DK148232C - 2-methoxyethylesteren af 4-hydroxy-2-methyl-2h-1,2-benzothiazin-3-carboxylsyre-1,1-dioxid og fremgangsmaade til omdannelse af denne til 4-hydroxy-2-methyl-n-2-pyridyl-2h-1,2-benzothiazin-3-carboxamid-1,1-dioxid (piroxicam) - Google Patents

2-methoxyethylesteren af 4-hydroxy-2-methyl-2h-1,2-benzothiazin-3-carboxylsyre-1,1-dioxid og fremgangsmaade til omdannelse af denne til 4-hydroxy-2-methyl-n-2-pyridyl-2h-1,2-benzothiazin-3-carboxamid-1,1-dioxid (piroxicam)

Info

Publication number: DK148232C
Authority: DK; Denmark
Prior art keywords: hydroxy; dioxide; methyl; benzothiazin; benzothiazine
Prior art date: 1980-09-29

Application number

DK428781A

Other languages

Danish (da)

English (en)

Other versions

DK428781A (da

DK148232B (da

Inventor

Joseph George Lombardino

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-09-29

Filing date

1981-09-28

Publication date

1985-10-21

1981-09-28 Application filed by Pfizer filed Critical Pfizer

1982-03-30 Publication of DK428781A publication Critical patent/DK428781A/da

1985-05-13 Publication of DK148232B publication Critical patent/DK148232B/da

1985-10-21 Application granted granted Critical

1985-10-21 Publication of DK148232C publication Critical patent/DK148232C/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Pyridine Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK428781A 1980-09-29 1981-09-28 2-methoxyethylesteren af 4-hydroxy-2-methyl-2h-1,2-benzothiazin-3-carboxylsyre-1,1-dioxid og fremgangsmaade til omdannelse af denne til 4-hydroxy-2-methyl-n-2-pyridyl-2h-1,2-benzothiazin-3-carboxamid-1,1-dioxid (piroxicam) DK148232C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US19171680		1980-09-29
US06/191,716 US4289879A (en)	1980-09-29	1980-09-29	Synthetic method and intermediate for piroxicam

Publications (3)

Publication Number	Publication Date
DK428781A DK428781A (da)	1982-03-30
DK148232B DK148232B (da)	1985-05-13
DK148232C true DK148232C (da)	1985-10-21

Family

ID=22706653

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK428781A DK148232C (da)	1980-09-29	1981-09-28	2-methoxyethylesteren af 4-hydroxy-2-methyl-2h-1,2-benzothiazin-3-carboxylsyre-1,1-dioxid og fremgangsmaade til omdannelse af denne til 4-hydroxy-2-methyl-n-2-pyridyl-2h-1,2-benzothiazin-3-carboxamid-1,1-dioxid (piroxicam)

Country Status (30)

Country	Link
US (1)	US4289879A (es)
EP (1)	EP0049099B1 (es)
JP (2)	JPS5788172A (es)
KR (1)	KR850000923B1 (es)
AR (1)	AR228373A1 (es)
AU (1)	AU528125B2 (es)
CA (1)	CA1171413A (es)
CS (1)	CS228520B2 (es)
DD (1)	DD202151A5 (es)
DE (1)	DE3171404D1 (es)
DK (1)	DK148232C (es)
EG (1)	EG16103A (es)
ES (1)	ES8206518A1 (es)
FI (1)	FI72719C (es)
GR (1)	GR75772B (es)
GT (1)	GT198171634A (es)
HK (1)	HK52287A (es)
HU (1)	HU186785B (es)
IE (1)	IE51598B1 (es)
IL (1)	IL63938A0 (es)
MY (1)	MY8700511A (es)
NO (1)	NO158061C (es)
NZ (1)	NZ198475A (es)
PH (1)	PH18475A (es)
PL (1)	PL130042B1 (es)
PT (1)	PT73738B (es)
SG (1)	SG23187G (es)
SU (1)	SU1122224A3 (es)
YU (1)	YU42428B (es)
ZA (1)	ZA816706B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4434164A (en)	1981-06-01	1984-02-28	Pfizer Inc.	Crystalline benzothiazine dioxide salts
IN158333B (es) *	1981-08-03	1986-10-18	Pfizer
GT198276334A (es) *	1981-08-03	1984-01-10		Procedimiento e inter-medios para la produccion de carboxamidas de benzotiazina.
US4376204A (en) *	1981-10-05	1983-03-08	Pfizer Inc.	3-Hydroxy 2-methyl benzisothiazolines as intermediates in production of piroxicam
IN159273B (es) *	1981-10-05	1987-04-25	Pfizer
CA1197244A (en) *	1982-04-16	1985-11-26	Medichem, S.A.	Process for the preparation of 4-hydroxy-2-methyl-2h- 1,2-benzothiazine-3-carboxamide-1,1-dioxides
SU1306476A3 (ru) *	1982-06-17	1987-04-23	Пфайзер,Инк (Фирма)	Способ получени 2-метил-3- @ -(2-пиридил)-карбамоил-3,4-дигидро-2 @ -1,2-бензтиазин-1,1-диоксида
EP0098422B1 (de) *	1982-07-07	1987-12-09	Siegfried Aktiengesellschaft	Verfahren zur Herstellung von 4-Hydroxy-2-methyl-N-2-pyridyl-2H-1,2-benzothiazin-3-carboxamid 1,1-dioxid
IT1153293B (it) *	1982-10-22	1987-01-14	Francia Famaceutici S R L	Derivati del 4-idrossi-2-metil-2h-1, 2-benzotiazina-3-carbossamide 1, 1-biossido e procedimento per la loro preparazione
FI72317C (fi) *	1983-10-06	1987-05-11	Pfizer	Foerfarande foer framstaellning av farmaceutiskt anvaendbar 2-metyl-4-hydroxi-2h-1,2-benzotiazin-1,1-dioxid -3-(n-2-pyridyl)-karboxamid och i foerfarandet anvaendbar mellanprodukt.
WO1987006933A1 (en) *	1986-05-16	1987-11-19	Pfizer Inc.	Benzothiazine dioxide derivatives
ES2002646A6 (es) *	1987-03-27	1988-09-01	Induspol Sa	Procedimiento para la obtencion de 4-hidroxi-2-metil-n-(2-piri-dil)-2h-1,2-benzotiacina-3-carboxamida 1,1-dioxido
WO1989003682A1 (en) *	1987-10-26	1989-05-05	Pfizer Inc.	Benzothiazine dioxide derivatives
FR2942797B1 (fr) *	2009-03-03	2011-04-29	Pf Medicament	Derives de benzothiazines, leur preparation et leur application a titre de medicaments

