DK154654C - Analogifremgangsmaade til fremstilling af immunmodulerende 2-oe2-acylamino-2-desoxy-(d)-glucosyl-3-oaa-alkancarboxylsyrepeptid-derivater eller farmaceutisk acceptable salte deraf - Google Patents

Analogifremgangsmaade til fremstilling af immunmodulerende 2-oe2-acylamino-2-desoxy-(d)-glucosyl-3-oaa-alkancarboxylsyrepeptid-derivater eller farmaceutisk acceptable salte deraf

Info

Publication number: DK154654C
Authority: DK; Denmark
Prior art keywords: acceptable; alkancarboxyl; oaa; desoxy; glucosyl
Prior art date: 1975-12-10

Application number

DK552476A

Other languages

English (en)

Other versions

DK154654B (da

DK552476A (da

Inventor

Gerhard Baschang

Albert Hartmann

Jaroslav Stanek

Alex Sele

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-12-10

Filing date

1976-12-09

Publication date

1989-05-08

1976-12-09 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1977-06-11 Publication of DK552476A publication Critical patent/DK552476A/da

1988-12-05 Publication of DK154654B publication Critical patent/DK154654B/da

1989-05-08 Application granted granted Critical

1989-05-08 Publication of DK154654C publication Critical patent/DK154654C/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
- C07K9/005—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure containing within the molecule the substructure with m, n > 0 and m+n > 0, A, B, D, E being heteroatoms; X being a bond or a chain, e.g. muramylpeptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Immunology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Crystallography & Structural Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Biotechnology (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK552476A 1975-12-10 1976-12-09 Analogifremgangsmaade til fremstilling af immunmodulerende 2-oe2-acylamino-2-desoxy-(d)-glucosyl-3-oaa-alkancarboxylsyrepeptid-derivater eller farmaceutisk acceptable salte deraf DK154654C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CH1604275A CH613709A5 (en)	1975-12-10	1975-12-10	Process for the preparation of glucosamine derivatives
CH1604275		1975-12-10

Publications (3)

Publication Number	Publication Date
DK552476A DK552476A (da)	1977-06-11
DK154654B DK154654B (da)	1988-12-05
DK154654C true DK154654C (da)	1989-05-08

Family

ID=4414012

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK552476A DK154654C (da)	1975-12-10	1976-12-09	Analogifremgangsmaade til fremstilling af immunmodulerende 2-oe2-acylamino-2-desoxy-(d)-glucosyl-3-oaa-alkancarboxylsyrepeptid-derivater eller farmaceutisk acceptable salte deraf

Country Status (30)

