DK1349856T3 - Isoindolin-1-on-glucokinase-aktivatorer - Google Patents

Isoindolin-1-on-glucokinase-aktivatorer

Info

Publication number: DK1349856T3
Authority: DK; Denmark
Prior art keywords: isoindolin; glucokinase activators; glucokinase; activators; diabetes
Prior art date: 2000-12-13

Application number

DK01986857T

Other languages

English (en)

Inventor

Kevin Richard Guertin

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-13

Filing date

2001-12-07

Publication date

2005-10-17

2001-12-07 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2005-10-17 Application granted granted Critical

2005-10-17 Publication of DK1349856T3 publication Critical patent/DK1349856T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Diabetes (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Breeding Of Plants And Reproduction By Means Of Culturing (AREA)

DK01986857T 2000-12-13 2001-12-07 Isoindolin-1-on-glucokinase-aktivatorer DK1349856T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US25527300P	2000-12-13	2000-12-13
US31871501P	2001-09-13	2001-09-13
PCT/EP2001/014404 WO2002048106A2 (en)	2000-12-13	2001-12-07	Isoindolin-1-one glucokinase activators

Publications (1)

Publication Number	Publication Date
DK1349856T3 true DK1349856T3 (da)	2005-10-17

Family

ID=26944583

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01986857T DK1349856T3 (da)	2000-12-13	2001-12-07	Isoindolin-1-on-glucokinase-aktivatorer

Country Status (36)

Country	Link
US (1)	US6482951B2 (da)
EP (1)	EP1349856B1 (da)
JP (1)	JP4021766B2 (da)
KR (1)	KR100520651B1 (da)
CN (1)	CN1247574C (da)
AT (1)	ATE297922T1 (da)
AU (2)	AU2002238415B2 (da)
BG (1)	BG107903A (da)
BR (1)	BR0116169A (da)
CA (1)	CA2430579C (da)
CY (1)	CY1105587T1 (da)
CZ (1)	CZ20031882A3 (da)
DE (1)	DE60111570T2 (da)
DK (1)	DK1349856T3 (da)
EG (1)	EG24358A (da)
ES (1)	ES2243578T3 (da)
HK (1)	HK1063314A1 (da)
HR (1)	HRP20030450B1 (da)
HU (1)	HUP0400587A3 (da)
IL (2)	IL156264A0 (da)
MA (1)	MA26973A1 (da)
MX (1)	MXPA03005170A (da)
MY (1)	MY136741A (da)
NO (1)	NO325810B1 (da)
NZ (1)	NZ526236A (da)
PA (1)	PA8534601A1 (da)
PE (1)	PE20020593A1 (da)
PL (1)	PL366006A1 (da)
PT (1)	PT1349856E (da)
RS (1)	RS50933B (da)
RU (1)	RU2249590C2 (da)
SI (1)	SI1349856T1 (da)
SK (1)	SK8732003A3 (da)
TW (1)	TWI294876B (da)
UY (1)	UY27069A1 (da)
WO (1)	WO2002048106A2 (da)