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3501466A (en) *	1967-11-30	1970-03-17	Mcneilab Inc	3-carbamoyl and 3-alkoxycarbonyl benzothiazine-1,1-dioxides
US3591584A (en) *	1968-08-27	1971-07-06	Pfizer	Benzothiazine dioxides
US3787324A (en) *	1971-03-01	1974-01-22	Warner Lambert Co	4-hydroxy-3-(3-isoxazolocarbamyl)-2h-1,2-benzothiazine 1,dioxides and process for their production
US3853862A (en) *	1973-04-23	1974-12-10	Pfizer	Production of 4-hydroxy-1,2-benzothiazine-3-carboxamides
US4074048A (en) *	1976-05-10	1978-02-14	Warner-Lambert Company	Process for the preparation of 4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides

1980
- 1980-09-29 US US06/191,716 patent/US4289879A/en not_active Expired - Lifetime
1981
- 1981-09-23 DE DE8181304370T patent/DE3171404D1/de not_active Expired
- 1981-09-23 EP EP81304370A patent/EP0049099B1/en not_active Expired
- 1981-09-23 EG EG541/81A patent/EG16103A/xx active
- 1981-09-25 GT GT198171634A patent/GT198171634A/es unknown
- 1981-09-25 YU YU2309/81A patent/YU42428B/xx unknown
- 1981-09-25 CA CA000386690A patent/CA1171413A/en not_active Expired
- 1981-09-25 IL IL63938A patent/IL63938A0/xx not_active IP Right Cessation
- 1981-09-25 IE IE2233/81A patent/IE51598B1/en not_active IP Right Cessation
- 1981-09-25 AR AR286875A patent/AR228373A1/es active
- 1981-09-28 KR KR1019810003626A patent/KR850000923B1/ko active
- 1981-09-28 PT PT73738A patent/PT73738B/pt not_active IP Right Cessation
- 1981-09-28 JP JP56153540A patent/JPS5788172A/ja active Granted
- 1981-09-28 DD DD81233629A patent/DD202151A5/de not_active IP Right Cessation
- 1981-09-28 PL PL1981233212A patent/PL130042B1/pl unknown
- 1981-09-28 SU SU813338298A patent/SU1122224A3/ru active
- 1981-09-28 CS CS817107A patent/CS228520B2/cs unknown
- 1981-09-28 GR GR66142A patent/GR75772B/el unknown
- 1981-09-28 NZ NZ198475A patent/NZ198475A/xx unknown
- 1981-09-28 ES ES505851A patent/ES8206518A1/es not_active Expired
- 1981-09-28 NO NO813290A patent/NO158061C/no unknown
- 1981-09-28 DK DK428781A patent/DK148232C/da not_active IP Right Cessation
- 1981-09-28 HU HU812792A patent/HU186785B/hu not_active IP Right Cessation
- 1981-09-28 ZA ZA816706A patent/ZA816706B/xx unknown
- 1981-09-28 AU AU75698/81A patent/AU528125B2/en not_active Ceased
- 1981-09-28 FI FI813003A patent/FI72719C/fi not_active IP Right Cessation
- 1981-09-29 PH PH26285A patent/PH18475A/en unknown
1985
- 1985-11-06 JP JP60248694A patent/JPS61112064A/ja active Granted
1987
- 1987-03-09 SG SG231/87A patent/SG23187G/en unknown
- 1987-07-09 HK HK522/87A patent/HK52287A/xx unknown
- 1987-12-30 MY MY511/87A patent/MY8700511A/xx unknown