Country	Link
JP (1)	JPS5273820A (da)
AR (2)	AR224091A1 (da)
AT (1)	AT365607B (da)
AU (1)	AU508764B2 (da)
BE (1)	BE849214A (da)
CA (1)	CA1262400A (da)
CH (2)	CH613709A5 (da)
CS (4)	CS205027B2 (da)
DD (1)	DD129781A5 (da)
DE (1)	DE2655500A1 (da)
DK (1)	DK154654C (da)
ES (2)	ES454118A1 (da)
FI (1)	FI64164C (da)
FR (1)	FR2361902A1 (da)
GB (1)	GB1570625A (da)
GR (1)	GR61647B (da)
HK (1)	HK32883A (da)
HU (1)	HU177970B (da)
IE (1)	IE44190B1 (da)
IL (1)	IL51076A (da)
MY (1)	MY8400123A (da)
NL (1)	NL7613666A (da)
NO (1)	NO144850C (da)
NZ (1)	NZ182837A (da)
PL (4)	PL110353B1 (da)
PT (1)	PT65946B (da)
SE (1)	SE445923B (da)
SG (1)	SG11083G (da)
SU (3)	SU660589A3 (da)
ZA (1)	ZA767333B (da)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4186194A (en) *	1973-10-23	1980-01-29	Agence Nationale De Valorisation De La Recherche (Anvar)	Water soluble agents effective as immunological adjuvants for stimulating, in the host the immune response to various antigens and compositions, notably vaccines containing said water soluble agents
US4370265A (en) *	1974-10-22	1983-01-25	Agence Nationale De Valorisation	Water soluble agents effective as immunological adjuvants for stimulating in the host the immune response to various antigens and compositions, notably vaccines containing said water soluble agents
GB1571133A (en) *	1976-04-26	1980-07-09	Syntex Inc	Immuniological adjuvant peptidoglycans compounds and methods of preparation thereof
EP0002677B1 (en)	1977-12-02	1982-10-13	Takeda Chemical Industries, Ltd.	Glucosamine-peptide derivatives and their pharmaceutical compositions
CA1138436A (en) *	1978-02-24	1982-12-28	Gerhard Baschang	Process for the manufacture of novel antigens
US4397844A (en) *	1978-02-24	1983-08-09	Ciba-Geigy Corporation	Antigen derivatives and processes for their preparation
FR2420545A1 (fr) *	1978-03-20	1979-10-19	Anvar	Nouveaux esters de l'acide n-acetyl-muramyl-aminoacyl-glutamique ou des derives de substitution de celui-ci a proprietes anti-infectieuses et/ou d'adjuvants immunologiques
FR2442241A2 (fr) *	1978-03-20	1980-06-20	Anvar	Nouveaux composes esters de muramyl-peptide, leur preparation et les compositions pharmaceutiques les contenant, notamment sous forme de liposomes
FR2428050A1 (fr) *	1978-06-05	1980-01-04	Anvar	Oligomeres de composes du type muramyl-peptide et medicaments les contenant
FR2428051A1 (fr) *	1978-06-05	1980-01-04	Anvar	Nouveaux composes du type muramyl-peptide et medicaments les contenant
FR2446292A1 (fr) *	1979-01-12	1980-08-08	Anvar	Muramyl-peptides fixes sur polymeres peptidiques et medicaments les contenant
US4256735A (en) *	1979-01-29	1981-03-17	Merck & Co., Inc.	Immunologically active dipeptidyl saccharides and methods of preparation
FR2449697A1 (fr)	1979-02-20	1980-09-19	Anvar	Nouveaux muramyl-peptides substitues sur un azote peptidique et medicaments les contenant
JPS55111499A (en) *	1979-02-21	1980-08-28	Takeda Chem Ind Ltd	Glucosamine derivative and its preparation
JPS5618996A (en) *	1979-06-21	1981-02-23	Dai Ichi Seiyaku Co Ltd	Muramyldipeptide derivative
FI75578C (fi)	1979-07-25	1988-07-11	Ciba Geigy Ag	Analogifoerfarande foer framstaellning av farmakologiskt verkande lipofila fosfatidylmuramylpeptider.
JPS5649396A (en) *	1979-09-28	1981-05-02	Dai Ichi Seiyaku Co Ltd	Novel muramyldipeptide derivative
DE3070457D1 (en) *	1979-10-02	1985-05-15	Ciba Geigy Ag	Combinatory compositions for use in a method for enhancing the activity of antibiotics, antibiotic preparations having enhanced activity and process for their production
FI803077A (fi)	1979-10-12	1981-04-13	Ciba Geigy Ag	Foerfarande foer framstaellning av myramylpeptider
US4409209A (en) *	1979-10-12	1983-10-11	Ciba-Geigy Corporation	Novel phosphorylmuramyl peptides and processes for the manufacture thereof
US4406889A (en) *	1980-02-15	1983-09-27	Ciba-Geigy Corporation	Derivatives of aldohexoses, intermediates, processes for their manufacture, preparations containing such compounds, and their use
US4368190A (en) *	1980-04-17	1983-01-11	Merck & Co., Inc.	Immunologically active dipeptidyl 4-O-,6-O-acyl-2-amino-2-deoxy-D-glucose derivatives and methods for their preparation
US4310514A (en)	1980-05-05	1982-01-12	Merck & Co., Inc.	Immunologically active dipeptidyl 5-0,6-0-acyl-2-amino-2-deoxy-D-glucofuranose derivatives and methods of preparation
EP0056560A1 (de) *	1981-01-19	1982-07-28	Ciba-Geigy Ag	Antibiotische Präparate mit gesteigerter Wirksamkeit, Verfahren zu deren Herstellung und Verfahren zur Steigerung der antibiotischen Wirkung von Antibiotika
GR78246B (da) *	1981-01-23	1984-09-26	Ciba Geigy Ag
JPS6042398A (ja) *	1983-08-18	1985-03-06	Toshiyuki Hamaoka	ムラミルジペプチド活性エステル誘導体
EP0541486A1 (de) *	1991-11-07	1993-05-12	Ciba-Geigy Ag	Polycyclische Konjugate
WO2006118327A1 (ja) *	2005-04-27	2006-11-09	Oxygenix Co Ltd	カチオン性アミノ酸型脂質
US10610564B2 (en)	2015-02-26	2020-04-07	Stc.Unm	IRGM and precision autophagy controls for antimicrobial and inflammatory disease states and methods of detection of autophagy
US10927147B2 (en)	2015-12-10	2021-02-23	Bharat Biotech International Limited	Muramyl peptide derivative compound, synthesis and uses thereof
US12134664B2 (en)	2015-12-10	2024-11-05	Bharat Biotech International Ltd.	Muramyl peptide derivatives
EP3389643B1 (en) *	2015-12-15	2023-05-03	Bharat Biotech International Limited	Novel muramyl peptide derivative compound, synthesis and uses thereof
EP3672939A1 (en)	2017-08-21	2020-07-01	Celgene Corporation	Processes for preparation of (s)-tert-butyl 4,5-diamino-5-oxopentanoate

