DK143278C - Analogifremgangsmaade til fremstilling af n-(r-tetrahydrofurfuryl)-noroxymorphon eller syreadditionssalte deraf - Google Patents

Analogifremgangsmaade til fremstilling af n-(r-tetrahydrofurfuryl)-noroxymorphon eller syreadditionssalte deraf

Info

Publication number: DK143278C
Authority: DK; Denmark
Prior art keywords: noroxymorphone; tetrahydrofurfuryl; analogue; preparation; acid addition
Prior art date: 1975-08-27

Application number

DK386876A

Other languages

Danish (da)

English (en)

Other versions

DK143278B (da

DK386876A (da

Inventor

H Merz

A Langbein

K Stockhaus

H Wick

Original Assignee

Boehringer Sohn Ingelheim

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-08-27

Filing date

1976-08-26

Publication date

1981-12-07

1976-08-26 Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim

1977-02-28 Publication of DK386876A publication Critical patent/DK386876A/da

1981-08-03 Publication of DK143278B publication Critical patent/DK143278B/da

1981-12-07 Application granted granted Critical

1981-12-07 Publication of DK143278C publication Critical patent/DK143278C/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Addiction (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DK386876A 1975-08-27 1976-08-26 Analogifremgangsmaade til fremstilling af n-(r-tetrahydrofurfuryl)-noroxymorphon eller syreadditionssalte deraf DK143278C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE2538075		1975-08-27
DE19752538075 DE2538075A1 (de)	1975-08-27	1975-08-27	N-tetrahydrofurfuryl-noroxymorphone, deren saeureadditionssalze, diese enthaltende arzneimittel sowie verfahren zu ihrer herstellung

Publications (3)

Publication Number	Publication Date
DK386876A DK386876A (da)	1977-02-28
DK143278B DK143278B (da)	1981-08-03
DK143278C true DK143278C (da)	1981-12-07

Family

ID=5954931

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK386876A DK143278C (da)	1975-08-27	1976-08-26	Analogifremgangsmaade til fremstilling af n-(r-tetrahydrofurfuryl)-noroxymorphon eller syreadditionssalte deraf

Country Status (33)

Country	Link
US (1)	US4100288A (es)
JP (1)	JPS5231100A (es)
AT (1)	AT350737B (es)
AU (1)	AU499926B2 (es)
BE (1)	BE845563A (es)
BG (2)	BG27545A3 (es)
CA (1)	CA1068266A (es)
CH (5)	CH622521A5 (es)
CS (2)	CS192599B2 (es)
DD (1)	DD127145A5 (es)
DE (1)	DE2538075A1 (es)
DK (1)	DK143278C (es)
ES (5)	ES450897A1 (es)
FI (1)	FI762430A (es)
FR (1)	FR2321888A1 (es)
GB (1)	GB1519719A (es)
GR (1)	GR61158B (es)
HU (1)	HU176929B (es)
IE (1)	IE44069B1 (es)
IL (1)	IL50355A (es)
LU (1)	LU75667A1 (es)
MX (1)	MX4133E (es)
NL (1)	NL7609485A (es)
NO (1)	NO145793C (es)
NZ (1)	NZ181864A (es)
PH (1)	PH13780A (es)
PL (2)	PL110724B1 (es)
PT (1)	PT65521B (es)
RO (1)	RO69457A (es)
SE (1)	SE7609495L (es)
SU (2)	SU612631A3 (es)
YU (1)	YU208176A (es)
ZA (1)	ZA765120B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4272541A (en) *	1978-06-02	1981-06-09	Miles Laboratories, Inc.	7,8 and 7-8 Substituted 4,5α-epoxymorphinan-6-one compounds, and methods of treating pain and drug dependence with them
US4272540A (en) *	1979-04-24	1981-06-09	Sisa, Incorporated	14-Methoxymorphinan-6-one compounds and therapeutic methods of treating pain and drug dependence with them
DE3220831A1 (de) *	1982-06-03	1983-12-08	Boehringer Ingelheim KG, 6507 Ingelheim	N-(2-methoxyethyl)-noroxymorphon, dessen saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung
US8183376B2 (en) *	2006-04-21	2012-05-22	Nektar Therapeutics	Stereoselective reduction of a morphinone
NZ605234A (en) *	2010-07-08	2015-02-27	Alkermes Pharma Ireland Ltd	Process for the synthesis of substituted morphinans
US9211293B2 (en)	2011-12-15	2015-12-15	Alkermes Pharma Ireland Limited	Opioid agonist antagonist combinations
EP3003311A2 (en)	2013-05-24	2016-04-13	Alkermes Pharma Ireland Limited	Methods for treating depressive symptoms
ES2770978T3 (es)	2013-05-24	2020-07-06	Alkermes Pharma Ireland Ltd	Análogos de morfanos y morfinanos y métodos de uso
AU2019224127B2 (en)	2018-02-23	2021-12-09	Rhodes Technologies	Novel opioid compounds and uses thereof
WO2022101444A1 (en)	2020-11-12	2022-05-19	Alkermes Pharma Ireland Limited	Immediate release multilayer tablet