Also Published As

Publication number	Publication date
YU42428B (en)	1988-08-31
FI813003L (fi)	1982-03-30
IE51598B1 (en)	1987-01-21
CA1171413A (en)	1984-07-24
AU7569881A (en)	1982-04-08
PT73738A (en)	1981-10-01
SG23187G (en)	1987-07-10
JPS632434B2 (es)	1988-01-19
MY8700511A (en)	1987-12-31
PL130042B1 (en)	1984-07-31
IL63938A0 (en)	1981-12-31
HK52287A (en)	1987-07-17
NO813290L (no)	1982-03-30
HU186785B (en)	1985-09-30
DE3171404D1 (en)	1985-08-22
DD202151A5 (de)	1983-08-31
PH18475A (en)	1985-07-18
GR75772B (es)	1984-08-02
NO158061B (no)	1988-03-28
KR830007604A (ko)	1983-11-04
NO158061C (no)	1988-07-06
GT198171634A (es)	1983-03-19
PL233212A1 (es)	1982-08-30
AR228373A1 (es)	1983-02-28
EG16103A (en)	1987-10-30
YU230981A (en)	1983-06-30
CS228520B2 (en)	1984-05-14
NZ198475A (en)	1984-07-31
ES505851A0 (es)	1982-08-16
ES8206518A1 (es)	1982-08-16
EP0049099B1 (en)	1985-07-17
JPH0315638B2 (es)	1991-03-01
PT73738B (en)	1983-11-08
US4289879A (en)	1981-09-15
JPS5788172A (en)	1982-06-01
JPS61112064A (ja)	1986-05-30
AU528125B2 (en)	1983-04-14
DK428781A (da)	1982-03-30
SU1122224A3 (ru)	1984-10-30
FI72719B (fi)	1987-03-31
FI72719C (fi)	1987-07-10
KR850000923B1 (ko)	1985-06-28
DK148232B (da)	1985-05-13
ZA816706B (en)	1982-09-29
EP0049099A3 (en)	1982-09-08
EP0049099A2 (en)	1982-04-07
IE812233L (en)	1982-03-29

Publication	Publication Date	Title
DK155665C (da)	1989-09-04	Analogifremgangsmaade til fremstilling af carbostyrilforbindelser
DK158932C (da)	1991-01-21	Fremgangsmaade til fremstilling af pancreatinpiller
NO161118C (no)	1989-07-05	Fremgangsmaate for utvinning av for fysiologiske formaal direkte anvendbart ren-licithin.
NO156006C (no)	1987-07-08	Fremgangsmaate til fremstilling av avvannede alifatiske alkoholer.
NO801328L (no)	1981-11-09	Anordning ved rygglene.
DK574481A (da)	1982-07-03	Fremgangsmaade til fremstilling af pyridylmethylestere
DK157193C (da)	1990-04-09	Analogifremgangsmaade til fremstilling af carbostyrilforbindelser
IT7924911A0 (it)	1979-08-03	Collegamento di elementi costruttivi.
DK148232C (da)	1985-10-21	2-methoxyethylesteren af 4-hydroxy-2-methyl-2h-1,2-benzothiazin-3-carboxylsyre-1,1-dioxid og fremgangsmaade til omdannelse af denne til 4-hydroxy-2-methyl-n-2-pyridyl-2h-1,2-benzothiazin-3-carboxamid-1,1-dioxid (piroxicam)
NO157861C (no)	1988-06-01	Analogifremgangsmaate til fremstilling av aminopyridaziner.
ES269846Y (es)	1984-01-16	Disposicion de tratamiento de pestanas.
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NL7803780A (nl)	1978-10-17	Werkwijze voor het fractioneren van talg.
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IT7923783A0 (it)	1979-06-21	Procedimento per la determinazione di caratteristiche reologiche di sostanze viscoso-elastiche.
DK151273C (da)	1988-07-04	Fremgangsmaade til fremstilling af cholesterolbiosynteseinhibitoren mb- 530a.
FI802438A (fi)	1982-02-05	Gasblaosroer foer inmatning av reaktionsaemnen i metallurgiska smaeltor
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DK255279A (da)	1979-12-21	Piperidinderivater af 1,3,5-triazoxycloheptan-2,4-dion samt fremgangsmaade til fremstilling og anvendelse af disse
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DK149026C (da)	1986-07-07	Analogifremgangsmaade til fremstilling af adeninnucleosidderivater

Legal Events

Date	Code	Title	Description
1994-05-24	PBP	Patent lapsed