DK1387844T3 - Retinolderivaters forstærkning af aktive stoffer ved micellær fremstilling - Google Patents
Retinolderivaters forstærkning af aktive stoffer ved micellær fremstillingInfo
- Publication number
- DK1387844T3 DK1387844T3 DK02701856T DK02701856T DK1387844T3 DK 1387844 T3 DK1387844 T3 DK 1387844T3 DK 02701856 T DK02701856 T DK 02701856T DK 02701856 T DK02701856 T DK 02701856T DK 1387844 T3 DK1387844 T3 DK 1387844T3
- Authority
- DK
- Denmark
- Prior art keywords
- reinforcement
- active substances
- micellar preparation
- retinol derivatives
- derivatives
- Prior art date
Links
- 239000013543 active substance Substances 0.000 title 1
- 230000002787 reinforcement Effects 0.000 title 1
- 150000004609 retinol derivatives Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229930012538 Paclitaxel Natural products 0.000 abstract 2
- 238000009472 formulation Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 229960001592 paclitaxel Drugs 0.000 abstract 2
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 231100000433 cytotoxic Toxicity 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 125000001444 retinoyl group Chemical class O=C([*])/C([H])=C(C([H])([H])[H])/C([H])=C([H])/C([H])=C(C([H])([H])[H])/C([H])=C([H])/C1=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
- 159000000000 sodium salts Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/203—Retinoic acids ; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/20—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/22—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/09—Geometrical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cosmetics (AREA)
- Epoxy Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0101702A SE0101702D0 (sv) | 2001-05-15 | 2001-05-15 | Novel potentiating compounds |
| US30279001P | 2001-07-03 | 2001-07-03 | |
| PCT/SE2002/000380 WO2002092600A1 (en) | 2001-05-15 | 2002-03-05 | Retinol derivatives potentiation of active substances by micellar preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1387844T3 true DK1387844T3 (da) | 2007-10-15 |
Family
ID=20284111
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07106715T DK1826198T3 (da) | 2001-05-15 | 2002-03-05 | Fremgangsmåde til syntese af natriumsaltene af retinoylderivater |
| DK02701856T DK1387844T3 (da) | 2001-05-15 | 2002-03-05 | Retinolderivaters forstærkning af aktive stoffer ved micellær fremstilling |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07106715T DK1826198T3 (da) | 2001-05-15 | 2002-03-05 | Fremgangsmåde til syntese af natriumsaltene af retinoylderivater |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6642271B2 (da) |
| EP (3) | EP1826198B1 (da) |
| JP (1) | JP4147114B2 (da) |
| AT (2) | ATE364586T1 (da) |
| AU (1) | AU2002235085B2 (da) |
| CA (1) | CA2445478C (da) |
| DE (2) | DE60233276D1 (da) |
| DK (2) | DK1826198T3 (da) |
| ES (2) | ES2288183T3 (da) |
| HK (1) | HK1110574A1 (da) |
| PT (2) | PT1826198E (da) |
| SE (1) | SE0101702D0 (da) |
| WO (1) | WO2002092600A1 (da) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0101702D0 (sv) | 2001-05-15 | 2001-05-15 | Ardenia Investments Ltd | Novel potentiating compounds |
| SE0202311D0 (sv) * | 2002-07-23 | 2002-07-23 | Ardenia Investments Ltd | Novel compounds, cytotoxic preparations comprising said compounds, methods of manufacture of said preparations, as well as methods of treatment |
| CN100360502C (zh) * | 2002-07-23 | 2008-01-09 | 阿登尼亚投资有限公司 | 视黄醇衍生物、它们在治疗癌症和增强其它细胞毒性剂功效中的应用 |
| US9572886B2 (en) | 2005-12-22 | 2017-02-21 | Nitto Denko Corporation | Agent for treating myelofibrosis |
| TW200918099A (en) * | 2007-09-14 | 2009-05-01 | Nitto Denko Corp | Drug carriers |
| WO2009078755A1 (en) * | 2007-12-19 | 2009-06-25 | Ardenia Investments, Ltd. | Drug delivery system for administration of a water soluble, cationic and amphiphilic pharmaceutically active substance |
