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DE69811930D1 - Tricyclische triazolobenzazepinderivate, verfahren zu ihrer herstellung und antiallergische mittel - Google Patents

Tricyclische triazolobenzazepinderivate, verfahren zu ihrer herstellung und antiallergische mittel

Info

Publication number
DE69811930D1
DE69811930D1 DE69811930T DE69811930T DE69811930D1 DE 69811930 D1 DE69811930 D1 DE 69811930D1 DE 69811930 T DE69811930 T DE 69811930T DE 69811930 T DE69811930 T DE 69811930T DE 69811930 D1 DE69811930 D1 DE 69811930D1
Authority
DE
Germany
Prior art keywords
production
alkyl
allergic agents
chem
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69811930T
Other languages
English (en)
Other versions
DE69811930T2 (de
Inventor
Yasuo Ohtsuka
Toshio Nishizuka
Sohjiro Shiokawa
Seiji Tsutsumi
Mami Kawaguchi
Hideo Kitagawa
Hiromi Takata
T Shishikura
T Ishikura
Kenichi Fushihara
Yumiko Okada
Sachiko Miyamoto
Maki Shiobara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meiji Seika Kaisha Ltd
Original Assignee
Meiji Seika Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Kaisha Ltd filed Critical Meiji Seika Kaisha Ltd
Application granted granted Critical
Publication of DE69811930D1 publication Critical patent/DE69811930D1/de
Publication of DE69811930T2 publication Critical patent/DE69811930T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE69811930T 1997-09-29 1998-09-29 Tricyclische triazolobenzazepinderivate, verfahren zu ihrer herstellung und antiallergische mittel Expired - Lifetime DE69811930T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP26461197 1997-09-29
JP5206398 1998-03-04
PCT/JP1998/004363 WO1999016770A1 (fr) 1997-09-29 1998-09-29 Derives de triazolobenzazepine tricyclique, leur procede de production et antiallergique

Publications (2)

Publication Number Publication Date
DE69811930D1 true DE69811930D1 (de) 2003-04-10
DE69811930T2 DE69811930T2 (de) 2003-12-18

Family

ID=26392670

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69811930T Expired - Lifetime DE69811930T2 (de) 1997-09-29 1998-09-29 Tricyclische triazolobenzazepinderivate, verfahren zu ihrer herstellung und antiallergische mittel

Country Status (25)

Country Link
US (3) US6372735B1 (de)
EP (1) EP1026167B1 (de)
JP (1) JP3188482B2 (de)
KR (1) KR100389140B1 (de)
CN (2) CN1312135C (de)
AT (1) ATE233764T1 (de)
AU (1) AU744636B2 (de)
BR (1) BR9814055B1 (de)
CA (1) CA2305307C (de)
DE (1) DE69811930T2 (de)
DK (1) DK1026167T3 (de)
ES (1) ES2191963T3 (de)
HK (1) HK1032782A1 (de)
HU (1) HUP0004020A3 (de)
ID (1) ID24101A (de)
IL (1) IL135303A0 (de)
NO (2) NO319542B1 (de)
NZ (1) NZ503601A (de)
PL (1) PL339544A1 (de)
PT (1) PT1026167E (de)
RU (1) RU2198885C2 (de)
SK (1) SK283869B6 (de)
TR (1) TR200000808T2 (de)
TW (1) TW510902B (de)
WO (1) WO1999016770A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2346858T3 (es) * 2001-12-26 2010-10-21 Meiji Seika Kaisha Ltd. Sustancia amorfa de un derivado triciclico de triazolobenzazepina.
ES2283781T3 (es) * 2002-02-01 2007-11-01 Meiji Seika Kaisha, Ltd. Procedimiento para producir un compuesto de 1,2,3-triazol.
RS20050002A (en) 2002-07-09 2007-09-21 Bristol Myers Squibb Company, Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method
JP4579681B2 (ja) 2002-07-09 2010-11-10 ブリストル−マイヤーズ スクイブ カンパニー 抗糖尿病薬および抗肥満薬として有用な置換ヘテロシクロ誘導体および方法
EP1642900A1 (de) * 2003-06-19 2006-04-05 Meiji Seika Kaisha Ltd. Als neue kristalline substanz hergestelltes tricyclisches triazolobenzazepinderivat
WO2004113451A1 (ja) * 2003-06-20 2004-12-29 Meiji Seika Kaisha, Ltd. 難溶性物質と水溶性高分子との共沈物およびその製造方法
DE602005003951T4 (de) 2004-05-14 2012-10-11 Millennium Pharmaceuticals, Inc. Verbindungen und verfahren zur inhibierung der mitotischen progression durch hemmung von aurorakinase
KR20080110760A (ko) * 2006-03-02 2008-12-19 메이지 세이카 가부시키가이샤 삼환성 트리아졸로벤즈아제핀 유도체를 포함하는 알레르기성 안질환 또는 알레르기성 비질환용 예방 또는 치료제
JP5588172B2 (ja) * 2006-09-25 2014-09-10 フォルシュングフェアブント ベルリン エー．ファウ． プロリンが豊富なペプチドの構造的模倣薬およびその医薬用途
CL2007003244A1 (es) 2006-11-16 2008-04-04 Millennium Pharm Inc Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer.
KR101216756B1 (ko) * 2007-12-18 2012-12-28 메이지 세이카 파루마 가부시키가이샤 염증성 장질환의 예방 또는 치료제
US20100183601A1 (en) 2008-12-22 2010-07-22 Millennium Pharmaceuticals, Inc. Combination of Aurora Kinase Inhibitors and Anti-CD20 Antibodies
JO3635B1 (ar) 2009-05-18 2020-08-27 Millennium Pharm Inc مركبات صيدلانية صلبة وطرق لانتاجها
AU2010339691B2 (en) * 2010-01-07 2015-04-02 Alkermes Pharma Ireland Limited Prodrugs of heteraromatic compounds
US8653064B2 (en) 2010-02-19 2014-02-18 Millennium Pharmaceuticals, Inc. Crystalline forms of sodium 4-{[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-D][2]benzazepin-2-yl]amino}-2-methoxybenzoate
US20130303519A1 (en) 2012-03-20 2013-11-14 Millennium Pharmaceuticals, Inc. Methods of treating cancer using aurora kinase inhibitors
JP6360881B2 (ja) 2013-03-22 2018-07-18 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 触媒的ｍｔｏｒｃ１／２阻害薬及びオーロラａキナーゼの選択的阻害薬の組合せ
JP2018524292A (ja) 2015-07-21 2018-08-30 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． オーロラキナーゼインヒビターと化学療法剤の投与