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SE0102299D0 (sv)	2001-06-26	2001-06-26	Astrazeneca Ab	Compounds
SE0102764D0 (sv)	2001-08-17	2001-08-17	Astrazeneca Ab	Compounds
AU2003302279B2 (en)	2002-10-03	2008-06-12	Novartis Ag	Substituted (thiazol-2-yl) -amide or sulfonamide as glycokinase activators useful in the treatment of Type 2 diabetes
ES2293005T3 (es)	2002-10-03	2008-03-16	F. Hoffmann-La Roche Ag	Indol-3-carboxamidas como activadores de la glucocinasa.
GB0226931D0 (en)	2002-11-19	2002-12-24	Astrazeneca Ab	Chemical compounds
AU2003294376A1 (en) *	2003-01-06	2004-08-10	Eli Lilly And Company	Heteroaryl compounds
PL378117A1 (pl) *	2003-02-11	2006-03-06	Prosidion Limited	Tricyklopodstawione związki amidowe
WO2004072066A1 (en) *	2003-02-11	2004-08-26	Prosidion Limited	Tri(cyclo) substituted amide glucokinase activator compounds
US7320992B2 (en) *	2003-08-25	2008-01-22	Amgen Inc.	Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use
US7781451B2 (en) *	2004-04-02	2010-08-24	Novartis Ag	Thiazolopyridine derivatives, pharmaceut ical conditions containing them and methods of treating glucokinase mediated conditions
AU2005229416B2 (en)	2004-04-02	2009-03-26	Novartis Ag	Sulfonamide-thiazolpyridine derivatives as glucokinase activators useful the treatment of type 2 diabetes
BRPI0615236A2 (pt) *	2005-08-31	2011-05-10	Astellas Pharma Inc	derivado de tiazol
JP2007063225A (ja) *	2005-09-01	2007-03-15	Takeda Chem Ind Ltd	イミダゾピリジン化合物
WO2007039177A2 (en)	2005-09-29	2007-04-12	Sanofi-Aventis	Phenyl- and pyridinyl- 1, 2 , 4 - oxadiazolone derivatives, processes for their preparation and their use as pharmaceuticals
GT200600429A (es) *	2005-09-30	2007-04-30		Compuestos organicos
GT200600428A (es) *	2005-09-30	2007-05-21		Compuestos organicos
WO2007053657A1 (en) *	2005-11-01	2007-05-10	Janssen Pharmaceutica N.V.	Substituted pyrrolones as allosteric modulators of glucokinase
CN101321747A (zh) *	2005-11-01	2008-12-10	詹森药业有限公司	作为葡萄糖激酶变构调节剂的取代的环烷基吡咯酮类
JP2009518286A (ja) *	2005-11-01	2009-05-07	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	グルコキナーゼのアロステリックモジュレーターとしてのジヒドロイソインドロン
WO2007053503A1 (en) *	2005-11-01	2007-05-10	Janssen Pharmaceutica N.V.	Substituted dihydroisoindolones as allosteric modulators of glucokinase
US20090005391A1 (en) *	2005-11-03	2009-01-01	Matthew Colin Thor Fyfe	Tricyclo Substituted Amides
US20070197532A1 (en) *	2005-11-18	2007-08-23	Cao Sheldon X	Glucokinase activators
US8034822B2 (en)	2006-03-08	2011-10-11	Takeda San Diego, Inc.	Glucokinase activators