| WO2009078754A1 (en) | 2007-12-19 | 2009-06-25 | Ardenia Investments, Ltd. | Drug delivery system for administration of poorly water soluble pharmaceutically active substances |
| WO2009078756A1 (en) * | 2007-12-19 | 2009-06-25 | Ardenia Investments, Ltd. | Drug delivery system for administration of a water soluble, cationic and amphiphilic pharmaceutically active substance |
| EP2323693B1 (en) * | 2008-07-30 | 2017-11-08 | Nitto Denko Corporation | Drug carriers |
| BR112018011414B1 (pt) | 2015-12-09 | 2022-09-20 | Oasmia Pharmaceutical Ab | Método para produzir derivados de ácido n-retinoilaminoalcano sulfônico |
| GB2550346B (en) | 2016-05-13 | 2021-02-24 | Phytoceutical Ltd | Micelles |
| CN107149684B (zh) * | 2017-05-08 | 2019-10-25 | 西南大学 | 半胱氨酸双加氧酶、基因及其催化产物半胱亚磺酸的新用途 |
| CN110218168B (zh) * | 2018-03-02 | 2022-09-20 | 上海现代药物制剂工程研究中心有限公司 | 一种n-(全反式-视黄酰基)-l-半胱磺酸甲酯的钠盐的制备方法 |
| CN112321465B (zh) * | 2019-07-18 | 2023-06-06 | 上海现代药物制剂工程研究中心有限公司 | 一种含苯基化合物、其中间体、制备方法及应用 |
| CN112239418B (zh) * | 2019-07-18 | 2023-07-07 | 上海现代药物制剂工程研究中心有限公司 | 视黄醇类化合物及其钠盐的制备方法 |
| WO2024068553A1 (en) | 2022-09-26 | 2024-04-04 | Vivesto Ab | Solubilizing compounds |
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-
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- 2001-05-15 SE SE0101702A patent/SE0101702D0/xx unknown
-
2002
- 2002-03-05 EP EP07106715A patent/EP1826198B1/en not_active Expired - Lifetime
- 2002-03-05 PT PT07106715T patent/PT1826198E/pt unknown
- 2002-03-05 JP JP2002589484A patent/JP4147114B2/ja not_active Expired - Lifetime
- 2002-03-05 ES ES02701856T patent/ES2288183T3/es not_active Expired - Lifetime
- 2002-03-05 DE DE60233276T patent/DE60233276D1/de not_active Expired - Lifetime
- 2002-03-05 EP EP09167175A patent/EP2116524B1/en not_active Expired - Lifetime
- 2002-03-05 WO PCT/SE2002/000380 patent/WO2002092600A1/en active IP Right Grant
- 2002-03-05 EP EP02701856A patent/EP1387844B1/en not_active Expired - Lifetime
- 2002-03-05 ES ES07106715T patent/ES2331264T3/es not_active Expired - Lifetime
- 2002-03-05 AT AT02701856T patent/ATE364586T1/de active
- 2002-03-05 AT AT07106715T patent/ATE438616T1/de active IP Right Revival
- 2002-03-05 DK DK07106715T patent/DK1826198T3/da active
- 2002-03-05 DK DK02701856T patent/DK1387844T3/da active
- 2002-03-05 CA CA002445478A patent/CA2445478C/en not_active Expired - Lifetime
- 2002-03-05 AU AU2002235085A patent/AU2002235085B2/en not_active Expired
- 2002-03-05 DE DE60220666T patent/DE60220666T2/de not_active Expired - Lifetime
- 2002-03-05 PT PT02701856T patent/PT1387844E/pt unknown
- 2002-03-15 US US10/098,873 patent/US6642271B2/en not_active Expired - Lifetime
-
2008
- 2008-02-01 HK HK08101276.5A patent/HK1110574A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE364586T1 (de) | 2007-07-15 |
| CA2445478C (en) | 2009-05-26 |
| US20030050343A1 (en) | 2003-03-13 |
| US6642271B2 (en) | 2003-11-04 |
| DE60233276D1 (de) | 2009-09-17 |
| SE0101702D0 (sv) | 2001-05-15 |
| DE60220666D1 (de) | 2007-07-26 |
| EP1387844B1 (en) | 2007-06-13 |
| EP2116524B1 (en) | 2012-10-03 |
| DK1826198T3 (da) | 2009-12-07 |
| EP1826198A1 (en) | 2007-08-29 |
| AU2002235085B2 (en) | 2006-12-07 |
| HK1110574A1 (en) | 2008-07-18 |
| JP4147114B2 (ja) | 2008-09-10 |
| EP2116524A1 (en) | 2009-11-11 |
| WO2002092600A1 (en) | 2002-11-21 |
| EP1826198B1 (en) | 2009-08-05 |
| DE60220666T2 (de) | 2008-02-28 |
| PT1826198E (pt) | 2009-09-28 |
| ATE438616T1 (de) | 2009-08-15 |
| EP1387844A1 (en) | 2004-02-11 |
| CA2445478A1 (en) | 2002-11-21 |
| PT1387844E (pt) | 2007-08-24 |
| JP2005508287A (ja) | 2005-03-31 |
| ES2331264T3 (es) | 2009-12-28 |
| ES2288183T3 (es) | 2008-01-01 |
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