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4186194A (en) *	1973-10-23	1980-01-29	Agence Nationale De Valorisation De La Recherche (Anvar)	Water soluble agents effective as immunological adjuvants for stimulating, in the host the immune response to various antigens and compositions, notably vaccines containing said water soluble agents

1975
- 1975-12-10 CH CH1604275A patent/CH613709A5/xx not_active IP Right Cessation
1976
- 1976-12-08 GB GB51228/76A patent/GB1570625A/en not_active Expired
- 1976-12-08 CA CA000267474A patent/CA1262400A/en not_active Expired
- 1976-12-08 GR GR52361A patent/GR61647B/el unknown
- 1976-12-08 NL NL7613666A patent/NL7613666A/xx not_active Application Discontinuation
- 1976-12-08 DE DE19762655500 patent/DE2655500A1/de active Granted
- 1976-12-08 SU SU762428152A patent/SU660589A3/ru active
- 1976-12-09 FI FI763541A patent/FI64164C/fi not_active IP Right Cessation
- 1976-12-09 CS CS768063A patent/CS205027B2/cs unknown
- 1976-12-09 IL IL51076A patent/IL51076A/xx unknown
- 1976-12-09 FR FR7637091A patent/FR2361902A1/fr active Granted
- 1976-12-09 DK DK552476A patent/DK154654C/da not_active IP Right Cessation
- 1976-12-09 NO NO764191A patent/NO144850C/no unknown
- 1976-12-09 CS CS768063A patent/CS205026B2/cs unknown
- 1976-12-09 AT AT0909276A patent/AT365607B/de not_active IP Right Cessation
- 1976-12-09 CS CS768063A patent/CS205025B2/cs unknown
- 1976-12-09 DD DD7600196215A patent/DD129781A5/xx unknown
- 1976-12-09 IE IE2689/76A patent/IE44190B1/en not_active IP Right Cessation
- 1976-12-09 ZA ZA767333A patent/ZA767333B/xx unknown
- 1976-12-09 NZ NZ182837A patent/NZ182837A/xx unknown
- 1976-12-09 SE SE7613851A patent/SE445923B/xx not_active IP Right Cessation
- 1976-12-09 BE BE173091A patent/BE849214A/xx not_active IP Right Cessation
- 1976-12-09 PT PT65946A patent/PT65946B/pt unknown
- 1976-12-09 AU AU20422/76A patent/AU508764B2/en not_active Expired
- 1976-12-09 CS CS768063A patent/CS205028B2/cs unknown
- 1976-12-09 HU HU76CI1702A patent/HU177970B/hu unknown
- 1976-12-10 PL PL1976194291A patent/PL110353B1/pl not_active IP Right Cessation
- 1976-12-10 ES ES454118A patent/ES454118A1/es not_active Expired
- 1976-12-10 JP JP51147903A patent/JPS5273820A/ja active Granted
- 1976-12-10 PL PL1976210828A patent/PL110794B1/pl unknown
- 1976-12-10 PL PL1976210827A patent/PL110787B1/pl unknown
- 1976-12-10 AR AR265799A patent/AR224091A1/es active
- 1976-12-10 PL PL1976210826A patent/PL112672B1/pl unknown
1977
- 1977-09-08 SU SU772518658A patent/SU1060118A3/ru active
- 1977-09-08 SU SU772521659A patent/SU747430A3/ru active
- 1977-09-30 AR AR269405A patent/AR220686A1/es active
- 1977-12-28 ES ES465514A patent/ES465514A1/es not_active Expired
1978
- 1978-08-24 CH CH898378A patent/CH614718A5/xx not_active IP Right Cessation
1983
- 1983-03-14 SG SG110/83A patent/SG11083G/en unknown
- 1983-08-25 HK HK328/83A patent/HK32883A/xx unknown
1984
- 1984-12-30 MY MY123/84A patent/MY8400123A/xx unknown

