DK1487859T3 - Fremstillingsmetoder til at fremstille Eplerenon - Google Patents

Fremstillingsmetoder til at fremstille Eplerenon

Info

Publication number: DK1487859T3
Authority: DK; Denmark
Prior art keywords: eplerenone; making; preparation methods; 7alpha; processes
Prior art date: 2002-03-22

Application number

DK03745535T

Other languages

Danish (da)

English (en)

Inventor

Bruce Allen Pearlman

Amphlett Greg Padilla

Jeffrey L Havens

Sonja S Mackey

Haifeng Wu

Original Assignee

Pharmacia & Upjohn Co Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-03-22

Filing date

2003-03-21

Publication date

2008-10-06

2003-03-21 Application filed by Pharmacia & Upjohn Co Llc filed Critical Pharmacia & Upjohn Co Llc

2008-10-06 Application granted granted Critical

2008-10-06 Publication of DK1487859T3 publication Critical patent/DK1487859T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Catalysts (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK03745535T 2002-03-22 2003-03-21 Fremstillingsmetoder til at fremstille Eplerenon DK1487859T3 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US36678402P	2002-03-22	2002-03-22
US41187402P	2002-09-19	2002-09-19
US42559602P	2002-11-12	2002-11-12
PCT/US2003/007793 WO2003082895A2 (en)	2002-03-22	2003-03-21	Process to prepare eplerenone

Publications (1)

Publication Number	Publication Date
DK1487859T3 true DK1487859T3 (da)	2008-10-06

Family

ID=28678917

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK03745535T DK1487859T3 (da)	2002-03-22	2003-03-21	Fremstillingsmetoder til at fremstille Eplerenon

Country Status (23)

Country	Link
US (2)	US20040024202A1 (ko)
EP (2)	EP1490390A2 (ko)
JP (2)	JP2005523306A (ko)
KR (3)	KR20050028907A (ko)
CN (2)	CN1653081A (ko)
AT (1)	ATE404577T1 (ko)
AU (2)	AU2003259022A1 (ko)
BR (2)	BR0308660A (ko)
CA (2)	CA2474072A1 (ko)
CY (1)	CY1108453T1 (ko)
DE (1)	DE60322852D1 (ko)
DK (1)	DK1487859T3 (ko)
ES (1)	ES2310666T3 (ko)
HK (1)	HK1078588A1 (ko)
IL (2)	IL164159A0 (ko)
MX (2)	MXPA04009216A (ko)
MY (1)	MY138479A (ko)
PL (2)	PL373189A1 (ko)
PT (1)	PT1487859E (ko)
RS (2)	RS83104A (ko)
SI (1)	SI1487859T1 (ko)
TW (2)	TW200401781A (ko)
WO (2)	WO2003082895A2 (ko)

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US7235655B2 (en)	2002-03-22	2007-06-26	Pharmacia & Upjohn Company	Processes to prepare eplerenone
CL2004000574A1 (es) *	2003-03-21	2005-02-11	Pharmacia Corp Sa Organizada B	Proceso para preparar un compuesto 17-espirolactona o la sal de lactona abierta por carbonilacion del correspondiente 17-alquenil o alquinil derivado, los intermediarios que se usan y su proceso de obtencion.
HUP0402466A2 (en) *	2004-11-30	2006-07-28	Richter Gedeon Vegyeszet	Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main, intermediates of the process
CN1310941C (zh) *	2005-07-13	2007-04-18	南京大学	依普利酮的合成方法
CN1321128C (zh) *	2005-07-15	2007-06-13	浙江医药股份有限公司新昌制药厂	孕甾－4－烯－7，21－二甲酸，9，11－环氧－17－羟基－3－氧代，γ－内酯，甲酯，(7α,11α,17α)－的制备方法
WO2007025780A2 (en) *	2005-09-02	2007-03-08	Recordati Ireland Limited	Aldosterone receptor antagonists
JP2007297352A (ja) *	2006-05-02	2007-11-15	Toho Earthtech Inc	ヨウ化アルキルの製造方法および２−アルキル置換シクロヘキサノンの製造方法
EP2171077B1 (en) *	2007-07-11	2012-11-28	DSM IP Assets B.V.	Enantioselective reduction
WO2009111574A2 (en) *	2008-03-05	2009-09-11	Evestra, Inc.	BISMETHYLENE-17α CARBOLACTONES AND RELATED USES
WO2010068500A2 (en) *	2008-11-25	2010-06-17	Evestra, Inc.	PROGESTATIONAL 3-(6,6-ETHYLENE-17b-HYDROXY-3-OXO-17a-PREGNA-4-ENE-17a -YL) PROPIONIC ACID g-LACTONES
CN102464551B (zh) *	2010-11-17	2014-03-26	中国石油化工股份有限公司	异丁烯歧化反应制四甲基乙烯的方法
US9562068B2 (en)	2014-10-17	2017-02-07	Industriale Chimica, S.R.L.	Process for the preparation of 7 α-(methoxycarbonyl)-3-OXO-17alpha-pregn-4,9(11)-dien-21,17-carbolactone, a useful intermediate for the synthesis of molecules with pharmacological activity
CN105753930A (zh) *	2016-03-30	2016-07-13	北京万全德众医药生物技术有限公司	依普利酮的一种合成方法
CN108003156B (zh) *	2018-01-29	2021-04-20	辽宁科技大学	一种咪唑并吡啶基1,2-乙二酮衍生物的合成方法