PE20080251A1 (es)	2006-05-04	2008-04-25	Boehringer Ingelheim Int	Usos de inhibidores de dpp iv
WO2007143434A2 (en)	2006-05-31	2007-12-13	Takeda San Diego, Inc.	Indazole and isoindole derivatives as glucokinase activating agents
WO2008074694A1 (en) *	2006-12-20	2008-06-26	F. Hoffmann-La Roche Ag	Crystallization of glucokinase activators
EP2091947A2 (en)	2006-12-20	2009-08-26	Takeda San Diego, Inc.	Glucokinase activators
TW200831081A (en) *	2006-12-25	2008-08-01	Kyorin Seiyaku Kk	Glucokinase activator
TW200902489A (en) *	2007-03-07	2009-01-16	Kyorin Seiyaku Kk	Glucokinase-activating substance
US8173645B2 (en) *	2007-03-21	2012-05-08	Takeda San Diego, Inc.	Glucokinase activators
TW200934772A (en) *	2008-01-15	2009-08-16	Lilly Co Eli	Crystalline(R)-2-(4-cyclopropanesulphonyl-phenyl)-N-pyrazin-2-yl-3-(tetrahydropyran-4-yl)-propionamide
PT2231640E (pt) *	2008-01-24	2012-08-23	Merck Patent Gmbh	Derivados beta-aminoácido para o tratamento de diabetes
MX2010011778A (es) *	2008-04-28	2010-11-30	Kyorin Seiyaku Kk	Derivados de ciclopentil acrilamida.
UY31830A (es) *	2008-05-16	2010-01-05	Takeda Pharmaceutical	Activadores de glucoquinasa
GEP20135793B (en) *	2008-09-11	2013-03-25	Pfizer	Heteroaryls amide derivatives and their use as glucokinase activators
ES2624780T3 (es)	2010-03-31	2017-07-17	The Scripps Research Institute	Reprogramación de células
US8178689B2 (en) *	2010-06-17	2012-05-15	Hoffman-La Roche Inc.	Tricyclic compounds
WO2012027331A1 (en)	2010-08-27	2012-03-01	Ironwood Pharmaceuticals, Inc.	Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
WO2012118972A2 (en)	2011-03-01	2012-09-07	Synegy Pharmaceuticals Inc.	Process of preparing guanylate cyclase c agonists
US8470866B2 (en)	2011-05-03	2013-06-25	Hoffmann-La Roche Inc.	Isoindolinone derivatives
LT3004076T (lt) *	2013-05-27	2020-01-10	F. Hoffmann-La Roche Ag	Nauji 3,4-dihidro-2h-izochinolin-1-ono ir 2,3-dihidro-izoindol-1-ono junginiai
US10011637B2 (en)	2013-06-05	2018-07-03	Synergy Pharmaceuticals, Inc.	Ultra-pure agonists of guanylate cyclase C, method of making and using same
WO2016030534A1 (en)	2014-08-29	2016-03-03	Tes Pharma S.R.L.	INHIBITORS OF α-AMINO-β-CARBOXYMUCONIC ACID SEMIALDEHYDE DECARBOXYLASE
CA3038185A1 (en)	2016-10-14	2018-04-19	Tes Pharma S.R.L.	Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
KR20210111248A (ko)	2018-11-20	2021-09-10	테스 파마 에스.알.엘.	α-아미노-β-카르복시뮤콘산 세미알데하이드 데카르복실라제의 저해제
CN116283717A (zh) *	2023-01-06	2023-06-23	暨南大学	一种藁本内酯衍生物及其制备方法和应用