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH446370A (de)	1964-03-05	1967-11-15	Hoffmann La Roche	Verfahren zur Herstellung von Phenanthren-Derivaten
DE2238839A1 (de) *	1972-08-07	1974-02-14	Boehringer Sohn Ingelheim	Neue morphinon-derivate, deren saeureadditionssalze, verfahren zu ihrer herstellung sowie ihre verwendung zur herstellung von arzneimitteln

1975
- 1975-08-27 DE DE19752538075 patent/DE2538075A1/de not_active Withdrawn
1976
- 1976-07-28 AT AT553976A patent/AT350737B/de not_active IP Right Cessation
- 1976-08-12 PH PH18780A patent/PH13780A/en unknown
- 1976-08-13 US US05/714,045 patent/US4100288A/en not_active Expired - Lifetime
- 1976-08-13 RO RO7687297A patent/RO69457A/ro unknown
- 1976-08-21 ES ES450897A patent/ES450897A1/es not_active Expired
- 1976-08-23 SU SU762389512A patent/SU612631A3/ru active
- 1976-08-24 FI FI762430A patent/FI762430A/fi not_active Application Discontinuation
- 1976-08-25 IL IL50355A patent/IL50355A/xx unknown
- 1976-08-25 BG BG034062A patent/BG27545A3/xx unknown
- 1976-08-25 CS CS778646A patent/CS192599B2/cs unknown
- 1976-08-25 CS CS765528A patent/CS192564B2/cs unknown
- 1976-08-25 CH CH1079676A patent/CH622521A5/de not_active IP Right Cessation
- 1976-08-25 BG BG034743A patent/BG27546A4/xx unknown
- 1976-08-25 DD DD194461A patent/DD127145A5/xx unknown
- 1976-08-26 DK DK386876A patent/DK143278C/da active
- 1976-08-26 MX MX764858U patent/MX4133E/es unknown
- 1976-08-26 ZA ZA00765120A patent/ZA765120B/xx unknown
- 1976-08-26 PT PT65521A patent/PT65521B/pt unknown
- 1976-08-26 NZ NZ181864A patent/NZ181864A/xx unknown
- 1976-08-26 GR GR51547A patent/GR61158B/el unknown
- 1976-08-26 NO NO762932A patent/NO145793C/no unknown
- 1976-08-26 CA CA259,909A patent/CA1068266A/en not_active Expired
- 1976-08-26 NL NL7609485A patent/NL7609485A/xx not_active Application Discontinuation
- 1976-08-26 JP JP51102168A patent/JPS5231100A/ja active Pending
- 1976-08-26 LU LU75667A patent/LU75667A1/xx unknown
- 1976-08-26 GB GB35603/76A patent/GB1519719A/en not_active Expired
- 1976-08-26 PL PL1976213963A patent/PL110724B1/pl unknown
- 1976-08-26 SE SE7609495A patent/SE7609495L/xx not_active Application Discontinuation
- 1976-08-26 YU YU02081/76A patent/YU208176A/xx unknown
- 1976-08-26 AU AU17201/76A patent/AU499926B2/en not_active Expired
- 1976-08-26 PL PL1976192020A patent/PL109091B1/pl unknown