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69427023T2 (de) * 1993-12-28 2001-10-31 Meiji Seika K.K., Tokio/Tokyo Tricyclische benzazepin-und benzothiazepin derivate
JP3537446B2 (ja) * 1995-06-15 2004-06-14 明治製菓株式会社 三環性ベンゾアゼピン化合物
KR19990087585A (ko) * 1996-03-08 1999-12-27 돈 리사 로얄 신경학적 활성제로서의 아졸로벤즈아제핀 유도체
US20070059533A1 (en) * 2005-09-12 2007-03-15 Burdette Steven R Thermal reflow of glass and fused silica body

Also Published As

Publication number Publication date
DE69811930T2 (de) 2003-12-18
DK1026167T3 (da) 2003-05-26
TW510902B (en) 2002-11-21
IL135303A0 (en) 2001-05-20
US7022860B2 (en) 2006-04-04
CN1278262A (zh) 2000-12-27
EP1026167A1 (de) 2000-08-09
KR100389140B1 (ko) 2003-06-25
PT1026167E (pt) 2003-07-31
WO1999016770A1 (fr) 1999-04-08
NZ503601A (en) 2002-02-01
NO319542B1 (no) 2005-08-29
CA2305307C (en) 2004-11-30
KR20010030784A (ko) 2001-04-16
US20020137739A1 (en) 2002-09-26
TR200000808T2 (tr) 2000-08-21
RU2198885C2 (ru) 2003-02-20
ES2191963T3 (es) 2003-09-16
CN1312135C (zh) 2007-04-25
HUP0004020A3 (en) 2002-12-28
US6372735B1 (en) 2002-04-16
SK4252000A3 (en) 2000-10-09
NO20001500D0 (no) 2000-03-23
HK1032782A1 (en) 2002-08-30
BR9814055A (pt) 2000-09-26
ID24101A (id) 2000-07-06
EP1026167B1 (de) 2003-03-05
CN1523019A (zh) 2004-08-25
PL339544A1 (en) 2000-12-18
NO20001500L (no) 2000-05-18
CN1155599C (zh) 2004-06-30
CA2305307A1 (en) 1999-04-08
US7238812B2 (en) 2007-07-03
BR9814055B1 (pt) 2009-05-05
US20060074074A1 (en) 2006-04-06
ATE233764T1 (de) 2003-03-15
AU9186998A (en) 1999-04-23
EP1026167A4 (de) 2001-07-11
NO20043765L (no) 2000-05-18
AU744636B2 (en) 2002-02-28
SK283869B6 (sk) 2004-03-02
JP3188482B2 (ja) 2001-07-16
HUP0004020A2 (hu) 2001-09-28

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