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FR2687147A1 (fr) *	1992-02-11	1993-08-13	Union Pharma Scient Appl	Nouveaux derives d'alpha-amino n-pyridyl benzene propanamide, leurs procedes de preparation, compositions pharmaceutiques les contenant.
CZ301366B6 (cs)	1999-03-29	2010-02-03	F. Hoffmann-La Roche Ag	2-Fenyl-3-cykloalkylpropionamidová sloucenina, zpusob její prípravy a farmaceutický prostredek s jejím obsahem
PT1280801E (pt)	2000-05-03	2005-11-30	Hoffmann La Roche	Activadores da glucoquinase que contem hidantoina
ES2230309T3 (es)	2000-05-08	2005-05-01	F. Hoffmann-La Roche Ag	Fenilacetamidas sustituidas y su empleo con ativadores de qucokinasa.

2001
- 2001-12-06 US US10/010,978 patent/US6482951B2/en not_active Expired - Fee Related
- 2001-12-07 DK DK01986857T patent/DK1349856T3/da active
- 2001-12-07 AU AU2002238415A patent/AU2002238415B2/en not_active Ceased
- 2001-12-07 SI SI200130381T patent/SI1349856T1/xx unknown
- 2001-12-07 AT AT01986857T patent/ATE297922T1/de active
- 2001-12-07 HU HU0400587A patent/HUP0400587A3/hu unknown
- 2001-12-07 IL IL15626401A patent/IL156264A0/xx unknown
- 2001-12-07 WO PCT/EP2001/014404 patent/WO2002048106A2/en active IP Right Grant
- 2001-12-07 ES ES01986857T patent/ES2243578T3/es not_active Expired - Lifetime
- 2001-12-07 CA CA2430579A patent/CA2430579C/en not_active Expired - Fee Related
- 2001-12-07 NZ NZ526236A patent/NZ526236A/xx unknown
- 2001-12-07 MX MXPA03005170A patent/MXPA03005170A/es active IP Right Grant
- 2001-12-07 CZ CZ20031882A patent/CZ20031882A3/cs unknown
- 2001-12-07 RU RU2003120512/04A patent/RU2249590C2/ru not_active IP Right Cessation
- 2001-12-07 KR KR10-2003-7007869A patent/KR100520651B1/ko not_active IP Right Cessation
- 2001-12-07 PL PL01366006A patent/PL366006A1/xx unknown
- 2001-12-07 AU AU3841502A patent/AU3841502A/xx active Pending
- 2001-12-07 PT PT01986857T patent/PT1349856E/pt unknown
- 2001-12-07 BR BR0116169-5A patent/BR0116169A/pt not_active Application Discontinuation
- 2001-12-07 JP JP2002549637A patent/JP4021766B2/ja not_active Expired - Fee Related
- 2001-12-07 RS YUP-477/03A patent/RS50933B/sr unknown
- 2001-12-07 CN CNB018206107A patent/CN1247574C/zh not_active Expired - Fee Related
- 2001-12-07 DE DE60111570T patent/DE60111570T2/de not_active Expired - Lifetime
- 2001-12-07 EP EP01986857A patent/EP1349856B1/en not_active Expired - Lifetime
- 2001-12-07 SK SK873-2003A patent/SK8732003A3/sk unknown
- 2001-12-10 EG EG20011316A patent/EG24358A/xx active
- 2001-12-10 TW TW090130510A patent/TWI294876B/zh not_active IP Right Cessation
- 2001-12-10 PA PA20018534601A patent/PA8534601A1/es unknown
- 2001-12-11 MY MYPI20015613A patent/MY136741A/en unknown
- 2001-12-11 PE PE2001001234A patent/PE20020593A1/es not_active Application Discontinuation
- 2001-12-12 UY UY27069A patent/UY27069A1/es not_active Application Discontinuation
2003
- 2003-06-02 IL IL156264A patent/IL156264A/en not_active IP Right Cessation
- 2003-06-04 HR HR20030450A patent/HRP20030450B1/xx not_active IP Right Cessation
- 2003-06-12 MA MA27197A patent/MA26973A1/fr unknown
- 2003-06-12 NO NO20032674A patent/NO325810B1/no not_active IP Right Cessation
- 2003-06-13 BG BG107903A patent/BG107903A/bg unknown
2004
- 2004-08-11 HK HK04106031A patent/HK1063314A1/xx not_active IP Right Cessation
2005
- 2005-09-15 CY CY20051101133T patent/CY1105587T1/el unknown

