313816A1 (de) *	1983-04-16	1984-10-18	Hoechst Ag, 6230 Frankfurt	Neue kristallmodifikation von ceftazidim
GB8406218D0 (en) *	1984-03-09	1984-04-11	Glaxo Group Ltd	Process
US4537959A (en) *	1984-03-26	1985-08-27	Eli Lilly And Company	Crystalline cephalosporin antibiotic salt
JPS60231683A (ja) *	1984-05-02	1985-11-18	Teijin Ltd	セフアロスポリン誘導体その製造法及びそれを有効成分とする抗菌剤
US4616080A (en) *	1984-07-02	1986-10-07	Eli Lilly And Company	Simplified process of forming crystalline ceftazidime pentahydrate
US4626534A (en) *	1984-07-23	1986-12-02	Eli Lilly And Company	Pharmaceutical formulation
IL75800A (en) *	1984-07-23	1988-11-30	Lilly Co Eli	Pharmaceutical formulations comprising ceftazidime pentahydrate and amorphous lactose
ATE60607T1 (de) *	1984-11-08	1991-02-15	Lilly Co Eli	Verfahren zur herstellung von kristallinischem ceftazidime-pentahydrat.
US4659813A (en) *	1984-11-08	1987-04-21	Eli Lilly And Company	Crystallization process for ceftazidime derivative
US4910301A (en) *	1985-08-05	1990-03-20	Bristol-Myers Company	Cefepime cephalosporin salts
US5244891A (en) *	1985-08-05	1993-09-14	Bristol-Myers Squibb Company	Injectable compositions of cefepime dihydrochloride hydrate
US4994451A (en) *	1988-01-19	1991-02-19	Bristol-Myers Company	Cephalosporin salts and injectable compositions
US4954624A (en) *	1986-10-07	1990-09-04	Sandoz Ltd.	Process for the production of cephalosporin derivatives
AT387390B (de) *	1986-10-07	1989-01-10	Biochemie Gmbh	Verfahren zur herstellung des antibiotikums (6r,7r)-7-(2-(2-amino-4-thiazolyl)-2-(2-carboxy
US5021564A (en) *	1987-02-02	1991-06-04	Eli Lilly And Company	Process for preparing ceftazidime pentahydrate
JP2533151B2 (ja) *	1987-02-02	1996-09-11	イーライ・リリー・アンド・カンパニー	抗生物質製造の改良法
WO1988010262A1 (fr) *	1987-06-25	1988-12-29	Banyu Pharmaceutical Co., Ltd.	Compose cristallin de cephalosporine
KR950010084B1 (ko) *	1987-06-25	1995-09-06	반유세이야꾸 가부시끼가이샤	결정성 세팔로스포린 화합물, 그의 제조법 및 그의 제조 중간체
GB8802622D0 (en) *	1988-02-05	1988-03-02	Glaxo Group Ltd	Chemical compound
KR940000112B1 (ko) *	1990-07-05	1994-01-05	주식회사 대웅제약	신규의 3-치환 세펨화합물 및 그의 제조방법
US5831085A (en) *	1997-01-16	1998-11-03	Lupin Laboratories Limited	Process for manufacture of cephalosporin such as ceftazidime and intermediate thereof
CN1328281C (zh) *	2004-11-16	2007-07-25	广州白云山制药股份有限公司	头孢他啶的纯化方法
CN102875576A (zh) *	2012-10-31	2013-01-16	苏州致君万庆药业有限公司	一种抗菌素头孢他啶的合成、注射用头孢他啶及其制备方法
CN102924483B (zh) *	2012-10-31	2015-06-17	海南合瑞制药股份有限公司	一种头孢他啶晶体化合物、其制备方法及其无菌混合粉形式的药物组合物
CN104876949A (zh) *	2015-05-28	2015-09-02	浙江长典医药有限公司	一种小儿用头孢他啶化合物实体及其制剂
CN106420658A (zh) *	2016-09-23	2017-02-22	临沂草之美医药科技有限公司	一种治疗外科手术感染的药物头孢他啶胶囊
CN109111467A (zh) *	2017-06-22	2019-01-01	宁应	一种51/4水头孢他啶化合物及其药物组合物制剂

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR228726A1 (es) *	1978-05-26	1983-04-15	Glaxo Group Ltd	Procedimiento para la preparacion del antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)acetamido)-3-(1-piridiniometil)cef-3-em-4-carboxilato

