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DK120741B - Analogifremgangsmåde til fremstilling af benzensulfonyluringstoffer eller salte deraf. - Google Patents

Analogifremgangsmåde til fremstilling af benzensulfonyluringstoffer eller salte deraf.

Info

Publication number
DK120741B
DK120741B DK541565AA DK541565A DK120741B DK 120741 B DK120741 B DK 120741B DK 541565A A DK541565A A DK 541565AA DK 541565 A DK541565 A DK 541565A DK 120741 B DK120741 B DK 120741B
Authority
DK
Denmark
Prior art keywords
salts
preparation
analogous process
benzenesulfonyl urea
benzenesulfonyl
Prior art date
Application number
DK541565AA
Other languages
English (en)
Inventor
F Schmidt
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK120741B publication Critical patent/DK120741B/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/64Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/52Y being a hetero atom
    • C07C311/54Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
    • C07C311/57Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/59Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to carbon atoms of rings other than six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/22Nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/04Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/68Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK541565AA 1963-10-19 1965-10-22 Analogifremgangsmåde til fremstilling af benzensulfonyluringstoffer eller salte deraf. DK120741B (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DEF41042A DE1185180B (de) 1963-10-19 1963-10-19 Verfahren zur Herstellung von Benzolsulfonylharnstoffen
DEF0042062 1964-02-20
DEF0042933 1964-05-21
DEF0043268 1964-06-26

Publications (1)

Publication Number Publication Date
DK120741B true DK120741B (da) 1971-07-12

Family

ID=27436911

Family Applications (7)

Application Number Title Priority Date Filing Date
DK506164AA DK119052B (da) 1963-10-19 1964-10-14 Analogifremgangsmåde til fremstilling af benzensulfonylurinstoffer eller salte deraf.
DK542065AA DK120588B (da) 1963-10-19 1965-10-22 Analogifremgangsmåde til fremstilling af benzensulfonylurinstoffer eller salte deraf.
DK541765AA DK120742B (da) 1963-10-19 1965-10-22 Analogifremgangsmåde til fremstilling af benzensulfonylurinstoffer eller salte deraf.
DK541565AA DK120741B (da) 1963-10-19 1965-10-22 Analogifremgangsmåde til fremstilling af benzensulfonyluringstoffer eller salte deraf.
DK541665AA DK119455B (da) 1963-10-19 1965-10-22 Analogifremgangsmåde til fremstilling af benzensulfonylurinstoffer eller salte deraf.
DK541965AA DK120534B (da) 1963-10-19 1965-10-22 Analogifremgangsmåde til fremstilling af benzen sulfonylurinstoffer eller salte deraf.
DK541865AA DK119105B (da) 1963-10-19 1965-10-22 Analogifremgangsmåde til fremstilling af benzensulfonylurinstoffer eller salte deraf.

Family Applications Before (3)

Application Number Title Priority Date Filing Date
DK506164AA DK119052B (da) 1963-10-19 1964-10-14 Analogifremgangsmåde til fremstilling af benzensulfonylurinstoffer eller salte deraf.
DK542065AA DK120588B (da) 1963-10-19 1965-10-22 Analogifremgangsmåde til fremstilling af benzensulfonylurinstoffer eller salte deraf.
DK541765AA DK120742B (da) 1963-10-19 1965-10-22 Analogifremgangsmåde til fremstilling af benzensulfonylurinstoffer eller salte deraf.

Family Applications After (3)

Application Number Title Priority Date Filing Date
DK541665AA DK119455B (da) 1963-10-19 1965-10-22 Analogifremgangsmåde til fremstilling af benzensulfonylurinstoffer eller salte deraf.
DK541965AA DK120534B (da) 1963-10-19 1965-10-22 Analogifremgangsmåde til fremstilling af benzen sulfonylurinstoffer eller salte deraf.
DK541865AA DK119105B (da) 1963-10-19 1965-10-22 Analogifremgangsmåde til fremstilling af benzensulfonylurinstoffer eller salte deraf.