Also Published As

Publication number	Publication date
EP1349856B1 (en)	2005-06-15
HRP20030450B1 (en)	2006-02-28
DE60111570D1 (de)	2005-07-21
SK8732003A3 (en)	2004-04-06
CN1247574C (zh)	2006-03-29
TWI294876B (en)	2008-03-21
NZ526236A (en)	2004-12-24
YU47703A (sh)	2006-05-25
NO20032674L (no)	2003-06-12
CY1105587T1 (el)	2010-07-28
CA2430579C (en)	2010-01-26
AU3841502A (en)	2002-06-24
UY27069A1 (es)	2002-07-31
RU2249590C2 (ru)	2005-04-10
NO20032674D0 (no)	2003-06-12
WO2002048106A2 (en)	2002-06-20
JP4021766B2 (ja)	2007-12-12
RS50933B (sr)	2010-08-31
HUP0400587A2 (hu)	2004-06-28
MA26973A1 (fr)	2004-12-20
BG107903A (bg)	2004-02-27
PE20020593A1 (es)	2002-07-06
US20020082260A1 (en)	2002-06-27
PA8534601A1 (es)	2002-08-26
BR0116169A (pt)	2003-12-23
AU2002238415B2 (en)	2007-01-04
PT1349856E (pt)	2005-09-30
JP2004521095A (ja)	2004-07-15
KR20030064817A (ko)	2003-08-02
DE60111570T2 (de)	2006-05-11
KR100520651B1 (ko)	2005-10-11
MY136741A (en)	2008-11-28
NO325810B1 (no)	2008-07-21
US6482951B2 (en)	2002-11-19
HK1063314A1 (en)	2004-12-24
CZ20031882A3 (cs)	2003-12-17
PL366006A1 (en)	2005-01-24
HRP20030450A2 (en)	2005-04-30
ES2243578T3 (es)	2005-12-01
ATE297922T1 (de)	2005-07-15
SI1349856T1 (en)	2005-10-31
HUP0400587A3 (en)	2011-03-28
MXPA03005170A (es)	2003-09-22
IL156264A (en)	2010-11-30
CN1481382A (zh)	2004-03-10
CA2430579A1 (en)	2002-06-20
WO2002048106A3 (en)	2002-11-28
IL156264A0 (en)	2004-01-04
EG24358A (en)	2009-03-04
EP1349856A2 (en)	2003-10-08

Publication	Publication Date	Title
DK1349856T3 (da)	2005-10-17	Isoindolin-1-on-glucokinase-aktivatorer
MY135222A (en)	2008-02-29	Substituted phenylacetamides and their use as glucokinase activators
PT1282611E (pt)	2005-02-28	Fenilacetamidas substituidas e sua utilizacao como activadores da glucocinase
MY180762A (en)	2020-12-08	Combination therapy comprising glucose reabsorption inhibitors and ppar modulators.
PT1311504E (pt)	2005-10-31	Tetrazolil-fenil-acetamidas activadoras da glucoquinase
MY136764A (en)	2008-11-28	Indole-3-carboxamides as glucokinase (gk) activators
MXPA05008406A (es)	2006-02-17	Compuestos de amida tri(ciclo)-sustituida.
DE60121988D1 (de)	2006-09-14	Kombinationstherapie mit antidiabetischen und antikonvulsiven mitteln
DE602004026113D1 (de)	2010-04-29	Glp-1-verbindungen
DE60134251D1 (de)	2008-07-10	Verwendung von glp-2-peptiden
CY1109972T1 (el)	2014-09-10	Χρηση τοξινης αλλαντιασης για τη θεραπευτικη αγωγη του πονου της νεραλγιας
ATE320457T1 (de)	2006-04-15	Polyurethanlösungen mit alkoxysilanstruktureinheiten
IS5570A (is)	2000-07-21	Meðhöndlun á risaeitlingasarkmeini með tálmum viðeitilfrumueiturslóðinni
DE60229414D1 (de)	2008-11-27	Verwendung von aplidine in der behandlung von pankreaskrebs
BR0314139A (pt)	2005-07-12	Derivados de 1,4-pirazina substituìdos
ATE305796T1 (de)	2005-10-15	Präparationen von vitamin e in kombination mit afamin
JO2238B1 (en)	2004-10-07	Glycine stimulants iswindline 1- on
DE10342518A1 (de)	2005-05-12	Plasminogen-Aktivatoren mit verringerter Lysin-Bindungskapazität
MXPA04000418A (es)	2004-03-18	Tratamiento de dolor cronico con 3-heterocicloxi- y -cicloalquiloxi-3-fenilpropanaminas.
MX2007004040A (es)	2007-05-24	Uso para alfa-simpatomimeticos con estructura de 2-imidazolina.
MXPA04003673A (es)	2004-07-23	Uso de aplidina para el tratamiento de cancer pancreatico.
UA70017A (en)	2004-09-15	Method for conservative treatment of chronic tonsillitis in adults
DK200000263Y6 (da)	2001-06-22	Bandage til behandling af tryksår, liggesår og lignede lidelser.