1980
- 1980-09-09 US US06/185,883 patent/US4329453A/en not_active Expired - Lifetime
- 1980-10-01 GB GB8031703A patent/GB2063871B/en not_active Expired
- 1980-10-01 NO NO802913A patent/NO156246C/no unknown
- 1980-10-01 HU HU802393A patent/HU184835B/hu unknown
- 1980-10-01 AU AU62882/80A patent/AU539519B2/en not_active Expired
- 1980-10-01 AT AT0490080A patent/AT368161B/de not_active IP Right Cessation
- 1980-10-01 UA UA2987392A patent/UA7208A1/uk unknown
- 1980-10-01 BE BE0/202301A patent/BE885489A/fr not_active IP Right Cessation
- 1980-10-01 ZA ZA00806081A patent/ZA806081B/xx unknown
- 1980-10-01 ES ES495534A patent/ES8106908A1/es not_active Expired
- 1980-10-01 DD DD80224266A patent/DD153376A5/de not_active IP Right Cessation
- 1980-10-01 CS CS806627A patent/CS214721B2/cs unknown
- 1980-10-01 FR FR8021033A patent/FR2466467A1/fr active Granted
- 1980-10-01 YU YU2497/80A patent/YU42357B/xx unknown
- 1980-10-01 JP JP13822480A patent/JPS5657791A/ja active Granted
- 1980-10-01 FI FI803126A patent/FI71157C/fi not_active IP Right Cessation
- 1980-10-01 GR GR63023A patent/GR69123B/el unknown
- 1980-10-01 NL NLAANVRAGE8005443,A patent/NL190329C/xx not_active IP Right Cessation
- 1980-10-01 MX MX809068U patent/MX6545E/es unknown
- 1980-10-01 DK DK414780A patent/DK155525C/da not_active IP Right Cessation
- 1980-10-01 RO RO102255A patent/RO82721B/ro unknown
- 1980-10-01 SE SE8006861A patent/SE449614B/sv not_active IP Right Cessation
- 1980-10-01 IT IT49783/80A patent/IT1144006B/it active Protection Beyond IP Right Term
- 1980-10-01 CH CH734180A patent/CH645118A5/de not_active IP Right Cessation
- 1980-10-01 PT PT71860A patent/PT71860B/pt unknown
- 1980-10-01 CA CA000361346A patent/CA1142919A/en not_active Expired
- 1980-10-01 PL PL1980227019A patent/PL126606B1/pl unknown
- 1980-10-01 DE DE3037102A patent/DE3037102C2/de not_active Expired
- 1980-10-01 CY CY1338A patent/CY1338A/xx unknown
- 1980-10-01 BG BG049206A patent/BG33586A3/xx unknown
- 1980-10-01 SU SU802987392A patent/SU942599A3/ru active
- 1980-10-02 KR KR1019800003810A patent/KR840001776B1/ko active
1985
- 1985-12-30 MY MY315/85A patent/MY8500315A/xx unknown
1986
- 1986-05-29 KE KE3641A patent/KE3641A/xx unknown
- 1986-10-16 HK HK786/86A patent/HK78686A/xx not_active IP Right Cessation
1994
- 1994-05-26 EC EC1994001099A patent/ECSP941099A/es unknown

Also Published As

Publication number	Publication date
NO156246B (no)	1987-05-11
FI803126L (fi)	1981-04-03
YU249780A (en)	1983-02-28
ES495534A0 (es)	1981-09-01
DD153376A5 (de)	1982-01-06
NL190329B (nl)	1993-08-16
SU942599A3 (ru)	1982-07-07
FR2466467A1 (fr)	1981-04-10
US4329453A (en)	1982-05-11
HU184835B (en)	1984-10-29
JPH0128036B2 (ro)	1989-05-31
DK155525B (da)	1989-04-17
KR830004317A (ko)	1983-07-09
NL8005443A (nl)	1981-04-06
DK414780A (da)	1981-04-03
CY1338A (en)	1987-01-16
CA1142919A (en)	1983-03-15
PT71860B (en)	1982-04-02
RO82721A (ro)	1984-09-29
SE449614B (sv)	1987-05-11
BE885489A (fr)	1981-04-01
ATA490080A (de)	1982-01-15
AT368161B (de)	1982-09-27
AU6288280A (en)	1981-04-09
IT1144006B (it)	1986-10-29
ZA806081B (en)	1982-05-26
BG33586A3 (en)	1983-03-15
PT71860A (en)	1980-11-01
PL227019A1 (ro)	1981-06-05
CH645118A5 (de)	1984-09-14
YU42357B (en)	1988-08-31
MY8500315A (en)	1985-12-31
RO82721B (ro)	1984-10-30
FR2466467B1 (ro)	1984-02-10
NO802913L (no)	1981-04-03
NL190329C (nl)	1994-01-17
IT8049783A0 (it)	1980-10-01
CS214721B2 (en)	1982-05-28
AU539519B2 (en)	1984-10-04
KR840001776B1 (ko)	1984-10-19
UA7208A1 (uk)	1995-06-30
SE8006861L (sv)	1981-04-03
DE3037102A1 (de)	1981-04-23
KE3641A (en)	1986-07-11
NO156246C (no)	1987-08-19
MX6545E (es)	1985-07-10
GB2063871B (en)	1983-06-02
GB2063871A (en)	1981-06-10
HK78686A (en)	1986-10-24
ES8106908A1 (es)	1981-09-01
FI71157C (fi)	1986-11-24
PL126606B1 (en)	1983-08-31
ECSP941099A (es)	1995-01-16
GR69123B (ro)	1982-05-03
JPS5657791A (en)	1981-05-20
FI71157B (fi)	1986-08-14
DE3037102C2 (de)	1986-04-10