- 1976-08-26 BE BE170118A patent/BE845563A/xx unknown
- 1976-08-26 IE IE1911/76A patent/IE44069B1/en unknown
- 1976-08-26 HU HU76BO1629A patent/HU176929B/hu unknown
- 1976-08-27 FR FR7625985A patent/FR2321888A1/fr active Granted
- 1976-12-09 ES ES454084A patent/ES454084A1/es not_active Expired
- 1976-12-09 ES ES454087A patent/ES454087A2/es not_active Expired
- 1976-12-09 ES ES454085A patent/ES454085A1/es not_active Expired
- 1976-12-09 ES ES454086A patent/ES454086A1/es not_active Expired
1977
- 1977-05-31 SU SU772485952A patent/SU638262A3/ru active
1980
- 1980-09-18 CH CH699380A patent/CH624114A5/de not_active IP Right Cessation
- 1980-09-18 CH CH699580A patent/CH624116A5/de not_active IP Right Cessation
- 1980-09-18 CH CH699480A patent/CH624115A5/de not_active IP Right Cessation
- 1980-09-18 CH CH699680A patent/CH624117A5/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
NO145793B (no)	1982-02-22
ES454087A2 (es)	1977-11-16
CH624117A5 (es)	1981-07-15
AT350737B (de)	1979-06-11
ZA765120B (en)	1978-05-30
BE845563A (fr)	1977-02-28
PT65521A (de)	1976-09-01
DE2538075A1 (de)	1977-03-17
NO145793C (no)	1982-06-02
RO69457A (ro)	1981-04-30
BG27546A4 (en)	1979-11-12
GR61158B (en)	1978-09-30
US4100288A (en)	1978-07-11
PH13780A (en)	1980-09-26
CH624116A5 (es)	1981-07-15
DD127145A5 (es)	1977-09-07
NZ181864A (en)	1978-06-20
YU208176A (en)	1982-08-31
DK143278B (da)	1981-08-03
NL7609485A (nl)	1977-03-01
NO762932L (es)	1977-03-01
LU75667A1 (es)	1977-09-13
CH624115A5 (es)	1981-07-15
PT65521B (de)	1978-07-04
CH624114A5 (es)	1981-07-15
ES454086A1 (es)	1977-11-16
IE44069B1 (en)	1981-08-12
IL50355A0 (en)	1976-10-31
ATA553976A (de)	1978-11-15
ES450897A1 (es)	1977-12-01
AU1720176A (en)	1978-03-02
HU176929B (hu)	1981-06-28
IL50355A (en)	1979-11-30
MX4133E (es)	1982-01-06
BG27545A3 (en)	1979-11-12
SE7609495L (sv)	1977-02-28
IE44069L (en)	1977-02-27
FR2321888B1 (es)	1980-01-11
GB1519719A (en)	1978-08-02
FR2321888A1 (fr)	1977-03-25
CS192564B2 (en)	1979-08-31
AU499926B2 (en)	1979-05-03
CA1068266A (en)	1979-12-18
PL110724B1 (en)	1980-07-31
DK386876A (da)	1977-02-28
ES454085A1 (es)	1977-11-16
CH622521A5 (es)	1981-04-15
SU612631A3 (ru)	1978-06-25
ES454084A1 (es)	1977-11-16
SU638262A3 (ru)	1978-12-15
CS192599B2 (en)	1979-08-31
PL109091B1 (en)	1980-05-31
FI762430A (es)	1977-02-28
JPS5231100A (en)	1977-03-09
PL192020A1 (pl)	1979-03-12

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