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US3759791A (en) *	1970-12-10	1973-09-18	Searle & Co	Selective microbiological preparation of androst-4-ene-3,17-dione
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DE3344057A1 (de) *	1982-12-09	1984-06-14	Ciba-Geigy Ag, Basel	Eine neue lactonverbindung und pharmazeutische zusammensetzungen davon, sowie verfahren zu ihrer herstellung
JPS59139400A (ja) *	1983-01-31	1984-08-10	Shionogi & Co Ltd	抗アルドステロン活性ステロイド誘導体
US4559332A (en) *	1983-04-13	1985-12-17	Ciba Geigy Corporation	20-Spiroxanes and analogues having an open ring E, processes for their manufacture, and pharmaceutical preparations thereof
AU607948B2 (en) *	1986-10-10	1991-03-21	Aventis Pharma S.A.	9-alpha-hydroxy steroids and process for their preparation
FR2610933B1 (fr) *	1987-02-18	1989-06-09	Roussel Uclaf	Nouveaux 19-nor steroides substitues en position 7, leur preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant
DE3903988A1 (de) *	1989-02-10	1990-08-30	Basf Ag	Oxidierte diphenylheteroalkane, ihre herstellung und verwendung
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AU680818B2 (en) *	1992-05-21	1997-08-14	Endorecherche Inc.	Improved antiandrogens
US5502222A (en) *	1994-06-01	1996-03-26	Schering Corporation	Process for preparing delta 9,11 and 21-chloro corticosteroids
EA009176B1 (ru) *	1995-12-11	2007-12-28	Дж.Д.Серл Энд Ко.	Способ получения 7-альфа-карбоксил-9,11-эпоксистероидов и промежуточных продуктов, используемых для их получения, и общий способ эпоксидирования по олефиновым двойным связям
JP2001509792A (ja) *	1996-12-11	2001-07-24	ジー．ディー．サールアンドカンパニー	９，１１−エポキシステロイドの製造法ならびに該方法に有用な中間体
US6887991B1 (en) *	1996-12-11	2005-05-03	G. D. Searle & Company	Processes for preparation of 9, 11-epoxy steroids and intermediates useful therein
US7235655B2 (en) *	2002-03-22	2007-06-26	Pharmacia & Upjohn Company	Processes to prepare eplerenone