Publication	Publication Date	Title
DK155525C (da)	1989-09-04	Fremgangsmaade til fremstilling af (6r,7r)-7-oe(z)-2-(2-aminotiazol-4-yl)-2-(2-karboxyprop-2-oxyimino)-acetamidoaa-3-(1-pyridiniummetyl)-ceph-3-em-4-karboxylat-pentahydrat
DK540080A (da)	1981-06-20	Fremgangsmaade til fremstilling af 2-amino-4-hydroxyquinazolinderivater
DK478980A (da)	1981-05-13	Fremgangsmaade til fremstilling af imidazol-5-eddikesyrederivater
DK157685C (da)	1990-07-09	Analogifremgangsmaade til fremstilling af (6r,7r)-7-oe(z)-2-(2-aminotiazol)-4-yl)-2-(2-karboxyprop-2-oxyimino)-acetamidoaa-3-(1-pyridiniummetyl)-ceph-3-em-4-karboxylat eller ugiftige salte eller ugiftige metabolisk labile estere deraf
DK42480A (da)	1980-08-06	Fremgangsmaade til fremstilling af 1-aryl-2-acylamido-3-fluor-1-propanoler
MX157171A (es)	1988-10-31	Procedimiento para preparar compuestos 1-oxa,aza-y tia-espirociclos
DK491780A (da)	1981-06-19	Fremgangsmaade til fremstilling af cephalosporansyrederivater
DK75077A (da)	1977-10-13	Fremgangsmade til fremstilling af cephemforbindelser
ES514796A0 (es)	1983-10-01	Procedimiento para preparar compuestos tetrakisazoicos.
DK143491A (da)	1991-08-06	Fremgangsmaade til fremstilling af 3-oen-phenylacetylaminopiperidinaa-2,6-dion
DK502078A (da)	1979-05-15	Frefmgangsmaade til fremstilling af cephalosporansyrederivater
DK158669C (da)	1991-01-21	Fremgangsmaade til fremstilling af 6beta-halogensubstituerede penicillansyrederivater.
ES519006A0 (es)	1984-02-01	Procedimiento para preparar 2-(2-dimetilaminoetiltio)-3-fenilquinolina.
DK447380A (da)	1981-04-24	Fremgangsmaade til fremstilling af d3-vitaminforbindelser
DK99980A (da)	1980-09-09	Fremgangsmaade til fremstilling af mercaptoacyldihydropyrazolcarboxylsyrederivater
DK289580A (da)	1981-01-07	Fremgangsmaade til fremstilling af heterocycliske phenoxyaminer
ES509044A0 (es)	1983-04-01	Procedimiento para preparar derivados de fenilsulfonilurea sustituidos.
ES517333A0 (es)	1984-04-16	Procedimientos para preparar derivados piridazinona.
ES506842A0 (es)	1983-12-01	Procedimiento para preparar derivados 3-aminopropoxifenili- cos.
AR228869A1 (es)	1983-04-29	Procedimiento para preparar nuevos compuestos cefalosporanicos
ES517824A0 (es)	1983-08-16	Procedimiento para preparar derivados de cefalosporina.
DK135480A (da)	1980-10-01	Fremgangsmaade til fremstilling af 2-(2-pyridyl)-tetrahydrothiopen-derivater
DK159449C (da)	1991-03-04	Fremgangsmaade til fremstilling af natrium-cefuroxim
DK454579A (da)	1980-04-28	Fremgangsmaade til fremstilling af 6-piperidino-2,4-diaminopyrimidin-3-oxid
DK188881A (da)	1981-10-30	Fremgangsmaade til fremstilling af 2-guanidinthiazol-derivater

Legal Events

Date	Code	Title	Description
2000-11-06	PUP	Patent expired