Country Status (21)

Country Link
US (2) US3426067A (da)
AT (5) AT262309B (da)
BE (1) BE654561A (da)
CH (1) CH529115A (da)
CY (1) CY436A (da)
DE (1) DE1185180B (da)
DK (7) DK119052B (da)
ES (1) ES312472A1 (da)
FI (1) FI44597B (da)
FR (2) FR1473834A (da)
GB (1) GB1080705A (da)
IL (1) IL22259A (da)
IS (1) IS765B6 (da)
IT (1) IT1061504B (da)
LU (1) LU47099A1 (da)
MC (1) MC488A1 (da)
MY (1) MY6800113A (da)
NL (1) NL6412137A (da)
NO (1) NO118548B (da)
OA (1) OA01367A (da)
SE (8) SE311151B (da)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1185180B (de) * 1963-10-19 1965-01-14 Hoechst Ag Verfahren zur Herstellung von Benzolsulfonylharnstoffen
DE1493672C3 (de) * 1964-08-01 1974-05-02 Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt Verfahren zur Herstellung von Benzolsulfonylharnstoffen
DE1443905C3 (de) * 1964-10-30 1979-03-15 Hoechst Ag, 6000 Frankfurt benzolsulfonyl] -N'-cyclohexylharnstoff, Verfahren zu seiner Herstellung und seine Verwendung
DE1518816C3 (de) * 1965-03-24 1975-05-22 Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt Benzolsulfonylharnstoffe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
US4066639A (en) * 1965-05-06 1978-01-03 Hoechst Aktiengesellschaft Benzene-sulfonyl semicarbazides and process for preparing them
US3454635A (en) * 1965-07-27 1969-07-08 Hoechst Ag Benzenesulfonyl-ureas and process for their manufacture
DE1518895C3 (de) * 1965-12-02 1978-12-07 Hoechst Ag, 6000 Frankfurt Benzolsulfonylharnstoffe, Verfahren zu ihrer Herstellung und deren Verwendung
DE1244174C2 (de) * 1965-09-10 1968-01-18 Hoechst Ag Verfahren zur Herstellung von Benzolsulfonylharnstoffen
US3932503A (en) * 1966-05-28 1976-01-13 Hoechst Aktiengesellschaft Benzenesulfonyl ureas
US3932658A (en) * 1969-02-25 1976-01-13 Hoechst Aktiengesellschaft Composition and method for lower blood sugar containing N-[4-(β-<2-methoxy-5-chloro-benzamido>-ethyl)-benzenesulfonyl]-N'-cyclopentyl-urea
NL138933B (nl) * 1969-03-26 1973-05-15 Erba Carlo Spa Werkwijze voor het bereiden van benzeensulfonylureumderivaten met bloedsuikerspiegelverlagende werking.
BE754454A (fr) * 1969-08-06 1971-02-05 Bayer Ag Nouveaux composes hypoglycemiques du type d'arylsulfonylurees et d'arylsulfonylsemicarbazides contenant des groupes carbonamide
ES384463A1 (es) * 1970-09-23 1973-10-01 Uriach & Cia Sa J Procedimiento para la obtencion de n-4 - (beta-o-anisamido etil) - bencenosulfonil - n'ciclopentilcarbamida.
US4072758A (en) * 1970-09-23 1978-02-07 J. Uriach Y Cia, S.A. Compositions and methods for effecting glucoreduction
US3957866A (en) * 1970-09-23 1976-05-18 J. Uriach & Cia S.A. Cyclopentyl carbamide derivative and process for its production
BE791638A (fr) * 1971-11-20 1973-05-21 Hoechst Ag Sulfonyl-urees, leur procede de preparation et leurs applications
DE2230543A1 (de) * 1972-06-22 1974-01-17 Hoechst Ag Benzolsulfonylharnstoffe und verfahren zu ihrer herstellung
US4067998A (en) * 1974-02-11 1978-01-10 The Dow Chemical Company 2-((3,5-Di-tert-butylphenyl)thio) alkanoic acids and derivatives
DE2413514C3 (de) * 1974-03-21 1982-03-04 Hoechst Ag, 6000 Frankfurt N-Acylaminoathylbenzolsulfonyl-N'-methylharnstoffe, Verfahren zu ihrer Herstellung und deren Verwendung
AU528362B2 (en) * 1978-06-22 1983-04-28 Societe D:Etudes De Produits Chimiques Phenoxy isobutyramides
DE3211934A1 (de) * 1982-03-31 1983-10-13 Hoechst Ag, 6230 Frankfurt Salicylsaeurederivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung
US4916163A (en) * 1985-06-04 1990-04-10 The Upjohn Company Spray-dried lactose formulation of micronized glyburide
DK0612724T3 (da) * 1993-02-23 1997-06-16 Hoechst Ag Substituerede benzensulfonylurinstoffer og -thiourinstoffer, fremgangsmåde til deres fremstilling og deres anvendelse som farmaceutika
HU226462B1 (en) * 1995-02-17 2008-12-29 Hoechst Ag Substituted benzol-sulfonyl-ureas and -thioureas, process for producing them, pharmaceutical compositions containing them, and their use
AU762832B2 (en) * 1998-09-10 2003-07-03 Sanofi-Aventis Deutschland Gmbh Use of benzenesulfonyl(thio)ureas for the treatment and prophylaxis of dysfunctions of the autonomous nervous system and use of benzenesulfonyl(thio)ureas in combination with beta-receptor blockers
DE19923086A1 (de) 1999-05-20 2000-11-23 Aventis Pharma Gmbh Cinnamoylaminoalkyl-substituierte Benzolsulfonamidderivate, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
US20010036479A1 (en) 2000-01-14 2001-11-01 Gillian Cave Glyburide composition
DE10054481A1 (de) 2000-11-03 2002-05-08 Aventis Pharma Gmbh Acylaminoalkyl-substituierte Benzolsulfonamidderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE10054482A1 (de) 2000-11-03 2002-05-08 Aventis Pharma Gmbh Heteroarylacryloylaminoalkyl-substituierte Benzolsulfonamidderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
AU2003224917A1 (en) * 2002-04-11 2003-10-27 Carbomer Diabetes imaging probes
US20060201981A1 (en) * 2003-06-30 2006-09-14 Meyer Dean E Clip support member for golf bag
WO2006071960A2 (en) * 2004-12-28 2006-07-06 Kinex Pharmaceuticals, Llc Compositions and methods of treating cell proliferation disorders
CA2611376C (en) * 2005-06-13 2013-09-10 Merck Sharp & Dohme Limited Therapeutic agents
US8883852B2 (en) 2008-10-22 2014-11-11 University of Pittburgh—Of the Commonwealth System of Higher Education Radioprotective agents
WO2012079164A1 (en) * 2010-12-16 2012-06-21 The Governing Council Of The University Of Toronto Activators of cylindrical proteases
WO2018215818A1 (en) 2017-05-24 2018-11-29 The University Of Queensland Novel compounds and uses
CN112979571B (zh) * 2021-02-24 2023-01-31 中国药科大学 一类akr1c3选择性抑制剂及其制备方法与用途
WO2022245627A1 (en) * 2021-05-17 2022-11-24 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services A facile and odor-free approach to convert sulfonyl urea derivatives to chalcogenide sulfonyl urea derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL218580A (da) * 1960-04-28
DE1185180B (de) * 1963-10-19 1965-01-14 Hoechst Ag Verfahren zur Herstellung von Benzolsulfonylharnstoffen