2003
- 2003-03-21 WO PCT/US2003/007793 patent/WO2003082895A2/en active Application Filing
- 2003-03-21 CN CNA038113430A patent/CN1653081A/zh active Pending
- 2003-03-21 PL PL03373189A patent/PL373189A1/xx unknown
- 2003-03-21 AU AU2003259022A patent/AU2003259022A1/en not_active Abandoned
- 2003-03-21 MX MXPA04009216A patent/MXPA04009216A/es unknown
- 2003-03-21 WO PCT/US2003/007792 patent/WO2003082894A2/en active Application Filing
- 2003-03-21 DK DK03745535T patent/DK1487859T3/da active
- 2003-03-21 RS YU83104A patent/RS83104A/sr unknown
- 2003-03-21 PT PT03745535T patent/PT1487859E/pt unknown
- 2003-03-21 MX MXPA04009178A patent/MXPA04009178A/es not_active Application Discontinuation
- 2003-03-21 RS YU90504A patent/RS90504A/sr unknown
- 2003-03-21 EP EP03716548A patent/EP1490390A2/en not_active Withdrawn
- 2003-03-21 DE DE60322852T patent/DE60322852D1/de not_active Expired - Lifetime
- 2003-03-21 JP JP2003580359A patent/JP2005523306A/ja not_active Ceased
- 2003-03-21 BR BR0308660-7A patent/BR0308660A/pt not_active IP Right Cessation
- 2003-03-21 KR KR1020047014956A patent/KR20050028907A/ko not_active Application Discontinuation
- 2003-03-21 KR KR10-2004-7014916A patent/KR20040097201A/ko active IP Right Grant
- 2003-03-21 EP EP03745535A patent/EP1487859B1/en not_active Expired - Lifetime
- 2003-03-21 IL IL16415903A patent/IL164159A0/xx unknown
- 2003-03-21 CN CNB038065908A patent/CN100473660C/zh not_active Expired - Lifetime
- 2003-03-21 TW TW092106344A patent/TW200401781A/zh unknown
- 2003-03-21 CA CA002474072A patent/CA2474072A1/en not_active Abandoned
- 2003-03-21 SI SI200331329T patent/SI1487859T1/sl unknown
- 2003-03-21 CA CA002480151A patent/CA2480151A1/en not_active Abandoned
- 2003-03-21 ES ES03745535T patent/ES2310666T3/es not_active Expired - Lifetime
- 2003-03-21 BR BR0308466-3A patent/BR0308466A/pt not_active IP Right Cessation
- 2003-03-21 AU AU2003220251A patent/AU2003220251A1/en not_active Abandoned
- 2003-03-21 IL IL16416603A patent/IL164166A0/xx unknown
- 2003-03-21 AT AT03745535T patent/ATE404577T1/de active
- 2003-03-21 JP JP2003580358A patent/JP2005528371A/ja not_active Withdrawn
- 2003-03-21 KR KR1020107027095A patent/KR20100131018A/ko not_active Application Discontinuation
- 2003-03-21 PL PL03372460A patent/PL372460A1/xx unknown
- 2003-03-21 TW TW092106310A patent/TWI283245B/zh active
- 2003-03-21 US US10/392,857 patent/US20040024202A1/en not_active Abandoned
- 2003-03-22 MY MYPI20031014A patent/MY138479A/en unknown
2005
- 2005-11-18 HK HK05110391.9A patent/HK1078588A1/xx not_active IP Right Cessation
2006
- 2006-12-21 US US11/614,538 patent/US20070129332A1/en not_active Abandoned
2008
- 2008-10-24 CY CY20081101205T patent/CY1108453T1/el unknown

Also Published As

Publication number	Publication date
WO2003082895A2 (en)	2003-10-09
RS90504A (en)	2006-10-27
JP2005528371A (ja)	2005-09-22
IL164159A0 (en)	2005-12-18
ATE404577T1 (de)	2008-08-15
SI1487859T1 (sl)	2008-10-31
KR20050028907A (ko)	2005-03-23
EP1487859A2 (en)	2004-12-22
MY138479A (en)	2009-06-30
BR0308660A (pt)	2005-01-25
EP1490390A2 (en)	2004-12-29
CY1108453T1 (el)	2014-04-09
KR20040097201A (ko)	2004-11-17
WO2003082894A3 (en)	2004-04-15
PL372460A1 (en)	2005-07-25
US20040024202A1 (en)	2004-02-05
TWI283245B (en)	2007-07-01
MXPA04009178A (es)	2004-11-26
BR0308466A (pt)	2005-04-26
PT1487859E (pt)	2008-10-23
WO2003082894A2 (en)	2003-10-09
CN1633445A (zh)	2005-06-29
EP1487859B1 (en)	2008-08-13
KR20100131018A (ko)	2010-12-14
DE60322852D1 (de)	2008-09-25
IL164166A0 (en)	2005-12-18
PL373189A1 (en)	2005-08-22
JP2005523306A (ja)	2005-08-04
AU2003220251A1 (en)	2003-10-13
AU2003259022A1 (en)	2003-10-13
CN1653081A (zh)	2005-08-10
RS83104A (en)	2006-10-27
CN100473660C (zh)	2009-04-01
TW200401781A (en)	2004-02-01
CA2474072A1 (en)	2003-10-09
CA2480151A1 (en)	2003-10-09
US20070129332A1 (en)	2007-06-07
MXPA04009216A (es)	2005-01-25
ES2310666T3 (es)	2009-01-16
WO2003082895A3 (en)	2004-04-22
HK1078588A1 (en)	2006-03-17
TW200404079A (en)	2004-03-16

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BRPI0417205A (pt)	2007-02-06	composições farmacêuticas
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