Also Published As

Publication number	Publication date
DK154654B (da)	1988-12-05
PL194291A1 (pl)	1978-10-23
PT65946B (en)	1978-06-14
HK32883A (en)	1983-09-02
BE849214A (fr)	1977-06-09
SG11083G (en)	1983-09-16
FI763541A (da)	1977-06-11
ATA909276A (de)	1981-06-15
IE44190L (en)	1977-06-10
DE2655500A1 (de)	1977-06-23
FR2361902B1 (da)	1980-11-07
JPS5273820A (en)	1977-06-21
ES465514A1 (es)	1978-09-16
CS205026B2 (en)	1981-04-30
PL112672B1 (en)	1980-10-31
CA1262400A (en)	1989-10-17
NO144850C (no)	1981-11-25
PT65946A (en)	1977-01-01
NO144850B (no)	1981-08-17
CS205028B2 (en)	1981-04-30
PL110794B1 (en)	1980-07-31
FR2361902A1 (fr)	1978-03-17
SU660589A3 (ru)	1979-04-30
JPS638118B2 (da)	1988-02-19
CH613709A5 (en)	1979-10-15
PL110353B1 (en)	1980-07-31
DE2655500C2 (da)	1988-12-22
IE44190B1 (en)	1981-09-09
AR224091A1 (es)	1981-10-30
AR220686A1 (es)	1980-11-28
ZA767333B (en)	1977-11-30
CH614718A5 (en)	1979-12-14
HU177970B (en)	1982-02-28
FI64164C (fi)	1983-10-10
NO764191L (da)	1977-06-13
IL51076A (en)	1980-09-16
CS205027B2 (en)	1981-04-30
PL110787B1 (en)	1980-07-31
SE7613851L (sv)	1977-06-11
CS205025B2 (en)	1981-04-30
DK552476A (da)	1977-06-11
AU2042276A (en)	1978-06-15
FI64164B (fi)	1983-06-30
NL7613666A (nl)	1977-06-14
MY8400123A (en)	1984-12-31
ES454118A1 (es)	1978-03-01
SU747430A3 (ru)	1980-07-23
NZ182837A (en)	1978-07-28
GB1570625A (en)	1980-07-02
GR61647B (en)	1978-12-05
AT365607B (de)	1982-02-10
DD129781A5 (de)	1978-02-08
IL51076A0 (en)	1977-02-28
SE445923B (sv)	1986-07-28
AU508764B2 (en)	1980-04-03
SU1060118A3 (ru)	1983-12-07