Also Published As

Publication number Publication date
SE334605B (da) 1971-05-03
GB1080705A (en) 1967-08-23
MC488A1 (fr) 1965-06-04
CY436A (en) 1968-03-22
NL6412137A (da) 1965-04-20
DE1185180B (de) 1965-01-14
AT278027B (de) 1970-01-26
FI44597B (da) 1971-08-31
DK119052B (da) 1970-11-09
AT261627B (de) 1968-05-10
DK120534B (da) 1971-06-14
US3507961A (en) 1970-04-21
DK119105B (da) 1970-11-16
US3426067A (en) 1969-02-04
MY6800113A (en) 1968-12-31
AT267541B (de) 1969-01-10
SE334606B (da) 1971-05-03
DK119455B (da) 1971-01-11
DE1443890B2 (de) 1973-02-01
SE334621B (da) 1971-05-03
DK120742B (da) 1971-07-12
SE334604B (da) 1971-05-03
SE334603B (da) 1971-05-03
SE334608B (da) 1971-05-03
IS765B6 (is) 1970-12-01
SE311151B (da) 1969-06-02
DE1443894A1 (de) 1969-04-24
DE1443878B2 (de) 1973-02-01
DE1443890A1 (de) 1969-02-20
DE1443878A1 (de) 1968-12-12
FR4316M (da) 1966-08-01
AT262308B (de) 1968-06-10
IT1061504B (it) 1983-04-11
FR1473834A (fr) 1967-03-24
AT262309B (de) 1968-06-10
SE334607B (da) 1971-05-03
LU47099A1 (da) 1966-04-07
DK120588B (da) 1971-06-21
BE654561A (da) 1965-04-20
ES312472A1 (es) 1967-04-01
NO118548B (da) 1970-01-12
OA01367A (fr) 1969-07-04
IL22259A (en) 1969-05-28
IS1424A7 (is) 1964-10-16
CH529115A (de) 1972-10-15

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