DK1026167T3 - Tricykliske triazolobenzazepinderivater, fremgangsmåde til fremstilling af disse samt antiallergiske midler - Google Patents
Tricykliske triazolobenzazepinderivater, fremgangsmåde til fremstilling af disse samt antiallergiske midlerInfo
- Publication number
- DK1026167T3 DK1026167T3 DK98944289T DK98944289T DK1026167T3 DK 1026167 T3 DK1026167 T3 DK 1026167T3 DK 98944289 T DK98944289 T DK 98944289T DK 98944289 T DK98944289 T DK 98944289T DK 1026167 T3 DK1026167 T3 DK 1026167T3
- Authority
- DK
- Denmark
- Prior art keywords
- antiallergic agents
- preparation
- alkyl
- chem
- alkoxy
- Prior art date
Links
- 239000000043 antiallergic agent Substances 0.000 title abstract 2
- QDEVEJYEXBFIJD-UHFFFAOYSA-N triazolo[4,5-i][1]benzazepine Chemical class C1=CC2=CC=CC=NC2=C2C1=NN=N2 QDEVEJYEXBFIJD-UHFFFAOYSA-N 0.000 title abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26461197 | 1997-09-29 | ||
| JP5206398 | 1998-03-04 | ||
| PCT/JP1998/004363 WO1999016770A1 (fr) | 1997-09-29 | 1998-09-29 | Derives de triazolobenzazepine tricyclique, leur procede de production et antiallergique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1026167T3 true DK1026167T3 (da) | 2003-05-26 |
Family
ID=26392670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98944289T DK1026167T3 (da) | 1997-09-29 | 1998-09-29 | Tricykliske triazolobenzazepinderivater, fremgangsmåde til fremstilling af disse samt antiallergiske midler |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US6372735B1 (fr) |
| EP (1) | EP1026167B1 (fr) |
| JP (1) | JP3188482B2 (fr) |
| KR (1) | KR100389140B1 (fr) |
| CN (2) | CN1312135C (fr) |
| AT (1) | ATE233764T1 (fr) |
| AU (1) | AU744636B2 (fr) |
| BR (1) | BR9814055B1 (fr) |
| CA (1) | CA2305307C (fr) |
| DE (1) | DE69811930T2 (fr) |
| DK (1) | DK1026167T3 (fr) |
| ES (1) | ES2191963T3 (fr) |
| HK (1) | HK1032782A1 (fr) |
| HU (1) | HUP0004020A3 (fr) |
| ID (1) | ID24101A (fr) |
| IL (1) | IL135303A0 (fr) |
| NO (2) | NO319542B1 (fr) |
| NZ (1) | NZ503601A (fr) |
| PL (1) | PL339544A1 (fr) |
| PT (1) | PT1026167E (fr) |
| RU (1) | RU2198885C2 (fr) |
| SK (1) | SK283869B6 (fr) |
| TR (1) | TR200000808T2 (fr) |
| TW (1) | TW510902B (fr) |
| WO (1) | WO1999016770A1 (fr) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2346858T3 (es) * | 2001-12-26 | 2010-10-21 | Meiji Seika Kaisha Ltd. | Sustancia amorfa de un derivado triciclico de triazolobenzazepina. |
| ES2283781T3 (es) * | 2002-02-01 | 2007-11-01 | Meiji Seika Kaisha, Ltd. | Procedimiento para producir un compuesto de 1,2,3-triazol. |
| RS20050002A (en) | 2002-07-09 | 2007-09-21 | Bristol Myers Squibb Company, | Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method |
| JP4579681B2 (ja) | 2002-07-09 | 2010-11-10 | ブリストル−マイヤーズ スクイブ カンパニー | 抗糖尿病薬および抗肥満薬として有用な置換ヘテロシクロ誘導体および方法 |
| EP1642900A1 (fr) * | 2003-06-19 | 2006-04-05 | Meiji Seika Kaisha Ltd. | Derive triazolobenzazepine tricyclique produit sous forme de nouvelle substance cristalline |
| WO2004113451A1 (fr) * | 2003-06-20 | 2004-12-29 | Meiji Seika Kaisha, Ltd. | Produit de coprecipitation d'une substance peu soluble et d'un polymere soluble dans l'eau, et procede de production de celui-ci |
| DE602005003951T4 (de) | 2004-05-14 | 2012-10-11 | Millennium Pharmaceuticals, Inc. | Verbindungen und verfahren zur inhibierung der mitotischen progression durch hemmung von aurorakinase |
| KR20080110760A (ko) * | 2006-03-02 | 2008-12-19 | 메이지 세이카 가부시키가이샤 | 삼환성 트리아졸로벤즈아제핀 유도체를 포함하는 알레르기성 안질환 또는 알레르기성 비질환용 예방 또는 치료제 |
| JP5588172B2 (ja) * | 2006-09-25 | 2014-09-10 | フォルシュングフェアブント ベルリン エー．ファウ． | プロリンが豊富なペプチドの構造的模倣薬およびその医薬用途 |
| CL2007003244A1 (es) | 2006-11-16 | 2008-04-04 | Millennium Pharm Inc | Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer. |