Publication	Publication Date	Title
DK154654C (da)	1989-05-08	Analogifremgangsmaade til fremstilling af immunmodulerende 2-oe2-acylamino-2-desoxy-(d)-glucosyl-3-oaa-alkancarboxylsyrepeptid-derivater eller farmaceutisk acceptable salte deraf
DK145339C (da)	1983-03-21	Analogifremgangsmaade til fremstilling af 4-amino-5-hexensyre eller farmaceutisk acceptable salte deraf
DK149449C (da)	1986-11-24	Analogifremgangsmaade til fremstilling af carbostyrilderivater eller farmaceutisk acceptable salte deraf
DK152495C (da)	1988-07-25	Analogifremgangsmaade til fremstilling af n2-arylsulfonyl-l-argininamider eller farmaceutisk tolerable salte deraf
DK346276A (da)	1977-02-02	Fremgangsmade til fremstilling af alfa-phenylbenzylidenderivater af aminosyrer
DK152114C (da)	1988-06-20	Analogifremgangsmaade til fremstilling af propenylaminer eller farmaceutisk acceptable salte deraf
DK146538C (da)	1984-04-09	Analogifremgangsmaade til fremstilling af 7alfa-methoxycephalosporinderivater eller farmaceutisk acceptable salte deraf
DK151330C (da)	1988-04-25	Analogifremgangsmaade til fremstilling af aminoalkoholderivater eller farmaceutiske acceptable salte deraf
DK154950C (da)	1989-05-29	Analogifremgangsmaade til fremstilling af 1-(benzazolylalkyl)-piperidinderivater eller de farmaceutisk acceptable syreadditionssalte deraf
DK149230C (da)	1986-08-11	Analogifremgangsmaade til fremstilling af 5-benzoyl-6-hydroxy-indan-1-carboxylsyrederivater eller farmaceutisk acceptable salte deraf
DK155670C (da)	1989-09-18	Analogifremgangsmaade til fremstilling af sesquiterpenderivater eller farmaceutisk acceptable salte deraf
DK158658C (da)	1990-12-31	Analogifremgangsmaade til fremstilling af 9-aminoalkylfluorener eller farmaceutisk acceptable salte deraf
DK150196C (da)	1987-07-06	Analogifremgangsmaade til fremstilling af 0-(3-amino-2-hydroxypropyl)-amidoximderivater eller farmaceutisk acceptable salte deraf
DK145263C (da)	1983-03-07	Analogifremgangsmaade til fremstilling af imidazothiaziner eller farmaceutisk acceptable salte deraf
DK149077C (da)	1986-06-16	Analogifremgangsmaade til fremstilling af encephalin-analoge pentapeptidamidderivater eller farmaceutisk acceptable syreadditionssalte deraf
DK143105C (da)	1981-11-09	Analogifremgangsmaade til fremstilling af aminobenzocycloheptenderivater eller farmaceutisk acceptable additionssalte deraf
DK155520C (da)	1989-10-16	Analogifremgangsmaade til fremstilling af aminosyrederivater eller fysiologisk acceptable salte deraf
DK144033C (da)	1982-04-26	Analogifremgangsmaade til fremstilling af l-3-(3,4-dihydroxy-phenyl)-2-methyl-alanin-peptider eller farmakologisk acceptable salte deraf
DK152208C (da)	1988-08-08	Analogifremgangsmaade til fremstilling af 2-phenylamino-phenyleddikesyreamider eller farmaceutisk acceptable salte deraf
DK143278C (da)	1981-12-07	Analogifremgangsmaade til fremstilling af n-(r-tetrahydrofurfuryl)-noroxymorphon eller syreadditionssalte deraf
DK144793C (da)	1982-11-01	Analogifremgangsmaade til fremstilling af dihydro- eller tetrahydroiminothiaziner eller farmaceutisk acceptable syreadditionssalte deraf
DK149093C (da)	1986-06-23	Analogifremgangsmaade til fremstilling af pentapeptidderivater eller farmaceutisk acceptable salte deraf
DK162102C (da)	1992-02-24	Analogifremgangsmaade til fremstilling af 3-o-(beta-d-glucoronopyranosyl)-sojasapogenol b eller farmaceutisk acceptable salte deraf
DK148019C (da)	1985-07-01	Analogifremgangsmaade til fremstilling af 2-pyridylaminobenzoesyrer eller farmaceutisk acceptable salte deraf
DK147577C (da)	1985-03-18	Analogifremgangsmaade til fremstilling af 2-phenyl-bicyclooctan- eller -octenaminer eller farmaceutisk acceptable syreadditionssalte deraf

Legal Events

Date	Code	Title	Description
1994-08-22	PBP	Patent lapsed