| KR101216756B1 (ko) * | 2007-12-18 | 2012-12-28 | 메이지 세이카 파루마 가부시키가이샤 | 염증성 장질환의 예방 또는 치료제 |
| US20100183601A1 (en) | 2008-12-22 | 2010-07-22 | Millennium Pharmaceuticals, Inc. | Combination of Aurora Kinase Inhibitors and Anti-CD20 Antibodies |
| JO3635B1 (ar) | 2009-05-18 | 2020-08-27 | Millennium Pharm Inc | مركبات صيدلانية صلبة وطرق لانتاجها |
| AU2010339691B2 (en) * | 2010-01-07 | 2015-04-02 | Alkermes Pharma Ireland Limited | Prodrugs of heteraromatic compounds |
| US8653064B2 (en) | 2010-02-19 | 2014-02-18 | Millennium Pharmaceuticals, Inc. | Crystalline forms of sodium 4-{[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-D][2]benzazepin-2-yl]amino}-2-methoxybenzoate |
| US20130303519A1 (en) | 2012-03-20 | 2013-11-14 | Millennium Pharmaceuticals, Inc. | Methods of treating cancer using aurora kinase inhibitors |
| JP6360881B2 (ja) | 2013-03-22 | 2018-07-18 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 触媒的ｍｔｏｒｃ１／２阻害薬及びオーロラａキナーゼの選択的阻害薬の組合せ |
| JP2018524292A (ja) | 2015-07-21 | 2018-08-30 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | オーロラキナーゼインヒビターと化学療法剤の投与 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69427023T2 (de) * | 1993-12-28 | 2001-10-31 | Meiji Seika K.K., Tokio/Tokyo | Tricyclische benzazepin-und benzothiazepin derivate |
| JP3537446B2 (ja) * | 1995-06-15 | 2004-06-14 | 明治製菓株式会社 | 三環性ベンゾアゼピン化合物 |
| KR19990087585A (ko) * | 1996-03-08 | 1999-12-27 | 돈 리사 로얄 | 신경학적 활성제로서의 아졸로벤즈아제핀 유도체 |
| US20070059533A1 (en) * | 2005-09-12 | 2007-03-15 | Burdette Steven R | Thermal reflow of glass and fused silica body |
-
1998
- 1998-09-29 TW TW087116198A patent/TW510902B/zh not_active IP Right Cessation
- 1998-09-29 US US09/509,494 patent/US6372735B1/en not_active Expired - Lifetime
- 1998-09-29 CN CNB2003101047539A patent/CN1312135C/zh not_active Expired - Fee Related
- 1998-09-29 HU HU0004020A patent/HUP0004020A3/hu unknown
- 1998-09-29 PL PL98339544A patent/PL339544A1/xx unknown
- 1998-09-29 NZ NZ503601A patent/NZ503601A/en unknown
- 1998-09-29 SK SK425-2000A patent/SK283869B6/sk unknown
- 1998-09-29 RU RU2000111517/04A patent/RU2198885C2/ru not_active IP Right Cessation
- 1998-09-29 CA CA002305307A patent/CA2305307C/fr not_active Expired - Fee Related
- 1998-09-29 PT PT98944289T patent/PT1026167E/pt unknown
- 1998-09-29 AT AT98944289T patent/ATE233764T1/de active
- 1998-09-29 TR TR2000/00808T patent/TR200000808T2/xx unknown
- 1998-09-29 BR BRPI9814055-8A patent/BR9814055B1/pt not_active IP Right Cessation
- 1998-09-29 CN CNB98810735XA patent/CN1155599C/zh not_active Expired - Fee Related
- 1998-09-29 EP EP98944289A patent/EP1026167B1/fr not_active Expired - Lifetime
- 1998-09-29 IL IL13530398A patent/IL135303A0/xx unknown
- 1998-09-29 WO PCT/JP1998/004363 patent/WO1999016770A1/fr not_active Application Discontinuation
- 1998-09-29 ES ES98944289T patent/ES2191963T3/es not_active Expired - Lifetime
- 1998-09-29 JP JP51996999A patent/JP3188482B2/ja not_active Expired - Fee Related
- 1998-09-29 DK DK98944289T patent/DK1026167T3/da active
- 1998-09-29 AU AU91869/98A patent/AU744636B2/en not_active Ceased
- 1998-09-29 KR KR10-2000-7003362A patent/KR100389140B1/ko not_active IP Right Cessation
- 1998-09-29 ID IDW20000808A patent/ID24101A/id unknown
- 1998-09-29 DE DE69811930T patent/DE69811930T2/de not_active Expired - Lifetime
-
2000
- 2000-03-23 NO NO20001500A patent/NO319542B1/no unknown
-
2001
- 2001-05-22 HK HK01103502A patent/HK1032782A1/xx not_active IP Right Cessation
-
2002
- 2002-02-13 US US10/073,326 patent/US7022860B2/en not_active Expired - Fee Related
-
2004
- 2004-09-08 NO NO20043765A patent/NO20043765L/no not_active Application Discontinuation
-
2005
- 2005-11-09 US US11/269,828 patent/US7238812B2/en not_active Expired - Fee Related
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